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prof. dr. O.L. (Olaf) Cremer

prof. dr. O.L. (Olaf) Cremer

Full Professor
prof. dr. O.L. (Olaf) Cremer
  • Intensive Care Medicine

Research Programs

Infection & Immunity

Biography

Biography

Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:

1 - diagnostic uncertainty in early detection of sepsis

2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation

3 - decision support for diagnosis and treatment of sepsis

Cremer has been mentoring 18 PhD students to date.

Side Activities

Committees and advisory boards

2023 - Chair of the Science & Innovation Committee, Dutch Society of Intensive Care (NVIC)

2023 - ISAB member for the International Clinical Research Center (ICRC), St. Anne's Univeristy Hospital, Brno, Czech Republic

2023 - Advisory board member for Research and Innovation, Dutch Association of Medical Specialists (FMS) 

2021 - GlaxoSmithKline (otilimab drug development) - money paid to UMCU

2021 - Parexel (adrenomed ENCOURAGE program) - money paid to UMCU

 

Industry collaborations

2015-2019 - ImmuneXpress Inc. (Seattle, WA) – Unrestricted research grant (105K)

2021-2022 - Abionic SA (Epalinges, Switzerland) – Unrestricted research grant (60K)

2022-2024 - Prolira BV (Utrecht, Netherlands) - In kind contributions to research (50K)

2023-2026 - Presymptom Health Ltd. (Porton Down, UK) - In kind and in cash contributions to research

 

Speaker fees

2022 - Committee for European Education in Anaesthesiology

 

Memberships

ESICM

NVIC

Research Output (236)

Cohort profile of PLUTO:a perioperative biobank focusing on prediction and early diagnosis of postoperative complications

de Mul Nikki, Verlaan Diede, Ruurda Jelle P, van Grevenstein Wilhelmina M U, Hagendoorn Jeroen, de Borst Gert-Jan, Vriens Menno R, de Bree Remco, Zweemer Ronald P, Vogely Charles, Haitsma Mulier Jelle L G, Vernooij Lisette M, Reitsma Johannes B, de Zoete Marcel R, Top Janetta, Kluijtmans Jan A J, Hoefer Imo E, Noordzij Peter, Rettig Thijs, Marsman Marije, de Smet Anne Marie G A, Derde Lennie, van Waes Judith, Rijsdijk Mienke, Schellekens Willem Jan M, Bonten Marc J M, Slooter Arjen J C, Cremer Olaf L 19 Apr 2023, In: BMJ Open. 13 16 p.

Advanced glycation end products for preoperative frailty screening in older cardiac surgery patients

Smoor Rosa M, van Dongen Eric P A, Verwijmeren Lisa, Emmelot-Vonk Mariëlle H, Vernooij Lisette M, Cremer Olaf L, Noordzij Peter G 6 Apr 2023, In: Journal of the American Geriatrics Society. 71 , p. 2520-2529 10 p.

Association between age and the host response in critically ill patients with sepsis

Michels Erik H A, Butler Joe M, Reijnders Tom D Y, Cremer Olaf L, Scicluna Brendon P, Uhel Fabrice, Peters-Sengers Hessel, Schultz Marcus J, Knight Julian C, van Vught Lonneke A, van der Poll Tom, 13 Dec 2022, In: Critical care (London, England). 26

Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning

Dam Tariq A, Roggeveen Luca F, van Diggelen Fuda, Fleuren Lucas M, Jagesar Ameet R, Otten Martijn, de Vries Heder J, Gommers Diederik, Cremer Olaf L, Bosman Rob J, Rigter Sander, Wils Evert-Jan, Frenzel Tim, Dongelmans Dave A, de Jong Remko, Peters Marco A A, Kamps Marlijn J A, Ramnarain Dharmanand, Nowitzky Ralph, Nooteboom Fleur G C A, de Ruijter Wouter, Urlings-Strop Louise C, Smit Ellen G M, Mehagnoul-Schipper D Jannet, Dormans Tom, de Jager Cornelis P C, Hendriks Stefaan H A, Achterberg Sefanja, Oostdijk Evelien, Reidinga Auke C, Festen-Spanjer Barbara, Brunnekreef Gert B, Cornet Alexander D, van den Tempel Walter, Boelens Age D, Koetsier Peter, Lens Judith, Faber Harald J, Karakus A, Entjes Robert, de Jong Paul, Rettig Thijs C D, Arbous Sesmu, Vonk Sebastiaan J J, Machado Tomas, Herter Willem E, de Grooth Harm-Jan, Thoral Patrick J, Girbes Armand R J, Hoogendoorn Mark, 20 Oct 2022, In: Annals of Intensive Care. 12

Comparative clinical manifestations and immune effects of cytomegalovirus infections following distinct types of immunosuppression

Ong David S Y, Chong Ga-Lai M, Chemaly Roy F, Cremer Olaf L Oct 2022, In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 28 , p. 1335-1344 10 p.

Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients:A retrospective cohort study in the Netherlands comparing the value of registry data with high-granular electronic health records

Vagliano Iacopo, Schut Martijn C, Abu-Hanna Ameen, Dongelmans Dave A, de Lange Dylan W, Gommers Diederik, Cremer Olaf L, Bosman Rob J, Rigter Sander, Wils Evert-Jan, Frenzel Tim, de Jong Remko, Peters Marco A A, Kamps Marlijn J A, Ramnarain Dharmanand, Nowitzky Ralph, Nooteboom Fleur G C A, de Ruijter Wouter, Urlings-Strop Louise C, Smit Ellen G M, Mehagnoul-Schipper D Jannet, Dormans Tom, de Jager Cornelis P C, Hendriks Stefaan H A, Achterberg Sefanja, Oostdijk Evelien, Reidinga Auke C, Festen-Spanjer Barbara, Brunnekreef Gert B, Cornet Alexander D, van den Tempel Walter, Boelens Age D, Koetsier Peter, Lens Judith, Faber Harald J, Karakus A, Entjes Robert, de Jong Paul, Rettig Thijs C D, Reuland M C, Arbous Sesmu, Fleuren Lucas M, Dam Tariq A, Thoral Patrick J, Lalisang Robbert C A, Tonutti Michele, de Bruin Daan P, Elbers Paul W G, de Keizer Nicolette F, 22 Sep 2022, In: International Journal of Medical Informatics. 167

Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients:A Multicenter Retrospective Cohort Study

Exterkate Lotte, van Tienhoven Arne J, Haaksma Mark E, Heldeweg Micah L A, Fleuren Lucas, Thoral Patrick, Dam Tariq A, Heunks Leo M A, Gommers Diederik, Cremer Olaf L, Bosman Rob J, Rigter Sander, Wils Evert-Jan, Frenzel Tim, Vlaar Alexander P, Dongelmans Dave A, de Jong Remko, Peters Marco, Kamps Marlijn J A, Ramnarain Dharmanand, Nowitzky Ralph, Nooteboom Fleur G C A, de Ruijter Wouter, Urlings-Strop Louise C, Smit Ellen G M, Mehagnoul-Schipper D Jannet, Dormans Tom, de Jager Cornelis P C, Hendriks Stefaan H A, Achterberg Sefanja, Oostdijk Evelien, Reidinga Auke C, Festen-Spanjer Barbara, Brunnekreef Gert B, Cornet Alexander D, van den Tempel Walter, Boelens Age D, Koetsier Peter, Lens Judith, Faber Harald J, Karakus A, Entjes Robert, de Jong Paul, Rettig Thijs C D, Arbous Sesmu, Vonk Bas, Machado Tomas, Girbes Armand R J, Sieswerda Elske, Elbers Paul W G, Tuinman Pieter R 8 Sep 2022, In: Shock (Augusta, Ga.). 58 , p. 358-365 8 p.

Incidence of transfusion-related acute lung injury temporally associated with solvent/detergent plasma use in the ICU:A retrospective before and after implementation study

Klanderman Robert B, van Mourik Nielsvan, Eggermont Dorus, Peters Anna-Linda, Tuinman Pieter R, Bosman Rob, Endeman Henrik, Cremer Olaf L, Arbous Sesmu M, Vlaar Alexander P J Sep 2022, In: Transfusion. 62 , p. 1752-1762 11 p.

Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units:A retrospective cohort study

Noordermeer Tessa, Schutgens Roger E G, Visser Chantal, Rademaker Emma, de Maat Moniek P M, Jansen A J Gerard, Limper Maarten, Cremer Olaf L, Kruip Marieke J H A, Endeman Henrik, Maas Coen, de Laat Bas, Urbanus Rolf T, Aug 2022, In: Research and practice in thrombosis and haemostasis. 6

Donor-recipient sex is associated with transfusion-related outcomes in critically ill patients

Alshalani Abdulrahman, Uhel Fabrice, Cremer Olaf L, Schultz Marcus J, de Vooght Karen M K, van Bruggen Robin, Acker Jason P, Juffermans Nicole P 14 Jun 2022, In: Blood Advances. 6 , p. 3260-3267 8 p.

All research output

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