drs. R.M. (Rachel) Brouwer

drs. R.M. (Rachel) Brouwer

Assistant Professor
  • Psychiatry

Research Programs




Rachel Brouwer obtained her PhD in the field of mathematics under supervision of Prof. J. van den Berg, at the Center of Mathematics and Computer Science in 2005. The title of her PhD was “Percolation, forest-fires and monomer-dimers, or the hunt for self-organized criticality”.

Since april 2006, she is working in the Department of Psychiatry of the University Medical Center Utrecht, were she is senior researcher on the BrainSCALE project, a longitudinal twin study into healthy development of brain and cognition during puberty, and the genetic and environmental components that influence this development. She is involved in the twin studies of the department, and in development of post-processing of MRI data and its statistical analysis.

Research lines

BrainSCALE project; a longitudinal twin-sibling study in adolescence into brain and cognition

ENIGMA-plasticity; through the ENIGMA consortium we investigate the genetics of brain plasticity measured through longitudinal MRI

Selected publications

Rachel M Brouwer, Matthew S Panizzon, David C Glahn, Derrek P Hibar, Xue Hua, Neda Jahanshad, Lucija Abramovic, Greig I de Zubicaray, Carol E Franz, Narelle K Hansell, Ian B Hickie, Marinka M G Koenis, Nicholas G Martin, Karen A Mather, Katie L McMahon, Hugo G Schnack, Lachlan T Strike, Suzanne C Swagerman, Anbupalam Thalamuthu, Wei Wen & 9 others, 2017, Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human brain mapping DOI.

Bohlken, M. M., Brouwer, R. M., Mandl, R. C. W., Kahn, R. S. & Hulshoff Pol, H. E. (2016) Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure. Schizophrenia Bulletin. 425p. 1167-1175

Brouwer, R. M., Hedman, A. M., van Haren, N. E. M., Schnack, H. G., Brans, R. G. H., Smit, D. J., Kahn, R. S., Boomsma, D. I. & Hulshoff Pol, H. E. (2014) Heritability of brain volume change and its relation to intelligence. Neuroimage. 100p. 676-683 8 p.

van Soelen IL, Brouwer RM, van Baal GC, Schnack HG, Peper JS, Chen L, Kahn RS, Boomsma DI, Pol HE (2013): Heritability of volumetric brain changes and height in children entering puberty. Hum Brain Map Mar;34(3):713-25.


Research Output (106)

Contributing factors to advanced brain aging in depression and anxiety disorders

Han Laura K.M., Schnack Hugo G., Brouwer Rachel M., Veltman Dick J., van der Wee Nic J.A., van Tol Marie José, Aghajani Moji, Penninx Brenda W.J.H. dec 2021, In: Translational Psychiatry. 11

De‐identification procedures for magnetic resonance images and the impact on structural brain measures at different ages

Buimer Elizabeth, Schnack Hugo, Caspi Yaron, van Haren Neeltje, Milchenko Mikhail, Pas P, ADNI , Hulshoff Pol Hilleke, Brouwer Rachel 11 mei 2021, In: Human Brain Mapping. 42 , p. 3643-3655

Reliability modelling of resting-state functional connectivity

Teeuw Jalmar, Hulshoff Pol Hilleke E., Boomsma Dorret I., Brouwer Rachel M. 1 mei 2021, In: NeuroImage. 231 12 p.

Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia

Teeuw Jalmar, Ori Anil P S, Brouwer Rachel M, de Zwarte Sonja M C, Schnack Hugo G, Hulshoff Pol Hilleke E, Ophoff Roel A 17 apr 2021, In: Schizophrenia Research. 231 , p. 189-197 9 p.

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Sønderby Ida E, van der Meer Dennis, Moreau Clara, Kaufmann Tobias, Walters G Bragi, Ellegaard Maria, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Micael, Armstrong Nicola J, Bernard Manon, Blackburn Nicholas B, Blangero John, Boomsma Dorret I, Brodaty Henry, Brouwer Rachel M, Bülow Robin, Bøen Rune, Cahn Wiepke, Calhoun Vince D, Caspers Svenja, Ching Christopher R K, Cichon Sven, Ciufolini Simone, Crespo-Facorro Benedicto, Curran Joanne E, Dale Anders M, Dalvie Shareefa, Dazzan Paola, de Geus Eco J C, de Zubicaray Greig I, de Zwarte Sonja M C, Desrivieres Sylvane, Doherty Joanne L, Donohoe Gary, Draganski Bogdan, Ehrlich Stefan, Eising Else, Espeseth Thomas, Fejgin Kim, Fisher Simon E, Fladby Tormod, Frei Oleksandr, Frouin Vincent, Fukunaga Masaki, Gareau Thomas, Hillegers Manon H J, Hulshoff Pol Hilleke E, Ophoff Roel A, 22 mrt 2021, In: Translational Psychiatry. 11 16 p.

Diffusion MRI derived free-water imaging measures in patients with schizophrenia and their non-psychotic siblings

Chang Xiao, Mandl René C W, Pasternak Ofer, Brouwer Rachel M, Cahn Wiepke, Collin Guusje 2 jan 2021, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109 9 p.

Active Selection of Classification Features

Kok Thomas T., Brouwer Rachel M., Mandl Rene M., Schnack Hugo G., Krempl Georg 2021, p. 184-195 12 p.

The Speed of Development of Adolescent Brain Age Depends on Sex and Is Genetically Determined

Brouwer Rachel M, Schutte Jelle, Janssen Ronald, Boomsma Dorret I, Hulshoff Pol Hilleke E, Schnack Hugo G 19 okt 2020, In: Cerebral Cortex. 31 , p. 1296-1306 11 p.

The YOUth study:Rationale, design, and study procedures

Onland-Moret N. Charlotte, Buizer-Voskamp Jacobine E., Albers Maria E.W.A., Brouwer Rachel M., Buimer Elizabeth E.L., Hessels Roy S., de Heus Roel, Huijding Jorg, Junge Caroline M.M., Mandl René C.W., Pas Pascal, Vink Matthijs, van der Wal Juliëtte J.M., Hulshoff Pol Hilleke E., Kemner Chantal 7 okt 2020, In: Developmental Cognitive Neuroscience. 46 , p. 1-16

The YOUth cohort study:MRI protocol and test-retest reliability in adults

Buimer Elizabeth E.L., Pas Pascal, Brouwer Rachel M., Froeling Martijn, Hoogduin Hans, Leemans Alexander, Luijten Peter, van Nierop Bastiaan J., Raemaekers Mathijs, Schnack Hugo G., Teeuw Jalmar, Vink Matthijs, Visser Fredy, Hulshoff Pol Hilleke E., Mandl René C.W. okt 2020, In: Developmental Cognitive Neuroscience. 45 , p. 1-15

All research output

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