dr. P.C.J.L. (Patricia) Bruijning-Verhagen

dr. P.C.J.L. (Patricia) Bruijning-Verhagen

Associate Professor
dr. P.C.J.L. (Patricia) Bruijning-Verhagen
  • Julius Center, dept. Epidemiology & Health Economics
  • Julius Center Research Program Infectious Diseases





Dr. Bruijning is a pediatrician and epidemiologist. She studies common childhood infections, vaccination and emerging infectious diseases including COVID-19. Her research has a strong focus on Public Health and policy. She has been PI of several large scale vaccine studies, including rotavirus, influenza, pneumococcal and COVID-19 vaccines evaluating vaccine effectiveness, immunogenicity, timing and implementation. Her scientific work has been instrumental in vaccine Advisory Statements by the Dutch Health Counsel, where served as an external advisor, in clinical guidelines and in vaccine policy decisions. She holds a cross-appointment at the RIVM Center for Infectious Disease Control, where she contributed to numerous vaccine guidelines. She has a strong interest in understanding dynamics of (emerging) infectious diseases and the role of children in transmission, for which she obtained a VENI career grant in 2015 and a VIDI career grant in 2020. She is has lead three large scale population transmission studies on COVID-19 funded by ZonMw and the European Commission.  With her VIDI career grant she is studying interactions between key respiratory viruses in children, including SARS-CoV2, and their implications for vaccination policies. She has published >80 articles including peer-reviewed papers, professional guidelines, scientific reports and publications for the lay public. She has a strong international network as evidenced by her involvement in several international emerging infections research consortia funded by the Innovative Medicine Initiative and the European Commission (ZIKAction, OneHealth-PACT, RECOVER, COVID-RED, Neo-Deco, VACCELERATE). She is a member of the COVID-19 taskforce of the Dutch Pediatric Society and of the COVID-19 scientific committee of the Federation of Medical Specialists. She served as scientific advisor on COVID-19 for the Minister of Health and of Education. She coordinates and teaches MSc courses in infectious diseases epidemiology and vaccines (Utrecht University, McGill University) and vaccinology masterclasses for healthcare professionals. She communicates actively on Twitter (@P_Bruijning) about infectious diseases and vaccines.



Side Activities

Board-member of the Vaccinology Masterclass Foundaton (professional education on vaccinology)

Member of the Dutch Vaccination Alliance (Ministery of Health)

Member of COVID-19 team Dutch Pediatric Association

Member of taskforce COVID-19 antigen testing Ministery of Health



Fellowship and Awards

NWO VIDI Grant 2020

NWO VENI Grant 2015

ESPID Small Grant Award, European Society for Pediatric Infectious Diseases

Maria Raiche Graduate Student Scholarship Award, McGill University

Vaccinology Student Research Award, Health Agency Canada

Research Output (85)

The impact of variant and vaccination on SARS-CoV-2 symptomatology; three prospective household cohorts

Westerhof Ilse, de Hoog Marieke, Ieven Margareta, Lammens Christine, van Beek Janko, Rozhnova Ganna, Eggink Dirk, Euser Sjoerd, Wildenbeest Joanne, Duijts Liesbeth, van Houten Marlies, Goossens Herman, Giaquinto Carlo, Bruijning-Verhagen Patricia Mar 2023, In: International Journal of Infectious Diseases. 128 , p. 140-147 8 p.

Enhancing Public Health Communication Regarding Vaccine Trials:Design and Development of the Pan-European VACCELERATE Toolkit

Argyropoulos Christos D, Leckler Janina, Salmanton-García Jon, Constantinou Marinos, Alexandrou Alexandra, Themistocleous Sophia, Noula Evgenia, Shiamakkides George, Nearchou Andria, Stewart Fiona A, Albus Kerstin, Koniordou Markela, Kopsidas Ioannis, Spivak Orly, Hellemans Margot, Hendrickx Greet, Davis Ruth Joanna, Azzini Anna Maria, Simon Paula Valle, Carcas Antonio Javier, Askling Helena Hervius, Vene Sirkka, Prellezo Jana Baranda, Álvarez-Barco Elena, Macken Alan J, Di Marzo Romina, Luís Catarina, Olesen Ole F, Frias Iniesta Jesus A, Barta Imre, Tóth Krisztina, Akova Murat, Bonten Marc M J, Cohen-Kandli Miriam, Cox Rebecca Jane, Součková Lenka, Husa Petr, Jancoriene Ligita, Launay Odile, Lundgren Jens, Mallon Patrick, Armeftis Charis, Marques Laura, Naucler Pontus, Ochando Jordi, Tacconelli Evelina, van Damme Pierre, Zaoutis Theoklis, Hofstraat Sanne, Bruijning-Verhagen Patricia, Zeitlinger Markus, Cornely Oliver A, Pana Zoi Dorothea 28 Feb 2023, In: JMIR public health and surveillance. 9 , p. 1-8

SARS-CoV-2 outbreaks in secondary school settings in the Netherlands during fall 2020; silent circulation

Jonker Lotte, Linde Kimberly J., de Hoog Marieke L.A., Sprado Robin, Huisman Robin C., Molenkamp Richard, Oude Munnink Bas B., Dohmen Wietske, Heederik Dick J.J., Eggink Dirk, Welkers Matthijs R.A., Vennema Harry, Fraaij Pieter L.A., Koopmans Marion P.G., Wouters Inge M., Bruijning-Verhagen Patricia C.J.L. 26 Dec 2022, In: BMC Infectious Diseases. 22

Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis:a propensity score matched cohort study

van Straalen Joeri W., de Roock Sytze, Giancane Gabriella, Consolaro Alessandro, Rygg Marite, Nordal Ellen B., Rubio-Pérez Nadina, Jelusic Marija, De Inocencio Jaime, Vojinovic Jelena, Wulffraat Nico M., Bruijning-Verhagen Patricia C.J., Ruperto Nicolino, Swart Joost F., Pallotti Chiara, Scala Silvia, Angioloni Simona, Villa Luca, 14 Nov 2022, In: Pediatric rheumatology online journal. 20

Longitudinal Household Assessment of Respiratory Illness in Children and Parents During the COVID-19 Pandemic

de Hoog Marieke L.A., Sluiter-Post Judith G.C., Westerhof Ilse, Fourie Elandri, Heuvelman Valerie D., Boom Trisja T., Euser Sjoerd M., Badoux Paul, Reusken Chantal, Bont Louis J., Sanders Elisabeth A.M., Jaddoe Vincent W.V., Herpers Bjorn L., Eggink Dirk, Wildenbeest Joanne G., Duijts Liesbeth, van Houten Marlies A., Bruijning-Verhagen Patricia C.J.L. 20 Oct 2022, In: JAMA network open. 5

Randomized, Double-Blind, Placebo-Controlled Trial of a Throat Spray with Selected Lactobacilli in COVID-19 Outpatients

De Boeck Ilke, Cauwenberghs Eline, Spacova Irina, Gehrmann Thies, Eilers Tom, Delanghe Lize, Wittouck Stijn, Bron Peter A, Henkens Tim, Gamgami Imane, Simons Alix, Claes Ingmar, Mariën Joachim, Ariën Kevin K, Bakokimi Diana, Loens Katherine, Jacobs Kevin, Ieven Margareta, Bruijning-Verhagen Patricia, Delputte Peter, Coenen Samuel, Verhoeven Veronique, Lebeer Sarah 26 Sep 2022, In: Microbiology spectrum. 10

Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands:A test-negative case-control study

Niessen F A, Knol M J, Hahné S J M, , Bonten M J M, Bruijning-Verhagen P C J L 12 Aug 2022, In: Vaccine. 40 , p. 5044-5049 6 p.

Detection of Potential Arbovirus Infections and Pregnancy Complications in Pregnant Women in Jamaica Using a Smartphone App (ZIKApp):Pilot Evaluation Study

Ruiz-Burga Elisa, Bruijning-Verhagen Patricia, Palmer Paulette, Sandcroft Annalisa, Fernandes Georgina, de Hoog Marieke, Bryan Lenroy, Pierre Russell, Bailey Heather, Giaquinto Carlo, Thorne Claire, Christie Celia D C, 27 Jul 2022, In: JMIR formative research. 6

Transmission of SARS-CoV-2 within households:a remote prospective cohort study in European countries

Verberk Janneke D M, de Hoog Marieke L A, Westerhof Ilse, van Goethem Sam, Lammens Christine, Ieven Greet, de Bruin Erwin, Eggink Dirk, Bielicki Julia A, Coenen Samuel, van Beek Janko, Bonten Marc J M, Goossens Herman, Bruijning-Verhagen Patricia C J L 28 May 2022, In: European Journal of Epidemiology. 37 , p. 549-561 13 p.

Rotavirusvaccinatie voor alle jonge kinderen

Wilschut Jan C, Bruijning-Verhagen Patricia C J L, Postma Maarten J 6 Apr 2022, In: Nederlands Tijdschrift voor Geneeskunde. 166

All research output

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