prof. dr. W. (Wiepke) Cahn

Full Professor
prof. dr. W. (Wiepke) Cahn
  • Psychiatry

Research Programs




Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders and lifestyle psychiatry.

Wiepke Cahn has (co)authored more than 300 papers and book chapters and has been chief editor of ‘handboek schizofrenie spectrum stoornissen’ and author of 'focus op familie'. Her non-research-based activities consist of treating patients and their families with psychotic and affective disorders.

Research Line

Physical health in psychiatric disorders and lifestyle psychiatry.

Most recent key publications

  1. Liemburg EJ, Bruins J, van Beveren N, Islam MA, Alizadeh BZ; GROUP investigators. Cannabis and a lower BMI in psychosis: What is the role of AKT1? Schizophr Res. 2016 Oct;176(2-3):95-9.
  2. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.
  3. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.
  4. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.
  5. Cahn W, Ramlal D, Bruggeman R, de Haan L, Scheepers FE, van Soest MM, Assies J, Slooff CJ. [Prevention and treatment of somatic complications arising from the use of antipsychotics]. Tijdschr Psychiatr. 2008;50(9):579-91.


Side Activities

  • GGz Breburg Supervisory Board

    Full Professor, Altrecht Science

Fellowship and Awards

    • Move2 project - 
    • Tactic project -
    • Lifestyle - A multi-modal lifestyle intervention program in routine clinical care for children with mental disorders.
    • Focus
    • Melia project -  
    • Psychosis Prognosis Predictor 
    • Genetic Risk and Outcome of Psychosis (GROUP project) Collaboration between AMC, UMCG en Universiteit van Maastricht and various psychiatric institutions in the Netherlands
    • Topfit project – i.s.m. met sportgeneeskunde
    • GRUMPY or Depressed – i.s.m. de sociale faculteit UU
    • Adding in- and outpatient parmacotherapeutic treatment information – i.s.m. de faculteit farmaceutische wetenschappen
    • International panel study on the appropriate pharmacological management of early schizophrenia – RAND/UCLA study

Research Output (288)

Neutrophil fluorescence in clozapine users is attributable to a 14kDa secretable protein

de With Sera A.J., Man Wai H., Maas Coen, Ten Berg Maarten, Cahn Wiepke, Koekman Arnold C., van Solinge Wouter W., Tak Tamar 1 okt 2020, In: Pharmacology research & perspectives. 8 , p. 1-8

Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis

van Dellen Edwin, Börner Corinna, Schutte Maya, van Montfort Simone, Abramovic Lucija, Boks Marco P., Cahn Wiepke, van Haren Neeltje, Mandl René, Stam Cornelis J., Sommer Iris 2 sep 2020, In: npj Schizophrenia. 6

Neuroharmony:A new tool for harmonizing volumetric MRI data from unseen scanners

Garcia-Dias Rafael, Scarpazza Cristina, Baecker Lea, Vieira Sandra, Pinaya Walter H L, Corvin Aiden, Redolfi Alberto, Nelson Barnaby, Crespo-Facorro Benedicto, McDonald Colm, Tordesillas-Gutiérrez Diana, Cannon Dara, Mothersill David, Hernaus Dennis, Morris Derek, Setien-Suero Esther, Donohoe Gary, Frisoni Giovanni, Tronchin Giulia, Sato João, Marcelis Machteld, Kempton Matthew, van Haren Neeltje E M, Gruber Oliver, McGorry Patrick, Amminger Paul, McGuire Philip, Gong Qiyong, Kahn René S, Ayesa-Arriola Rosa, van Amelsvoort Therese, Ortiz-García de la Foz Victor, Calhoun Vince, Cahn Wiepke, Mechelli Andrea 4 jul 2020, In: NeuroImage. 220

Bariatric surgery in patients with psychiatric comorbidity:Significant weight loss and improvement of physical quality of life

Vermeer Karlijn J, Monpellier Valerie M, Cahn Wiepke, Janssen Ignace M C 18 mei 2020, In: Clinical obesity. 10 , p. 1-8

Polygenic risk score for schizophrenia was not associated with glycemic level (HbA1c) in patients with non-affective psychosis:Genetic Risk and Outcome of Psychosis (GROUP) cohort study

Habtewold Tesfa Dejenie, Islam Md Atiqul, Liemburg Edith J., Bartels-Velthuis Agna A.A., van Beveren Nico J., Cahn Wiepke, de Haan Lieuwe, Delespaul Philippe, Meijer Carin J., Myin-Germeys Inez, Kahn Rene S., Schirmbeck Frederike, Simons Claudia J.P., van Amelsvoort Therese, van Haren Neeltje E., van Os Jim, van Winkel Ruud, Bruggeman Richard, Alizadeh Behrooz Z., 1 mei 2020, In: Journal of Psychosomatic Research. 132 , p. 1-8

Changes in the intracranial volume from early adulthood to the sixth decade of life:A longitudinal study

Caspi Yaron, Brouwer Rachel M, Schnack Hugo G, van de Nieuwenhuijzen Marieke E, Cahn Wiepke, Kahn René S, Niessen Wiro J, van der Lugt Aad, Pol Hilleke Hulshoff 24 apr 2020, In: NeuroImage. 220 , p. 1-16

The genetic architecture of the human cerebral cortex

Grasby Katrina L, Jahanshad Neda, Painter Jodie N, Colodro-Conde Lucía, Bralten Janita, Hibar Derrek P, Lind Penelope A, Pizzagalli Fabrizio, Ching Christopher R K, McMahon Mary Agnes B, Shatokhina Natalia, Zsembik Leo C P, Thomopoulos Sophia I, Zhu Alyssa H, Strike Lachlan T, Agartz Ingrid, Alhusaini Saud, Almeida Marcio A A, Alnæs Dag, Amlien Inge K, Andersson Micael, Ard Tyler, Armstrong Nicola J, Ashley-Koch Allison, Atkins Joshua R, Bernard Manon, Brouwer Rachel M, Buimer Elizabeth E L, Bülow Robin, Bürger Christian, Cannon Dara M, Chakravarty Mallar, Chen Qiang, Cheung Joshua W, Couvy-Duchesne Baptiste, Dale Anders M, Dalvie Shareefa, de Araujo Tânia K, de Zubicaray Greig I, de Zwarte Sonja M C, Klein Marieke, van Haren Neeltje E M, Veldink Jan H, Ayesa-Arriola Rosa, Cahn Wiepke, Hillegers Manon H J, Hulshoff Pol Hilleke E, Kahn René S, Ophoff Roel A, Sommer Iris E, 20 mrt 2020, In: Science. 367

Using machine learning to predict mental healthcare consumption in non-affective psychosis

Kwakernaak Sascha, van Mens Kasper, Cahn Wiepke, Janssen Richard, 5 mrt 2020, In: Schizophrenia Research. 218 , p. 166-172 7 p.

Cognition and violent behavior in psychotic disorders:A nationwide case-control study

Lamsma Jelle, Cahn Wiepke, Fazel Seena, mrt 2020, In: Schizophrenia Research: Cognition. 19 , p. 1-6

De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia

Rees Elliott, Han Jun, Morgan Joanne, Carrera Noa, Escott-Price Valentina, Pocklington Andrew J., Duffield Madeleine, Hall Lynsey S., Legge Sophie E., Pardiñas Antonio F., Richards Alexander L., Roth Julian, Lezheiko Tatyana, Kondratyev Nikolay, Kaleda Vasilii, Golimbet Vera, Parellada Mara, González-Peñas Javier, Arango Celso, Alizadeh Behrooz Z., van Amelsvoort Therese, Bruggeman Richard, Cahn Wiepke, de Haan Lieuwe, Luykx Jurjen J., Rutten Bart P.F., van Os Jim, van Winkel Ruud, Gawlik Micha, Kirov George, Walters James T.R., Holmans Peter, O’Donovan Michael C., Owen Michael J., 1 feb 2020, In: Nature Neuroscience. 23 , p. 179-184 6 p.

All research output