prof. dr. J.H. (Joke) de Boer

prof. dr. J.H. (Joke) de Boer

Full Professor
prof. dr. J.H. (Joke) de Boer
  • Department of Ophthalmology

Research Programs

Infection & Immunity



Prof.dr. Joke de Boer is an ophthalmologist and acknowledged expert in inflammatory eye diseases with a special interest in noninfectious and infectious uveitis in adults and children. Noninfectious uveitis is a vision-threatening chronic, progressive inflammation of the interior eye. Current treatment strategies with immunosuppressive medications may fail to prevent the decline in visual function. Her research focusses on the underlying pathogenesis of noninfectious uveitis and development of new treatment strategies for this blinding disease in collaboration with the Laboratory of Translational Immunology. To this end, she uses the ‘Systems Medicine’ approach that combines in-depth phenotyping of the peripheral immune-compartment of patients and computational modeling of the derived high-throughput data to reveal the true perpetrating epigenetic mechanisms that drive noninfectious uveitis. The nature of this approach makes it very well suited for identifying novel biomarkers to improve treatment and disease outcome in patients with noninfectious uveitis in the near future. Other research topics are aqueous humor analysis in infectious uveitis in collaboration with the virology section of the department of medical microbiology .  Joke de Boer is member of the International Uveitis Study Group, the national guideline committee for uveitis and the European guideline committee for uveitis associated with juvenile idiopathic arthritis.

Side Activities

Member of the International Uveitis Study Group

Member of tehe European paediatric ophthalmology society

Member of the Dutch Ophthalmology society

Member of the Dutch uveitis study group

Member of the Multinational Interdisciplinary working group of uveitis in children

Member of the Dutch "kennis agenda"of ophthalology

Member of James Lind aliance of Juvenile idiopathic artritis

Chair of addendum biologicals of the Dutch guideline of uveitis

Chair Quality committee Dutch Ophthalmology society

Board member of uveitis guideline committee Dutch Ophthalmology society

Member of the Fluorescein Angiography Netherlands club.

Member of the Dutch pediatric ophthalmology study group

Member of the European guideline committee for uveitis associated with juvenile idiopathic arthritis

Fellowship and Awards

1994    AER Montpellier, best paper award for “Low mature TGF-â2 in aqueous humour during uveitis”.

2011    ODAS price for paediatric ophthalmology

2011    The Clinical Uveitis Research Award from the European Uveitis Patient Interest Association

Research Output (123)

Next-Generation HLA Sequence Analysis Uncovers Shared Risk Alleles Between Clinically Distinct Forms of Childhood Uveitis

Wennink Roos A W, de Boer Joke H, Hiddingh Sanne, Haasnoot Anne-Mieke J W, Kalinina Ayuso Viera, de Hoop Talitha, van Setten Jessica, Spierings Eric, Kuiper Jonas J W 1 jul 2021, In: Investigative ophthalmology & visual science. 62 , p. 1-12

Anterior uveitis in paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2

Wong Chung Justin E.R.E., Engin Ö, Wolfs T. F.W., Renson T. J.C., de Boer J. H. 3 apr 2021, In: The Lancet. 397 , p. e10

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

Venema Wouter J, Hiddingh Sanne, de Boer Joke H, Claas Frans H J, Mulder Arend, den Hollander Anneke I, Stratikos Efstratios, Sarkizova Siranush, van der Veken Lars T, Janssen George M C, van Veelen Peter A, Kuiper Jonas J W 25 feb 2021, In: Frontiers in Immunology. 12 15 p.

The efficacy of adalimumab in treating patients with central multifocal choroiditis

de Groot Evianne L., Ossewaarde - van Norel Jeannette, Ho Lintje, ten Dam - van Loon Ninette H., de Boer Joke H. dec 2020, In: American Journal of Ophthalmology Case Reports. 20 , p. 1-5

Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis

Wennink Roos A.W., Pandit Aridaman, Haasnoot Anne Mieke J.W., Hiddingh Sanne, Kalinina Ayuso Viera, Wulffraat Nico M., Vastert Bas J., Radstake Timothy R.D.J., de Boer Joke H., Kuiper Jonas J.W. 17 sep 2020, In: Frontiers in Immunology. 11

Effects of DTL electrode position on the amplitude and implicit time of the electroretinogram

Brouwer Anna H, de Wit Gerard C, de Boer Joke H, van Genderen Maria M 1 jun 2020, In: Documenta Ophthalmologica. 140 , p. 201-209 9 p.

cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non-Hodgkin orbital lymphoma and idiopathic orbital inflammation

Laban Kamil G., Rijken Rianne, Hiddingh Sanne, Mertens Jorre S., van der Veen Rob L.P., Eenhorst Christine A.E., Pandit Aridaman, Radstake Timothy R.D.J., de Boer Joke H., Kalmann Rachel, Kuiper Jonas J.W. apr 2020, In: European Journal of Immunology. 50 , p. 548-557 10 p.

Health-related quality of life in patients with immune mediated inflammatory diseases:A cross-sectional, multidisciplinary study

Spierings Julia, Sloeserwij Annemiek, Vianen Marieke E., de Boer Joke H., Sigurdsson Vigfus, van de Wijgert Janneke H.H.M., van Laar Jacob M. 26 mrt 2020, In: Clinical Immunology. 214

Electroretinogram abnormalities in non-infectious uveitis often persist

Brouwer Anna H, de Wit Gerard C, Ten Dam Ninette H, Wijnhoven Ralph, van Genderen Maria M, de Boer Joke H 19 mrt 2020, In: Acta Ophthalmologica. 98 , p. 627-633 7 p.


Buelens Tom, Ossewaarde-van Norel Jeannette, de Boer Joke H., Nubourgh Isabelle, Glibert Gérald, Kamgang Semeu Prochore, Fils Jean François, Caspers Laure, Postelmans Laurence, Willermain François 1 mrt 2020, In: Retina-The Journal of Retinal and Vitreous Diseases. 40 , p. 581-590 10 p.

All research output

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