prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

Full Professor
prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange
  • Intensive Care Medicine
  • NVIC bedrijfsvoering

Research Programs



Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since. 

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center ( As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 150,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the majority of the Dutch ICUs. Part of his current research is derived from this large national database: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

Since 2017 he is the chair of the scientific section on "Health Safety Research and Outcome" (HSRO) of the European Society of Intensive Care Medicine (ESICM).

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

  1. critically ill intoxicated patient
  2. critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants 
  3. critically ill patients with the use of biomarkers

Research Output (225)

The impact of frailty on survival in elderly intensive care patients with COVID-19:the COVIP study

Jung Christian, Flaatten Hans, Fjølner Jesper, Bruno Raphael Romano, Wernly Bernhard, Artigas Antonio, Bollen Pinto Bernardo, Schefold Joerg C, Wolff Georg, Kelm Malte, Beil Michael, Sviri Sigal, van Heerden Peter Vernon, Szczeklik Wojciech, Czuczwar Miroslaw, Elhadi Muhammed, Joannidis Michael, Oeyen Sandra, Zafeiridis Tilemachos, Marsh Brian, Andersen Finn H, Moreno Rui, Cecconi Maurizio, Leaver Susannah, Boumendil Ariane, De Lange Dylan W, Guidet Bertrand, 19 apr 2021, In: Critical care (London, England). 25

Clinically relevant potential drug-drug interactions in intensive care patients: A large retrospective observational multicenter study

de Lange Prof.dr. D.W. (Dylan) apr 2021, In: Journal of Critical Care. 62 , p. 124-130 7 p.

Is secondary chemical exposure of hospital personnel of clinical importance?

De Groot Ronald, Van Zoelen Gerard A, Leenders Marianne E C, Van Riel Antoinette J H P, De Vries Irma, De Lange Dylan W apr 2021, In: Clinical Toxicology . 59 , p. 269-278 10 p.

Propensity-Adjusted Comparison of Mortality of Elderly Versus Very Elderly Ventilated Patients

Wernly Bernhard, Bruno Raphael Romano, Frutos-Vivar Fernando, Peñuelas Oscar, Rezar Richard, Raymondos Konstantinos, Muriel Alfonso, Du Bin, Thille Arnaud W, Ríos Fernando, González Marco, Del-Sorbo Lorenzo, Marín Maria Del Carmen, Pinheiro Bruno Valle, Soares Marco Antonio, Nin Nicolas, Maggiore Salvatore M, Bersten Andrew, Kelm Malte, Amin Pravin, Cakar Nahit, Young Suh Gee, Abroug Fekri, Jibaja Manuel, Matamis Dimitros, Zeggwagh Amine Ali, Sutherasan Yuda, Guidet Bertrand, De Lange Dylan W, Beil Michael, Svri Sigal, van Heerden Vernon, Flaatten Hans, Anzueto Antonio, Osmani Venet, Esteban Andrés, Jung Christian 2 mrt 2021, In: Respiratory Care. 66 , p. 814-821 8 p.

Reliability of the Clinical Frailty Scale in very elderly ICU patients:a prospective European study

Flaatten Hans, Guidet Bertrand, Andersen Finn H, Artigas Antonio, Cecconi Maurizio, Boumendil Ariane, Elhadi Muhammed, Fjølner Jesper, Joannidis Michael, Jung Christian, Leaver Susannah, Marsh Brian, Moreno Rui, Oeyen Sandra, Nalapko Yuriy, Schefold Joerg C, Szczeklik Wojciech, Walther Sten, Watson Ximena, Zafeiridis Tilemachos, de Lange Dylan W, 3 feb 2021, In: Annals of Intensive Care. 11 7 p.

Mortality of Older Patients Admitted to an ICU:A Systematic Review

Vallet Helene, Schwarz Gabriele Leonie, Flaatten Hans, de Lange Dylan W, Guidet Bertrand, Dechartres Agnes 2021, In: Critical care medicine. 49 , p. 324-334 11 p.

Acute Coronary Syndrome and Recreational Drug Use: an Amsterdam-based retrospective study

Gresnigt Femke, Hulshof Meike, Franssen Eric, de Lange Dylan, Riezebos Robert 1 nov 2020, In: Clinical Toxicology. 58 , p. 1139-1140

Cardiovascular complications at the Emergency Department following cannabis intoxication

Gresnigt Femke, van den Brink Lianne, Franssen Eric, de Lange Dylan, Riezebos Robert 1 nov 2020, In: Clinical Toxicology. 58 , p. 1140-1141

Self-reported Cocaine Use in Amsterdam Emergency Department Chest Pain Patients is Reliable

Gresnigt Femke, Janszen Almay, Franssen Eric, de Lange Dylan, Riezebos Robert 1 nov 2020, In: Clinical Toxicology. 58 , p. 1141-1142

Sex-specific outcome disparities in very old patients admitted to intensive care medicine:a propensity matched analysis

Wernly Bernhard, Bruno Raphael Romano, Kelm Malte, Boumendil Ariane, Morandi Alessandro, Andersen Finn H, Artigas Antonio, Finazzi Stefano, Cecconi Maurizio, Christensen Steffen, Faraldi Loredana, Lichtenauer Michael, Muessig Johanna M, Marsh Brian, Moreno Rui, Oeyen Sandra, Öhman Christina Agvald, Pinto Bernado Bollen, Soliman Ivo W, Szczeklik Wojciech, Niederseer David, Valentin Andreas, Watson Ximena, Leaver Susannah, Boulanger Carole, Walther Sten, Schefold Joerg C, Joannidis Michael, Nalapko Yuriy, Elhadi Muhammed, Fjølner Jesper, Zafeiridis Tilemachos, De Lange Dylan W, Guidet Bertrand, Flaatten Hans, Jung Christian, 29 okt 2020, In: Scientific Reports. 10

All research output

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