prof. dr. J.H. (Joke) de Boer
Full Professor
- Department of Ophthalmology
Contact
Biography
Prof.dr. Joke de Boer is an ophthalmologist and acknowledged expert in inflammatory eye diseases with a special interest in noninfectious and infectious uveitis in adults and children. Noninfectious uveitis is a vision-threatening chronic, progressive inflammation of the interior eye. Current treatment strategies with immunosuppressive medications may fail to prevent the decline in visual function. Her research focusses on the underlying pathogenesis of noninfectious uveitis and development of new treatment strategies for this blinding disease in collaboration with the Laboratory of Translational Immunology. To this end, she uses the ‘Systems Medicine’ approach that combines in-depth phenotyping of the peripheral immune-compartment of patients and computational modeling of the derived high-throughput data to reveal the true perpetrating epigenetic mechanisms that drive noninfectious uveitis. The nature of this approach makes it very well suited for identifying novel biomarkers to improve treatment and disease outcome in patients with noninfectious uveitis in the near future. Other research topics are aqueous humor analysis in infectious uveitis in collaboration with the virology section of the department of medical microbiology . Joke de Boer is member of the International Uveitis Study Group, the national guideline committee for uveitis and the European guideline committee for uveitis associated with juvenile idiopathic arthritis.
Side Activities
Member of the International Uveitis Study Group
Member of tehe European paediatric ophthalmology society
Member of the Dutch Ophthalmology society
Member of the Dutch uveitis study group
Member of the Multinational Interdisciplinary working group of uveitis in children
Member of the Dutch "kennis agenda"of ophthalology
Member of James Lind aliance of Juvenile idiopathic artritis
Chair of addendum biologicals of the Dutch guideline of uveitis
Chair Quality committee Dutch Ophthalmology society
Board member of uveitis guideline committee Dutch Ophthalmology society
Member of the Fluorescein Angiography Netherlands club.
Member of the Dutch pediatric ophthalmology study group
Member of the European guideline committee for uveitis associated with juvenile idiopathic arthritis
Fellowship and Awards
1994 AER Montpellier, best paper award for “Low mature TGF-â2 in aqueous humour during uveitis”.
2011 ODAS price for paediatric ophthalmology
2011 The Clinical Uveitis Research Award from the European Uveitis Patient Interest Association
Research Output (108)
Prolonged Cone b-Wave on Electroretinography Is Associated with Severity of Inflammation in Noninfectious Uveitis
Brouwer Anna H., de Wit Gerard C., ten Dam Ninette H., Wijnhoven Ralph, van Genderen Maria M., de Boer Joke H. nov 2019, In: American Journal of Ophthalmology. 207 , p. 121-129 9 p.
Risk of Rhegmatogenous Retinal Detachment in Acute Retinal Necrosis With and Without Prophylactic Intervention
Risseeuw Sara, de Boer Joke H., ten Dam – van Loon Ninette H., van Leeuwen Redmer 1 okt 2019, In: American Journal of Ophthalmology. 206 , p. 140-148 9 p.
Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC)
Foeldvari Ivan, Klotsche Jens, Simonini Gabriele, Edelsten Clive, Angeles-Han Sheila T., Bangsgaard Regitze, de Boer Joke, Brumm Gabriele, Torrent Rosa Bou, Constantin Tamas, DeLibero Cinzia, Diaz Jesus, Gerloni Valeria Maria, Guedes Margarida, Heiligenhaus Arnd, Kotaniemi Kaisu, Leinonen Sanna, Minden Kirsten, Miranda Vasco, Miserocchi Elisabetta, Nielsen Susan, Niewerth Martina, Pontikaki Irene, de Vicuna Carmen Garcia, Zilhao Carla, Yeh Steven, Anton Jordi, Calzada Joan 1 okt 2019, In: Pediatric rheumatology online journal. 17 14 p.
Ophthalmological characteristics and treatment outcomes of conjunctivitis in patients receiving dupilumab for moderate-to-severe atopic dermatitis
Lans A., Van Luijk C. M., Bakker D. S., Ariens L. F. M., Thijs J. L., Van der Schaft J., De Boer J. H., Knol E. F., De Bruin-Weller M. S., Balak D. M. W. aug 2019, In: Allergy. 74 , p. 714-714
Prolonged cone b-wave on electroretinography is associated with more severe inflammation in non-infectious uveitis
Brouwer Anna, van Genderen Maria M., de Wit Gerard, ten Dam Ninette, Wijnhoven Ralph, de Boer Joke jul 2019, In: Investigative ophthalmology & visual science. 60
Predicting uveitis in juvenile idiopathic arthritis:from biomarkers to clinical practice
Haasnoot Anne-Mieke J. W., Kuiper Jonas J. W., de Boer Joke H. 3 jun 2019, In: Expert Review of Clinical Immunology. 15 , p. 657-666 10 p.
Uveitis as an immune-related toxicity during checkpoint inhibitor immunotherapy
Ayuso V. Kalinina, Ossewaarde-van Norel J., Kouwenberg C., Suijkerbuijk K. P. M., Kuiper J. J. W., de Boer J. H. mrt 2019, In: Acta Ophthalmologica. 97 , p. 16-16
Blood monocytes distinguish individuals with orbital lymphoma
Laban K. G., Kalmann R., Hiddingh S., Mertens J., Rijken R., Pandit A., Eenhorst C., van der Veen R., de Boer J. H., Radstake T. R. D. J., Kuiper J. J. W. mrt 2019, In: Acta Ophthalmologica. 97 , p. 28-28
Prolonged cone b-wave on electroretinography is associated with severity of inflammation in non-infectious uveitis
Brouwer A. H., van Genderen M. M., de Wit G., ten Dam N. H., Wijnhoven R., de Boer J. H. mrt 2019, In: Acta Ophthalmologica. 97 , p. 17-17
Tocilizumab as an effective treatment in children with refractory intermediate and panuveitis
Wennink R. A. W., Ayuso V. Kalinina, de Vries L., Vastert S. J., de Boer J. H. mrt 2019, In: Acta Ophthalmologica. 97 , p. 16-16