dr. R. (Roel) de Heus

dr. R. (Roel) de Heus

Assistant Professor - medical
dr. R. (Roel) de Heus
  • Birth Center Obstetrics - Medical



During his gynaecology training Roel de Heus finished his PhD “Maternal and Fetal effects of Tocolytic drugs” at the University of Utrecht in 2008 and worked for 6 months at the Mt Sinai Hospital in Toronto at the department of Maternal and Fetal medicine in 2012.

His clinical work as a gynaecologist at the Obstetrical department has its focus on fetal medicine / prenatal diagnosis, combining state of the art imaging techniques such as 2D/3D ultrasound and fetal MRI with genetic testing.

His aim is to improve patient care and more specific in the field of prenatal diagnosis and early developmental medicine. Focus within the research theme Brain on normal and abnormal early brain development. To study maternal and environmental influences on normal fetal brain development during pregnancy and its impact on child development as a part of the YOUth cohort (prof.dr. C. Kemner). Intra-uterine development, an important landmark for future health. Furthermore, to study and unravel mechanisms of abnormal fetal and neonatal brain development due to underlying congenital malformations, placental insufficiency or preterm birth to improve diagnosis, identify prognostic biomarkers and possible windows for neuroprotection to prevent perinatal brain damage.

Research Output (39)

The YOUth study:Rationale, design, and study procedures

Onland-Moret N. Charlotte, Buizer-Voskamp Jacobine E., Albers Maria E.W.A., Brouwer Rachel M., Buimer Elizabeth E.L., Hessels Roy S., de Heus Roel, Huijding Jorg, Junge Caroline M.M., Mandl René C.W., Pas Pascal, Vink Matthijs, van der Wal Juliëtte J.M., Hulshoff Pol Hilleke E., Kemner Chantal 7 okt 2020, In: Developmental Cognitive Neuroscience. 46 , p. 1-16

Effect of maternal diabetes on fetal heart function on echocardiography:systematic review and meta-analysis

Depla A L, de Wit L, Steenhuis T J, Slieker M G, Voormolen D N, Scheffer P G, de Heus R, van Rijn B B, Bekker M N 30 jul 2020, In: Ultrasound in Obstetrics and Gynecology. 57 , p. 539-550 12 p.

Gastro-intestinal function and quality of life are favorable in adolescent and adult gastroschisis patients

Snoep Maartje C., de Heus Roel, Manten Gwendolyn T.R., Lap Chiara C.M.M., Snoeker Barbara A.M., Lindeboom Maud Y.A. 1 feb 2020, In: Early Human Development. 141 8 p.

Automatic brain tissue segmentation in fetal MRI using convolutional neural networks

Khalili N., Lessmann N., Turk E., Claessens N., de Heus R., Kolk T., Viergever M. A., Benders M. J. N. L., Isgum I. dec 2019, In: Magnetic Resonance Imaging. 64 , p. 77-89 13 p.

Functional Connectome of the Fetal Brain

Turk Elise, van den Heuvel Marion I., Benders Manon J., de Heus Roel, Franx Arie, Manning Janessa H., Hect Jasmine L., Hernandez-Andrade Edgar, Hassan Sonia S., Romero Roberto, Kahn René S., Thomason Moriah E., van den Heuvel Martijn P. 4 nov 2019, In: Journal of Neuroscience. 39 , p. 9716-9724 9 p.

Brain and CSF Volumes in Fetuses and Neonates with Antenatal Diagnosis of Critical Congenital Heart Disease:A Longitudinal MRI Study

Claessens N H P, Khalili N, Isgum I, Ter Heide H, Steenhuis T J, Turk E, Jansen N J G, de Vries L S, Breur J M P J, de Heus R, Benders M J N L 28 mrt 2019, In: American Journal of Neuroradiology. 40 , p. 885-891 7 p.

Automatic extraction of the intracranial volume in fetal and neonatal MR scans using convolutional neural networks

Khalili Nadieh, Turk E., Benders M. J.N.L., Moeskops P., Claessens N. H.P., de Heus R., Franx A., Wagenaar N., Breur J. M.P.J., Viergever M. A., Išgum I. 1 jan 2019, In: NeuroImage. Clinical. 24 , p. 102061 13 p.

Duration and time trends in hospital stay for very preterm infants differ across European regions*

Maier Rolf F., Blondel Béatrice, Piedvache Aurélie, Misselwitz Bjoern, Petrou Stavros, Van Reempts Patrick, Franco Francesco, Barros Henrique, Gadzinowski Janusz, Boerch Klaus, Van Heijst Arno, Draper Elizabeth S., Zeitlin Jennifer, Martens E., Martens G., Hasselager A., Huusom L., Pedersen P., Peitersen B., Pryds O., Weber T., Ancel P. Y., Bréart G., Chabernaud J. L., Delmas D., Papiernik E., Gortner L., Künzel W., Schmidt S., Agostino R., Di Lallo D., Paesano R., Den Ouden L., De Heus R., Gerrits J., Hukkelhoven C., Hulscher M., Kollée C. L., Koopman-Esseboom C., Visser G., Breborowics G., Mazela J., Campos I., Carrapato M., Rodrigues T., Boyle E., Field D., Konje J., Manktelow B. N., Fenton A., dec 2018, In: Pediatric Critical Care Medicine. 19 , p. 1153-1161 9 p.

Intra- and interobserver agreement for fetal cerebral measurements in 3D-ultrasonography

Albers Maria E.W.A., Buisman Erato T.I.A., Kahn René S., Franx Arie, Onland-Moret N. Charlotte, de Heus Roel aug 2018, In: Human Brain Mapping. 39 , p. 3277-3284 8 p.

First trimester placental vascularization and angiogenetic factors are associated with adverse pregnancy outcome

Leijnse Johanna E.W., de Heus Roel, de Jager Wilco, Rodenburg Wendy, Peeters Louis L.H., Franx Arie, Eijkelkamp Niels 1 jul 2018, In: Pregnancy Hypertension. 13 , p. 87-94 8 p.

All research output

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