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prof. dr. J.C. (Hans) Clevers

Full Professor

  • Molecular Cancer Research
  • Hubrecht Institute

prof. dr. J.C. (Hans) Clevers

Biography

Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. From 2002-2012 he was director of the Hubrecht Institute in Utrecht and from 2012-2015 he was President of the Royal Netherlands Academy of Arts and Sciences (KNAW). His research group is part of the Hubrecht institute.

He is Chevalier de la Legion d'Honneur since 2005 and Knight in the Order of the Netherlands Lion since 2012.

Side Activities

  • Honorary professorship:

    2002 –  Honorary professor at Changsha-Hunan, China

     

    Membership:

    Member European Molecular Biology Organisation (EMBO)

    Member of the Royal Netherlands Academy of Sciences

    Member of the International Society for Stem Cell Research (ISSCR)

    Member of the Scientific Advisory Board of ISREC, Swiss Institute for Experimental Cancer Research

    Member Scientific Committee of the Louis-Jeantet Foundation for Medicine

    Member of the American Association for Cancer Research (AACR)

    Member of the National Scientific Advisory Board NKI-AVL

    Member of the scientific advisory board of “de Anatomische Les”

    Member of the Academia Europaea

    Member of the Scientific Advisory Board of the MRC Clinical Sciences Centre

    Member of the American Academy of Arts and Sciences

    Member of the The Royal Holland Society of Sciences and Humanities

    Member of the Gairdner Foundation medical advisory board

    Foreign Associate of the US National Academy of Sciences

    Member of the Scientific advisory committee (SAC) of the Princess Máxima Center for Pediatric Oncology

     

    He is member of a several Editorial Boards, among them are the EMBO Journal, Gastroenterology, Cell and Genes & Development,Cell Stem Cell and the Annual Review of Cancer Biology

Fellowship and Awards

  • 2000     Catharijne-prize for medical science

    2001     Award from the European Society for Clinical Investigation

    2001     Spinoza-award

    2004     Louis-Jeantet Prize for Medicine

    2005     The Science and Society Prize

    2005     The French honor of “Chevalier de la Legion d'Honneur”

    2005     Katharine Berkan Judd Award

    2006     Rabbi Shai Shacknai Memorial Prize for Immunology and Cancer Research

    2008     Josephine Nefkens Prize for Cancer Research (Erasmus MC, Rotterdam)

    2008     Meyenburg Cancer Research Award

    2009     The Queen Wilhelmina Dutch Cancer Society Award

    2010     The United European Gastroenterology Federation (UEGF) Research Prize

    2011     The Ernst Jung Medical Award

    2011     Kolff prize

    2012     Association pour la Recherche sur le Cancer (ARC) Léopold Griffuel Prize

    2012     William Beaumont prize of the American Gastroenterology Association

    2012     The Heineken Prize for Medicine

    2012     Ridder in de Orde van de Nederlandse Leeuw

    2013     The Breakthrough Prize in Life Sciences

    2014     Massachusetts General Hospital Award in Cancer Research

    2014     TEFAF Oncology Chair 2014

    2014     Fellow of the AACR Academy

    2014     Struyvenberg European Society for Clinical Investigation (ESCI) medal

    2014     National Icon 2014

Research Output (525)

Enteroendocrine Dynamics - New Tools Reveal Hormonal Plasticity in the Gut

Beumer Joep, Gehart Helmuth, Clevers Hans 1 okt 2020, In: Endocrine reviews. 41 12 p.

Intestinal Regeneration:Regulation by the Microenvironment

Hageman Joris H., Heinz Maria C., Kretzschmar Kai, van der Vaart Jelte, Clevers Hans, Snippert Hugo J.G. 24 aug 2020, In: Developmental Cell. 54 , p. 435-446 12 p.

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer

Whittle James R., Vaillant François, Surgenor Elliot, Policheni Antonia N., Giner Göknur, Capaldo Bianca D., Chen Huei Rong, Liu He K., Dekkers Johanna F., Sachs Norman, Clevers Hans, Fellowes Andrew, Green Thomas, Xu Huiling, Fox Stephen B., Herold Marco J., Smyth Gordon K., Gray Daniel H.D., Visvader Jane E., Lindeman Geoffrey J. 1 aug 2020, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 26 , p. 4120-4134 15 p.

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte Chris Jenske, Espejo Valle-Inclan Jose, Hami Nizar, Lõhmussaar Kadi, Kopper Oded, Vreuls Celien Philomena Henrieke, Jonges Geertruida Nellie, van Diest Paul, Nguyen Luan, Clevers Hans, Kloosterman Wigard Pieter, Cuppen Edwin, Snippert Hugo Johannes Gerhardus, Zweemer Ronald Peter, Witteveen Petronella Oda, Stelloo Ellen 16 jun 2020, In: Cell Reports. 31 8 p.

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

Lõhmussaar Kadi, Kopper Oded, Korving Jeroen, Begthel Harry, Vreuls Celien P.H., van Es Johan H., Clevers Hans 27 mei 2020, In: Nature Communications. 11

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Dijkstra Krijn K, Monkhorst Kim, Schipper Luuk J, Hartemink Koen J, Smit Egbert F, Kaing Sovann, de Groot Rosa, Wolkers Monika C, Clevers Hans, Cuppen Edwin, Voest Emile E 5 mei 2020, In: Cell Reports. 31 , p. 107588

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Dekkers Johanna F., Whittle James R., Vaillant François, Chen Huei Rong, Dawson Caleb, Liu Kevin, Geurts Maarten H., Herold Marco J., Clevers Hans, Lindeman Geoffrey J., Visvader Jane E. 1 mei 2020, In: Journal of the National Cancer Institute. 112 , p. 540-544 5 p.

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Rosenbluth Jennifer M, Schackmann Ron C J, Gray G Kenneth, Selfors Laura M, Li Carman Man-Chung, Boedicker Mackenzie, Kuiken Hendrik J, Richardson Andrea, Brock Jane, Garber Judy, Dillon Deborah, Sachs Norman, Clevers Hans, Brugge Joan S 6 apr 2020, In: Nature Communications. 11 14 p.

The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies

Busslinger Georg A, Lissendorp Fianne, Franken Ingrid A, van Hillegersberg Richard, Ruurda Jelle P, Clevers Hans, de Maat Michiel F G apr 2020, In: Open Biology. 10 6 p.

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Calandrini Camilla, Schutgens Frans, Oka Rurika, Margaritis Thanasis, Candelli Tito, Mathijsen Luka, Ammerlaan Carola, van Ineveld Ravian L., Derakhshan Sepide, de Haan Sanne, Dolman Emmy, Lijnzaad Philip, Custers Lars, Begthel Harry, Kerstens Hindrik H.D., Visser Lindy L., Rookmaaker Maarten, Verhaar Marianne, Tytgat Godelieve A.M., Kemmeren Patrick, de Krijger Ronald R., Al-Saadi Reem, Pritchard-Jones Kathy, Kool Marcel, Rios Anne C., van den Heuvel-Eibrink Marry M., Molenaar Jan J., van Boxtel Ruben, Holstege Frank C.P., Clevers Hans, Drost Jarno 11 mrt 2020, In: Nature Communications. 11

All Research Output (525)