prof. dr. O.L. (Olaf) Cremer

Full Professor
prof. dr. O.L. (Olaf) Cremer
  • Intensive Care Medicine

Research Programs

Infection & Immunity



Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:

1 - diagnostic uncertainty in early detection of sepsis

2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation

3 - decision support for diagnosis and treatment of sepsis

Cremer has been mentoring 11 PhD students to date.

Research Output (187)

Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis

van Vught Lonneke A, Uhel Fabrice, Ding Chao, Van't Veer Cees, Scicluna Brendon P, Peters-Sengers Hessel, Klein Klouwenberg Peter M C, Nürnberg Peter, Cremer Olaf L, Schultz Marcus J, van der Poll Tom, 17 feb 2021, In: Journal of thrombosis and haemostasis : JTH. 19 , p. 1049-1063 15 p.

An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID-19 patients

Spijkerman Roy, Jorritsma Nikita Kn, Bongers Suzanne H, Bindels Bas Jj, Jukema Bernard N, Hesselink Lillian, Hietbrink Falco, Leenen Luke Ph, van Goor Harriët Mr, Vrisekoop N, Kaasjager Karin Ah, Koenderman Leo, , Cremer Olaf 22 jan 2021, In: Scandinavian Journal of Immunology. 93 8 p.

Glycoproteoform Profiles of Individual Patients' Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode

Čaval Tomislav, Lin Yu-Hsien, Varkila Meri, Reiding Karli R, Bonten Marc J M, Cremer Olaf L, Franc Vojtech, Heck Albert J R 14 jan 2021, In: Frontiers in Immunology. 11

O-serotype distribution of Escherichia coli bloodstream infection isolates in critically ill patients in The Netherlands

Verboom D M, Varkila M R J, Morrow B, Davies T, Ibarra de Palacios P, Poolman J, Hermans P W M, Dudley E G, Roberts E, Cremer O L, Bonten M J M 2021, In: Vaccine. 39 , p. 1670-1674 5 p.

Large-scale ICU data sharing for global collaboration:the first 1633 critically ill COVID-19 patients in the Dutch Data Warehouse

Fleuren Lucas M, de Bruin Daan P, Tonutti Michele, Lalisang Robbert C A, Elbers Paul W G, , Cremer Olaf, Rademaker E, Slooter AJ 2021, In: Intensive Care Medicine. 47 , p. 478-481 4 p.

Pulmonary congestion and mortality during venoarterial extracorporeal membrane oxygenation (VA-ECMO):does time matter?

van der Wal Pieter S, Zwetsloot Peter-Paul, Cremer Olaf L, Donker Dirk W, Meuwese Christiaan L 19 dec 2020, In: European journal of internal medicine. 86 , p. 107-107 1 p.

The predictive validity for mortality of the driving pressure and the mechanical power of ventilation

van Meenen David M P, Serpa Neto Ary, Paulus Frederique, Merkies Coen, Schouten Laura R, Bos Lieuwe D, Horn Janneke, Juffermans Nicole P, Cremer Olaf L, van der Poll Tom, Schultz Marcus J, 18 dec 2020, In: Intensive Care Medicine Experimental. 8 , p. 1-12

Prognostic classification based on P/F and PEEP in invasively ventilated ICU patients with hypoxemia-insights from the MARS study

Simonis Fabienne D, Schouten Laura R A, Cremer Olaf L, Ong David S Y, Amoruso Gabriele, Cinella Gilda, Schultz Marcus J, Bos Lieuwe D, 18 dec 2020, In: Intensive Care Medicine Experimental. 8 , p. 1-11

The leukocyte non-coding RNA landscape in critically ill patients with sepsis

Scicluna Brendon P, Uhel Fabrice, van Vught Lonneke A, Wiewel Maryse A, Hoogendijk Arie J, Baessman Ingelore, Franitza Marek, Nürnberg Peter, Horn Janneke, Cremer Olaf L, Bonten Marc J, Schultz Marcus J, van der Poll Tom, 11 dec 2020, In: eLife. 9 , p. 1-23 23 p.

A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality:An Observational Cohort Study

van Mourik Niels, Geerts Bart F, Binnekade Jan M, Veelo Denise P, Bos Lieuwe D J, Wiersinga W Joost, van der Poll Tom, Cremer Olaf L, Schultz Marcus J, Vlaar Alexander P J okt 2020, In: Critical care explorations. 2 , p. e0219

All research output

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