prof. dr. O.L. (Olaf) Cremer

Full Professor

  • DVF Medisch

prof. dr. O.L. (Olaf) Cremer

Research Programs


Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:

1 - diagnostic uncertainty in early detection of sepsis

2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation

3 - decision support for diagnosis and treatment of sepsis

Cremer has been mentoring 11 PhD students to date.

Research Output (170)

Elevated trefoil factor 3 plasma levels in critically ill patients with abdominal sepsis or non-infectious abdominal illness

Meijer Mariska T, Uhel Fabrice, Cremer Olaf L, Scicluna Brendon P, Schultz Marcus J, van der Poll Tom, 27 jun 2020, In: Cytokine. 133 5 p.

Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis:a prospective cohort study

Uhel Fabrice, Peters-Sengers Hessel, Falahi Fahimeh, Scicluna Brendon P, van Vught Lonneke A, Bonten Marc J, Cremer Olaf L, Schultz Marcus J, van der Poll Tom, 8 jun 2020, In: Intensive Care Medicine. 46 , p. 1576-1589 14 p.

Occurrence and Risk Factors of Chronic Pain After Critical Illness

Koster-Brouwer Maria E., Rijsdijk Mienke, Van Os Wouter K.M., Soliman Ivo W., Slooter Arjen J.C., De Lange Dylan W., Van Dijk Diederik, Bonten Marc J.M., Cremer Olaf L. 10 feb 2020, In: Critical Care Medicine. 48 , p. 680-687 8 p.

Correction to:Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study

Klein Klouwenberg Peter M C, Spitoni Cristian, van der Poll Tom, Bonten Marc J, Cremer Olaf L, 6 feb 2020, In: Critical care (London, England). 24

Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill

Boshuizen Margit, Binnekade Jan M, Nota Benjamin, van de Groep Kirsten, Cremer Olaf L, Horn Janneke, Schultz Marcus J, van Bruggen Robin, Juffermans Nicole P feb 2020, In: Transfusion Medicine and Hemotherapy. 47 , p. 61-67 7 p.

Preemptive Treatment of Herpes Simplex Virus Reactivation in Critically Ill Patients?-Not Based on Current Data

Ong David S Y, Cremer Olaf L, Bonten Marc J M 16 dec 2019, In: JAMA Internal Medicine. 180 , p. 272-273 2 p.

Predicting the clinical trajectory in critically ill patients with sepsis:a cohort study

Klein Klouwenberg Peter M C, Spitoni Cristian, van der Poll Tom, Bonten Marc J, Cremer Olaf L, 12 dec 2019, In: Critical care (London, England). 23

A pilot study of a novel molecular host response assay to diagnose infection in patients after high-risk gastro-intestinal surgery

Verboom Diana M, Koster-Brouwer Maria E, Ruurda Jelle P, van Hillegersberg Richard, van Berge Henegouwen Mark I, Gisbertz Suzanne S, Scicluna Brendon P, Bonten Marc J M, Cremer Olaf L dec 2019, In: Journal of Critical Care. 54 , p. 83-87 5 p.

Associations between changes in oxygenation, dead space and driving pressure induced by the first prone position session and mortality in patients with acute respiratory distress syndrome

van Meenen David M, Roozeman Jan-Paul, Serpa Neto Ary, Pelosi Paolo, Gama de Abreu Marcelo, Horn Janneke, Cremer Olaf L, Paulus Frederique, Schultz Marcus J, dec 2019, In: Journal of Thoracic Disease. 11 , p. 5004-5013 10 p.

Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS

Morales-Quinteros Luis, Schultz Marcus J, Bringué Josep, Calfee Carolyn S, Camprubí Marta, Cremer Olaf L, Horn Janneke, van der Poll Tom, Sinha Pratik, Artigas Antonio, Bos Lieuwe D, 21 nov 2019, In: Annals of Intensive Care. 9

All Research Output (170)