prof. dr. W. (Wiepke) Cahn

prof. dr. W. (Wiepke) Cahn

Full Professor
prof. dr. W. (Wiepke) Cahn
  • Psychiatry

Research Programs




Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders and lifestyle psychiatry.

Wiepke Cahn has (co)authored more than 300 papers and book chapters and has been chief editor of ‘handboek schizofrenie spectrum stoornissen’ and author of 'focus op familie'. Her non-research-based activities consist of treating patients and their families with psychotic and affective disorders.

Research Line

Physical health in psychiatric disorders and lifestyle psychiatry.

Most recent key publications

  1. Liemburg EJ, Bruins J, van Beveren N, Islam MA, Alizadeh BZ; GROUP investigators. Cannabis and a lower BMI in psychosis: What is the role of AKT1? Schizophr Res. 2016 Oct;176(2-3):95-9.
  2. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.
  3. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.
  4. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.
  5. Cahn W, Ramlal D, Bruggeman R, de Haan L, Scheepers FE, van Soest MM, Assies J, Slooff CJ. [Prevention and treatment of somatic complications arising from the use of antipsychotics]. Tijdschr Psychiatr. 2008;50(9):579-91.


Side Activities

GGz Breburg Supervisory Board

Full Professor, Altrecht Science

Fellowship and Awards

  • Move2 project - 
  • Tactic project -
  • Lifestyle - A multi-modal lifestyle intervention program in routine clinical care for children with mental disorders.
  • Focus
  • Melia project -  
  • Psychosis Prognosis Predictor 
  • Genetic Risk and Outcome of Psychosis (GROUP project) Collaboration between AMC, UMCG en Universiteit van Maastricht and various psychiatric institutions in the Netherlands
  • Topfit project – i.s.m. met sportgeneeskunde
  • GRUMPY or Depressed – i.s.m. de sociale faculteit UU
  • Adding in- and outpatient parmacotherapeutic treatment information – i.s.m. de faculteit farmaceutische wetenschappen
  • International panel study on the appropriate pharmacological management of early schizophrenia – RAND/UCLA study

Research Output (304)

Relationship between social cognition, general cognition, and risk for suicide in individuals with a psychotic disorder

Dickhoff Justine, Opmeer Esther Marije, Heering Henriette Dorotheé, Bruggeman Richard, van Amelsvoort Therese, Bartels-Velthuis Agna A., Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Aleman André, van Tol Marie José 14 mei 2021, In: Schizophrenia Research. 231 , p. 227-236 10 p.

Author Correction: Functional connectome differences in individuals with hallucinations across the psychosis continuum

Schutte Maya J L, Bohlken Marc M, Collin Guusje, Abramovic Lucija, Boks Marco P M, Cahn Wiepke, Dauwan Meenakshi, van Dellen Edwin, van Haren Neeltje E M, Hugdahl Kenneth, Koops Sanne, Mandl René C W, Sommer Iris E C 14 apr 2021, In: Scientific Reports. 11 1 p.

Clinical, Biochemical and Genetic Variables Associated With Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders Using Second-Generation Antipsychotics:A Systematic Review

Sneller Marius H, de Boer Nini, Everaars Sophie, Schuurmans Max, Guloksuz Sinan, Cahn Wiepke, Luykx Jurjen J 29 mrt 2021, In: Frontiers in Psychiatry. 12 14 p.

Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients

Gangadin Shiral S, Cahn Wiepke, Scheewe Thomas W, Hulshoff Pol Hilleke E, Bossong Matthijs G 26 mrt 2021, In: Journal of Psychiatric Research. 138 , p. 83-88 6 p.

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Sønderby Ida E, van der Meer Dennis, Moreau Clara, Kaufmann Tobias, Walters G Bragi, Ellegaard Maria, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Micael, Armstrong Nicola J, Bernard Manon, Blackburn Nicholas B, Blangero John, Boomsma Dorret I, Brodaty Henry, Brouwer Rachel M, Bülow Robin, Bøen Rune, Cahn Wiepke, Calhoun Vince D, Caspers Svenja, Ching Christopher R K, Cichon Sven, Ciufolini Simone, Crespo-Facorro Benedicto, Curran Joanne E, Dale Anders M, Dalvie Shareefa, Dazzan Paola, de Geus Eco J C, de Zubicaray Greig I, de Zwarte Sonja M C, Desrivieres Sylvane, Doherty Joanne L, Donohoe Gary, Draganski Bogdan, Ehrlich Stefan, Eising Else, Espeseth Thomas, Fejgin Kim, Fisher Simon E, Fladby Tormod, Frei Oleksandr, Frouin Vincent, Fukunaga Masaki, Gareau Thomas, Hillegers Manon H J, Hulshoff Pol Hilleke E, Ophoff Roel A, 22 mrt 2021, In: Translational Psychiatry. 11 16 p.

A comparison of depressive symptom profiles between current major depressive disorder and schizophrenia spectrum disorder

Lange Sjors M M, Schirmbeck Frederike, Stek Max L, Murk Jansen Yentl R, van Rooijen Geeske, de Haan Lieuwe, Penninx Brenda W J H, Rhebergen Didi, , Cahn Wiepke, van Os Jim, Kahn René 16 jan 2021, In: Journal of Psychiatric Research. 135 , p. 143-151 9 p.

Functional connectome differences in individuals with hallucinations across the psychosis continuum

Schutte Maya J L, Bohlken Marc M, Collin Guusje, Abramovic Lucija, Boks Marco P M, Cahn Wiepke, Dauwan Meenakshi, van Dellen Edwin, van Haren Neeltje E M, Hugdahl Kenneth, Koops Sanne, Mandl René C W, Sommer Iris E C 13 jan 2021, In: Scientific Reports. 11 13 p.

Study protocol of a randomized, double-blind, placebo-controlled, multi-center trial to treat antipsychotic-induced weight gain:the Metformin-Lifestyle in antipsychotic users (MELIA) trial

de Boer Nini, Guloksuz Sinan, van Baal Caroline, Willebrands Leonie, Deenik Jeroen, Vinkers Christiaan H., Rossum Inge Winter van, Zinkstok Janneke, Wilting Ingeborg, Zantvoord Jasper B., Backx Frank, Swildens Wilma E., Schouw Marieke, Bogers Jan, Hulshof Folkwin, de Knijff Rudolf, Duindam Peter, Veereschild Mike, Bak Maarten, Frederix Geert, de Haan Lieuwe, van Os Jim, Cahn Wiepke, Luykx Jurjen J. 5 jan 2021, In: BMC Psychiatry. 21

Diffusion MRI derived free-water imaging measures in patients with schizophrenia and their non-psychotic siblings

Chang Xiao, Mandl René C W, Pasternak Ofer, Brouwer Rachel M, Cahn Wiepke, Collin Guusje 2 jan 2021, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109 9 p.

Leefstijl als medicijn in de psychiatrie

Deenik J, Vermeulen J M, Mocking R J T, Van Assche E, Cahn W nov 2020, In: Tijdschrift voor Psychiatrie. 62 , p. 920-922 3 p.

All research output

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