prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

Full Professor

  • Intensive Care Medicine
  • NVIC bedrijfsvoering

prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

Research Programs


Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since. 

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center ( As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 150,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the majority of the Dutch ICUs. Part of his current research is derived from this large national database: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

Since 2017 he is the chair of the scientific section on "Health Safety Research and Outcome" (HSRO) of the European Society of Intensive Care Medicine (ESICM).

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

  1. critically ill intoxicated patient
  2. critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants 
  3. critically ill patients with the use of biomarkers

Research Output (194)

Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit:a prospective cohort study

Schrijver Irene T, Kemperman Hans, Roest Mark, Kesecioglu Jozef, de Lange Dylan W 15 jun 2020, In: Critical care (London, England). 24 4 p.

The performance of acute versus antecedent patient characteristics for 1-year mortality prediction during intensive care unit admission:a national cohort study

Kerckhoffs Monika C, Brinkman Sylvia, de Keizer Nicolet, Soliman Ivo W, de Lange Dylan W, van Delden Johannes J M, van Dijk Diederik 11 jun 2020, In: Critical care (London, England). 24 9 p.

Should we deny ICU admission to the elderly?:Ethical considerations in times of COVID-19

Haas Lenneke E M, de Lange Dylan W, van Dijk Diederik, van Delden Johannes J M 9 jun 2020, In: Critical care (London, England). 24 3 p.

ICU beds:less is more? No

de Lange Dylan W, Soares Marcio, Pilcher David 26 mei 2020, In: Intensive Care Medicine. 46 , p. 1597-1599

Sepsis at ICU admission does not decrease 30-day survival in very old patients:a post-hoc analysis of the VIP1 multinational cohort study

Ibarz Mercedes, Boumendil Ariane, Haas Lenneke E M, Irazabal Marian, Flaatten Hans, de Lange Dylan W, Morandi Alessandro, Andersen Finn H, Bertolini Guido, Cecconi Maurizio, Christensen Steffen, Faraldi Loredana, Fjølner Jesper, Jung Christian, Marsh Brian, Moreno Rui, Oeyen Sandra, Öhman Christina Agwald, Bollen Pinto Bernardo, Soliman Ivo W, Szczeklik Wojciech, Valentin Andreas, Watson Ximena, Zaferidis Tilemachos, Guidet Bertrand, Artigas Antonio, 13 mei 2020, In: Annals of Intensive Care. 10 12 p.

Hyperthermia exacerbates the acute effects of psychoactive substances on neuronal activity measured using microelectrode arrays (MEAs) in rat primary cortical cultures in vitro

Zwartsen Anne, Hondebrink Laura, de Lange Dylan W, Westerink Remco H S 19 apr 2020, In: Toxicology and Applied Pharmacology. 397 8 p.

Performance of the quick SOFA in very old ICU patients admitted with sepsis

Haas Lenneke E M, Termorshuizen Fabian, de Lange Dylan W, van Dijk Diederik, de Keizer Nicolette F apr 2020, In: Acta Anaesthesiologica Scandinavica. 64 , p. 508-516 9 p.

Prophylaxis Against Invasive Fungal Disease for Neutropenic Children and Young Adults

de Lange Dylan W, Brüggemann Roger J M 10 mrt 2020, In: JAMA - The Journal of The American Medical Association. 323 , p. 997-998 2 p.

Organising international research in critical care medicine:current challenges and potential solutions

De Waele Jan J, de Lange Dylan W mrt 2020, In: The Lancet Respiratory Medicine. 8 , p. 245-246 2 p.

Improving medication safety in the Intensive Care by identifying relevant drug-drug interactions - Results of a multicenter Delphi study

Bakker Tinka, Klopotowska Joanna E, de Keizer Nicolette F, van Marum Rob, van der Sijs Heleen, de Lange Dylan W, de Jonge Evert, Abu-Hanna Ameen, Dongelmans Dave A, 21 feb 2020, In: Journal of Critical Care. 57 , p. 134-140 7 p.

All Research Output (194)