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prof. dr. W.L. (Wouter) de Laat

prof. dr. W.L. (Wouter) de Laat

Full Professor
prof. dr. W.L. (Wouter) de Laat
  • Group Burgering, section Molecular Cancer Research
  • Department of Genetics
  • Hubrecht Institute

Research Programs

Strategic Program Cancer

Biography

Biography

Wouter de Laat studied biology at the Utrecht University. During his PhD (1998) at the Erasmus University Rotterdam (Prof. Jan Hoeijmakers) he investigated the molecular mechanism of nucleotide excision repair. He identified one of the nucleases and characterized the interplay between repair factors at the site of the lesion. As a postdoc, he joined the group of Prof. Frank Grosveld to work on beta-globin gene activation. In 2000 he received a career grant (VIDI) to work on long-range gene activation. His group used 3C technology, and later developed 4C technology, to demonstrate chromatin loops between genes and enhancers and to uncover long-range DNA contacts within and between chromosomes.
In 2008 he received an ERC Young Investigator Grant. In September 2008 de Laat moved his group to the Hubrecht Institute, where he continued his work on genome structure and function. In January 2009 he was appointed professor in Biomedical Genomics at the University Medical Center Utrecht. He received a prestigious VICI career grant in 2012.

Side Activities

  • Mentor UAF, Universitair Asielfonds    
  • Founder of Cergentis. Cergentis was acquired by Solvias in 2022. Wouter de Laat no longer has financial interest/role in Cergentis.
  • Scientific Editor Frontiers in Cell and Developmental Biology
  • Scientific Advisory Board Max Planck Institute for Molecular Genetics Berlin
     

Fellowship and Awards

VIDI (2000)

VICI (2012)

ERC Starting Grant (2008)

EMBO Member

Research Output (89)

Current challenges in understanding the role of enhancers in disease

Zaugg Judith Barbara, Sahlén Pelin, Andersson Robin, Alberich-Jorda Meritxell, de Laat Wouter, Deplancke Bart, Ferrer Jorge, Mandrup Susanne, Natoli Gioacchino, Plewczynski Dariusz, Rada-Iglesias Alvaro, Spicuglia Salvatore Dec 2022, In: Nature Structural and Molecular Biology. 29 , p. 1148-1158 11 p.

Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes

Rinzema Niels J., Sofiadis Konstantinos, Tjalsma Sjoerd J.D., Verstegen Marjon J.A.M., Oz Yuva, Valdes-Quezada Christian, Felder Anna Karina, Filipovska Teodora, van der Elst Stefan, de Andrade dos Ramos Zaria, Han Ruiqi, Krijger Peter H.L., de Laat Wouter Jun 2022, In: Nature Structural and Molecular Biology. 29 , p. 563-574 12 p.

Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization

Bellefroid Maxime, Rodari Anthony, Galais Mathilde, Krijger Peter H.L., Tjalsma Sjoerd J.D., Nestola Lorena, Plant Estelle, Vos Erica S.M., Cristinelli Sara, Van Driessche Benoit, Vanhulle Caroline, Ait-Ammar Amina, Burny Arsène, Ciuffi Angela, De Laat Wouter, Van Lint Carine 8 Apr 2022, In: Nucleic acids research. 50 , p. 3190-3202 13 p.

Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing

Allahyar Amin, Pieterse Mark, Swennenhuis Joost, Los-de Vries G. Tjitske, Yilmaz Mehmet, Leguit Roos, Meijers Ruud W.J., van der Geize Robert, Vermaat Joost, Cleven Arjen, van Wezel Tom, Diepstra Arjan, van Kempen Léon C., Hijmering Nathalie J., Stathi Phylicia, Sharma Milan, Melquiond Adrien S.J., de Vree Paula J.P., Verstegen Marjon J.A.M., Krijger Peter H.L., Hajo Karima, Simonis Marieke, Rakszewska Agata, van Min Max, de Jong Daphne, Ylstra Bauke, Feitsma Harma, Splinter Erik, de Laat Wouter Dec 2021, In: Nature Communications. 12 , p. 1-15

A public–private partnership model for COVID-19 diagnostics

Krijger Peter H.L., Hoek Tim A., Boersma Sanne, Donders Lieke I.P.M., Broeders Maaike M.C., Pieterse Mark, Toonen Pim W., Logister Ive, Verhagen Bram M.P., Verstegen Marjon J.A.M., van Ravesteyn Thomas W., Roymans Rene J.T.M., Mattiroli Francesca, Vandesompele Jo, Nijhuis Monique, Meijer Stefan, van Weert Anton, Dekker Edwin, Dom Fred J., Ruijtenbeek Rob, van der Velden Lieven B.J., van de Bovenkamp Jeroen H.B., Bosch Martijn, de Laat Wouter, Tanenbaum Marvin E. Oct 2021, In: Nature Biotechnology. 39 , p. 1182-1184 3 p.

Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression

Vos Erica S.M., Valdes-Quezada Christian, Huang Yike, Allahyar Amin, Verstegen Marjon J.A.M., Felder Anna Karina, van der Vegt Floor, Uijttewaal Esther C.H., Krijger Peter H.L., de Laat Wouter 5 Aug 2021, In: Molecular Cell. 81 , p. 3082-3095.e6

Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture

Tjalsma Sjoerd Jd, de Laat Wouter Apr 2021, In: Current Opinion in Genetics & Development. 67 , p. 10-17 8 p.

How chromosome topologies get their shape:views from proximity ligation and microscopy methods

Huang Yike, Neijts Roel, de Laat Wouter Nov 2020, In: FEBS letters. 594 , p. 3439-3449 11 p.

Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart

Man Joyce Ck, van Duijvenboden Karel, Krijger Peter Hl, Hooijkaas Ingeborg B, van der Made Ingeborg, de Gier-de Vries Corrie, Wakker Vincent, Creemers Esther E, de Laat Wouter, Boukens Bastiaan J, Christoffels Vincent M 27 Oct 2020, In: Circulation research. 128 , p. 115-129 15 p.

Recently Evolved Enhancers Emerge with High Interindividual Variability and Less Frequently Associate with Disease

Castelijns Bas, Baak Mirna L, Geeven Geert, Vermunt Marit W, Wiggers Caroline R M, Timpanaro Ilia S, Kondova Ivanela, de Laat Wouter, Creyghton Menno P 23 Jun 2020, In: Cell Reports. 31 , p. 1-18

All research output

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