prof. dr. J.H. (Joke) de Boer Full Professor

Department of Ophthalmology

Contact

jboer@umcutrecht.nl

Research Programs

Infection & Immunity

Biography

Prof.dr. Joke de Boer is an ophthalmologist and acknowledged expert in inflammatory eye diseases with a special interest in noninfectious and infectious uveitis in adults and children. Noninfectious uveitis is a vision-threatening chronic, progressive inflammation of the interior eye. Current treatment strategies with immunosuppressive medications may fail to prevent the decline in visual function. Her research focusses on the underlying pathogenesis of noninfectious uveitis and development of new treatment strategies for this blinding disease in collaboration with the Laboratory of Translational Immunology. To this end, she uses the ‘Systems Medicine’ approach that combines in-depth phenotyping of the peripheral immune-compartment of patients and computational modeling of the derived high-throughput data to reveal the true perpetrating epigenetic mechanisms that drive noninfectious uveitis. The nature of this approach makes it very well suited for identifying novel biomarkers to improve treatment and disease outcome in patients with noninfectious uveitis in the near future. Other research topics are aqueous humor analysis in infectious uveitis in collaboration with the virology section of the department of medical microbiology . Joke de Boer is member of the International Uveitis Study Group, the national guideline committee for uveitis and the European guideline committee for uveitis associated with juvenile idiopathic arthritis.

Side Activities

Member of the International Uveitis Study Group

Member of tehe European paediatric ophthalmology society

Member of the Dutch Ophthalmology society

Member of the Dutch uveitis study group

Member of the Multinational Interdisciplinary working group of uveitis in children

Member of the Dutch "kennis agenda"of ophthalology

Member of James Lind aliance of Juvenile idiopathic artritis

Chair of addendum biologicals of the Dutch guideline of uveitis

Chair Quality committee Dutch Ophthalmology society

Board member of uveitis guideline committee Dutch Ophthalmology society

Member of the Fluorescein Angiography Netherlands club.

Member of the Dutch pediatric ophthalmology study group

Member of the European guideline committee for uveitis associated with juvenile idiopathic arthritis

Fellowship and Awards

1994    AER Montpellier, best paper award for “Low mature TGF-â2 in aqueous humour during uveitis”.

2011    ODAS price for paediatric ophthalmology

2011    The Clinical Uveitis Research Award from the European Uveitis Patient Interest Association

Research Output (92)

Prolonged Cone b-Wave on Electroretinography Is Associated with Severity of Inflammation in Noninfectious Uveitis

Brouwer Anna H., de Wit Gerard C., ten Dam Ninette H., Wijnhoven Ralph, van Genderen Maria M., de Boer Joke H. nov 2019, In: American Journal of Ophthalmology. 207 , p. 121-129 9 p.

Risk of Rhegmatogenous Retinal Detachment in Acute Retinal Necrosis With and Without Prophylactic Intervention

Risseeuw Sara, de Boer Joke H., ten Dam – van Loon Ninette H., van Leeuwen Redmer 1 okt 2019, In: American Journal of Ophthalmology. 206 , p. 140-148 9 p.

Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC)

Foeldvari Ivan, Klotsche Jens, Simonini Gabriele, Edelsten Clive, Angeles-Han Sheila T., Bangsgaard Regitze, de Boer Joke, Brumm Gabriele, Torrent Rosa Bou, Constantin Tamas, DeLibero Cinzia, Diaz Jesus, Gerloni Valeria Maria, Guedes Margarida, Heiligenhaus Arnd, Kotaniemi Kaisu, Leinonen Sanna, Minden Kirsten, Miranda Vasco, Miserocchi Elisabetta, Nielsen Susan, Niewerth Martina, Pontikaki Irene, de Vicuna Carmen Garcia, Zilhao Carla, Yeh Steven, Anton Jordi, Calzada Joan 1 okt 2019, In: Pediatric rheumatology online journal. 17 14 p.

Prolonged cone b-wave on electroretinography is associated with more severe inflammation in non-infectious uveitis

Brouwer Anna, van Genderen Maria M., de Wit Gerard, ten Dam Ninette, Wijnhoven Ralph, de Boer Joke jul 2019, In: Investigative ophthalmology & visual science. 60

Prolonged cone b-wave on electroretinography is associated with severity of inflammation in non-infectious uveitis

Brouwer A. H., van Genderen M. M., de Wit G., ten Dam N. H., Wijnhoven R., de Boer J. H. mrt 2019, In: Acta Ophthalmologica. 97 , p. 17-17

The effectiveness of immunosuppressive therapy in patients with central multifocal choroiditis: a retrospective cohort study

de Groot E. L., Ossewaarde-van Norel J., de Boer J. H., ten Dam-van Loon N. H. mrt 2019, In: Acta Ophthalmologica. 97 , p. 16-16

Risk factors for glaucoma surgery secondary to childhood uveitis

van Meerwijk C. L. L. I., Wieringa W. G., de Boer J. H., Jansonius N. M., Los L. I. mrt 2019, In: Acta Ophthalmologica. 97 , p. 17-17

CCR6+T cells are an early predictor of the need for systemic immunomodulatory treatment in non-infectious uveitis

Verhagen F. H., Hiddingh S., Rijken R., Pandit A., Leijten E., Nordkamp M. O., ten Dam-van Loon N. H., Nierkens S., Imhof S. M., de Boer J. H., Radstake T. R. D. J., Kuiper J. J. W. mrt 2019, In: Acta Ophthalmologica. 97 , p. 18-18

Blood monocytes distinguish individuals with orbital lymphoma

Laban K. G., Kalmann R., Hiddingh S., Mertens J., Rijken R., Pandit A., Eenhorst C., van der Veen R., de Boer J. H., Radstake T. R. D. J., Kuiper J. J. W. mrt 2019, In: Acta Ophthalmologica. 97 , p. 28-28

Clinical Manifestations, Prognosis, and Vaccination Status of Patients With Rubella Virus-Associated Uveitis

Groen-Hakan Fahriye, van de Laar Suzanne, van der Eijk-Baltissen Annemiek A., ten Dam-van Loon Ninette, de Boer Joke, Rothova Aniki 13 feb 2019, In: American Journal of Ophthalmology. 202 , p. 37-46 10 p.

All Research Output (92)