prof. dr. R. de Bree MD

Full Professor

  • Department of Head and Neck Oncology
  • MS Hoofd-Hals Chirurgische Oncologie

prof. dr. R. de Bree MD

Research Programs


Remco de Bree (1966) studied medicine in Utrecht, The Netherlands. His PhD research on the VU University Medical Center was about the clinical application of radiolabelled monoclonal antibodies in head and neck cancer patients. In 1999 he finished his training in otolaryngology. Thereafter, he was a fellow in head and neck surgery for 2 years at the same hospital, where he worked as a head and neck surgeon for 14 years and became full professor for clinical oncological research at the department of otolaryngology - head and neck surgery in 2006. Since 2015 he is full professor and head of the department of Head and Neck Surgical Oncology at the UMC Utrecht Cancer Center of the University Medical Center Utrecht, The Netherlands. His special interests are the clinical applications and improvements of diagnostic imaging techniques, sentinel node procedure, quality of life and reconstructive surgery in head and neck cancer patients. He has authored and co-authored over 200 articles in international peer-reviewed journals. He was the principal investigator and coordinator of several (inter)national multicenter trials, is a member of the Research steering committee of the Dutch Head and Neck Society (NWHHT), is a member of several editorial boards and member of the Cochrane Ear, Nose & Throat Disorders Group. 

Side Activities

  • Lid Clinical Audit Board van de Dutch Head and Neck Audit (DHNA)

    Lid Scientific Advisory Board Dutch Oncology Research Platform (DORP)

    Voorzitter Research stuurgroep Nederlandse  werkgroep Hoofd-Hals Tumoren (NWHHT)

    Voorzitter Herziening richtlijn Hoofd-Halsoncologie

    Lid kerngroep richtlijncommissie Nederlandse Werkgroep Hoofd-Hals Tumoren (NWHHT)

    Lid Algemeen Bestuur Patiëntenvereniging Hoofd-Hals (PVHH)

Fellowship and Awards

  • 1996 Best PhD thesis Dutch Otolaryngology Society

Research Output (280)

The Predictive Value of Low Skeletal Muscle Mass Assessed on Cross-Sectional Imaging for Anti-Cancer Drug Toxicity:A Systematic Review and Meta-Analysis

Huiskamp Laura F J, Chargi Najiba, Devriese Lot A, May Anne M, Huitema Alwin D R, de Bree Remco 23 nov 2020, In: Journal of Clinical medicine. 9 , p. 3780

Metastatic Squamous Cell Carcinoma to the Cervical Lymph Nodes From an Unknown Primary Cancer:Management in the HPV Era

Civantos Francisco J, Vermorken Jan B, Shah Jatin P, Rinaldo Alessandra, Suárez Carlos, Kowalski Luiz P, Rodrigo Juan P, Olsen Kerry, Strojan Primoz, Mäkitie Antti A, Takes Robert P, de Bree Remco, Corry June, Paleri Vinidh, Shaha Ashok R, Hartl Dana M, Mendenhall William, Piazza Cesare, Hinni Michael, Robbins K Thomas, Tong Ng Wai, Sanabria Alvaro, Coca-Pelaz Andres, Langendijk Johannes A, Hernandez-Prera Juan, Ferlito Alfio 10 nov 2020, In: Frontiers in oncology. 10 , p. 593164

New Developments in Imaging for Sentinel Lymph Node Biopsy in Early-Stage Oral Cavity Squamous Cell Carcinoma

Mahieu Rutger, de Maar Josanne S, Nieuwenhuis Eliane R, Deckers Roel, Moonen Chrit, Alic Lejla, Ten Haken Bennie, de Keizer Bart, Bree Remco de 20 okt 2020, In: Cancers. 12 , p. 1-26 26 p.

The Additional Value of Ultrafast DCE-MRI to DWI-MRI and 18F-FDG-PET to Detect Occult Primary Head and Neck Squamous Cell Carcinoma

Martens Roland M, Stappen Ruud van der, Koopman Thomas, Noij Daniel P, Comans Emile F, Zwezerijnen Gerben J, Vergeer Marije R, Leemans C René, de Bree Remco, Boellaard Ronald, Castelijns Jonas A, de Graaf Pim 30 sep 2020, In: Cancers. 12 , p. 1-15 15 p.

Considerations for environmentally sustainable head and neck surgical oncology practice

Sanabria Alvaro, Kowalski Luiz P, Nixon Iain J, Shaha Ashok, De Bree Remco, Mäkitie Antti A, Rinaldo Alessandra, Ferlito Alfio 12 sep 2020, In: American journal of otolaryngology. 41 , p. 102719

Predictive value of quantitative 18F-FDG-PET radiomics analysis in patients with head and neck squamous cell carcinoma

Martens Roland M, Koopman Thomas, Noij Daniel P, Pfaehler Elisabeth, Übelhör Caroline, Sharma Sughandi, Vergeer Marije R, Leemans C René, Hoekstra Otto S, Yaqub Maqsood, Zwezerijnen Gerben J, Heymans Martijn W, Peeters Carel F W, de Bree Remco, de Graaf Pim, Castelijns Jonas A, Boellaard Ronald 7 sep 2020, In: EJNMMI Research. 10

Sentinel lymph node detection in oral cancer: a within-patient comparison between [Tc-99m]Tc-tilmanocept and [Tc-99m]Tc-nanocolloid:a within-patient comparison between [99mTc]Tc-tilmanocept and [99mTc]Tc-nanocolloid

den Toom Inne J, Mahieu Rutger, van Rooij Rob, van Es Robert J J, Hobbelink Monique G G, Krijger Gerard C, Tijink Bernard M, de Keizer Bart, de Bree Remco 25 aug 2020, In: European Journal of Nuclear Medicine and Molecular Imaging.

Adherence to pretreatment and intratreatment imaging of head and neck squamous cell carcinoma patients undergoing (chemo) radiotherapy in a research setting

Martens Roland M, Koopman Thomas, Noij Daniel P, de Bree Remco, Vergeer Marije R, Zwezerijnen Gerben, Leemans C René, de Graaf Pim, Boellaard Ronald, Castelijns Jonas A 9 jul 2020, In: Clinical imaging. 69 , p. 82-90 9 p.

Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients:The Dutch Experience

den Toom Inne J, Boeve Koos, Lobeek Daphne, Bloemena Elisabeth, Donswijk Maarten L, de Keizer Bart, Klop W Martin C, Leemans C René, Willems Stefan M, Takes Robert P, Witjes Max J H, de Bree Remco 3 jul 2020, In: Cancers. 12 12 p.

Prostate-specific membrane antigen (PSMA) expression in adenoid cystic carcinoma of the head and neck

Klein Nulent Thomas J W, Valstar Matthijs H, Smit Laura A, Smeele Ludwig E, Zuithoff Nicolaas P A, de Keizer Bart, de Bree Remco, van Es Robert J J, Willems Stefan M 5 jun 2020, In: BMC Cancer. 20 9 p.

All Research Output (280)