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prof. dr. ir. E.P.J.G. (Edwin) Cuppen

prof. dr. ir. E.P.J.G. (Edwin) Cuppen

Full Professor
prof. dr. ir. E.P.J.G. (Edwin) Cuppen
  • Group Cuppen, section Genetics

Biography

Biography

Edwin Cuppen is initiator and scientific director of the Hartwig Medical Foundation (part-time since 2015 and full time since 2021), a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors and that also maintains one of the world’s largest databases of cancer whole genome sequencing data enriched with clinical patient data. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute, the Hubrecht Institute and the UMC Utrecht. His expertise is in cancer genomics and functional genetics.

Side Activities

Academic advisory activities

Scientific Advisory Board InteRNA Technologies BV (miRNA-based therapeutics) (personal remuneration)

Advisory Board Clinical Whole Genome Sequencing Illumina (remuneration transfered to employer)

Employment at other organisation

Full time Scientific Director Hartwig Medical Foundation

Minimal appointment at UMC Utrecht

Fellowship and Awards

European Young Investigator Award 2005

NWO Vici grant 2013

Research Output (365)

MutationalPatterns:the one stop shop for the analysis of mutational processes

Manders Freek, Brandsma Arianne M, de Kanter Jurrian, Verheul Mark, Oka Rurika, van Roosmalen Markus J, van der Roest Bastiaan, van Hoeck Arne, Cuppen Edwin, van Boxtel Ruben Dec 2022, In: BMC Genomics. 23 , p. 1-18

Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests

Meijer Titia G, Nguyen Luan, Van Hoeck Arne, Sieuwerts Anieta M, Verkaik Nicole S, Ladan Marjolijn M, Ruigrok-Ritstier Kirsten, van Deurzen Carolien H M, van de Werken Harmen J G, Lips Esther H, Linn Sabine C, Memari Yasin, Davies Helen, Nik-Zainal Serena, Kanaar Roland, Martens John W M, Cuppen Edwin, Jager Agnes, van Gent Dik C 24 Jun 2022, In: Oncogene. 41 , p. 3498-3506 9 p.

Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

Vlaar Judith M, Borgman Anouska, Kalkhoven Eric, Westland Denise, Besselink Nicolle, Shale Charles, Faltas Bishoy M, Priestley Peter, Kuijk Ewart, Cuppen Edwin 16 Jun 2022, In: Scientific Reports. 12 , p. 1-12

Genome-wide analysis of somatic noncoding mutation patterns in cancer

Dietlein Felix, Wang Alex B, Fagre Christian, Tang Anran, Besselink Nicolle J M, Cuppen Edwin, Li Chunliang, Sunyaev Shamil R, Neal James T, Van Allen Eliezer M 8 Apr 2022, In: Science. 376 , p. 1-12

Different responses to DNA damage determine ageing differences between organs

Vougioukalaki Maria, Demmers Joris, Vermeij Wilbert P, Baar Marjolein, Bruens Serena, Magaraki Aristea, Kuijk Ewart, Jager Myrthe, Merzouk Sarra, Brandt Renata M C, Kouwenberg Janneke, van Boxtel Ruben, Cuppen Edwin, Pothof Joris, Hoeijmakers Jan H J 4 Mar 2022, In: Aging Cell. 21 , p. 1-18

Distinct Genomic Profiles Are Associated with Treatment Response and Survival in Ovarian Cancer

de Witte Chris J, Kutzera Joachim, van Hoeck Arne, Nguyen Luan, Boere Ingrid A, Jalving Mathilde, Ottevanger Petronella B, van Schaik-van de Mheen Christa, Stevense Marion, Kloosterman Wigard P, Zweemer Ronald P, Cuppen Edwin, Witteveen Petronella O 2 Mar 2022, In: Cancers. 14 , p. 1-18

Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma

Nakauma-González J Alberto, Rijnders Maud, van Riet Job, van der Heijden Michiel S, Voortman Jens, Cuppen Edwin, Mehra Niven, van Wilpe Sandra, Oosting Sjoukje F, Rijstenberg L Lucia, Westgeest Hans M, Zwarthoff Ellen C, de Wit Ronald, van der Veldt Astrid A M, van de Werken Harmen J G, Lolkema Martijn P J, Boormans Joost L 24 Jan 2022, In: European Urology. 81 , p. 331-336 6 p.

Patients With Rare Cancers in the Drug Rediscovery Protocol (DRUP) benefit from Genomics - Guided Treatment

Hoes Louisa R, van Berge Henegouwen Jade M, van der Wijngaart Hanneke, Zeverijn Laurien J, van der Velden Daphne L, van de Haar Joris, Roepman Paul, de Leng Wendy J, Jansen Anne M L, van Werkhoven Erik, van der Noort Vincent, Huitema Alwin D R, Gort Eelke H, de Groot Jan Willem B, Kerver Emile D, de Groot Derk Jan, Erdkamp Frans, Beerepoot Laurens V, Hendriks Mathijs P, Smit Egbert F, van der Graaf Winette T A, van Herpen Carla M L, Labots Mariette, Hoeben Ann, Morreau Hans, Lolkema Martijn P, Cuppen Edwin, Gelderblom Hans J, Verheul Henk M W, Voest Emile E 19 Jan 2022, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 28 , p. 1402-1411 10 p.

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

Nguyen Luan, Jager Myrthe, Lieshout Ruby, de Ruiter Petra E, Locati Mauro D, Besselink Nicolle, van der Roest Bastiaan, Janssen Roel, Boymans Sander, de Jonge Jeroen, IJzermans Jan N M, Doukas Michail, Verstegen Monique M A, van Boxtel Ruben, van der Laan Luc J W, Cuppen Edwin, Kuijk Ewart 18 Nov 2021, In: Communications biology. 4

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

van Riet Job, van de Werken Harmen J G, Cuppen Edwin, Eskens Ferry A L M, Tesselaar Margot, van Veenendaal Linde M, Klümpen Heinz-Josef, Dercksen Marcus W, Valk Gerlof D, Lolkema Martijn P, Sleijfer Stefan, Mostert Bianca 29 Jul 2021, In: Nature Communications. 12 , p. 1-14

All research output

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