prof. dr. W. (Wiepke) Cahn

prof. dr. W. (Wiepke) Cahn

Full Professor
prof. dr. W. (Wiepke) Cahn
  • Psychiatry

Research Programs




Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders and lifestyle psychiatry.

Wiepke Cahn has (co)authored more than 300 papers and book chapters and has been chief editor of the textbooks 'schizophrenia spectrum disorders' and 'lifestyle psychiatry' and is the author of 'focus on the families with psychiatric problems'. Her non-research-based activities consist of treating patients and their families with psychiatric and somatic co-morbidities.

Research Line

Physical health in psychiatric disorders and lifestyle psychiatry.

Key publications

1. de Boer N, Cahn W. Antipsychotic-induced weight gain: Is the weight over? New guidelines needed. Acta Psychiatr Scand. 2022 Sep;146(3):185-189

2. Burin LM, Hahn MK, da Rocha NS, van Amelsvoort T, Bartels-Velthuis AA, Bruggeman R, de Haan L, Schirmbeck F, Simons CJP, van Os J, Cahn W. Long-term treatment of antipsychotics and combined therapy with other psychotropic medications inducing weight gain in patients with non-affective psychotic disorder: Evidence from GROUP, a longitudinal study. Psychiatry Res. 2022 Aug;314:114680. 

3. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.

4. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.

5. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.


Side Activities

GGz Breburg Supervisory Board

Full Professor, Altrecht Science

Chair Social Run Foundation 

Committee Member of the national psychosis guidelines

Mind Ypsilon Advisory Board

Fellowship and Awards

  • Move2 (MUVA) project 
  • Tactic project 
  • Lifestyle - A multi-modal lifestyle intervention program in routine clinical care for children with mental disorders.
  • MELIA project   
  • Psychosis Prognosis Predictor 
  • Genetic Risk and Outcome of Psychosis (GROUP project) Collaboration between AMC, UMCG en Universiteit van Maastricht and various psychiatric institutions in the Netherlands
  • Topfit project – i.s.m. met sportgeneeskunde
  • GRUMPY or Depressed – i.s.m. de sociale faculteit UU

Research Output (340)

Effect of stressful life events on subclinical psychotic symptoms in first-degree relatives and healthy controls

Lachowicz Aleksandra M., Vaessen Thomas, van Aubel Evelyne, Butjosa Anna, Reininghaus Ulrich, Myin-Germeys Inez, van Amelsvoort Therese, Bartels-Velthuis Agna A., Bruggeman Richard, Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Dec 2022, In: Schizophrenia Research. 250 , p. 92-99 8 p.

Muva physical activity intervention to improve social functioning in people with a severe mental illness:study protocol of a pragmatic stepped wedge cluster randomized trial

Koomen Lisanne Elisabeth Maria, van de Meent Ilona Hendrika Theodora, Deenik Jeroen, van Dellen Edwin, Schnack Hugo Gerard, van Werkhoven Henri, Swildens Wilma Elisabeth, van Meijel Berno, Staal Wouter, Jörg Frederike, Scheepers Floortje, Cahn Wiepke 11 Nov 2022, In: BMC Psychiatry. 22

Lifestyle interventions for people with a severe mental illness living in supported housing:A systematic review and meta-analysis

Koomen Lisanne E.M., van der Horst Marte Z., Deenik Jeroen, Cahn Wiepke 28 Oct 2022, In: Frontiers in Psychiatry. 13

Medicamenteuze interventies bij antipsychotica-geïnduceerde gewichtstoename:Een update

de Boer Nini, Wilting I, Cahn Wiepke, Luykx JJ 1 Sep 2022, In: Psyfar. 2022 3 p.

Antipsychotic-induced weight gain:Is the weight over? New guidelines needed

de Boer Nini, Cahn Wiepke Sep 2022, In: Acta Psychiatrica Scandinavica. 146 , p. 185-189 5 p.

Long-term treatment of antipsychotics and combined therapy with other psychotropic medications inducing weight gain in patients with non-affective psychotic disorder:Evidence from GROUP, a longitudinal study

Burin Luisa M., Hahn Margaret K., da Rocha Neusa S., van Amelsvoort Therese, Bartels-Velthuis Agna A., Bruggeman Richard, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Cahn Wiepke Aug 2022, In: Psychiatry Research. 314

Cardiorespiratory fitness and self-reported physical activity levels of referring mental healthcare professionals, and their attitudes and referral practices related to exercise and physical health

Deenik Jeroen, Koomen Lisanne E M, Scheewe Thomas W, van Deursen Frank P, Cahn Wiepke 21 Jul 2022, In: Journal of Psychiatric Research. 154 , p. 19-27 9 p.

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Trubetskoy Vassily, Pardiñas Antonio F, Qi Ting, Panagiotaropoulou Georgia, Awasthi Swapnil, Bigdeli Tim B, Bryois Julien, Chen Chia-Yen, Dennison Charlotte A, Hall Lynsey S, Lam Max, Watanabe Kyoko, Frei Oleksandr, Ge Tian, Harwood Janet C, Koopmans Frank, Magnusson Sigurdur, Richards Alexander L, Sidorenko Julia, Wu Yang, Zeng Jian, Grove Jakob, Kim Minsoo, Li Zhiqiang, Voloudakis Georgios, Zhang Wen, Adams Mark, Agartz Ingrid, Atkinson Elizabeth G, Agerbo Esben, Al Eissa Mariam, Albus Margot, Alexander Madeline, Alizadeh Behrooz Z, Alptekin Köksal, Als Thomas D, Amin Farooq, Arolt Volker, Arrojo Manuel, Athanasiu Lavinia, Azevedo Maria Helena, Bacanu Silviu A, Bass Nicholas J, Cahn Wiepke, Gülöksüz Sinan, Rutten Bart P F, Kahn René S, Ophoff Roel A, van Os Jim, Weinberger Daniel R, 8 Apr 2022, In: Nature. 604 , p. 502-508 7 p.

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Brouwer Rachel M, Klein Marieke, Grasby Katrina L, Schnack Hugo G, Jahanshad Neda, Teeuw Jalmar, Thomopoulos Sophia I, Sprooten Emma, Franz Carol E, Gogtay Nitin, Kremen William S, Panizzon Matthew S, Olde Loohuis Loes M, Whelan Christopher D, Aghajani Moji, Alloza Clara, Alnæs Dag, Artiges Eric, Ayesa-Arriola Rosa, Barker Gareth J, Bastin Mark E, Blok Elisabet, Bøen Erlend, Breukelaar Isabella A, Bright Joanna K, Buimer Elizabeth E L, Bülow Robin, Cannon Dara M, Ciufolini Simone, Crossley Nicolas A, Damatac Christienne G, Dazzan Paola, de Mol Casper L, de Zwarte Sonja M C, Desrivières Sylvane, Díaz-Caneja Covadonga M, Janssen Joost, Koevoets Martijn G J C, Mandl René C W, Setiaman Nikita, van Haren Neeltje E M, Westeneng Henk-Jan, van Eijk Kristel R, Cahn Wiepke, Hillegers Manon, Kahn Rene S, Ophoff Roel A, van den Berg Leonard H, Veldink Jan H, Hulshoff Pol Hilleke E, Apr 2022, In: Nature Neuroscience. 25 , p. 421-432 12 p.

Effectiveness and implementation of a multidisciplinary lifestyle focused approach in the treatment of inpatients with mental illness (MULTI +):a stepped wedge study protocol

den Bleijker N M, van Schothorst M M E, Hendriksen I J M, Cahn W, de Vries N K, van Harten P N, Deenik J 31 Mar 2022, In: BMC Psychiatry. 22 , p. 1-11

All research output

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