prof. dr. J.H. (Joke) de Boer

prof. dr. J.H. (Joke) de Boer

Full Professor
prof. dr. J.H. (Joke) de Boer
  • Department of Ophthalmology

Research Programs

Infection & Immunity



Prof.dr. Joke de Boer is an ophthalmologist and acknowledged expert in inflammatory eye diseases with a special interest in noninfectious and infectious uveitis in adults and children. Noninfectious uveitis is a vision-threatening chronic, progressive inflammation of the interior eye. Current treatment strategies with immunosuppressive medications may fail to prevent the decline in visual function. Her research focusses on the underlying pathogenesis of noninfectious uveitis and development of new treatment strategies for this blinding disease in collaboration with the Laboratory of Translational Immunology. To this end, she uses the ‘Systems Medicine’ approach that combines in-depth phenotyping of the peripheral immune-compartment of patients and computational modeling of the derived high-throughput data to reveal the true perpetrating epigenetic mechanisms that drive noninfectious uveitis. The nature of this approach makes it very well suited for identifying novel biomarkers to improve treatment and disease outcome in patients with noninfectious uveitis in the near future. Other research topics are aqueous humor analysis in infectious uveitis in collaboration with the virology section of the department of medical microbiology .  Joke de Boer is member of the International Uveitis Study Group, the national guideline committee for uveitis and the European guideline committee for uveitis associated with juvenile idiopathic arthritis.

Side Activities

Member of the International Uveitis Study Group

Member of the European paediatric ophthalmology society

Member of the Dutch Ophthalmology society

Member of the Dutch uveitis study group

Member of the Multinational Interdisciplinary working group of uveitis in children

Member of the Dutch "kennis agenda"of ophthalology

Member of James Lind aliance of Juvenile idiopathic artritis

Chair of addendum biologicals of the Dutch guideline of uveitis

Chair Quality committee Dutch Ophthalmology society

Board member of uveitis guideline committee Dutch Ophthalmology society

Member of the Fluorescein Angiography Netherlands club.

Member of the Dutch pediatric ophthalmology study group

Member of the European guideline committee for uveitis associated with juvenile idiopathic arthritis

Host of the international uveitis symposium ISU 2022, Utrecht, the Netherlands

Fellowship and Awards

1994    AER Montpellier, best paper award for “Low mature TGF-â2 in aqueous humour during uveitis”.

2011    ODAS price for paediatric ophthalmology

2011    The Clinical Uveitis Research Award from the European Uveitis Patient Interest Association

Research Output (139)

Meningococcal ACWY conjugate vaccine immunogenicity in adolescents with primary or secondary immune deficiencies, a prospective observational cohort study

Ohm Milou, van Straalen Joeri W, de Joode-Smink Gerrie, van Montfrans Joris, Bartels Marije, van Wildenbeest Joanne G, Lindemans Caroline A, Wennink Roos Aw, de Boer Joke H, Sanders Elisabeth Am, Verduyn-Lunel Frans M, Berbers Guy Am, Wulffraat Nico M, Jansen Marc H A 20 Jul 2023, In: Pediatric rheumatology online journal. 21 , p. 1-6

Meningococcal ACWY conjugate vaccine immunogenicity and safety in adolescents with juvenile idiopathic arthritis and inflammatory bowel disease:A prospective observational cohort study

Ohm Milou, van Straalen Joeri W, Zijlstra Marieke, de Joode-Smink Gerrie, Jasmijn Sellies Anne, Swart Joost F, Vastert Sebastiaan J, van Montfrans Joris M, Bartels Marije, van Royen-Kerkhof Annet, Wildenbeest Joanne G, Lindemans Caroline A, Wolters Victorien, Wennink Roos A W, de Boer Joke H, Knol Mirjam J, Heijstek Marloes W, Sanders Elisabeth A M, Verduyn-Lunel Frans M, Berbers Guy A M, Wulffraat Nico M, Jansen Marc H A 15 May 2023, In: Vaccine. 41 , p. 3782-3789 8 p.

Methotrexate therapy associated with a reduced rate of new-onset uveitis in patients with biological-naïve juvenile idiopathic arthritis

van Straalen Joeri W, Akay Görkem, Kouwenberg Carlyn V, de Roock Sytze, Kalinina Ayuso Viera, Wulffraat Nico M, de Boer Joke, Swart Joost F Apr 2023, In: RMD Open. 9 , p. 1-8

Improved clinical outcomes in patients with juvenile idiopathic arthritis associated uveitis in the last decade

Wennink Roos A.W., Kalinina Ayuso Viera, Pameijer Els M., Dekkers Coco C., Bozkir Irem, de Boer Joke H. Nov 2022, In: Acta Ophthalmologica. 100 , p. 781-787 7 p.

A Network of Serum Proteins Predict the Need for Systemic Immunomodulatory Therapy at Diagnosis in Noninfectious Uveitis

Kuiper Jonas J W, Verhagen Fleurieke H, Hiddingh Sanne, Wennink Roos A W, Hansen Anna M, Casey Kerry A, Hoefer Imo E, Haitjema Saskia, Drylewicz Julia, Yakin Mehmet, Sen H Nida, Radstake Timothy R D J, de Boer Joke H Sep 2022, In: Ophthalmology science. 2 , p. 1-9

Clinical Course and Outcome in Pediatric Idiopathic Chronic Anterior Uveitis

Kouwenberg Carlyn V., Wennink Roos A. W., Shahabi Mahfam, Bozkir Irem, Ayuso Viera Koopman-kalinina, De Boer Joke H. Sep 2022, In: American Journal of Ophthalmology. 241 , p. 198-205 8 p.

The International Vitreoretinal B-Cell Lymphoma Registry:a protocol paper

Smith Justine R., Farrall Alexandra L., Davis Janet L., De Boer Joke H., Hall Anthony J., Mochizuki Manabu, Sen H. Nida, Takase Hiroshi, Dam-Van Loon Ninette H.Ten, Touitou Valérie, Vasconcelos-Santos Daniel V., Wilson David J., Yeh Steven, Radford Mark H.B. Jul 2022, In: BMJ Open. 12 , p. 1-6

Ocular surface disease is common in moderate-to-severe atopic dermatitis patients

Achten Roselie E, Bakker Daphne S, van Luijk Chantal M, van der Wal M Marlot, de Graaf Marlies, van Wijk Femke, Zuithoff Nicolaas P A, van der Rijst Lisa P, Boesjes Celeste M, Thijs Judith L, de Boer Joke H, de Bruin-Weller Marjolein S 16 Mar 2022, In: Clinical and Experimental Allergy. 52 , p. 801-805 5 p.

A Blood Protein Signature Stratifies Clinical Response to csDMARD Therapy in Pediatric Uveitis

Wennink Roos A.W., Ayuso Viera Kalinina, Tao Weiyang, Delemarre Eveline M., de Boer Joke H., Kuiper Jonas J.W. 1 Feb 2022, In: Translational Vision Science and Technology. 11

Identification of Risk Factors for Dupilumab-associated Ocular Surface Disease in Patients with Atopic Dermatitis

Achten Roselie E, Van Luijk Chantal, Van der Rijst Lisa, Bakker Daphne, Spekhorst Lotte, Zuithoff Nicolaas, Schuttelaar Marie, Romeijn Geertruida, Voorberg Angelique, Kamsteeg Marijke, Haeck Inge, De Graaf Marlies, Thijs Judith, De Boer Joke, De Bruin-Weller Marjolein 31 Jan 2022, In: Acta Dermato-Venereologica. 102 , p. 1-7

All research output

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