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prof. dr. D.P.V. (Dominique) de Kleijn

prof. dr. D.P.V. (Dominique) de Kleijn

Full Professor
  • Department of Vascular Surgery

Side Activities

CSO/consultant, Persuasive BV

1 May 2020 → 

Advisory board, Ilias Biologics

6 Nov 2019 → …

Coordinator Large animal research, University Medical Center Utrecht

1 Sep 2019 → …

Local organisor and chairman Extracellular Vesicle Meetings Selectbio, Selectbio

1 Oct 2016 → …

Research Output (288)

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Slenders Lotte, Landsmeer Lennart P L, Cui Kai, Depuydt Marie A C, Verwer Maarten, Mekke Joost, Timmerman Nathalie, van den Dungen Noortje A M, Kuiper Johan, de Winther Menno P J, Prange Koen H M, Ma Wei Feng, Miller Clint L, Aherrahrou Redouane, Civelek Mete, de Borst Gert J, de Kleijn Dominique P V, Asselbergs Folkert W, den Ruijter Hester M, Boltjes Arjan, Pasterkamp Gerard, van der Laan Sander W, Mokry Michal Jan 2022, In: European heart journal open. 2

The power of genetic diversity in genome-wide association studies of lipids

Graham Sarah E, Clarke Shoa L, Wu Kuan-Han H, Kanoni Stavroula, Zajac Greg J M, Ramdas Shweta, Surakka Ida, Ntalla Ioanna, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Hwang Mi Yeong, Han Sohee, Narita Akira, Choudhury Ananyo, Bentley Amy R, Ekoru Kenneth, Verma Anurag, Trivedi Bhavi, Martin Hilary C, Hunt Karen A, Hui Qin, Klarin Derek, Zhu Xiang, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Ruotsalainen Sanni E, Havulinna Aki S, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 9 Dec 2021, In: Nature. 600 , p. 675-679 5 p.

Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors

Koh Cho Yeow, Shih Norrapat, Yip Christina Y.C., Li Aaron Wei Liang, Chen Weiming, Amran Fathiah S., Leong Esther Jia En, Iyer Janaki Krishnamoorthy, Croft Grace, Mazlan Muhammad Ibrahim Bin, Chee Yen Lin, Yap Eng Soo, Monroe Dougald M., Hoffman Maureane, Becker Richard C., de Kleijn Dominique P.V., Verma Vaishali, Gupta Amita, Chaudhary Vijay K., Richards A. Mark, Kini R. Manjunatha, Chan Mark Y. 25 Nov 2021, In: Nature Communications. 12 , p. 1-16

Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice

Kessler Elise L., Wang Jiong Wei, Kok Bart, Brans Maike A., Nederlof Angelique, van Stuijvenberg Leonie, Huang Chenyuan, Vink Aryan, Arslan Fatih, Efimov Igor R., Lam Carolyn S.P., Vos Marc A., de Kleijn Dominique P.V., Fontes Magda S.C., van Veen Toon A.B. 1 Nov 2021, In: International journal of molecular sciences. 22 , p. 1-13

Colchicine reduces extracellular vesicle NLRP3 inflammasome protein levels in chronic coronary disease:A LoDoCo2 biomarker substudy

Silvis Max J M, Fiolet Aernoud T L, Opstal Tjerk S J, Dekker Mirthe, Suquilanda Daniel, Zivkovic Minka, Duyvendak Michiel, The Salem H K, Timmers Leo, Bax Willem A, Mosterd Arend, Cornel Jan H, de Kleijn Dominique P V Oct 2021, In: Atherosclerosis. 334 , p. 93-100 8 p.

High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome

Dekker Mirthe, Waissi Farahnaz, Silvis Max J.M., Bennekom Joelle V., Schoneveld Arjan H., de Winter Robbert J., Isgum Ivana, Lessmann Nikolas, Velthuis Birgitta K., Pasterkamp Gerard, Mosterd Arend, Timmers Leo, de Kleijn Dominique P.V. 23 Sep 2021, In: Scientific Reports. 11 10 p.

A narrative review of plaque and brain imaging biomarkers for stroke risk stratification in patients with atherosclerotic carotid artery disease

Donners Simone J A, Toorop Raechel J, de Kleijn Dominique P V, de Borst Gert J Aug 2021, In: Annals of Translational Medicine. 9 , p. 1-15

Neutral Effects of Combined Treatment With GLP-1R Agonist Exenatide and MR Antagonist Potassium Canrenoate on Cardiac Function in Porcine and Murine Chronic Heart Failure Models

Demkes Evelyne J., Wenker Steven, Silvis Max J.M., van Nieuwburg Martijn M.J., Visser M. Joyce, Jansen Marlijn S., Brans Maike A.D., Velema Evelyn, Sluijter Joost P.G., Hoefer Imo E., de Kleijn Dominique P.V., Timmers Leo, de Jager Saskia C.A. 26 Jul 2021, In: Frontiers in Pharmacology. 12 11 p.

Monocyte-chemoattractant protein-1 levels in human atherosclerotic lesions associate with plaque vulnerability

Georgakis Marios K., van der Laan Sander W., Asare Yaw, Mekke Joost M., Haitjema Saskia, Schoneveld Arjan H., de Jager Saskia C.A., Nurmohamed Nick S., Kroon Jeffrey, Stroes Erik S.G., de Kleijn Dominique P.V., de Borst Gert J., Maegdefessel Lars, Soehnlein Oliver, Pasterkamp Gerard, Dichgans Martin 8 Apr 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41 , p. 2038-2048 11 p.

Pre-Operative Plasma Extracellular Vesicle Proteins are Associated with a High Risk of Long Term Secondary Major Cardiovascular Events in Patients Undergoing Carotid Endarterectomy

Timmerman Nathalie, Waissi Farahnaz, Dekker Mirthe, van de Pol Qiu Ying, van Bennekom Joelle, Schoneveld Arjan, klein Avink Marjet J.M., de Winter Robbert J., Pasterkamp Gerard, de Borst Gert J., de Kleijn Dominique P.V. 2021, In: European Journal of Vascular and Endovascular Surgery. 62 , p. 705-715 11 p.

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