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prof. dr. ir. E.P.J.G. (Edwin) Cuppen

Full Professor

  • Center for Molecular Medicine
  • Group Cuppen, section Genetics

prof. dr. ir. E.P.J.G. (Edwin) Cuppen

Research Programs

Biography

Edwin Cuppen is scientific director of the Hartwig Medical Foundation, a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors. Edwin is also professor of Human Genetics at the Center for Molecular Medicine of the University Medical Center in Utrecht and invited member of the virtual national cancer research organisation Oncode Institute. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute and the Hubrecht Institute. His current research focuses on understanding the causes and consequences of de novo genetic variation, specifically in relation to cancer, by using systematic genomics and data integration approaches.

Side Activities

  • Academic advisory activities

    Member 'wetenschappelijke raad KiKa' (scientific council foundation Children Cancer Free) (not remunerated)

    Scientific Advisory Board InteRNA Technologies BV (miRNA-based therapeutics) (personal remuneration)

    Advisory Board Clinical Whole Genome Sequencing Illumina (remeration transfered to employer)

    Employment at other organisation

    Scientific Director Hartwig Medical Foundation

Fellowship and Awards

  • European Young Investigator Award 2005

    NWO Vici grant 2013

Research Output (339)

Publisher Correction:The mutational impact of culturing human pluripotent and adult stem cells

Kuijk Ewart, Jager Myrthe, van der Roest Bastiaan, Locati Mauro D, Van Hoeck Arne, Korzelius Jerome, Janssen Roel, Besselink Nicolle, Boymans Sander, van Boxtel Ruben, Cuppen Edwin 4 aug 2020, In: Nature Communications. 11 , p. 3932

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte Chris Jenske, Espejo Valle-Inclan Jose, Hami Nizar, Lõhmussaar Kadi, Kopper Oded, Vreuls Celien Philomena Henrieke, Jonges Geertruida Nellie, van Diest Paul, Nguyen Luan, Clevers Hans, Kloosterman Wigard Pieter, Cuppen Edwin, Snippert Hugo Johannes Gerhardus, Zweemer Ronald Peter, Witteveen Petronella Oda, Stelloo Ellen 16 jun 2020, In: Cell Reports. 31 8 p.

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Jiao Wei, Atwal Gurnit, Polak Paz, Karlic Rosa, Cuppen Edwin, Danyi Alexandra, de Ridder Jeroen, van Herpen Carla, Lolkema Martijn P, Steeghs Neeltje, Getz Gad, Morris Quaid, Stein Lincoln D, 5 feb 2020, In: Nature Communications. 11 12 p.

Biallelic variants in POLR3GL cause endosteal hyperostosis and oligodontia

Terhal Paulien A, Vlaar Judith M, Middelkamp Sjors, Nievelstein Rutger A J, Nikkels Peter G J, Ross Jamila, Créton Marijn, Bos Jeroen W, Voskuil-Kerkhof Elsbeth S M, Cuppen Edwin, Knoers Nine, van Gassen Koen L I jan 2020, In: European Journal of Human Genetics. 28 , p. 31-39 9 p.

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Driehuis Else, Van Hoeck Arne, Moore Kat, Kolders Sigrid, Francies Hayley E., Gulersonmez M. Can, Stigter Edwin C.A., Burgering Boudewijn, Geurts Veerle, Gracanin Ana, Bounova Gergana, Morsink Folkert H., Vries Robert, Boj Sylvia, Van Es Johan, Offerhaus G. Johan A., Kranenburg Onno, Garnett Mathew J., Wessels Lodewyk, Cuppen Edwin, Brosens Lodewijk A.A., Clevers Hans 9 dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116 , p. 26580-26590 11 p.

Prioritization of genes driving congenital phenotypes of patients with de novo genomic structural variants

Middelkamp Sjors, Vlaar Judith M, Giltay Jacques, Korzelius Jerome, Besselink Nicolle, Boymans Sander, Janssen Roel, de la Fonteijne Lisanne, van Binsbergen Ellen, van Roosmalen Markus J, Hochstenbach Ron, Giachino Daniela, Talkowski Michael E, Kloosterman Wigard P, Cuppen Edwin 4 dec 2019, In: Genome Medicine. 11

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

van Dessel Lisanne F., van Riet Job, Smits Minke, Zhu Yanyun, Hamberg Paul, van der Heijden Michiel S., Bergman Andries M., van Oort Inge M., de Wit Ronald, Voest Emile E., Steeghs Neeltje, Yamaguchi Takafumi N., Livingstone Julie, Boutros Paul C., Martens John W. M., Sleijfer Stefan, Cuppen Edwin, Zwart Wilbert, van de Werken Harmen J. G., Mehra Niven, Lolkema Martijn P. 20 nov 2019, In: Nature Communications. 10

Pan-cancer whole-genome analyses of metastatic solid tumours

Priestley Peter, Baber Jonathan, Lolkema Martijn P, Steeghs Neeltje, de Bruijn Ewart, Shale Charles, Duyvesteyn Korneel, Haidari Susan, van Hoeck Arne, Onstenk Wendy, Roepman Paul, Voda Mircea, Bloemendal Haiko J, Tjan-Heijnen Vivianne C G, van Herpen Carla M L, Labots Mariette, Witteveen Petronella O, Smit Egbert F, Sleijfer Stefan, Voest Emile E, Cuppen Edwin 23 okt 2019, In: Nature. 575 , p. 210-216 7 p.

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

Ooft Salo N, Weeber Fleur, Dijkstra Krijn K, McLean Chelsea M, Kaing Sovann, van Werkhoven Erik, Schipper Luuk, Hoes Louisa, Vis Daniel J, van de Haar Joris, Prevoo Warner, Snaebjornsson Petur, van der Velden Daphne, Klein Michelle, Chalabi Myriam, Boot Henk, van Leerdam Monique, Bloemendal Haiko J, Beerepoot Laurens V, Wessels Lodewyk, Cuppen Edwin, Clevers Hans, Voest Emile E 9 okt 2019, In: Science Translational Medicine. 11

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

Christensen Sharon, Van der Roest Bastiaan, Besselink Nicolle, Janssen Roel, Boymans Sander, Martens John W M, Yaspo Marie-Laure, Priestley Peter, Kuijk Ewart, Cuppen Edwin, Van Hoeck Arne 8 okt 2019, In: Nature Communications. 10

All Research Output (339)