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prof. dr. W.L. (Wouter) de Laat

Full Professor

  • Group Burgering, section Molecular Cancer Research
  • DBG - department of Genetics
  • Hubrecht Institute

prof. dr. W.L. (Wouter) de Laat

Research Programs

Biography

Wouter de Laat studied biology at the Utrecht University. During his PhD (1998) at the Erasmus University Rotterdam (Prof. Jan Hoeijmakers) he investigated the molecular mechanism of nucleotide excision repair. He identified one of the nucleases and characterized the interplay between repair factors at the site of the lesion. As a postdoc, he joined the group of Prof. Frank Grosveld to work on beta-globin gene activation. In 2000 he received a career grant (VIDI) to work on long-range gene activation. His group used 3C technology, and later developed 4C technology, to demonstrate chromatin loops between genes and enhancers and to uncover long-range DNA contacts within and between chromosomes.
In 2008 he received an ERC Young Investigator Grant. In September 2008 de Laat moved his group to the Hubrecht Institute, where he continued his work on genome structure and function. In January 2009 he was appointed professor in Biomedical Genomics at the University Medical Center Utrecht. He received a prestigious VICI career grant in 2012.

Side Activities

  • Scientific board member KWF (Dutch Cancer Society)

    Supervisory board member HUB (Hubrecht Organoid Technology)

    Scientific editor Chromatin and Epigenetics

    Wouter de Laat is founder of and works one day per week as principal scientist for Cergentis (www.cergentis.com). Cergentis is a biotech company that provides services and kits for complete gene sequencing based on its proprietary Targeted Locus Amplification (TLA) Technology.

Fellowship and Awards

  • VIDI (2000)

    VICI (2012)

    ERC Starting Grant (2008)

    EMBO Member

Research Output (77)

Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation

van Ouwerkerk Antoinette F, Hall Amelia W, Kadow Zachary A, Lazarevic Sonja, Reyat Jasmeet S, Tucker Nathan R, Nadadur Rangarajan D, Bosada Fernanda M, Bianchi Valerio, Ellinor Patrick T, Fabritz Larissa, Martin James F, de Laat Wouter, Kirchhof Paulus, Moskowitz Ivan P, Christoffels Vincent M 19 jun 2020, In: Circulation research. 127 , p. 34-50 17 p.

Multi-contact 4C:long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies

Vermeulen Carlo, Allahyar Amin, Bouwman Britta A.M., Krijger Peter H.L., Verstegen Marjon J.A.M., Geeven Geert, Valdes-Quezada Christian, Renkens Ivo, Straver Roy, Kloosterman Wigard P., de Ridder Jeroen, de Laat Wouter 1 feb 2020, In: Nature Protocols. 15 , p. 364-397 34 p.

Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

Castelijns Bas, Baak Mirna L., Timpanaro Ilia S., Wiggers Caroline R.M., Vermunt Marit W., Shang Peng, Kondova Ivanela, Geeven Geert, Bianchi Valerio, de Laat Wouter, Geijsen Niels, Creyghton Menno P. 16 jan 2020, In: Nature Communications. 11 12 p.

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

Man Joyce C.K., Mohan Rajiv A., Boogaard Malou van den, Hilvering Catharina R.E., Jenkins Catherine, Wakker Vincent, Bianchi Valerio, Laat Wouter de, Barnett Phil, Boukens Bastiaan J., Christoffels Vincent M. 1 dec 2019, In: Nature Communications. 10 15 p.

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation

van den Boogaard Malou, van Weerd Jan Hendrik, Bawazeer Amira C, Hooijkaas Ingeborg B, van de Werken Harmen J G, Tessadori Federico, de Laat Wouter, Barnett Phil, Bakkers Jeroen, Christoffels Vincent M 3 sep 2019, In: Cell Reports. 28 , p. 2704-2714.e5

Noncoding deletions reveal a gene that is critical for intestinal function

Oz-Levi Danit, Olender Tsviya, Bar-Joseph Ifat, Zhu Yiwen, Marek-Yagel Dina, Barozzi Iros, Osterwalder Marco, Alkelai Anna, Ruzzo Elizabeth K, Han Yujun, Vos Erica S M, Reznik-Wolf Haike, Hartman Corina, Shamir Raanan, Weiss Batia, Shapiro Rivka, Pode-Shakked Ben, Tatarskyy Pavlo, Milgrom Roni, Schvimer Michael, Barshack Iris, Imai Denise M, Coleman-Derr Devin, Dickel Diane E, Nord Alex S, Afzal Veena, van Bueren Kelly Lammerts, Barnes Ralston M, Black Brian L, Mayhew Christopher N, Kuhar Matthew F, Pitstick Amy, Tekman Mehmet, Stanescu Horia C, Wells James M, Kleta Robert, de Laat Wouter, Goldstein David B, Pras Elon, Visel Axel, Lancet Doron, Anikster Yair, Pennacchio Len A jul 2019, In: Nature. 571 , p. 107-111 5 p.

DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

Redolfi Josef, Zhan Yinxiu, Valdes-Quezada Christian, Kryzhanovska Mariya, Guerreiro Isabel, Iesmantavicius Vytautas, Pollex Tim, Grand Ralph S, Mulugeta Eskeatnaf, Kind Jop, Tiana Guido, Smallwood Sebastien A, de Laat Wouter, Giorgetti Luca jun 2019, In: Nature Structural and Molecular Biology. 26 , p. 471-480 10 p.

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes

Laarman Melanie D., Geeven Geert, Barnett Phil, Rinkel Gabriël J.E., de Laat Wouter, Ruigrok Ynte M., Bakkers Jeroen, 7 mei 2019, In: Journal of the American Heart Association. 8

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo

Monroe Tanner O., Hill Matthew C., Morikawa Yuka, Leach John P., Heallen Todd, Cao Shuyi, Krijger Peter H.L., de Laat Wouter, Wehrens Xander H.T., Rodney George G., Martin James F. 25 mrt 2019, In: Developmental Cell. 48 , p. 765-779.e7

Enhancer hubs and loop collisions identified from single-allele topologies

Allahyar Amin, Vermeulen Carlo, Bouwman Britta A.M., Krijger Peter H.L., Verstegen Marjon J.A.M., Geeven Geert, van Kranenburg Melissa, Pieterse Mark, Straver Roy, Haarhuis Judith H.I., Jalink Kees, Teunissen Hans, Renkens Ivo J., Kloosterman Wigard P., Rowland Benjamin D., de Wit Elzo, de Ridder Jeroen, de Laat Wouter 1 aug 2018, In: Nature Genetics. 50 , p. 1151-1160 10 p.

All Research Output (77)