dr. P. (Petra) de Graaf
dr. P. (Petra) de Graaf
- Department of Urology
Research Programs
Biography
Biography
Lower urinary tracts symptoms, including urethral diseases, have a major impact on the quality of life. My major goal in research is creating tissue that surgeons can use in urethral reconstruction surgery. I use tissue engineering (TE) as an approach. Ideally, a TE urethra mimics the native urethra, consists of multiple cell layers of different origin, protects the underlying tissue as an efficient barrier from urine, is vascularized and resistant to mechanical forces during surgery. As in many patients undergoing urethral reconstruction surgery, the natural support of the urethra, the corpus spongiosum, is either absent or affected by fibrosis, we aim to integrate this support in our TE graft, providing the natural vascular environment.
Dr. De Graaf studied chemistry with a master in Biochemistry at Utrecht University (UU). Her PhD was performed at the faculty of biology (UU) in the laboratory of Prof. Arie Verkleij and Dr. Paul van Bergen en Henegouwen on lipid kinases. After a short postdoc in the LUMC Leiden, she returned to Utrecht for an extended postdoc in the lab of Prof. Marc Timmers. Here she introduced microscopy as a tool to study basic transcription regulation. Since 2014 she works as head of regenerative urology in the Regenerative Medicine Center Utrecht, department of Urology.
Side Activities
Editor Scientific Reports, Peer Review (various journals), Teaching
Research Output (36)
Jacobs Marleen E, de Kemp Vincent F, Albersen Maarten, de Kort Laetitia M O, de Graaf Petra Oct 2021, In: PLoS ONE. 16 , p. 1-14
Abou-Hassan Ali, Barros Alexandre, Buchholz Noor, Carugo Dario, Clavica Francesco, de Graaf Petra, de La Cruz Julia, Kram Wolfgang, Mergulhao Filipe, Reis Rui L., Skovorodkin Ilya, Soria Federico, Vainio Seppo, Zheng Shaokai Jul 2021, In: Expert Review of Medical Devices. 18 , p. 697-705 9 p.
van Dijk Christian G M, Brandt Maarten M, Poulis Nikolaos, Anten Jonas, van der Moolen Matthijs, Kramer Liana, Homburg Erik F G A, Louzao-Martinez Laura, Pei Jiayi, Krebber Merle M, van Balkom Bas W M, de Graaf Petra, Duncker Dirk J, Verhaar Marianne C, Luttge Regina, Cheng Caroline 24 Apr 2020, In: Lab on a chip. 20 , p. 1827-1844 18 p.
van Velthoven Melissa J J, Ramadan Rana, Zügel Franziska S, Klotz Barbara J, Gawlitta Debby, Costa Pedro F, Malda Jos, Castilho Miguel, de Kort Laetitia M O, de Graaf Petra 23 Feb 2020, In: Tissue engineering. Part C, Methods. 26 , p. 190-198 9 p.
De Graaf P., Ramadan R., Linssen E. C., Staller N. A., Hendrickx A. P.A., Pigot G. L.S., Meuleman E. J.H., Bouman H., Ozer M. C., Bosch J. L.H.R., De Kort L. M.O. 1 Dec 2019, In: Journal of Urology. 202 , p. 1085-1086 2 p.
Danovi Davide, Meulmeester Erik, Pasini Diego, Migliorini Domenico, Capra Maria, Frenk Ruth, de Graaf Petra, Francoz Sarah, Gasparini Patrizia, Gobbi Alberto, Helin Kristian, Pelicci Pier Giuseppe, Jochemsen Aart G., Marine Jean Christophe 1 Aug 2019, In: Molecular and Cellular Biology. 39
Viester M., Wanders , Gebben , Tsachouridis George, de Kort L., de Graaf P. Aug 2019, In: Neurourology and Urodynamics. 38 , p. S266-S267
Tsachouridis G, de Kemp Vincent, de Kort Laetitia, de Graaf Petra 21 Jun 2019, volume 2 14 p.
Jafari Narges, Giehr Pascal, Hesaraki Mahdi, Baas Roy, de Graaf Petra, Timmers H. T.Marc, Walter Jörn, Baharvand Hossein, Totonchi Mehdi Dec 2018, In: Journal of Cellular Biochemistry. 119 , p. 9781-9789 9 p.
de Graaf P, Ramadan R, Linssen E C, Staller N A, Hendrickx A P A, Pigot G L S, Meuleman E J H, Bouman M, Özer M, Bosch J L H R, de Kort L M O 9 Jul 2018, In: Histology and Histopathology. 33 , p. 1335-1345 11 p.