prof. dr. L.S. (Linda) de Vries

prof. dr. L.S. (Linda) de Vries

Professor Emeritus
prof. dr. L.S. (Linda) de Vries
  • Birth Center Neonatology - Medical



Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.


Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
4: Harwood Nash memorial lecture, Toronto, 2012
5: McCance Lecture (British Neonatal Society), 2004
6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (645)

Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy

Annink Kim V, de Vries Linda S, Groenendaal Floris, Eijsermans Rian M J C, Mocking Manouk, van Schooneveld Monique M J, Dudink Jeroen, van Straaten Henrica L M, Benders Manon J N L, Lequin Maarten, van der Aa Niek E dec 2021, In: Scientific Reports. 11

Neonatal stroke in premature neonates

Steggerda S. J., de Vries L. S. nov 2021, In: Seminars in perinatology. 45

Motor Developmental Delay After Cardiac Surgery in Children With a Critical Congenital Heart Defect:A Systematic Literature Review and Meta-analysis

Sprong Maaike C A, Broeders Willem, van der Net Janjaap, Breur Johannes M P J, de Vries Linda S, Slieker Martijn G, van Brussel Marco 1 okt 2021, In: Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association. 33 , p. 186-197 12 p.

Ultrasound measurements of brain structures differ between moderate-late preterm and full-term infants at term equivalent age

Boswinkel Vivian, Sok Femke I., Krüse-Ruijter Martine F., Nijholt Ingrid M., Jansen Fenna A.R., Haak Monique C., Boomsma Martijn F., de Vries Linda S., Steggerda Sylke J., van Wezel-Meijler Gerda sep 2021, In: Early Human Development. 160 , p. 1-8

Mild brain lesions do not affect brain volumes in moderate-late preterm infants

Boswinkel Vivian, Verschuur Anouk S, Nijholt Ingrid M, van Osch Jochen A C, Nijboer-Oosterveld Jacqueline, Beare Richard J, Slump Cornelis H, de Vries Linda S, Boomsma Martijn F, van Wezel-Meijler Gerda 17 aug 2021, In: European Journal of Paediatric Neurology. 34 , p. 91-98 8 p.

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse A, van Huffelen Alexander C, van Klink Nicole E C, Benders Manon J N L, de Vries Linda S, Leijten Frans S S, Jansen Floor E, Braun Kees P J, Zijlmans Maeike 16 apr 2021, In: Clinical Neurophysiology. 132 , p. 1452-1461 10 p.

Prognostic value of brain abnormalities for cognitive functioning in cerebral palsy:A prospective cohort study

Moll Irene, Voorman Jeanine M, Ketelaar Marjolijn, van Schie Petra E, Gorter Jan Willem, Lequin Maarten H, de Vries Linda S, Vermeulen R Jeroen 16 mrt 2021, In: European Journal of Paediatric Neurology. 32 , p. 56-65 10 p.

Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound:A Canadian Perspective

Mohammad Khorshid, Scott James N, Leijser Lara M, Zein Hussein, Afifi Jehier, Piedboeuf Bruno, de Vries Linda S, van Wezel-Meijler Gerda, Lee Shoo K, Shah Prakesh S 8 mrt 2021, In: Frontiers in Pediatrics. 9

Incidence of brain lesions in moderate-late preterm infants assessed by cranial ultrasound and MRI:The BIMP-study

Boswinkel Vivian, Krüse-Ruijter Martine F, Nijboer-Oosterveld Jacqueline, Nijholt Ingrid M, Edens Mireille A, Mulder-de Tollenaer Susanne M, Smit-Wu Mei-Nga, Boomsma Martijn F, de Vries Linda S, van Wezel-Meijler Gerda mrt 2021, In: European Journal of Radiology. 136

MRI Score Ability to Detect Abnormalities in Mild Hypoxic-Ischemic Encephalopathy

Machie Michelle, Weeke Lauren, de Vries Linda S, Rollins Nancy, Brown Larry, Chalak Lina mrt 2021, In: Pediatric Neurology. 116 , p. 32-38 7 p.

All research output

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