prof. dr. L.S. (Linda) de Vries

prof. dr. L.S. (Linda) de Vries

Professor Emeritus
prof. dr. L.S. (Linda) de Vries
  • Birth Center Neonatology - Medical



Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.


Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
4: Harwood Nash memorial lecture, Toronto, 2012
5: McCance Lecture (British Neonatal Society), 2004
6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (704)

Cranial MRI beyond the Neonatal Period and Neurodevelopmental Outcomes in Neonatal Encephalopathy Due to Perinatal Asphyxia:A Systematic Review

Parmentier Corline E J, Kropman Tobias, Groenendaal Floris, Lequin Maarten H, de Vries Linda S, Benders Manon J N L, Alderliesten Thomas 6 Dec 2023, In: Journal of Clinical medicine. 12 18 p.

Physical activity in relation to motor performance, exercise capacity, sports participation, parental perceptions, and overprotection in school aged children with a critical congenital heart defect

Sprong Maaike C.A., Noordstar Johannes J., Slieker Martijn G., de Vries Linda S., Takken Tim, van Brussel Marco 29 Sep 2023, In: Early Human Development. 186 , p. 1-10

Ultrasonographic Estimation of Ventricular Volume in Infants Born Preterm with Post- hemorrhagic Ventricular Dilatation:A Nested Substudy of the Randomized Controlled Early Versus Late Ventricular Intervention Study (ELVIS) Trial

Benavente-Fernández Isabel, Steggerda Sylke J, Liem Kian D, Lubián-López Simón, de Vries Linda S 22 Jun 2023, In: The Journal of Pediatrics. 261 , p. 1-8

Early recognition of characteristic conventional and amplitude-integrated EEG patterns of seizures in SCN2A and KCNQ3-related epilepsy in neonates

Pijpers Judith A, Au Ping Yee Billie, Weeke Lauren C, Vein Alla A, Smit Liesbeth S, Vilan Ana, Jacobs Elke, de Vries Linda S, Steggerda Sylke J, Cilio Maria Roberta, Carapancea Evelina, Cornet Marie-Coralie, Appendino Juan P, Peeters-Scholte Cacha M P C D 22 Jun 2023, In: Seizure. 110 , p. 212-219 8 p.

Do we need a brain MRI once or twice in infants treated with hypothermia?

de Vries Linda S, Groenendaal Floris 29 Apr 2023, In: Pediatric Research. 94 , p. 870-872 3 p.

Rapid exome sequencing as a first-tier test in neonates with suspected genetic disorder:results of a prospective multicenter clinical utility study in the Netherlands

Olde Keizer Richelle A C M, Marouane Abderrahim, Kerstjens-Frederikse Wilhelmina S, Deden A Chantal, Lichtenbelt Klaske D, Jonckers Tinneke, Vervoorn Marieke, Vreeburg Maaike, Henneman Lidewij, de Vries Linda S, Sinke Richard J, Pfundt Rolph, Stevens Servi J C, Andriessen Peter, van Lingen Richard A, Nelen Marcel, Scheffer Hans, Stemkens Daphne, Oosterwijk Cor, van Amstel Hans Kristian Ploos, de Boode Willem P, van Zelst-Stams Wendy A G, Frederix Geert W J, Vissers Lisenka E L M, 31 Mar 2023, In: European Journal of Pediatrics. 182 , p. 2683-2692 10 p.

Children Newly Diagnosed with Fetal and Neonatal Alloimmune Thrombocytopenia:Neurodevelopmental Outcome at School Age: Newly Diagnosed FNAIT: Follow-up Study

de Vos Thijs W, van Zagten Maud, de Haas Masja, Oepkes Dick, Tan Ratna N G B, van der Schoot C Ellen, Steggerda Sylke J, de Vries Linda S, Lopriore Enrico, van Klink Jeanine M M 16 Mar 2023, In: The Journal of Pediatrics. 258

Machine learning for the early prediction of infants with electrographic seizures in neonatal hypoxic-ischemic encephalopathy

Pavel Andreea M., O'Toole John M., Proietti Jacopo, Livingstone Vicki, Mitra Subhabrata, Marnane William P., Finder Mikael, Dempsey Eugene M., Murray Deirdre M., Boylan Geraldine B., Pavlidis Elena, Kharoshankaya Liudmila, Mathieson Sean R., Lightbody Gordon, O’Leary Jackie, Murray Mairead, Conway Jean, Dwyer Denis, Temko Andrey, Kiely Taragh, Ryan Anthony C., Rennie Janet M., de Vries Linda S., Weeke Lauren C., Toet Mona C., Harteman Johanneke C., Blennow Mats, Edqvist Ingela, Foran Adrienne, Pinnamaneni Raga Mallika, Colby-Milley Jessica, Shah Divyen K., Openshaw-Lawrence Nicola, Pressler Ronit M., Kapellou Olga, van Huffelen Alexander C., Feb 2023, In: Epilepsia. 64 , p. 456-468 13 p.

Heart rate variability analysis for the prediction of EEG grade in infants with hypoxic ischaemic encephalopathy within the first 12 h of birth

Pavel Andreea M, Mathieson Sean R., Livingstone Vicki, O’Toole John M., Pressler Ronit M., de Vries Linda S., Rennie Janet M., Mitra Subhabrata, Dempsey Eugene M., Murray Deirdre M., Marnane William P., Boylan Geraldine B., 4 Jan 2023, In: Frontiers in Pediatrics. 10 , p. 1-11

All research output

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