prof. dr. F.J.M. (Frank J.M.) BroekmansFull Professor
- Reproductive Medicine & Gynecology - Medical
Frank Broekmans (1956), MD, PhD, is a gynaecologist and Professor in Reproductive Endocrinology and Surgery at the University Medical Center Utrecht, since October 2010. He is head of the Department of Reproductive Medicine and chairman of the committee for Science management of division Female and Baby. He graduated from the Faculty of Medicine at the VU Medical Center Amsterdam in 1983, became consultant OBGYN in 1990, completed a Fellowship in Reproductive Medicine at the VU Medical Center Amsterdam in 1993, and received his PhD degree in 1995.
His scientific career has been devoted to the field of female reproductive ageing. Special focus has been on the normal ovarian ageing pattern, assessment of actual and future fertility status, genetic backgrounds of the variation in the ovarian ageing process, and recently the link between vascular and ovarian ageing. At present, he is supervising 6 PhD students. Within his field of interest he obtained several grants from the Dutch Organisation for Scientific Research (ZonMW) and the Dutch College for Health Care Insurance
He has held an Associate Editorship for Human Reproduction between 2005 and 2009, he is the former chairman of the Dutch Flemish Society for Studies on Fertility, he participates in several Advisory boards, is reviewer for Gynaecological Obstetrical Investigation, Fertility Sterility, Human Reproduction, and Journal of Clinical Endocrinology and Metabolism, he was a member of the Institutional Review Board UMC Utrecht between 2012 and 2014, he was chairman of the department Board on Ethical issues in Reproductive Medicine between 2012 and 2015, he was the coordinator of the Board of the Special Interest Group Reproductive Endocrinology of the European Society of Human Reproduction and Embryology between 2015-2017, he waschairman of the pillar Reproductive Medicine of the Dutch Society of Obstetrics and Gynaecology between 2015-2018 and has published over 258 peer-reviewed scientific papers, contributed 31 book chapters and presented over 137 invited lectures at international meetings.
1993-1995 Member Committee Lecture Meetings Vrije Universiteit Medical Center Amsterdam/Medical Center Amsterdam
1998-2001 Member Committee on Professional Interest Dutch Society for Obstetrics & Gynecology
1998-2008 Secretary Resident ObGyn Education Cluster Utrecht
2000-2003 Member Committee Lecture Meetings University Medical Center Utrecht
2000-2003 Acting Member Stafconvent University Medical Center Utrecht
2001-2003 Editor Magazine "Fertiliteit in de Praktijk" Serono Benelux
2004-today Reviewer Gynecological Obstetrical Investigation
2004-today Reviewer Fertility Sterility
2005-2006 Board Member Dutch Flemish Society for Studies on Fertility
2005-2009 Associate Editor Human Reproduction
2006-2014 Chairman Dutch Flemish Society for Studies on Fertility
2009-today Reviewer Human Reproduction
2009-today Co-Chairman Reproductive Medicine Research Consortium of the Dutch Society for Reproductive Medicine
2009-2014 Editor Compact Gynaecologie
2010-2015 Member Special Interest Group Reproductive Endocrinology ESHRE
2011-today Member advisory board Gedeon Richter
2011-today Member advisory board Merck Serono
2012-2014 Chairman implementation taskforce JCI, central protocol filing
2012-today Chairman Factor VIII Leiden group on Dutch IVF Budget adjustments
2012-2014 Member institutional reviewboard University Medical Center Utrecht KamerM
2012-2014 Chairman Committee for Science Management Division Female and Baby
2012-2015 Chairman Ethical Review Board Department Reproductive Medicine, Division Female and Baby
2015-2017 Coordinator Special Interest Group Reproductive Endocrinology ESHRE
2015-2018 Chairman pillar Reproductive Medicine, Society of Obstetrics and Gynecology
2017-today Member advisory board Ferring
Fellowship and Awards
Ongoing Research Support
Grants from Dutch Foundation for Scientific Research ZonMw
UMCU 2015 – 2018 Does endometrial scratching in women with implantation failure after a first IVF/ICSI cycle lead to lower costs due to a reduction in the number of subsequent IVF/ICSI cycles needed to achieve a live birth? – the SCRaTCH 1 study 440.000 euro
UMCU 2018 – 2021 Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault >30%)? – the SCRaTCH-OFO study 349.732 euro
UMCU 2018 – 2020 The Development, ValIdatioN and implEmentation of a simple, online FSH dose calculator for IVF treatment” (the DiVINE study) 97.000 euro
Grants from Merck B.V.
UMCU 2018 – 20.. Merck funding for ENORM biobanking and endometrial organoid development 40.000 euro
UMCU 2018 – 20.. Merck funding for Endometrial Biopsy Studies within the SCRaTCH study (SCRaTCH-2)250.000 euro
UMCU 2018 – 20.. Merck research grant for “Vascular and Ovarian ageing in the AMH Knock Out mouse 21.000 euro
UMCU 2018-2019 Merck research grant for PhD student Jori Leijdekkers 20.000 euro
Completed Research Support
Grants from UMC Reproductive Research fund
UMCU 1995 – 2005 project “Female Reproductive Ageing” 1.200.000 euro
UMCU 2004 – 2010 project “Embryonal development, implantation and early pregnancy” 210.000 euro
UMCU / VUB 2007 – 2010 project “Comparative, controlled trial of treatment of minor uterine cavity abnormalities diagnosed by office hysteroscopy screening in women indicated for IVF” 60.000 euro
UMCU 2007 - 2010 IMPORT: Individual Patient data for Ovarian Reserve Testing analysis 120.000 euro
UMCU 2005 - 2011 project “Long term health in WHO II patients” 360.000 euro
UMCU 2009 - 2012 CETRO TRIAL: Identifying the optimal GnRH antagonist treatment protocol 450.000 euro
UMCU 2008 - 2013 project “Genetic markers of menopausal age ”260.000 euro
Grant from Dutch College for Health Care Insurance
UMCU/AMC 2009 - 2010: project “Cost Effectiveness of IVF treatment in relation to female age and ovarian reserve tests" 109.000 euro
Grants from Dutch Foundation for Scientific Research
UMCU/EMC 2002 – 2005: Alternative approaches in IVF. 450.000 euro
UMCU 2011 - 2015: Optimisation of cost effectiveness through Individualised FSH Stimulation dosages for IVF Treatment - The OPTIMIST trial. 480.000 euro
UMCU 2011 - 2015: SIGnificance of routine Hysteroscopy prior to a first IVF Treatment cycle The INSIGHT trial. 493.000 euro
Research Output (352)
Ovarian Stimulation The Eshre Guideline Group On, Bosch Ernesto, Broer Simone, Griesinger Georg, Grynberg Michael, Humaidan Peter, Kolibianakis Estratios, Kunicki Michal, La Marca Antonio, Lainas George, Le Clef Nathalie, Massin Nathalie, Mastenbroek Sebastiaan, Polyzos Nikolaos, Sunkara Sesh Kamal, Timeva Tanya, Töyli Mira, Urbancsek Janos, Vermeulen Nathalie, Broekmans Frank 2020, In: Human Reproduction Open. 2020 13 p.
Individualized ovarian stimulation in IVF/ICSI treatment:it is time to stop using high FSH doses in predicted low responders
Leijdekkers Jori A, Torrance Helen L, Schouten Nienke E, van Tilborg Theodora C, Oudshoorn Simone C, Mol Ben Willem J, Eijkemans Marinus J C, Broekmans Frank J M 15 dec 2019, In: Human Reproduction. 35 , p. 1954-1963 10 p.
Leijdekkers Jori A, Torrance Helen L, Broekmans Frank Jm 22 nov 2019, In: Human Reproduction. 34 , p. 2557-2558 2 p.
Can Menopause Prediction Be Improved with Multiple AMH Measurements? Results from the Prospective Doetinchem Cohort Study
De Kat Annelien C., Van Der Schouw Yvonne T., Eijkemans Marinus J.C., Broer Simone L., Verschuren W. M.Monique, Broekmans Frank J.M. 1 nov 2019, In: Journal of Clinical Endocrinology and Metabolism. 104 , p. 5024-5031 8 p.
Corrigendum. The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study (vol 33, pg 2002-2009, 2018, 33)
Koedooder R., Singer M., Schoenmakers S., Savelkoul P. H.M., Morré S. A., De Jonge J. D., Poort L., Cuypers W. J.S.S., Beckers N. G.M., Broekmans F. J.M., Cohlen B. J., Den Hartog J. E., Fleischer K., Lambalk C. B., Smeenk J. M.J.S., Budding A. E., Laven J. S.E. 2 okt 2019, In: Human Reproduction. 34 , p. 2091-2092 2 p.
The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection:A prospective study
Koedooder R., Singer M., Schoenmakers S., Savelkoul P. H.M., Morré S. A., De Jonge J. D., Poort L., Cuypers W. J.S.S., Beckers N. G.M., Broekmans F. J.M., Cohlen B. J., Den Hartog J. E., Fleischer K., Lambalk C. B., Smeenk J. M.J.S., Budding A. E., Laven J. S.E. 4 jun 2019, In: Human Reproduction. 34 , p. 1042-1054 13 p.
Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis
Heijligers Malou, Peeters Andrea, van Montfoort Aafke, Nijsten Joyce, Janssen Etienne, Gunnewiek Femke Klein, de Rooy Rick, van Golde Ron, Coonen Edith, Meijer-Hoogeveen Madelon, Broekmans Frank, van der Hoeven Mark, Arens Yvonne, de Die-Smulders Christine 1 jun 2019, In: Fertility and Sterility. 111 , p. 1151-1158 8 p.
Leijdekkers Jori A, Eijkemans Marinus J C, van Tilborg Theodora C, Oudshoorn Simone C, van Golde Ron J T, Hoek Annemieke, Lambalk Cornelis B, de Bruin Jan Peter, Fleischer Kathrin, Mochtar Monique H, Kuchenbecker Walter K H, Laven Joop S E, Mol Ben Willem J, Torrance Helen L, Broekmans Frank J M, 1 jun 2019, In: Human Reproduction. 34 , p. 1030-1041 12 p.
Do female age and body weight modify the effect of individualized FSH dosing in IVF/ICSI treatment?:A secondary analysis of the OPTIMIST trial
Leijdekkers Jori A, van Tilborg Theodora C, Torrance Helen L, Oudshoorn Simone C, Brinkhuis Egbert A, Koks Carolien A M, Lambalk Cornelis B, de Bruin Jan Peter, Fleischer Kathrin, Mochtar Monique H, Kuchenbecker Walter K H, Laven Joop S E, Mol Ben Willem J, Broekmans Frank J M, Eijkemans Marinus J C, 24 mei 2019, In: Acta Obstetricia et Gynecologica Scandinavica. 98 , p. 1332-1340 9 p.
Evaluation of the Elecsys ® anti-Müllerian hormone assay for the prediction of hyper-response to controlled ovarian stimulation with a gonadotrophin-releasing hormone antagonist protocol.
Anckaert Ellen, Denk Barbara, He Ying, Torrance Helen L., Broekmans Frank, Hund Martin 1 mei 2019, In: European Journal of Obstetrics and Gynecology and Reproductive Biology. 236 , p. 133-138 6 p.