dr. P. (Petra) de Graaf

dr. P. (Petra) de Graaf

Assistant Professor
dr. P. (Petra) de Graaf



Lower urinary tracts symptoms, including urethral diseases, have a major impact on the quality of life. My major goal in research is creating tissue that surgeons can use in urethral reconstruction surgery. I use tissue engineering (TE) as an approach. Ideally, a TE urethra mimics the native urethra, consists of multiple cell layers of different origin, protects the underlying tissue as an efficient barrier from urine, is vascularized and resistant to mechanical forces during surgery. As in many patients undergoing urethral reconstruction surgery, the natural support of the urethra, the corpus spongiosum, is either absent or affected by fibrosis, we aim to integrate this support in our TE graft, providing the natural vascular environment. 

Dr. De Graaf studied chemistry with a master in Biochemistry at Utrecht University (UU). Her PhD was performed at the faculty of biology (UU) in the laboratory of Prof. Arie Verkleij and Dr. Paul van Bergen en Henegouwen on lipid kinases. After a short postdoc in the LUMC Leiden, she returned to Utrecht for an extended postdoc in the lab of Prof. Marc Timmers. Here she introduced microscopy as a tool to study basic transcription regulation. Since 2014 she works as head of regenerative urology in the Regenerative Medicine Center Utrecht, department of Urology.

Side Activities

Editor Scientific Reports, Peer Review (various journals), Teaching

Research Output (39)

Tissue engineering and regenerative medicine in hypospadias management

Tsachouridis G., Abbas Tariq, De Kort L. M.O., De Graaf Petra 29 Jun 2023, p. 127-136 10 p.

The rabbit model in preclinical hypospadias research:Strengths and limitations

Abbas Tariq, De Graaf Petra, Pablo Pennisi Cristian 29 Jun 2023, p. 37-52 16 p.

Extracellular matrix analysis of fibrosis:A step towards tissue engineering for urethral stricture disease

Linssen Emma C, Demmers Jeroen, van Dijk Christian G M, van Dam Roos, Nicese Maria Novella, Cheng Caroline, de Kort Laetitia M O, de Graaf Petra 2023, In: PLoS ONE. 18

The use of local therapy in preventing urethral strictures:A systematic review

Jacobs Marleen E, de Kemp Vincent F, Albersen Maarten, de Kort Laetitia M O, de Graaf Petra Oct 2021, In: PLoS ONE. 16 , p. 1-14

Potential strategies to prevent encrustations on urinary stents and catheters–thinking outside the box:a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative

Abou-Hassan Ali, Barros Alexandre, Buchholz Noor, Carugo Dario, Clavica Francesco, de Graaf Petra, de La Cruz Julia, Kram Wolfgang, Mergulhao Filipe, Reis Rui L., Skovorodkin Ilya, Soria Federico, Vainio Seppo, Zheng Shaokai Jul 2021, In: Expert Review of Medical Devices. 18 , p. 697-705 9 p.

A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

van Dijk Christian G M, Brandt Maarten M, Poulis Nikolaos, Anten Jonas, van der Moolen Matthijs, Kramer Liana, Homburg Erik F G A, Louzao-Martinez Laura, Pei Jiayi, Krebber Merle M, van Balkom Bas W M, de Graaf Petra, Duncker Dirk J, Verhaar Marianne C, Luttge Regina, Cheng Caroline 24 Apr 2020, In: Lab on a chip. 20 , p. 1827-1844 18 p.

Gel casting as an approach for tissue engineering of multilayered tubular structures

van Velthoven Melissa J J, Ramadan Rana, Zügel Franziska S, Klotz Barbara J, Gawlitta Debby, Costa Pedro F, Malda Jos, Castilho Miguel, de Kort Laetitia M O, de Graaf Petra 23 Feb 2020, In: Tissue engineering. Part C, Methods. 26 , p. 190-198 9 p.

Re:The Multilayered Structure of the Human Corpus Spongiosum

De Graaf P., Ramadan R., Linssen E. C., Staller N. A., Hendrickx A. P.A., Pigot G. L.S., Meuleman E. J.H., Bouman H., Ozer M. C., Bosch J. L.H.R., De Kort L. M.O. 1 Dec 2019, In: Journal of Urology. 202 , p. 1085-1086 2 p.

Correction for Danovi et al., "Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity".

Danovi Davide, Meulmeester Erik, Pasini Diego, Migliorini Domenico, Capra Maria, Frenk Ruth, de Graaf Petra, Francoz Sarah, Gasparini Patrizia, Gobbi Alberto, Helin Kristian, Pelicci Pier Giuseppe, Jochemsen Aart G., Marine Jean Christophe 1 Aug 2019, In: Molecular and Cellular Biology. 39


Viester M., Wanders , Gebben , Tsachouridis George, de Kort L., de Graaf P. Aug 2019, In: Neurourology and Urodynamics. 38 , p. S266-S267

All research output

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