prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

Full Professor
prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange
  • Intensive Care Medicine
  • NVIC bedrijfsvoering

Research Programs



Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since. 

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center ( As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 150,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the majority of the Dutch ICUs. Part of his current research is derived from this large national database: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

Since 2017 he is the chair of the scientific section on "Health Safety Research and Outcome" (HSRO) of the European Society of Intensive Care Medicine (ESICM).

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

  1. critically ill intoxicated patient
  2. critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants 
  3. critically ill patients with the use of biomarkers

Research Output (206)

Sex-specific outcome disparities in very old patients admitted to intensive care medicine:a propensity matched analysis

Wernly Bernhard, Bruno Raphael Romano, Kelm Malte, Boumendil Ariane, Morandi Alessandro, Andersen Finn H, Artigas Antonio, Finazzi Stefano, Cecconi Maurizio, Christensen Steffen, Faraldi Loredana, Lichtenauer Michael, Muessig Johanna M, Marsh Brian, Moreno Rui, Oeyen Sandra, Öhman Christina Agvald, Pinto Bernado Bollen, Soliman Ivo W, Szczeklik Wojciech, Niederseer David, Valentin Andreas, Watson Ximena, Leaver Susannah, Boulanger Carole, Walther Sten, Schefold Joerg C, Joannidis Michael, Nalapko Yuriy, Elhadi Muhammed, Fjølner Jesper, Zafeiridis Tilemachos, De Lange Dylan W, Guidet Bertrand, Flaatten Hans, Jung Christian, 29 okt 2020, In: Scientific Reports. 10

On predictions in critical care:The individual prognostication fallacy in elderly patients

Beil Michael, Sviri Sigal, Flaatten Hans, De Lange Dylan W, Jung Christian, Szczeklik Wojciech, Leaver Susannah, Rhodes Andrew, Guidet Bertrand, van Heerden P Vernon 13 okt 2020, In: Journal of Critical Care. 61 , p. 34-38 5 p.

De giftige groene knolamaniet

van Asten Suzanne A V, van Hemel-Rintjap Tina D, de Lange Dylan W, Mulder-Spijkerboer Henneke N, Kuijper Ed J 25 sep 2020, In: Nederlands Tijdschrift voor Geneeskunde. 164

The wave of very old people in the intensive care unit-A challenge in decision-making

van Heerden Peter Vernon, Sviri Sigal, Beil Michael, de Lange Dylan, Szczeklik Wojciech, Jung Christian, Guidet Bertrand, Leaver Susannah, Rhodes Andrew, Boumendil Ariane, Flaatten Hans 10 sep 2020, In: Journal of Critical Care. 60 , p. 290-293 4 p.

National registries:Lessons learnt from quality improvement initiatives in intensive care

Litton Edward, Guidet Bertrand, de Lange Dylan 18 aug 2020, In: Journal of Critical Care. 60 , p. 311-318 8 p.

Suboptimal Dosing of Fluconazole in Critically III Patients: Time To Rethink Dosing

Muilwijk Eline W, de Lange Dylan W, Schouten Jeroen A, Wasmann Roeland E, Ter Heine Rob, Burger David M, Colbers Angela, Haas Pieter J, Verweij Paul E, Pickkers Peter, Brüggemann Roger J 17 aug 2020, In: Antimicrobial Agents and Chemotherapy. 64 6 p.

Therapy limitation in octogenarians in German intensive care units is associated with a longer length of stay and increased 30 days mortality:A prospective multicenter study

Bruno Raphael Romano, Wernly Bernhard, Beil Michael, Muessig Johanna M, Rahmel Tim, Graf Tobias, Meybohm Patrick, Schaller Stefan J, Allgäuer Sebastian, Franz Marcus, Westphal Julian Georg, Barth Eberhard, Ebelt Henning, Fuest Kristina, Horacek Michael, Schuster Michael, Dubler Simon, Schering Stefan, Wolff Georg, Steiner Stephan, Rabe Christian, Dieck Thorben, Lauten Alexander, Sacher Anne Lena, Brenner Thorsten, Bloos Frank, Jánosi Rolf A, Simon Philipp, Utzolino Stefan, Kelm Malte, De Lange Dylan W, Guidet Bertrand, Flaatten Hans, Jung Christian 1 aug 2020, In: Journal of Critical Care. 60 , p. 58-63 6 p.

Comments to "Frailty is associated with hospital readmission in geriatric patients:a prognostic study" : Assessment of frailty in geriatric patients: let's keep it simple

Bruno Raphael Romano, Wernly Bernhard, Guidet Bertrand, Flaatten Hans, De Lange Dylan W, Jung Christian 18 jul 2020, In: European Geriatric Medicine. 11 , p. 885-886 2 p.

Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit:a prospective cohort study

Schrijver Irene T, Kemperman Hans, Roest Mark, Kesecioglu Jozef, de Lange Dylan W 15 jun 2020, In: Critical care (London, England). 24 4 p.

The association between influenza infections in primary care and intensive care admissions for severe acute respiratory infection (SARI):A modelling approach

van Asten Liselotte, Luna Pinzon Angie, van de Kassteele Jan, Donker Gé, de Lange Dylan W, Dongelmans Dave A, de Keizer Nicolette F, van der Hoek Wim 12 jun 2020, In: Influenza and Other Respiratory Viruses. 14 , p. 575-586 12 p.

All research output