dr. L.A.A. (Lodewijk) Brosens

dr. L.A.A. (Lodewijk) Brosens

Associate Professor - medical
dr. L.A.A. (Lodewijk) Brosens
  • Department of Pathology

Research Programs




2015-present: Associate professor of pathology, gastrointestinal and endocrine pathology, UMC Utrecht.

2014-2015: Post-doctoral research fellow department of pathology Johns Hopkins Hospital, Baltimore

2013: Pathologist, gastrointestinal pathology, Academic Medical Center Amsterdam

2008-2013: Pathology residency

2008: PhD, Gastrointestinal polyposis syndromes, clinical and molecular aspects of Familial Adenomatous Polyposis en Juvenile Polyposis, Utrecht University

2006: M.D. University of Amsterdam

2004: MSc. Biomedical Science, Vrije Universiteit, Amsterdam

2003-2004: Research fellow Departments of Pathology and Gastroenterology, Johns Hopkins Hospital, Baltimore

Side Activities

Member of the scientific committee Dutch Pancreatic Cancer Group (DPCG)

Member of scientific council pancreas parel (nationwide biobank)

Member of scientific committee LWH Foundation

Member of Dutch working group on Barrett's esophagus

WHO Classification of Tumours 5Th Edition - Tumours of the Digestive System, co-author

WHO Classification of Tumours 5Th Edition - Endocrine and Neuroendocrine tumours Tumours, co-author

Associate Editor BMC Cancer

Pathologist RadboudUMC (0,2 fte) gastrointestinal and pancreatic pathology

Visiting professor of pathology, University of Verona, Italy

Associate Editor Cancer Biology & Therapy


Fellowship and Awards

2018: University of Verona Internationalization Program Stipend

2014: MLDS Career Development Grant

2013: UICC Yamagiwa-Yoshida Memorial international study grant

2013: Nijbakker-Morra Stichting Stipend

Research Output (213)

Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites

Dayton Talya L, Alcala Nicolas, Moonen Laura, den Hartigh Lisanne, Geurts Veerle, Mangiante Lise, Lap Lisa, Dost Antonella F M, Beumer Joep, Levy Sonja, van Leeuwaarde Rachel S, Hackeng Wenzel M, Samsom Kris, Voegele Catherine, Sexton-Oates Alexandra, Begthel Harry, Korving Jeroen, Hillen Lisa, Brosens Lodewijk A A, Lantuejoul Sylvie, Jaksani Sridevi, Kok Niels F M, Hartemink Koen J, Klomp Houke M, Borel Rinkes Inne H M, Dingemans Anne-Marie, Valk Gerlof D, Vriens Menno R, Buikhuisen Wieneke, van den Berg José, Tesselaar Margot, Derks Jules, Speel Ernst Jan, Foll Matthieu, Fernández-Cuesta Lynnette, Clevers Hans 11 Dec 2023, In: Cancer Cell. 41 , p. 2083-2099.e9

Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3):study protocol for a multicenter randomized controlled trial

van Dam J L, Verkolf E M M, Dekker E N, Bonsing B A, Bratlie S O, Brosens L A A, Busch O R, van Driel L M J W, van Eijck C H J, Feshtali S, Ghorbani P, de Groot D J A, de Groot J W B, Haberkorn B C M, de Hingh I H, van der Holt B, Karsten T M, van der Kolk M B, Labori K J, Liem M S L, Loosveld O J L, Molenaar I Q, Polée M B, van Santvoort H C, de Vos-Geelen J, Wumkes M L, van Tienhoven G, Homs M Y V, Besselink M G, Wilmink J W, Groot Koerkamp B, Dec 2023, In: BMC Cancer. 23 , p. 728 8 p.

The Comprehensive Complication Index versus Clavien-Dindo grading after laparoscopic and open D2-gastrectomy in the multicenter randomized LOGICA-trial

Triemstra Lianne, de Jongh Cas, Tedone Fabrizio, Brosens Lodewijk A.A., Luyer Misha D.P., Stoot Jan H.M.B., Lagarde Sjoerd M., van Hillegersberg Richard, Ruurda Jelle P., Brenkman Hylke J.F., van der Veen Arjen, Nieuwenhuijzen Grard A.P., Ponten Jeroen E.H., Tegels Juul J.W., Hulsewe Karel W.E., Wijnhoven Bas P.L., Lanschot Jan J.B., de Steur Wobbe O., Hartgrink Henk H., Kouwenhoven Ewout A., van Det Marc J., Wassenaar Eelco B., van Duijvendijk P., Draaisma Werner A., Broeders Ivo A.M.J., van der Peet Donald L., Gisbertz Suzanne S., Dec 2023, In: European Journal of Surgical Oncology. 49 , p. 1-8

Graft dilatation and Barrett's esophagus in adults after gastric pull-up and jejunal interposition for long-gap esophageal atresia

van Tuyll van Serooskerken Eleonora Sofie, Gallo Gabriele, Weusten Bas L, Westerhof Jessie, Brosens Lodewijk Aa, Zwaveling Sander, Ruiterkamp Jetske, Hulscher Jan Bf, Arets Hubertus Gm, Bittermann Arnold Jn, van der Zee David C, Tytgat Stefaan Haj, Lindeboom Maud Ya 16 Sep 2023, In: World Journal of Gastrointestinal Endoscopy. 15 , p. 553-563 11 p.

Comprehensive characterisation of acinar cystic transformation of the pancreas:a systematic review

Mattiolo Paola, Wang Huamin, Basturk Olca, Brosens Lodewijk A A, Hong Seung-Mo, Adsay Volkan, Scarpa Aldo, Luchini Claudio 29 Aug 2023, In: Journal of Clinical Pathology. 76 , p. 740-746 7 p.

Surgical quality and prospective quality control of the D2-gastrectomy for gastric cancer in the multicenter randomized LOGICA-trial

de Jongh Cas, Triemstra Lianne, van der Veen Arjen, Brosens Lodewijk Aa, Nieuwenhuijzen Grard Ap, Stoot Jan Hmb, de Steur Wobbe O, Ruurda Jelle P, van Hillegersberg Richard, 12 Aug 2023, In: European Journal of Surgical Oncology. 49 8 p.

Somatic loss of ATM is a late event in pancreatic tumorigenesis

Paranal Raymond M, Jiang Zhengdong, Hutchings Danielle, Kryklyva Valentyna, Gauthier Christian, Fujikura Kohei, Nanda Neha, Huang Bo, Skaro Michael, Wolfgang Christopher L, He Jin, Klimstra David S, Brand Randall E, Singhi Aatur D, DeMarzo Angelo, Zheng Lei, Goggins Michael, Brosens Lodewijk Aa, Hruban Ralph H, Klein Alison P, Lotan Tamara, Wood Laura D, Roberts Nicholas J 22 Jun 2023, In: Journal of Pathology. 260 , p. 455-464 10 p.

Distal Versus Total D2-Gastrectomy for Gastric Cancer:a Secondary Analysis of Surgical and Oncological Outcomes Including Quality of Life in the Multicenter Randomized LOGICA-Trial

de Jongh Cas, van der Veen Arjen, Brosens Lodewijk A A, Nieuwenhuijzen Grard A P, Stoot Jan H M B, Ruurda Jelle P, van Hillegersberg Richard, 20 Jun 2023, In: Journal of Gastrointestinal Surgery. 27 , p. 1812-1824 13 p.

Impact of network treatment in patients with resected pancreatic cancer on use and timing of chemotherapy and survival

Hopstaken Jana S, Vissers Pauline A J, Quispel Rutger, de Vos-Geelen Judith, Brosens Lodewijk A A, de Hingh Ignace H J T, van der Geest Lydia G, Besselink Marc G, van Laarhoven Kees J H M, Stommel Martijn W J 1 Jun 2023, In: BJS open. 7

Adequacy of endoscopic recognition and surveillance of gastric intestinal metaplasia and atrophic gastritis:A multicentre retrospective study in low incidence countries

Honing Judith, Keith Tan W, Dieninyte Egle, O'Donovan Maria, Brosens Lodewijk, Weusten Bas, di Pietro Massimiliano Jun 2023, In: PLoS ONE. 18

All research output

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