prof. dr. L.S. (Linda) de Vries

Professor Emeritus
prof. dr. L.S. (Linda) de Vries
  • Birth Center Neonatology - Medical



Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.


Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
4: Harwood Nash memorial lecture, Toronto, 2012
5: McCance Lecture (British Neonatal Society), 2004
6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (632)

Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy

Annink Kim V, de Vries Linda S, Groenendaal Floris, Eijsermans Rian M J C, Mocking Manouk, van Schooneveld Monique M J, Dudink Jeroen, van Straaten Henrica L M, Benders Manon J N L, Lequin Maarten, van der Aa Niek E dec 2021, In: Scientific Reports. 11 , p. 5017

Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound:A Canadian Perspective

Mohammad Khorshid, Scott James N, Leijser Lara M, Zein Hussein, Afifi Jehier, Piedboeuf Bruno, de Vries Linda S, van Wezel-Meijler Gerda, Lee Shoo K, Shah Prakesh S 8 mrt 2021, In: Frontiers in Pediatrics. 9 , p. 618236

MRI Score Ability to Detect Abnormalities in Mild Hypoxic-Ischemic Encephalopathy

Machie Michelle, Weeke Lauren, de Vries Linda S, Rollins Nancy, Brown Larry, Chalak Lina mrt 2021, In: Pediatric Neurology. 116 , p. 32-38 7 p.

Incidence of brain lesions in moderate-late preterm infants assessed by cranial ultrasound and MRI:The BIMP-study

Boswinkel Vivian, Krüse-Ruijter Martine F, Nijboer-Oosterveld Jacqueline, Nijholt Ingrid M, Edens Mireille A, Mulder-de Tollenaer Susanne M, Smit-Wu Mei-Nga, Boomsma Martijn F, de Vries Linda S, van Wezel-Meijler Gerda mrt 2021, In: European Journal of Radiology. 136 , p. 109500

The ILAE classification of seizures and the epilepsies:Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures

Pressler Ronit M, Cilio Maria Roberta, Mizrahi Eli M, Moshé Solomon L, Nunes Magda L, Plouin Perrine, Vanhatalo Sampsa, Yozawitz Elissa, de Vries Linda S, Puthenveettil Vinayan Kollencheri, Triki Chahnez C, Wilmshurst Jo M, Yamatomo Hitoshi, Zuberi Sameer M 1 feb 2021, In: Epilepsia. 62 , p. 615-628 14 p.

Similar outcomes for antenatally or postnatally acquired haemorrhages

de Vries Linda S, de Vries Johanna I P feb 2021, In: Developmental Medicine and Child Neurology. 63 , p. 126 1 p.

Isoprostanes as Biomarker for White Matter Injury in Extremely Preterm Infants

Coviello Caterina, Perrone Serafina, Buonocore Giuseppe, Negro Simona, Longini Mariangela, Dani Carlo, de Vries Linda S, Groenendaal Floris, Vijlbrief Daniel C, Benders Manon J N L, Tataranno Maria Luisa 15 jan 2021, In: Frontiers in Pediatrics. 8 , p. 618622

White matter injury in infants with intraventricular haemorrhage:mechanisms and therapies

Ballabh Praveen, de Vries Linda S 2021, In: Nature Reviews Neurology. 17 , p. 199-214 16 p.

Association of early skin breaks and neonatal thalamic maturation:A modifiable risk?

Duerden Emma G, Grunau Ruth E, Chau Vann, Groenendaal Floris, Guo Ting, Chakravarty M Mallar, Benders Manon, Wagenaar Nienke, Eijsermans Rian, Koopman Corine, Synnes Anne, Vries Linda de, Miller Steven P 21 okt 2020, In: Neurology. 95 , p. e3420-e3427

A machine-learning algorithm for neonatal seizure recognition:a multicentre, randomised, controlled trial

Pavel Andreea M, Rennie Janet M, de Vries Linda S, Blennow Mats, Foran Adrienne, Shah Divyen K, Pressler Ronit M, Kapellou Olga, Dempsey Eugene M, Mathieson Sean R, Pavlidis Elena, van Huffelen Alexander C, Livingstone Vicki, Toet Mona C, Weeke Lauren C, Finder Mikael, Mitra Subhabrata, Murray Deirdre M, Marnane William P, Boylan Geraldine B 27 aug 2020, In: The Lancet. Child & adolescent health. 4 , p. 740-749 10 p.

All research output

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