prof. dr. W. (Wiepke) Cahn

prof. dr. W. (Wiepke) Cahn

Full Professor
prof. dr. W. (Wiepke) Cahn
  • Psychiatry

Research Programs




Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders and lifestyle psychiatry.

Wiepke Cahn has (co)authored more than 300 papers and book chapters and has been chief editor of the textbooks 'schizophrenia spectrum disorders' and 'lifestyle psychiatry' and is the author of 'focus on the families with psychiatric problems'. Her non-research-based activities consist of treating patients and their families with psychiatric and somatic co-morbidities.

Research Line

Physical health in psychiatric disorders and lifestyle psychiatry.

Key publications

1. de Boer N, Cahn W. Antipsychotic-induced weight gain: Is the weight over? New guidelines needed. Acta Psychiatr Scand. 2022 Sep;146(3):185-189

2. Burin LM, Hahn MK, da Rocha NS, van Amelsvoort T, Bartels-Velthuis AA, Bruggeman R, de Haan L, Schirmbeck F, Simons CJP, van Os J, Cahn W. Long-term treatment of antipsychotics and combined therapy with other psychotropic medications inducing weight gain in patients with non-affective psychotic disorder: Evidence from GROUP, a longitudinal study. Psychiatry Res. 2022 Aug;314:114680. 

3. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.

4. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.

5. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.


Side Activities

GGz Breburg Supervisory Board

Full Professor, Altrecht Science

Chair Social Run Foundation 

Committee Member of the national psychosis guidelines

Mind Ypsilon Advisory Board

Fellowship and Awards

  • Move2 (MUVA) project 
  • Tactic project 
  • Lifestyle - A multi-modal lifestyle intervention program in routine clinical care for children with mental disorders.
  • MELIA project   
  • Psychosis Prognosis Predictor 
  • Genetic Risk and Outcome of Psychosis (GROUP project) Collaboration between AMC, UMCG en Universiteit van Maastricht and various psychiatric institutions in the Netherlands
  • Topfit project – i.s.m. met sportgeneeskunde
  • GRUMPY or Depressed – i.s.m. de sociale faculteit UU

Research Output (334)

Antipsychotic-induced weight gain:Is the weight over? New guidelines needed

de Boer Nini, Cahn Wiepke Sep 2022, In: Acta Psychiatrica Scandinavica. 146 , p. 185-189 5 p.

Long-term treatment of antipsychotics and combined therapy with other psychotropic medications inducing weight gain in patients with non-affective psychotic disorder:Evidence from GROUP, a longitudinal study

Burin Luisa M., Hahn Margaret K., da Rocha Neusa S., van Amelsvoort Therese, Bartels-Velthuis Agna A., Bruggeman Richard, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Cahn Wiepke Aug 2022, In: Psychiatry Research. 314

Cardiorespiratory fitness and self-reported physical activity levels of referring mental healthcare professionals, and their attitudes and referral practices related to exercise and physical health

Deenik Jeroen, Koomen Lisanne E M, Scheewe Thomas W, van Deursen Frank P, Cahn Wiepke 21 Jul 2022, In: Journal of Psychiatric Research. 154 , p. 19-27 9 p.

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Trubetskoy Vassily, Pardiñas Antonio F, Qi Ting, Panagiotaropoulou Georgia, Awasthi Swapnil, Bigdeli Tim B, Bryois Julien, Chen Chia-Yen, Dennison Charlotte A, Hall Lynsey S, Lam Max, Watanabe Kyoko, Frei Oleksandr, Ge Tian, Harwood Janet C, Koopmans Frank, Magnusson Sigurdur, Richards Alexander L, Sidorenko Julia, Wu Yang, Zeng Jian, Grove Jakob, Kim Minsoo, Li Zhiqiang, Voloudakis Georgios, Zhang Wen, Adams Mark, Agartz Ingrid, Atkinson Elizabeth G, Agerbo Esben, Al Eissa Mariam, Albus Margot, Alexander Madeline, Alizadeh Behrooz Z, Alptekin Köksal, Als Thomas D, Amin Farooq, Arolt Volker, Arrojo Manuel, Athanasiu Lavinia, Azevedo Maria Helena, Bacanu Silviu A, Bass Nicholas J, Cahn Wiepke, Gülöksüz Sinan, Rutten Bart P F, Kahn René S, Ophoff Roel A, van Os Jim, Weinberger Daniel R, 8 Apr 2022, In: Nature. 604 , p. 502-508 7 p.

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Brouwer Rachel M, Klein Marieke, Grasby Katrina L, Schnack Hugo G, Jahanshad Neda, Teeuw Jalmar, Thomopoulos Sophia I, Sprooten Emma, Franz Carol E, Gogtay Nitin, Kremen William S, Panizzon Matthew S, Olde Loohuis Loes M, Whelan Christopher D, Aghajani Moji, Alloza Clara, Alnæs Dag, Artiges Eric, Ayesa-Arriola Rosa, Barker Gareth J, Bastin Mark E, Blok Elisabet, Bøen Erlend, Breukelaar Isabella A, Bright Joanna K, Buimer Elizabeth E L, Bülow Robin, Cannon Dara M, Ciufolini Simone, Crossley Nicolas A, Damatac Christienne G, Dazzan Paola, de Mol Casper L, de Zwarte Sonja M C, Desrivières Sylvane, Díaz-Caneja Covadonga M, Janssen Joost, Koevoets Martijn G J C, Mandl René C W, Setiaman Nikita, van Haren Neeltje E M, Westeneng Henk-Jan, van Eijk Kristel R, Cahn Wiepke, Hillegers Manon, Kahn Rene S, Ophoff Roel A, van den Berg Leonard H, Veldink Jan H, Hulshoff Pol Hilleke E, Apr 2022, In: Nature Neuroscience. 25 , p. 421-432 12 p.

Effectiveness and implementation of a multidisciplinary lifestyle focused approach in the treatment of inpatients with mental illness (MULTI +):a stepped wedge study protocol

den Bleijker N M, van Schothorst M M E, Hendriksen I J M, Cahn W, de Vries N K, van Harten P N, Deenik J 31 Mar 2022, In: BMC Psychiatry. 22 , p. 1-11

Longitudinal Allometry of Sulcal Morphology in Health and Schizophrenia

Janssen Joost, Alloza Clara, Díaz-Caneja Covadonga M, Santonja Javier, Pina-Camacho Laura, Gordaliza Pedro M, Fernández-Pena Alberto, Lois Noemi González, Buimer Elizabeth E L, van Haren Neeltje E M, Cahn Wiepke, Vieta Eduard, Castro-Fornieles Josefina, Bernardo Miquel, Arango Celso, Kahn René S, Hulshoff Pol Hilleke E, Schnack Hugo G 22 Mar 2022, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 , p. 3704-3715 12 p.

Modular-Level Functional Connectome Alterations in Individuals With Hallucinations Across the Psychosis Continuum

Schutte Maya J L, Voppel Alban, Collin Guusje, Abramovic Lucija, Boks Marco P M, Cahn Wiepke, van Haren Neeltje E M, Hugdahl Kenneth, Koops Sanne, Mandl René C W, Sommer Iris E C 18 Feb 2022, In: Schizophrenia bulletin. 48 , p. 684-694 11 p.

Validation and recalibration of OxMIV in predicting violent behaviour in patients with schizophrenia spectrum disorders

Lamsma Jelle, Yu Rongqin, Fazel Seena, van Amelsvoort Therese, Bartels-Velthuis Agna, Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia, 10 Jan 2022, In: Scientific Reports. 12 , p. 1-7

The efficacy of antipsychotics in the treatment of physical aggressive behavior in patients with dementia in nursing homes

Nawzad Sina, Cahn Wiepke, Abdullah-Koolmees Heshu 1 Jan 2022, In: Therapeutic advances in psychopharmacology. 12 , p. 1-5

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet