prof. dr. J.H. (Joke) de Boer

prof. dr. J.H. (Joke) de Boer

Full Professor
prof. dr. J.H. (Joke) de Boer

Research Programs

Infection & Immunity



Prof.dr. Joke de Boer is an ophthalmologist and acknowledged expert in inflammatory eye diseases with a special interest in noninfectious and infectious uveitis in adults and children. Noninfectious uveitis is a vision-threatening chronic, progressive inflammation of the interior eye. Current treatment strategies with immunosuppressive medications may fail to prevent the decline in visual function. Her research focusses on the underlying pathogenesis of noninfectious uveitis and development of new treatment strategies for this blinding disease in collaboration with the Laboratory of Translational Immunology. To this end, she uses the ‘Systems Medicine’ approach that combines in-depth phenotyping of the peripheral immune-compartment of patients and computational modeling of the derived high-throughput data to reveal the true perpetrating epigenetic mechanisms that drive noninfectious uveitis. The nature of this approach makes it very well suited for identifying novel biomarkers to improve treatment and disease outcome in patients with noninfectious uveitis in the near future. Other research topics are aqueous humor analysis in infectious uveitis in collaboration with the virology section of the department of medical microbiology .  Joke de Boer is member of the International Uveitis Study Group, the national guideline committee for uveitis and the European guideline committee for uveitis associated with juvenile idiopathic arthritis.

Side Activities

Member of the International Uveitis Study Group

Member of the European paediatric ophthalmology society

Member of the Dutch Ophthalmology society

Member of the Dutch uveitis study group

Member of the Multinational Interdisciplinary working group of uveitis in children

Member of the Dutch "kennis agenda"of ophthalology

Member of James Lind aliance of Juvenile idiopathic artritis

Chair of addendum biologicals of the Dutch guideline of uveitis

Chair Quality committee Dutch Ophthalmology society

Board member of uveitis guideline committee Dutch Ophthalmology society

Member of the Fluorescein Angiography Netherlands club.

Member of the Dutch pediatric ophthalmology study group

Member of the European guideline committee for uveitis associated with juvenile idiopathic arthritis

Host of the international uveitis symposium ISU 2022, Utrecht, the Netherlands

Fellowship and Awards

1994    AER Montpellier, best paper award for “Low mature TGF-â2 in aqueous humour during uveitis”.

2011    ODAS price for paediatric ophthalmology

2011    The Clinical Uveitis Research Award from the European Uveitis Patient Interest Association

Research Output (152)

CRB1-Associated Retinal Dystrophy Patients Have Expanded Lewis Glycoantigen-Positive T Cells

Moekotte Lude, Kuiper Jonas J.W., Hiddingh Sanne, Nguyen Xuan Thanh An, Boon Camiel J.F., van den Born L. Ingeborgh, de Boer Joke H., van Genderen Maria M. 3 Oct 2023, In: Investigative Ophthalmology and Visual Science. 64

Involvement of the systemic microcirculation in pediatric uveitis

Kouwenberg Carlyn V., Spierings Julia, de Groot Evianne L., de Boer Joke H., Kalinina Ayuso Viera 2 Oct 2023, In: Pediatric rheumatology online journal. 21 , p. 1-9 9 p.

The Role of the Retinal Nerve Fiber Layer Thickness on OCT in the Evaluation of Papillitis in Childhood Uveitis

Kouwenberg Carlyn V., Blom Laurens A., Vellinga Suzanne C., Bozkir Irem, de Boer Joke H., Ayuso Viera Koopman Kalinina Oct 2023, In: American Journal of Ophthalmology. 254 , p. 62-68 7 p.

Correction to:Risdiplam in Patients Previously Treated with Other Therapies for Spinal Muscular Atrophy: An Interim Analysis from the JEWELFISH Study (Neurology and Therapy, (2023), 12, 2, (543-557), 10.1007/s40120-023-00444-1)

Chiriboga Claudia A., Bruno Claudio, Duong Tina, Fischer Dirk, Mercuri Eugenio, Kirschner Janbernd, Kostera-Pruszczyk Anna, Jaber Birgit, Gorni Ksenija, Kletzl Heidemarie, Carruthers Imogen, Martin Carmen, Warren Francis, Scalco Renata S., Wagner Kathryn R., Muntoni Francesco, Deconinck Nicolas, Balikova Irina, Joniau Inge, Tahon Valentine, Wittevrongel Sylvia, Goemans Nathalie, Cassiman Catherine, Prove Lies, Vancampenhout Lisa, van den Hauwe Marleen, Van Impe Annelies, Cances Claude, Soler Vincent, De La Morandais Lauriane Maillard, Vovan Delphine, Cintas Pascal, Auriol Françoise, Mus Marianne, Alphonsa Gwennaelle, Bellio Valerie, Gil Mato Olaia, Flamein Florence, Evrard Cécile, Ziouche Amina, Bouacha-Allou Ikram, Debruyne Philippe, Derlyn Gilles, Defoort Sabine, Leroy Florian, Van der Pol Ludo, de Boer Joke, Imhof Saskia, Ruyten Thijs, Van Der Woude Danny, Oct 2023, In: Neurology and Therapy. 12 , p. 1799-1801 3 p.

Association of Risk Variants in the CFH Gene With Elevated Levels of Coagulation and Complement Factors in Idiopathic Multifocal Choroiditis

de Groot Evianne L., Ossewaarde-van Norel Jeannette, de Boer Joke H., Hiddingh Sanne, Bakker Bjorn, van Huet Ramon A.C., Ten Dam-van Loon Ninette H., Thiadens Alberta A.H.J., Meester-Smoor Magda A., de Jong-Hesse Yvonne, Los Leonoor I., den Hollander Anneke I., Boon Camiel J.F., Kiemeney Lambertus A., van Eijk Kristel R., Bakker Mark K., Hoyng Carel B., Kuiper Jonas J.W. 17 Aug 2023, In: JAMA ophthalmology. 141 , p. 737-745 9 p.

Exploring Imaging Characteristics Associated With Disease Activity in Idiopathic Multifocal Choroiditis:A Multimodal Imaging Approach

de Groot Evianne L., ten Dam-van Loon Ninette H., Kouwenberg Carlyn V., de Boer Joke H., Ossewaarde-van Norel Jeannette Aug 2023, In: American Journal of Ophthalmology. 252 , p. 45-58 14 p.

Meningococcal ACWY conjugate vaccine immunogenicity in adolescents with primary or secondary immune deficiencies, a prospective observational cohort study

Ohm Milou, van Straalen Joeri W, de Joode-Smink Gerrie, van Montfrans Joris, Bartels Marije, van Wildenbeest Joanne G, Lindemans Caroline A, Wennink Roos Aw, de Boer Joke H, Sanders Elisabeth Am, Verduyn-Lunel Frans M, Berbers Guy Am, Wulffraat Nico M, Jansen Marc H A 20 Jul 2023, In: Pediatric rheumatology online journal. 21 , p. 1-6

Meningococcal ACWY conjugate vaccine immunogenicity and safety in adolescents with juvenile idiopathic arthritis and inflammatory bowel disease:A prospective observational cohort study

Ohm Milou, van Straalen Joeri W, Zijlstra Marieke, de Joode-Smink Gerrie, Jasmijn Sellies Anne, Swart Joost F, Vastert Sebastiaan J, van Montfrans Joris M, Bartels Marije, van Royen-Kerkhof Annet, Wildenbeest Joanne G, Lindemans Caroline A, Wolters Victorien, Wennink Roos A W, de Boer Joke H, Knol Mirjam J, Heijstek Marloes W, Sanders Elisabeth A M, Verduyn-Lunel Frans M, Berbers Guy A M, Wulffraat Nico M, Jansen Marc H A 15 May 2023, In: Vaccine. 41 , p. 3782-3789 8 p.

Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

Hiddingh S., Pandit A., Verhagen F. H., Rijken R., Servaas N. H., Wichers C. G.K., Ten Dam-Van Loon N. H., Imhof S. M., Radstake T. R.D.J., de Boer J. H., Kuiper J. J.W. 12 Apr 2023, In: eLife. 12

Methotrexate therapy associated with a reduced rate of new-onset uveitis in patients with biological-naïve juvenile idiopathic arthritis

van Straalen Joeri W, Akay Görkem, Kouwenberg Carlyn V, de Roock Sytze, Kalinina Ayuso Viera, Wulffraat Nico M, de Boer Joke, Swart Joost F Apr 2023, In: RMD Open. 9 , p. 1-8

All research output

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