prof. dr. W. (Wiepke) Cahn

Full Professor
prof. dr. W. (Wiepke) Cahn
  • Psychiatry

Research Programs




Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders and lifestyle psychiatry.

Wiepke Cahn has (co)authored more than 300 papers and book chapters and has been chief editor of ‘handboek schizofrenie spectrum stoornissen’ and author of 'focus op familie'. Her non-research-based activities consist of treating patients and their families with psychotic and affective disorders.

Research Line

Physical health in psychiatric disorders and lifestyle psychiatry.

Most recent key publications

  1. Liemburg EJ, Bruins J, van Beveren N, Islam MA, Alizadeh BZ; GROUP investigators. Cannabis and a lower BMI in psychosis: What is the role of AKT1? Schizophr Res. 2016 Oct;176(2-3):95-9.
  2. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.
  3. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.
  4. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.
  5. Cahn W, Ramlal D, Bruggeman R, de Haan L, Scheepers FE, van Soest MM, Assies J, Slooff CJ. [Prevention and treatment of somatic complications arising from the use of antipsychotics]. Tijdschr Psychiatr. 2008;50(9):579-91.


Side Activities

GGz Breburg Supervisory Board

Full Professor, Altrecht Science

Fellowship and Awards

  • Move2 project - 
  • Tactic project -
  • Lifestyle - A multi-modal lifestyle intervention program in routine clinical care for children with mental disorders.
  • Focus
  • Melia project -  
  • Psychosis Prognosis Predictor 
  • Genetic Risk and Outcome of Psychosis (GROUP project) Collaboration between AMC, UMCG en Universiteit van Maastricht and various psychiatric institutions in the Netherlands
  • Topfit project – i.s.m. met sportgeneeskunde
  • GRUMPY or Depressed – i.s.m. de sociale faculteit UU
  • Adding in- and outpatient parmacotherapeutic treatment information – i.s.m. de faculteit farmaceutische wetenschappen
  • International panel study on the appropriate pharmacological management of early schizophrenia – RAND/UCLA study

Research Output (294)

A comparison of depressive symptom profiles between current major depressive disorder and schizophrenia spectrum disorder

Lange Sjors M M, Schirmbeck Frederike, Stek Max L, Murk Jansen Yentl R, van Rooijen Geeske, de Haan Lieuwe, Penninx Brenda W J H, Rhebergen Didi, , Cahn Wiepke, van Os Jim, Kahn René 16 jan 2021, In: Journal of Psychiatric Research. 135 , p. 143-151 9 p.

Functional connectome differences in individuals with hallucinations across the psychosis continuum

Schutte Maya J L, Bohlken Marc M, Collin Guusje, Abramovic Lucija, Boks Marco P M, Cahn Wiepke, Dauwan Meenakshi, van Dellen Edwin, van Haren Neeltje E M, Hugdahl Kenneth, Koops Sanne, Mandl René C W, Sommer Iris E C 13 jan 2021, In: Scientific Reports. 11 , p. 1108

Study protocol of a randomized, double-blind, placebo-controlled, multi-center trial to treat antipsychotic-induced weight gain:the Metformin-Lifestyle in antipsychotic users (MELIA) trial

de Boer Nini, Guloksuz Sinan, van Baal Caroline, Willebrands Leonie, Deenik Jeroen, Vinkers Christiaan H, Rossum Inge Winter-van, Zinkstok Janneke, Wilting Ingeborg, Zantvoord Jasper B, Backx Frank, Swildens Wilma E, Schouw Marieke, Bogers Jan, Hulshof Folkwin, de Knijff Rudolf, Duindam Peter, Veereschild Mike, Bak Maarten, Frederix Geert, de Haan Lieuwe, van Os Jim, Cahn Wiepke, Luykx Jurjen J 5 jan 2021, In: BMC Psychiatry. 21 , p. 4

Neutrophil fluorescence in clozapine users is attributable to a 14kDa secretable protein

de With Sera A.J., Man Wai H., Maas Coen, Ten Berg Maarten, Cahn Wiepke, Koekman Arnold C., van Solinge Wouter W., Tak Tamar 1 okt 2020, In: Pharmacology research & perspectives. 8 , p. 1-8

Dissimilarity in Sulcal Width Patterns in the Cortex can be Used to Identify Patients With Schizophrenia With Extreme Deficits in Cognitive Performance

Janssen Joost, Díaz-Caneja Covadonga M, Alloza Clara, Schippers Anouck, de Hoyos Lucía, Santonja Javier, Gordaliza Pedro M, Buimer Elizabeth E L, van Haren Neeltje E M, Cahn Wiepke, Arango Celso, Kahn René S, Hulshoff Pol Hilleke E, Schnack Hugo G 23 sep 2020, In: Schizophrenia bulletin. 47 , p. 552-561 10 p.

Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis

van Dellen Edwin, Börner Corinna, Schutte Maya, van Montfort Simone, Abramovic Lucija, Boks Marco P., Cahn Wiepke, van Haren Neeltje, Mandl René, Stam Cornelis J., Sommer Iris 2 sep 2020, In: npj Schizophrenia. 6

Neuroharmony:A new tool for harmonizing volumetric MRI data from unseen scanners

Garcia-Dias Rafael, Scarpazza Cristina, Baecker Lea, Vieira Sandra, Pinaya Walter H L, Corvin Aiden, Redolfi Alberto, Nelson Barnaby, Crespo-Facorro Benedicto, McDonald Colm, Tordesillas-Gutiérrez Diana, Cannon Dara, Mothersill David, Hernaus Dennis, Morris Derek, Setien-Suero Esther, Donohoe Gary, Frisoni Giovanni, Tronchin Giulia, Sato João, Marcelis Machteld, Kempton Matthew, van Haren Neeltje E M, Gruber Oliver, McGorry Patrick, Amminger Paul, McGuire Philip, Gong Qiyong, Kahn René S, Ayesa-Arriola Rosa, van Amelsvoort Therese, Ortiz-García de la Foz Victor, Calhoun Vince, Cahn Wiepke, Mechelli Andrea 4 jul 2020, In: NeuroImage. 220

Bariatric surgery in patients with psychiatric comorbidity:Significant weight loss and improvement of physical quality of life

Vermeer Karlijn J, Monpellier Valerie M, Cahn Wiepke, Janssen Ignace M C 18 mei 2020, In: Clinical obesity. 10 , p. 1-8

Polygenic risk score for schizophrenia was not associated with glycemic level (HbA1c) in patients with non-affective psychosis:Genetic Risk and Outcome of Psychosis (GROUP) cohort study

Habtewold Tesfa Dejenie, Islam Md Atiqul, Liemburg Edith J., Bartels-Velthuis Agna A.A., van Beveren Nico J., Cahn Wiepke, de Haan Lieuwe, Delespaul Philippe, Meijer Carin J., Myin-Germeys Inez, Kahn Rene S., Schirmbeck Frederike, Simons Claudia J.P., van Amelsvoort Therese, van Haren Neeltje E., van Os Jim, van Winkel Ruud, Bruggeman Richard, Alizadeh Behrooz Z., 1 mei 2020, In: Journal of Psychosomatic Research. 132 , p. 1-8

Changes in the intracranial volume from early adulthood to the sixth decade of life:A longitudinal study

Caspi Yaron, Brouwer Rachel M, Schnack Hugo G, van de Nieuwenhuijzen Marieke E, Cahn Wiepke, Kahn René S, Niessen Wiro J, van der Lugt Aad, Pol Hilleke Hulshoff 24 apr 2020, In: NeuroImage. 220 , p. 1-16

All research output

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