prof. dr. L.S. (Linda) de Vries

prof. dr. L.S. (Linda) de Vries

Professor Emeritus
prof. dr. L.S. (Linda) de Vries
  • Birth Center Neonatology - Medical



Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.


Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
4: Harwood Nash memorial lecture, Toronto, 2012
5: McCance Lecture (British Neonatal Society), 2004
6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (662)

Outcome Prediction and Inter-Rater Comparison of Four Brain Magnetic Resonance Imaging Scoring Systems of Infants with Perinatal Asphyxia and Therapeutic Hypothermia

Langeslag Juliette F, Groenendaal Floris, Roosendaal Stefan D, de Vries Linda S, Onland Wes, Leeflang Mariska M G, Groot Paul F C, van Kaam Anton H, de Haan Timo R, 31 Mar 2022, In: Neonatology. 119 , p. 311-319 9 p.

Impact of surgery and anesthesia during early brain development:a perfect storm

Keunen Kristin, Sperna Weiland Nicolaas H, de Bakker Bernadette S, de Vries Linda S, Stevens Markus F 10 Mar 2022, In: Paediatric Anaesthesia. 32 , p. 697-705 9 p.

Improved neonatal brain MRI segmentation by interpolation of motion corrupted slices

Verschuur Anouk S, Boswinkel Vivian, Tax Chantal M W, van Osch Jochen A C, Nijholt Ingrid M, Slump Cornelis H, de Vries Linda S, van Wezel-Meijler Gerda, Leemans Alexander, Boomsma Martijn F 7 Mar 2022, In: Journal of Neuroimaging. 32 , p. 480-492 13 p.

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

Parmentier Corline E J, de Vries Linda S, Groenendaal Floris 6 Mar 2022, In: Diagnostics (Basel, Switzerland). 12

Proceedings of the 13th International Newborn Brain Conference:Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring

Abend Nicholas et al. 2022, In: Journal of neonatal-perinatal medicine. 15 , p. 467-485 19 p.

Proceedings of the 13th International Newborn Brain Conference:Neuro-imaging studies

Abramsky Ramy et al. 2022, In: Journal of neonatal-perinatal medicine. 15 , p. 389-409 21 p.

A uniform description of perioperative brain MRI findings in infants with severe congenital heart disease:Results of a European collaboration

Stegeman R., Feldmann M., Claessens N. H.P., Jansen N. J.G., Breur J. M.P.J., de Vries L. S., Logeswaran T., Reich B., Knirsch W., Kottke R., Hagmann C., Latal B., Simpson J., Pushparajah K., Bonthrone A. F., Kelly C. J., Arulkumaran S., Rutherford M. A., Counsell S. J., Benders M. J.N.L., 1 Nov 2021, In: American Journal of Neuroradiology. 42 , p. 2034-2039 6 p.

Neonatal stroke in premature neonates

Steggerda S. J., de Vries L. S. Nov 2021, In: Seminars in perinatology. 45 , p. 1-9

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse, van Huffelen Alexander, van Klink Nicole, Benders Manon, de Vries Linda, Leijten Frans, Jansen Floor E., Braun Kees, Zijlmans Maeike Nov 2021, In: Epilepsia. 62 , p. 114-115

Neuroimaging in the term newborn with neonatal encephalopathy

Wisnowski Jessica L, Wintermark Pia, Bonifacio Sonia L, Smyser Christopher D, Barkovich A James, Edwards A David, de Vries Linda S, Inder Terrie E, Chau Vann, 29 Oct 2021, In: Seminars in Fetal & Neonatal Medicine. 26 , p. 1-13

All research output

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