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dr. P. (Petra) de Graaf

Assistant Professor
dr. P. (Petra) de Graaf
  • Department of Urology

Research Programs

Other research

Biography

Biography

Dr. De Graaf studied chemistry with a master in Biochemistry at Utrecht University (UU). Her PhD was performed at the faculty of biology (UU) in the laboratory of Prof. Arie Verkleij and Dr. Paul van Bergen en Henegouwen on lipid kinases. After a short postdoc in the LUMC Leiden, she returned to Utrecht for an extended postdoc in the lab of Prof. Marc Timmers. Here she introduced microscopy as a tool to study basic transcription regulation. Since 2014 she works in the department of Urology.

Her current research goal is to generate a tissue engineered (TE) source of urethra tissue for use in urethral reconstruction. Ideally, a TE urethra mimics the native urethra, consists of multiple cell layers of different origin, protects the underlying tissue as an efficient barrier from urine, is vascularized and resistant to mechanical forces during surgery. As in many patients undergoing urethral reconstruction surgery, the surrounding corpus spongiosum is either absent (in hypospadias patients) or affected by fibrosis, we aim to integrate the corpus spongiosum in our TE graft, providing the natural vascular environment. The molecular background helps to bring the science to life: experience and knowledge acquired through the years will lead to solutions for health and disease.

Research Output (34)

A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

van Dijk Christian G M, Brandt Maarten M, Poulis Nikolaos, Anten Jonas, van der Moolen Matthijs, Kramer Liana, Homburg Erik F G A, Louzao-Martinez Laura, Pei Jiayi, Krebber Merle M, van Balkom Bas W M, de Graaf Petra, Duncker Dirk J, Verhaar Marianne C, Luttge Regina, Cheng Caroline 24 apr 2020, In: Lab on a chip. 20 , p. 1827-1844 18 p.

Gel casting as an approach for tissue engineering of multilayered tubular structures

van Velthoven Melissa J J, Ramadan Rana, Zügel Franziska S, Klotz Barbara J, Gawlitta Debby, Costa Pedro F, Malda Jos, Castilho Miguel, de Kort Laetitia M O, de Graaf Petra 23 feb 2020, In: Tissue engineering. Part C, Methods. 26 , p. 190-198 9 p.

Re:The Multilayered Structure of the Human Corpus Spongiosum

De Graaf P., Ramadan R., Linssen E. C., Staller N. A., Hendrickx A. P.A., Pigot G. L.S., Meuleman E. J.H., Bouman H., Ozer M. C., Bosch J. L.H.R., De Kort L. M.O. 1 dec 2019, In: Journal of Urology. 202 , p. 1085-1086 2 p.

Correction for Danovi et al., "Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity".

Danovi Davide, Meulmeester Erik, Pasini Diego, Migliorini Domenico, Capra Maria, Frenk Ruth, de Graaf Petra, Francoz Sarah, Gasparini Patrizia, Gobbi Alberto, Helin Kristian, Pelicci Pier Giuseppe, Jochemsen Aart G., Marine Jean Christophe 1 aug 2019, In: Molecular and Cellular Biology. 39

BUCCAL MUCOSA IN PRIMARY HYPOSPADIAS SURGERY IN PREPUBERTAL BOYS AND A POSSIBLE CAUSE OF HIGH COMPLICATION RATE IN HYPOSPADIAS SURGERY. MOLECULAR CHARACTERIZATION AND ANDROGEN RECEPTOR LOCALIZATION IN BUCCAL MUCOSA AND URETHRA.

Viester M., Wanders , Gebben , Tsachouridis George, de Kort L., de Graaf P. aug 2019, In: Neurourology and Urodynamics. 38 , p. S266-S267

Scaffolds for reconstruction of penile corporal tissue

Tsachouridis G, de Kemp Vincent, de Kort Laetitia, de Graaf Petra 21 jun 2019, volume 2

Genomic integrity of ground-state pluripotency

Jafari Narges, Giehr Pascal, Hesaraki Mahdi, Baas Roy, de Graaf Petra, Timmers H. T.Marc, Walter Jörn, Baharvand Hossein, Totonchi Mehdi dec 2018, In: Journal of Cellular Biochemistry. 119 , p. 9781-9789

The multilayered structure of the human corpus spongiosum

de Graaf P, Ramadan R, Linssen E C, Staller N A, Hendrickx A P A, Pigot G L S, Meuleman E J H, Bouman M, Özer M, Bosch J L H R, de Kort L M O 9 jul 2018, In: Histology and Histopathology. 33 , p. 1335-1345 11 p.

GEL CASTING AS AN APPROACH FOR TISSUE ENGINEERING OF MULTILAYERED TUBULAR STRUCTURES: APPLICATION FOR URETHRAL RECONSTRUCTION

de Graaf P., van Velthoven M., Ramadan R., Klotz B. J., Gawlitta D., Castilho M., Malda J., Costa P., de Kort L. M. O. jul 2018, In: Neurourology and Urodynamics. 37 , p. S208-S209

Biomechanical Properties of the Pelvic Floor and its Relation to Pelvic Floor Disorders

Ruiz-Zapata Alejandra M., Feola Andrew J., Heesakkers John, de Graaf Petra, Blaganje Mija, Sievert Karl Dietrich 1 apr 2018, In: European Urology, Supplements. 17 , p. 80-90 11 p.

All research output

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