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prof. dr. J.C. (Hans) Clevers

Full Professor

  • Molecular Cancer Research
  • Hubrecht Institute

Research Output (525)

Enteroendocrine Dynamics - New Tools Reveal Hormonal Plasticity in the Gut

Beumer Joep, Gehart Helmuth, Clevers Hans 1 okt 2020, In: Endocrine reviews. 41 12 p.

Intestinal Regeneration:Regulation by the Microenvironment

Hageman Joris H., Heinz Maria C., Kretzschmar Kai, van der Vaart Jelte, Clevers Hans, Snippert Hugo J.G. 24 aug 2020, In: Developmental Cell. 54 , p. 435-446 12 p.

Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer

Whittle James R., Vaillant François, Surgenor Elliot, Policheni Antonia N., Giner Göknur, Capaldo Bianca D., Chen Huei Rong, Liu He K., Dekkers Johanna F., Sachs Norman, Clevers Hans, Fellowes Andrew, Green Thomas, Xu Huiling, Fox Stephen B., Herold Marco J., Smyth Gordon K., Gray Daniel H.D., Visvader Jane E., Lindeman Geoffrey J. 1 aug 2020, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 26 , p. 4120-4134 15 p.

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte Chris Jenske, Espejo Valle-Inclan Jose, Hami Nizar, Lõhmussaar Kadi, Kopper Oded, Vreuls Celien Philomena Henrieke, Jonges Geertruida Nellie, van Diest Paul, Nguyen Luan, Clevers Hans, Kloosterman Wigard Pieter, Cuppen Edwin, Snippert Hugo Johannes Gerhardus, Zweemer Ronald Peter, Witteveen Petronella Oda, Stelloo Ellen 16 jun 2020, In: Cell Reports. 31 8 p.

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

Lõhmussaar Kadi, Kopper Oded, Korving Jeroen, Begthel Harry, Vreuls Celien P.H., van Es Johan H., Clevers Hans 27 mei 2020, In: Nature Communications. 11

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Dijkstra Krijn K, Monkhorst Kim, Schipper Luuk J, Hartemink Koen J, Smit Egbert F, Kaing Sovann, de Groot Rosa, Wolkers Monika C, Clevers Hans, Cuppen Edwin, Voest Emile E 5 mei 2020, In: Cell Reports. 31 , p. 107588

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Dekkers Johanna F., Whittle James R., Vaillant François, Chen Huei Rong, Dawson Caleb, Liu Kevin, Geurts Maarten H., Herold Marco J., Clevers Hans, Lindeman Geoffrey J., Visvader Jane E. 1 mei 2020, In: Journal of the National Cancer Institute. 112 , p. 540-544 5 p.

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Rosenbluth Jennifer M, Schackmann Ron C J, Gray G Kenneth, Selfors Laura M, Li Carman Man-Chung, Boedicker Mackenzie, Kuiken Hendrik J, Richardson Andrea, Brock Jane, Garber Judy, Dillon Deborah, Sachs Norman, Clevers Hans, Brugge Joan S 6 apr 2020, In: Nature Communications. 11 14 p.

The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies

Busslinger Georg A, Lissendorp Fianne, Franken Ingrid A, van Hillegersberg Richard, Ruurda Jelle P, Clevers Hans, de Maat Michiel F G apr 2020, In: Open Biology. 10 6 p.

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Calandrini Camilla, Schutgens Frans, Oka Rurika, Margaritis Thanasis, Candelli Tito, Mathijsen Luka, Ammerlaan Carola, van Ineveld Ravian L., Derakhshan Sepide, de Haan Sanne, Dolman Emmy, Lijnzaad Philip, Custers Lars, Begthel Harry, Kerstens Hindrik H.D., Visser Lindy L., Rookmaaker Maarten, Verhaar Marianne, Tytgat Godelieve A.M., Kemmeren Patrick, de Krijger Ronald R., Al-Saadi Reem, Pritchard-Jones Kathy, Kool Marcel, Rios Anne C., van den Heuvel-Eibrink Marry M., Molenaar Jan J., van Boxtel Ruben, Holstege Frank C.P., Clevers Hans, Drost Jarno 11 mrt 2020, In: Nature Communications. 11