prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

Full Professor

  • Intensive Care Medicine
  • NVIC bedrijfsvoering

prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

Research Programs


Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since. 

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center ( As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 150,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the majority of the Dutch ICUs. Part of his current research is derived from this large national database: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

Since 2017 he is the chair of the scientific section on "Health Safety Research and Outcome" (HSRO) of the European Society of Intensive Care Medicine (ESICM).

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

  1. critically ill intoxicated patient
  2. critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants 
  3. critically ill patients with the use of biomarkers

Research Output (186)

Performance of the quick SOFA in very old ICU patients admitted with sepsis

Haas Lenneke E M, Termorshuizen Fabian, de Lange Dylan W, van Dijk Diederik, de Keizer Nicolette F apr 2020, In: Acta Anaesthesiologica Scandinavica. 64 , p. 508-516 9 p.

Prophylaxis Against Invasive Fungal Disease for Neutropenic Children and Young Adults

de Lange Dylan W, Brüggemann Roger J M 10 mrt 2020, In: JAMA - The Journal of The American Medical Association. 323 , p. 997-998 2 p.

Organising international research in critical care medicine:current challenges and potential solutions

De Waele Jan J, de Lange Dylan W mrt 2020, In: The Lancet Respiratory Medicine. 8 , p. 245-246 2 p.

Improving medication safety in the Intensive Care by identifying relevant drug-drug interactions - Results of a multicenter Delphi study

Bakker Tinka, Klopotowska Joanna E, de Keizer Nicolette F, van Marum Rob, van der Sijs Heleen, de Lange Dylan W, de Jonge Evert, Abu-Hanna Ameen, Dongelmans Dave A, 21 feb 2020, In: Journal of Critical Care. 57 , p. 134-140 7 p.

Occurrence and Risk Factors of Chronic Pain After Critical Illness

Koster-Brouwer Maria E., Rijsdijk Mienke, Van Os Wouter K.M., Soliman Ivo W., Slooter Arjen J.C., De Lange Dylan W., Van Dijk Diederik, Bonten Marc J.M., Cremer Olaf L. 10 feb 2020, In: Critical Care Medicine. 48 , p. 680-687 8 p.

Clinical Pharmacokinetics and Impact of Hematocrit on Monitoring and Dosing of Tacrolimus Early After Heart and Lung Transplantation

Sikma Maaike A, Hunault Claudine C, Huitema Alwin D R, De Lange Dylan W, Van Maarseveen Erik M 10 dec 2019, In: Clinical Pharmacokinetics. 59 , p. 403-408 6 p.

Diagnostic Accuracy of Procalcitonin and C-reactive Protein Is Insufficient to Predict Proven Infection:A Retrospective Cohort Study in Critically Ill Patients Fulfilling the Sepsis-3 Criteria

van Oers Jos A H, de Jong Evelien, Kemperman Hans, Girbes Armand R J, de Lange Dylan W 6 dec 2019, In: The journal of applied laboratory medicine. 5 , p. 62–72 11 p.

The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs:the VIP2 study

Guidet Bertrand, de Lange Dylan W, Boumendil Ariane, Leaver Susannah, Watson Ximena, Boulanger Carol, Szczeklik Wojciech, Artigas Antonio, Morandi Alessandro, Andersen Finn, Zafeiridis Tilemachos, Jung Christian, Moreno Rui, Walther Sten, Oeyen Sandra, Schefold Joerg C, Cecconi Maurizio, Marsh Brian, Joannidis Michael, Nalapko Yuriy, Elhadi Muhammed, Fjølner Jesper, Flaatten Hans, 29 nov 2019, In: Intensive Care Medicine. 46 , p. 57-69 13 p.

Validation of the clinical frailty score (CFS) in French language

Abraham Paul, Courvoisier Delphine S, Annweiler Cedric, Lenoir Cliff, Millien Thomas, Dalmaz Francoise, Flaatten Hans, Moreno Rui, Christensen Steffen, de Lange Dylan W, Guidet Bertrand, Bendjelid Karim, Walder Bernhard, Bollen Pinto Bernardo 21 nov 2019, In: BMC Geriatrics [E]. 19

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A, Hunault Claudine C, Van Maarseveen Erik M, Huitema Alwin D R, Van de Graaf Ed A, Kirkels Johannes H, Verhaar Marianne C, Grutters Jan C, Kesecioglu Jozef, De Lange Dylan W 19 nov 2019, In: European journal of drug metabolism and pharmacokinetics. 45 , p. 123-134 12 p.

All Research Output (186)