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prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

Full Professor
prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange
  • Intensive Care Medicine
  • NVIC bedrijfsvoering

Research Programs

Biography

Biography

Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since. 

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center (www.vergiftigingen.info). As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 150,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the majority of the Dutch ICUs. Part of his current research is derived from this large national database: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

Since 2017 he is the chair of the scientific section on "Health Safety Research and Outcome" (HSRO) of the European Society of Intensive Care Medicine (ESICM).

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

  1. critically ill intoxicated patient
  2. critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants 
  3. critically ill patients with the use of biomarkers

Research Output (237)

Publisher Correction:Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis

Wernly Bernhard, Bruno Raphael Romano, Kelm Malte, Boumendil Ariane, Morandi Alessandro, Andersen Finn H, Artigas Antonio, Finazzi Stefano, Cecconi Maurizio, Christensen Steffen, Faraldi Loredana, Lichtenauer Michael, Muessig Johanna M, Marsh Brian, Moreno Rui, Oeyen Sandra, Öhman Christina Agvald, Pinto Bernado Bollen, Soliman Ivo W, Szczeklik Wojciech, Niederseer David, Valentin Andreas, Watson Ximena, Leaver Susannah, Boulanger Carole, Walther Sten, Schefold Joerg C, Joannidis Michael, Nalapko Yuriy, Elhadi Muhammed, Fjølner Jesper, Zafeiridis Tilemachos, De Lange Dylan W, Guidet Bertrand, Flaatten Hans, Jung Christian dec 2021, In: Scientific Reports. 11 1 p.

Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe

Jung Christian, Fjølner Jesper, Bruno Raphael Romano, Wernly Bernhard, Artigas Antonio, Bollen Pinto Bernardo, Schefold Joerg C, Wolff Georg, Kelm Malte, Beil Michael, Sviri Sigal, van Heerden Peter Vernon, Szczeklik Wojciech, Czuczwar Miroslaw, Joannidis Michael, Oeyen Sandra, Zafeiridis Tilemachos, Andersen Finn H, Moreno Rui, Leaver Susannah, Boumendil Ariane, De Lange Dylan W, Guidet Bertrand, Flaatten Hans, 23 sep 2021, In: Critical care (London, England). 25 , p. 1-12 12 p.

The management of multi-morbidity in elderly patients:Ready yet for precision medicine in intensive care?

Beil Michael, Flaatten Hans, Guidet Bertrand, Sviri Sigal, Jung Christian, de Lange Dylan, Leaver Susannah, Fjølner Jesper, Szczeklik Wojciech, van Heerden Peter Vernon 10 sep 2021, In: Critical care (London, England). 25 , p. 1-7 7 p.

Antimicrobial stewardship, therapeutic drug monitoring and infection management in the ICU:results from the international A- TEAMICU survey

Lanckohr Christian, Boeing Christian, De Waele Jan J, de Lange Dylan W, Schouten Jeroen, Prins Menno, Nijsten Maarten, Povoa Pedro, Morris Andrew Conway, Bracht Hendrik 26 aug 2021, In: Annals of Intensive Care. 11 , p. 1-8 8 p.

Lactate is associated with mortality in very old intensive care patients suffering from COVID-19:results from an international observational study of 2860 patients

Bruno Raphael Romano, Wernly Bernhard, Flaatten Hans, Fjølner Jesper, Artigas Antonio, Bollen Pinto Bernardo, Schefold Joerg C, Binnebössel Stephan, Baldia Philipp Heinrich, Kelm Malte, Beil Michael, Sigal Sivri, van Heerden Peter Vernon, Szczeklik Wojciech, Elhadi Muhammed, Joannidis Michael, Oeyen Sandra, Zafeiridis Tilemachos, Wollborn Jakob, Arche Banzo Maria José, Fuest Kristina, Marsh Brian, Andersen Finn H, Moreno Rui, Leaver Susannah, Boumendil Ariane, De Lange Dylan W, Guidet Bertrand, Jung Christian, 21 aug 2021, In: Annals of Intensive Care. 11 , p. 1-9 9 p.

ICU-Mortality in Old and Very Old Patients Suffering From Sepsis and Septic Shock

Bruno Raphael Romano, Wernly Bernhard, Mamandipoor Behrooz, Rezar Richard, Binnebössel Stephan, Baldia Philipp Heinrich, Wolff Georg, Kelm Malte, Guidet Bertrand, De Lange Dylan W, Dankl Daniel, Koköfer Andreas, Danninger Thomas, Szczeklik Wojciech, Sigal Sviri, van Heerden Peter Vernon, Beil Michael, Fjølner Jesper, Leaver Susannah, Flaatten Hans, Osmani Venet, Jung Christian 9 jul 2021, In: Frontiers in medicine. 8 , p. 1-10 10 p.

Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU:a prospective cohort study

Fronczek Jakub, Polok Kamil, de Lange Dylan W, Jung Christian, Beil Michael, Rhodes Andrew, Fjølner Jesper, Górka Jacek, Andersen Finn H, Artigas Antonio, Cecconi Maurizio, Christensen Steffen, Joannidis Michael, Leaver Susannah, Marsh Brian, Morandi Alessandro, Moreno Rui, Oeyen Sandra, Agvald-Öhman Christina, Bollen Pinto Bernardo, Schefold Joerg C, Valentin Andreas, Walther Sten, Watson Ximena, Zafeiridis Tilemachos, Sviri Sigal, van Heerden Peter Vernon, Flaatten Hans, Guidet Bertrand, Szczeklik Wojciech, 1 jul 2021, In: Critical care (London, England). 25 , p. 1-9 9 p.

Metabolomic profiling of microbial disease etiology in community-acquired pneumonia

den Hartog Ilona, Zwep Laura B, Vestjens Stefan M T, Harms Amy C, Voorn G Paul, de Lange Dylan W, Bos Willem J W, Hankemeier Thomas, van de Garde Ewoudt M W, van Hasselt J G Coen 4 jun 2021, In: PLoS ONE. 16 , p. 1-15

Provision of critical care for the elderly in Europe:a retrospective comparison of national healthcare frameworks in intensive care units

Wernly Bernhard, Beil Michael, Bruno Raphael Romano, Binnebössel Stephan, Kelm Malte, Sigal Sviri, van Heerden Peter Vernon, Boumendil Ariane, Artigas Antonio, Cecconi Maurizio, Marsh Brian, Moreno Rui, Oeyen Sandra, Bollen Pinto Bernardo, Szczeklik Wojciech, Leaver Susannah, Walther Sten Mikael, Schefold Joerg C, Joannidis Michael, Fjølner Jesper, Zafeiridis Tilemachos, de Lange Dylan, Guidet Bertrand, Flaatten Hans, Jung Christian, 3 jun 2021, In: BMJ Open. 11 , p. 1-12

Mid-Regional Proadrenomedullin and Mid-Regional Proatrial Natriuretic Peptide Clearance Predicts Poor Outcomes Better Than Single Baseline Measurements in Critically Ill Patients With Pneumonia:A Retrospective Cohort Study

Van Oers Jos, Krabbe Johannes, Kemna Evelien, Kluiters Yvette, Vos Piet, De Lange Dylan, Girbes Armand, Beishuizen Albertus 28 mei 2021, In: Cureus. 13 , p. e15285

All research output

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