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prof. dr. ir. E.P.J.G. (Edwin) Cuppen Full Professor

  • Group Cuppen, section Genetics
  • Center for Molecular Medicine

E.P.J.G. Cuppen

Contact

Research Programs

Biography

Edwin Cuppen is scientific director of the Hartwig Medical Foundation, a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors. Edwin is also professor of Human Genetics at the Center for Molecular Medicine of the University Medical Center in Utrecht and invited member of the virtual national cancer research organisation Oncode Institute. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute and the Hubrecht Institute. His current research focuses on understanding the causes and consequences of de novo genetic variation, specifically in relation to cancer, by using systematic genomics and data integration approaches.

Side Activities

  • Academic advisory activities

    Member 'wetenschappelijke raad KiKa' (scientific council foundation Children Cancer Free) (not remunerated)

    Scientific Advisory Board InteRNA Technologies BV (miRNA-based therapeutics) (personal remuneration)

    Advisory Board Clinical Whole Genome Sequencing Illumina (remeration transfered to employer)

    Employment at other organisation

    Scientific Director Hartwig Medical Foundation

Fellowship and Awards

  • European Young Investigator Award 2005

    NWO Vici grant 2013

Research Output (297)

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

van Dessel Lisanne F., van Riet Job, Smits Minke, Zhu Yanyun, Hamberg Paul, van der Heijden Michiel S., Bergman Andries M., van Oort Inge M., de Wit Ronald, Voest Emile E., Steeghs Neeltje, Yamaguchi Takafumi N., Livingstone Julie, Boutros Paul C., Martens John W. M., Sleijfer Stefan, Cuppen Edwin, Zwart Wilbert, van de Werken Harmen J. G., Mehra Niven, Lolkema Martijn P. 20 nov 2019, In: Nature Communications. 10

Pan-cancer whole-genome analyses of metastatic solid tumours

Priestley Peter, Baber Jonathan, Lolkema Martijn P, Steeghs Neeltje, de Bruijn Ewart, Shale Charles, Duyvesteyn Korneel, Haidari Susan, van Hoeck Arne, Onstenk Wendy, Roepman Paul, Voda Mircea, Bloemendal Haiko J, Tjan-Heijnen Vivianne C G, van Herpen Carla M L, Labots Mariette, Witteveen Petronella O, Smit Egbert F, Sleijfer Stefan, Voest Emile E, Cuppen Edwin 23 okt 2019, In: Nature. 575 , p. 210-216 7 p.

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

Ooft Salo N, Weeber Fleur, Dijkstra Krijn K, McLean Chelsea M, Kaing Sovann, van Werkhoven Erik, Schipper Luuk, Hoes Louisa, Vis Daniel J, van de Haar Joris, Prevoo Warner, Snaebjornsson Petur, van der Velden Daphne, Klein Michelle, Chalabi Myriam, Boot Henk, van Leerdam Monique, Bloemendal Haiko J, Beerepoot Laurens V, Wessels Lodewyk, Cuppen Edwin, Clevers Hans, Voest Emile E 9 okt 2019, In: Science Translational Medicine. 11

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

Christensen Sharon, Van der Roest Bastiaan, Besselink Nicolle, Janssen Roel, Boymans Sander, Martens John W M, Yaspo Marie-Laure, Priestley Peter, Kuijk Ewart, Cuppen Edwin, Van Hoeck Arne 8 okt 2019, In: Nature Communications. 10

Comprehensive pan-cancer analysis of somatic mutations in drug transporters to reveal acquired and intrinsic drug resistance in 3149 metastatic cancer patients

Bins S., van de Geer W. S., van Riet J., Steeghs N., Verheul H. M. W., van Herpen C., Witteveen P. O., Tjan-Heijnen V. C. G., Lolkema M. P., Voest E. E., Sleijfer S., Cuppen E., van de Werken H. J. G., Mathijssen R. H. J. okt 2019, In: Annals of Oncology. 30

Drug Rediscovery Protocol: Expanded use of existing anticancer drugs

Voest E. E., van der Velden D. L., Hoes L., Van der Wijngaart H., Henegouwen M. Van Berge, Van Werkhoven E., Roepman P., Huitema A. D. R., van Herpen C., de Groot D. J., Devriese L., de Jonge M. J. A., Chalabi M., Smit E. F., Mehra N., Labots M., Sleijfer S., Cuppen E., Verheul H. M. W., Gelderblom H. okt 2019, In: Annals of Oncology. 30

Pan-cancer whole genome analyses of metastatic solid tumors

Cuppen E., Priestley P., Baber J., Lolkema M. P., Steeghs N., de Bruijn E., Duyvesteyn K., Haidari S., van Hoeck A., Roepman P., Shale C., Voda M., Tjan-Heijnen V. C. G., Bloemendal H., van Herpen C., Labots M., Witteveen P. O., Smit E. F., Sleijfer S., Voest E. E. okt 2019, In: Annals of Oncology. 30 , p. 864-864

HUMAN EXTRA HEPATIC BILE DUCT-DERIVED ORGANOIDS FOR STEM CELL CHARACTERIZATION AND DISEASE MODELING

Verstegen Monique, Roos Floris, Burka Ksenia, Gehart Helmuth, Jager Myrthe, de Wolf Maaike, Fuchs Sabine, Verkade Henkjan, Roest Henk, IJzermans Jan, Cuppen Edwin, van der Laan Luc okt 2019, In: Transplant International. 32 , p. 5-5

WGS implementation in standard cancer diagnostics for every cancer patient (WIDE)

Roepman P., Bosch L., Samsom K., Schipper L., de Bruijn E., Hoes L., Riethorst I., Schoenmaker L., van der Kolk L., van Snellenberg H., Voest E. E., Cuppen E., Monkhorst K., Meijer G. okt 2019, In: Annals of Oncology. 30 , p. 575-575

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies

Angus Lindsay, Smid Marcel, Wilting Saskia M, van Riet Job, Van Hoeck Arne, Nguyen Luan, Nik-Zainal Serena, Steenbruggen Tessa G, Tjan-Heijnen Vivianne C G, Labots Mariette, van Riel Johanna M G H, Bloemendal Haiko J, Steeghs Neeltje, Lolkema Martijn P, Voest Emile E, van de Werken Harmen J G, Jager Agnes, Cuppen Edwin, Sleijfer Stefan, Martens John W M 30 sep 2019, In: Nature Genetics. 51 , p. 1450-1458 9 p.

All Research Output (297)
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