drs. R.M. (Rachel) Brouwer

drs. R.M. (Rachel) Brouwer

Assistant Professor
  • Psychiatry

Research Programs




Rachel Brouwer obtained her PhD in the field of mathematics under supervision of Prof. J. van den Berg, at the Center of Mathematics and Computer Science in 2005. The title of her PhD was “Percolation, forest-fires and monomer-dimers, or the hunt for self-organized criticality”.

Since april 2006, she is working in the Department of Psychiatry of the University Medical Center Utrecht, were she is senior researcher on the BrainSCALE project, a longitudinal twin study into healthy development of brain and cognition during puberty, and the genetic and environmental components that influence this development. She is involved in the twin studies of the department, and in development of post-processing of MRI data and its statistical analysis.

Research lines

BrainSCALE project; a longitudinal twin-sibling study in adolescence into brain and cognition

ENIGMA-plasticity; through the ENIGMA consortium we investigate the genetics of brain plasticity measured through longitudinal MRI

Selected publications

Rachel M Brouwer, Matthew S Panizzon, David C Glahn, Derrek P Hibar, Xue Hua, Neda Jahanshad, Lucija Abramovic, Greig I de Zubicaray, Carol E Franz, Narelle K Hansell, Ian B Hickie, Marinka M G Koenis, Nicholas G Martin, Karen A Mather, Katie L McMahon, Hugo G Schnack, Lachlan T Strike, Suzanne C Swagerman, Anbupalam Thalamuthu, Wei Wen & 9 others, 2017, Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human brain mapping DOI.

Bohlken, M. M., Brouwer, R. M., Mandl, R. C. W., Kahn, R. S. & Hulshoff Pol, H. E. (2016) Genetic Variation in Schizophrenia Liability is Shared With Intellectual Ability and Brain Structure. Schizophrenia Bulletin. 425p. 1167-1175

Brouwer, R. M., Hedman, A. M., van Haren, N. E. M., Schnack, H. G., Brans, R. G. H., Smit, D. J., Kahn, R. S., Boomsma, D. I. & Hulshoff Pol, H. E. (2014) Heritability of brain volume change and its relation to intelligence. Neuroimage. 100p. 676-683 8 p.

van Soelen IL, Brouwer RM, van Baal GC, Schnack HG, Peper JS, Chen L, Kahn RS, Boomsma DI, Pol HE (2013): Heritability of volumetric brain changes and height in children entering puberty. Hum Brain Map Mar;34(3):713-25.


Research Output (118)

Schizophrenia and Bipolar Polygenic Risk Scores in Relation to Intracranial Volume

de Zwarte Sonja M C, Brouwer Rachel M, Kahn René S, van Haren Neeltje E M 14 Apr 2022, In: Genes. 13

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Brouwer Rachel M, Klein Marieke, Grasby Katrina L, Schnack Hugo G, Jahanshad Neda, Teeuw Jalmar, Thomopoulos Sophia I, Sprooten Emma, Franz Carol E, Gogtay Nitin, Kremen William S, Panizzon Matthew S, Olde Loohuis Loes M, Whelan Christopher D, Aghajani Moji, Alloza Clara, Alnæs Dag, Artiges Eric, Ayesa-Arriola Rosa, Barker Gareth J, Bastin Mark E, Blok Elisabet, Bøen Erlend, Breukelaar Isabella A, Bright Joanna K, Buimer Elizabeth E L, Bülow Robin, Cannon Dara M, Ciufolini Simone, Crossley Nicolas A, Damatac Christienne G, Dazzan Paola, de Mol Casper L, de Zwarte Sonja M C, Desrivières Sylvane, Díaz-Caneja Covadonga M, Janssen Joost, Koevoets Martijn G J C, Mandl René C W, Setiaman Nikita, van Haren Neeltje E M, Westeneng Henk-Jan, van Eijk Kristel R, Cahn Wiepke, Hillegers Manon, Kahn Rene S, Ophoff Roel A, van den Berg Leonard H, Veldink Jan H, Hulshoff Pol Hilleke E, Apr 2022, In: Nature Neuroscience. 25 , p. 421-432 12 p.

Multivariate Genetic Structure of Externalizing Behavior and Structural Brain Development in a Longitudinal Adolescent Twin Sample

Teeuw Jalmar, Klein Marieke, Mota Nina Roth, Brouwer Rachel M, van 't Ent Dennis, Al-Hassaan Zyneb, Franke Barbara, Boomsma Dorret I, Hulshoff Pol Hilleke E 15 Mar 2022, In: International journal of molecular sciences. 23

Adverse childhood experiences and fronto-subcortical structures in the developing brain

Buimer Elizabeth E L, Brouwer Rachel M, Mandl René C W, Pas Pascal, Schnack Hugo G, Hulshoff Pol Hilleke E 2022, In: Frontiers in Psychiatry. 13

Contributing factors to advanced brain aging in depression and anxiety disorders

Han Laura K.M., Schnack Hugo G., Brouwer Rachel M., Veltman Dick J., van der Wee Nic J.A., van Tol Marie José, Aghajani Moji, Penninx Brenda W.J.H. Dec 2021, In: Translational Psychiatry. 11 , p. 1-11

Alcohol use and brain morphology in adolescence:a longitudinal study in three different cohorts

El Marroun Hanan, Klapwijk Eduard T, Koevoets Martijn, Brouwer Rachel M, Peters Sabine, van 't Ent Dennis, Boomsma Dorret I, Muetzel Ryan, Crone Eveline A, Hulshoff Pol Hilleke E, Franken Ingmar H A 18 Aug 2021, In: European Journal of Neuroscience. 54 , p. 6012-6026 15 p.

De‐identification procedures for magnetic resonance images and the impact on structural brain measures at different ages

Buimer Elizabeth, Schnack Hugo, Caspi Yaron, van Haren Neeltje, Milchenko Mikhail, Pas P, ADNI , Hulshoff Pol Hilleke, Brouwer Rachel 11 May 2021, In: Human Brain Mapping. 42 , p. 3643-3655 13 p.

Reliability modelling of resting-state functional connectivity

Teeuw Jalmar, Hulshoff Pol Hilleke E., Boomsma Dorret I., Brouwer Rachel M. 1 May 2021, In: NeuroImage. 231 12 p.

Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia

Teeuw Jalmar, Ori Anil P S, Brouwer Rachel M, de Zwarte Sonja M C, Schnack Hugo G, Hulshoff Pol Hilleke E, Ophoff Roel A 17 Apr 2021, In: Schizophrenia Research. 231 , p. 189-197 9 p.

Active Selection of Classification Features

Kok Thomas T., Brouwer Rachel M., Mandl Rene M., Schnack Hugo G., Krempl Georg 13 Apr 2021, p. 184-195 12 p.

All research output

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