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prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange Full Professor

  • Intensive Care Medicine
  • NVIC bedrijfsvoering

D.W. de Lange


Research Programs


Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since. 

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center (www.vergiftigingen.info). As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 150,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the majority of the Dutch ICUs. Part of his current research is derived from this large national database: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

Since 2017 he is the chair of the scientific section on "Health Safety Research and Outcome" (HSRO) of the European Society of Intensive Care Medicine (ESICM).

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

  1. critically ill intoxicated patient
  2. critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants 
  3. critically ill patients with the use of biomarkers

Research Output (161)

The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs:the VIP2 study

Guidet Bertrand, de Lange Dylan W, Boumendil Ariane, Leaver Susannah, Watson Ximena, Boulanger Carol, Szczeklik Wojciech, Artigas Antonio, Morandi Alessandro, Andersen Finn, Zafeiridis Tilemachos, Jung Christian, Moreno Rui, Walther Sten, Oeyen Sandra, Schefold Joerg C, Cecconi Maurizio, Marsh Brian, Joannidis Michael, Nalapko Yuriy, Elhadi Muhammed, Fjølner Jesper, Flaatten Hans, 29 nov 2019, In: Intensive Care Medicine. 46 , p. 57-69 13 p.

Validation of the clinical frailty score (CFS) in French language

Abraham Paul, Courvoisier Delphine S, Annweiler Cedric, Lenoir Cliff, Millien Thomas, Dalmaz Francoise, Flaatten Hans, Moreno Rui, Christensen Steffen, de Lange Dylan W, Guidet Bertrand, Bendjelid Karim, Walder Bernhard, Bollen Pinto Bernardo 21 nov 2019, In: BMC Geriatrics [E]. 19

Inhalational Methanol Intoxication:Emerging Issues in the Netherlands Resulting From Illegal Drug Production

Wijnands-Kleukers Anja P G, Dijkman Wouter, Brogtrop Jeroen, Kamps Marlijn J A, De Lange Dylan W, Sikma Maaike A nov 2019, In: Annals of Emergency Medicine. 74 , p. 727-728 2 p.

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project

Blot Stijn, Antonelli Massimo, Arvaniti Kostoula, Blot Koen, Creagh-Brown Ben, de Lange Dylan, De Waele Jan, Deschepper Mieke, Dikmen Yalim, Dimopoulos George, Eckmann Christian, Francois Guy, Girardis Massimo, Koulenti Despoina, Labeau Sonia, Lipman Jeffrey, Lipovestky Fernando, Maseda Emilio, Montravers Philippe, Mikstacki Adam, Paiva José-Artur, Pereyra Cecilia, Rello Jordi, Timsit Jean-Francois, Vogelaers Dirk, 29 okt 2019, In: Intensive Care Medicine. 45 , p. 1703-1717 15 p.

Predicting the need for hospitalization of intoxicated patients: a pilot study

Hunault C. C., Hondebrink L., Rietjens S. J., Dekker D., de Vries I., de Lange D. W. 15 okt 2019, In: Toxicology Letters. 314 , p. S86-S87

Why would procalcitonin perform better in patients with a SOFA-score less than 8?

van Oers Jos A H, Nijsten Maarten W, de Jong Evelien, Beishuizen Albertus, de Lange Dylan W 1 okt 2019, In: International Journal of Infectious Diseases. 89 , p. 185-186 2 p.

Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings

Zwartsen Anne, de Korte Tessa, Nacken Peter, de Lange Dylan W, Westerink Remco H S, Hondebrink Laura 14 sep 2019, In: Journal of Molecular and Cellular Cardiology. 136 , p. 102-112 11 p.

The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring:protocol for a cluster randomized stepped-wedge trial

Bakker T, Klopotowska J E, Eslami S, de Lange D W, van Marum R, van der Sijs H, de Jonge E, Dongelmans D A, de Keizer N F, Abu-Hanna A 13 aug 2019, In: BMC Medical Informatics and Decision Making. 19

Emergency Department to ICU Time Is Associated With Hospital Mortality:A Registry Analysis of 14,788 Patients From Six University Hospitals in the Netherlands

Groenland Carline N L, Termorshuizen Fabian, Rietdijk Wim J R, van den Brule Judith, Dongelmans Dave A, de Jonge Evert, de Lange Dylan W, de Smet Anne Marie G A, de Keizer Nicolette F, Weigel Joachim D, Jewbali Lucia S D, Boersma Eric, den Uil Corstiaan A 7 aug 2019, In: Critical Care Medicine. 47 , p. 1564-1571 8 p.

Huge variation in obtaining ethical permission for a non-interventional observational study in Europe

de Lange Dylan W, Guidet Bertrand, Andersen Finn H, Artigas Antonio, Bertolini Guidio, Moreno Rui, Christensen Steffen, Cecconi Maurizio, Agvald-Ohman Christina, Gradisek Primoz, Jung Christian, Marsh Brian J, Oeyen Sandra, Bollen Pinto Bernardo, Szczeklik Wojciech, Watson Ximena, Zafeiridis Tilemachos, Flaatten Hans 3 jun 2019, In: BMC Medical Ethics [E]. 20

All Research Output (161)
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