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prof. dr. ir. E.P.J.G. (Edwin) Cuppen

prof. dr. ir. E.P.J.G. (Edwin) Cuppen

Full Professor
prof. dr. ir. E.P.J.G. (Edwin) Cuppen
  • Group Van Mil, section Molecular Cancer Research

Biography

Biography

Edwin Cuppen is initiator and scientific director of the Hartwig Medical Foundation (part-time since 2015 and full time since 2021), a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors and that also maintains one of the world’s largest databases of cancer whole genome sequencing data enriched with clinical patient data. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute, the Hubrecht Institute and the UMC Utrecht. His expertise is in cancer genomics and functional genetics.

Side Activities

Academic advisory activities

Scientific Advisory Board InteRNA Technologies BV (miRNA-based therapeutics) (personal remuneration)

Advisory Board Clinical Whole Genome Sequencing Illumina (remuneration transfered to employer)

Employment at other organisation

Full time Scientific Director Hartwig Medical Foundation

Minimal appointment at UMC Utrecht

Fellowship and Awards

European Young Investigator Award 2005

NWO Vici grant 2013

Research Output (375)

MutationalPatterns:the one stop shop for the analysis of mutational processes

Manders Freek, Brandsma Arianne M, de Kanter Jurrian, Verheul Mark, Oka Rurika, van Roosmalen Markus J, van der Roest Bastiaan, van Hoeck Arne, Cuppen Edwin, van Boxtel Ruben Dec 2022, In: BMC Genomics. 23 , p. 1-18

Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care

Cuppen Edwin, Elemento Olivier, Rosenquist Richard, Nikic Svetlana, IJzerman Maarten, Zaleski Isabelle Durand, Frederix Geert, Levin Lars-Åke, Mullighan Charles G, Buettner Reinhard, Pugh Trevor J, Grimmond Sean, Caldas Carlos, Andre Fabrice, Custers Ilse, Campo Elias, van Snellenberg Hans, Schuh Anna, Nakagawa Hidewaki, von Kalle Christof, Haferlach Torsten, Fröhling Stefan, Jobanputra Vaidehi Dec 2022, In: JCO Precision Oncology. 6

Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics

Schipper L. J., Samsom K. G., Snaebjornsson P., Battaglia T., Bosch L. J.W., Lalezari F., Priestley P., Shale C., van den Broek A. J., Jacobs N., Roepman P., van der Hoeven J. J.M., Steeghs N., Vollebergh M. A., Marchetti S., Cuppen E., Meijer G. A., Voest E. E., Monkhorst K. Dec 2022, In: ESMO open. 7

Study protocol of the GLOW study:maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics-a prospective multicenter cohort study

van Opijnen Mark P, Broekman Marike L D, de Vos Filip Y F, Cuppen Edwin, van der Hoeven Jacobus J M, van Linde Myra E, Compter Annette, Beerepoot Laurens V, van den Bent Martin J, Vos Maaike J, Fiebrich Helle-Brit, Koekkoek Johan A F, Hoeben Ann, Kho Kuan H, Driessen Chantal M L, Jeltema Hanne-Rinck, Robe Pierre A J T, Maas Sybren L N 4 Nov 2022, In: BMC Medical Genomics [E]. 15

Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue

Kuijk Ewart, Kranenburg Onno, Cuppen Edwin, Van Hoeck Arne 7 Oct 2022, In: Nature Communications. 13 , p. 5915

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Zingg Daniel, Bhin Jinhyuk, Yemelyanenko Julia, Kas Sjors M, Rolfs Frank, Lutz Catrin, Lee Jessica K, Klarenbeek Sjoerd, Silverman Ian M, Annunziato Stefano, Chan Chang S, Piersma Sander R, Eijkman Timo, Badoux Madelon, Gogola Ewa, Siteur Bjørn, Sprengers Justin, de Klein Bim, de Goeij-de Haas Richard R, Riedlinger Gregory M, Ke Hua, Madison Russell, Drenth Anne Paulien, van der Burg Eline, Schut Eva, Henneman Linda, van Miltenburg Martine H, Proost Natalie, Zhen Huiling, Wientjens Ellen, de Bruijn Roebi, de Ruiter Julian R, Boon Ute, de Korte-Grimmerink Renske, van Gerwen Bastiaan, Féliz Luis, Abou-Alfa Ghassan K, Ross Jeffrey S, van de Ven Marieke, Rottenberg Sven, Cuppen Edwin, Chessex Anne Vaslin, Ali Siraj M, Burn Timothy C, Jimenez Connie R, Ganesan Shridar, Wessels Lodewyk F A, Jonkers Jos 1 Sep 2022, In: Nature. 609 , p. E13-E13

Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology

Jobanputra Vaidehi, Wrzeszczynski Kazimierz O., Buttner Reinhard, Caldas Carlos, Cuppen Edwin, Grimmond Sean, Haferlach Torsten, Mullighan Charles, Schuh Anna, Elemento Olivier Sep 2022, In: Seminars in Cancer Biology. 84 , p. 23-31 9 p.

Analytical demands to use whole-genome sequencing in precision oncology

Meggendorfer Manja, Jobanputra Vaidehi, Wrzeszczynski Kazimierz O., Roepman Paul, de Bruijn Ewart, Cuppen Edwin, Buttner Reinhard, Caldas Carlos, Grimmond Sean, Mullighan Charles G., Elemento Olivier, Rosenquist Richard, Schuh Anna, Haferlach Torsten Sep 2022, In: Seminars in Cancer Biology. 84 , p. 16-22 7 p.

Clinical utility of whole-genome sequencing in precision oncology

Rosenquist Richard, Cuppen Edwin, Buettner Reinhard, Caldas Carlos, Dreau Helene, Elemento Olivier, Frederix Geert, Grimmond Sean, Haferlach Torsten, Jobanputra Vaidehi, Meggendorfer Manja, Mullighan Charles G., Wordsworth Sarah, Schuh Anna Sep 2022, In: Seminars in Cancer Biology. 84 , p. 32-39 8 p.

All research output

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