prof. dr. O.L. (Olaf) Cremer

prof. dr. O.L. (Olaf) Cremer

Full Professor
prof. dr. O.L. (Olaf) Cremer
  • Intensive Care Medicine

Research Programs

Infection & Immunity



Olaf Cremer (1971) was trained as an anesthesiologist, intensivist and clinical epidemiologist. He has worked as a consultant in the department of intensive care medicine of the UMCU since 2007. Dr. Cremer has designed and co-developed the patient data management system that is currently in use. His detailed knowledge of the system and computer programming skills allow him to explore this clinical database as a rich source of information for several research projects within the division.
Prof. Cremer obtained his PhD degree in 2005 with a doctoral thesis on goal-directed management of patients with severe traumatic brain injury. His thesis included both experimental clinical studies focused on cerebrovascular pathophysiology, as well as large cohort studies focused on patient outcomes. Since 2010 he has been studying the clinical epidemiology of infections in the ICU and/or the postoperative setting. He is one of the PI's of the MARS consortium, a multicentre collaboration aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis. More recently he initiated the PLUTO project, a longitudinal biorepository of patients undergoing elective surgery in the UMCU. The main focus areas of his research group include:

1 - diagnostic uncertainty in early detection of sepsis

2 - attributable morbidity and mortality of (nosocomial) sepsis and acute inflammation

3 - decision support for diagnosis and treatment of sepsis

Cremer has been mentoring 14 PhD students to date.

Side Activities

Advisory boards

2021 - GlaxoSmithKline (otilimab drug development) - money paid to UMCU

2021 - Parexel (adrenomed ENCOURAGE program) - money paid to UMCU


Industry collaborations

2015-2019 - ImmuneXpress Inc. (Seattle, WA) – Unrestricted research grant (105K)

2021-2022 - Abionic SA (Epalinges, Switzerland) – Unrestricted research grant (60K)





Research Output (194)

De sCepsis voorbij:oratie

Cremer Olaf 5 nov 2021, 26 p.

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

Fleuren Lucas M., Dam Tariq A., Tonutti Michele, de Bruin Daan P., Lalisang Robbert C.A., Gommers Diederik, Cremer Olaf L., Bosman Rob J., Rigter Sander, Wils Evert Jan, Frenzel Tim, Dongelmans Dave A., de Jong Remko, Peters Marco, Kamps Marlijn J.A., Ramnarain Dharmanand, Nowitzky Ralph, Nooteboom Fleur G.C.A., de Ruijter Wouter, Urlings-Strop Louise C., Smit Ellen G.M., Mehagnoul-Schipper D. Jannet, Dormans Tom, de Jager Cornelis P.C., Hendriks Stefaan H.A., Achterberg Sefanja, Oostdijk Evelien, Reidinga Auke C., Festen-Spanjer Barbara, Brunnekreef Gert B., Cornet Alexander D., van den Tempel Walter, Boelens Age D., Koetsier Peter, Lens Judith, Faber Harald J., Karakus A., Entjes Robert, de Jong Paul, Rettig Thijs C.D., Arbous Sesmu, Vonk Sebastiaan J.J., Fornasa Mattia, Machado Tomas, Houwert Taco, Hovenkamp Hidde, Noorduijn-Londono Roberto, Quintarelli Davide, Scholtemeijer Martijn G., de Beer Aletta A., 23 aug 2021, In: Critical care (London, England). 25

Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure:insights from the PRoVENT-COVID study

Schuijt Michiel T U, Schultz Marcus J, Paulus Frederique, Serpa Neto Ary, , Cremer Olaf 6 aug 2021, In: Critical care (London, England). 25 , p. 283

Editorial: Viral Infections in the Intensive Care Unit

Maraolo Alberto E, Barac Aleksandra, Cremer Olaf L, Ong David S Y 30 jun 2021, In: Frontiers in medicine. 8 , p. 1-3

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

Morales-Quinteros Luis, Neto Ary Serpa, Artigas Antonio, Blanch Lluis, Botta Michela, Kaufman David A, Schultz Marcus J, Tsonas Anissa M, Paulus Frederique, Bos Lieuwe D, , Cremer Olaf 17 mei 2021, In: Critical care (London, England). 25 13 p.

Associations of Body Mass Index with Ventilation Management and Clinical Outcomes in Invasively Ventilated Patients with ARDS Related to COVID-19-Insights from the PRoVENT-COVID Study

Schavemaker Renée, Schultz Marcus J, Lagrand Wim K, van Slobbe-Bijlsma Eline R, Serpa Neto Ary, Paulus Frederique, , Cremer Olaf 2 mrt 2021, In: Journal of Clinical medicine. 10 , p. 1-14 14 p.

Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis

van Vught Lonneke A, Uhel Fabrice, Ding Chao, Van't Veer Cees, Scicluna Brendon P, Peters-Sengers Hessel, Klein Klouwenberg Peter M C, Nürnberg Peter, Cremer Olaf L, Schultz Marcus J, van der Poll Tom, 17 feb 2021, In: Journal of thrombosis and haemostasis : JTH. 19 , p. 1049-1063 15 p.

An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID-19 patients

Spijkerman Roy, Jorritsma Nikita Kn, Bongers Suzanne H, Bindels Bas Jj, Jukema Bernard N, Hesselink Lillian, Hietbrink Falco, Leenen Luke Ph, van Goor Harriët Mr, Vrisekoop N, Kaasjager Karin Ah, Koenderman Leo, , Cremer Olaf 22 jan 2021, In: Scandinavian Journal of Immunology. 93 8 p.

Biological Subphenotypes of Acute Respiratory Distress Syndrome Show Prognostic Enrichment in Mechanically Ventilated Patients without Acute Respiratory Distress Syndrome

Heijnen Nanon F L, Hagens Laura A, Smit Marry R, Cremer Olaf L, Ong David S Y, van der Poll Tom, van Vught Lonneke A, Scicluna Brendon P, Schnabel Ronny M, van der Horst Iwan C C, Schultz Marcus J, Bergmans Dennis C J J, Bos Lieuwe Dj, 19 jan 2021, In: American Journal of Respiratory and Critical Care Medicine. 203 , p. 1503-1511 9 p.

Glycoproteoform Profiles of Individual Patients' Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode

Čaval Tomislav, Lin Yu-Hsien, Varkila Meri, Reiding Karli R, Bonten Marc J M, Cremer Olaf L, Franc Vojtech, Heck Albert J R 14 jan 2021, In: Frontiers in Immunology. 11

All research output

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