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dr. K.M. (Karin) de Winter-de Groot

dr. K.M. (Karin) de Winter-de Groot

PHD Candidate - Medical
dr. K.M. (Karin) de Winter-de Groot
  • Pulmonology patient care

Research Programs

Child Health

Side Activities

Chair Dutch Pediatric Pulmonology Society (NVK, from 2020 onwards, no payment)

Chair Dutch Advisory Board Neonatal Heelprick Screening for CF (NVK, from 2016 onwards, < €2200, payment from RIVM to UMCU)

Member Executive Committee European Neonatal Screening Working Group of ECFS (from 2016 onwards, no payment)

National Principal Investigator of studies Vertex Pharmaceuticals (from 2019 onwards, study related payments to UMCU, no personal payment)

Member DSMB Protea study (PI Tramper, Rotterdam) (from 2021 onwards, no payment)

Pediatric Pulmonologist (temporary 0-hours commission for weekend shifts (bronchoscopies), Radboud Medical Center Nijmegen (> €2200, personal payment)

Selection Committee ChristenUnie Culemborg (2017-2018 and 2021-2022)

 

 

Research Output (72)

Triple therapy for cystic fibrosis Phe508del-gating and -residual function genotypes

Barry Peter J., Mall Marcus A., Álvarez Antonio, Colombo Carla, de Winter-De Groot Karin M., Fajac Isabelle, McBennett Kimberly A., McKone Edward F., Ramsey Bonnie W., Sutharsan Sivagurunathan, Taylor-Cousar Jennifer L., Tullis Elizabeth, Ahluwalia Neil, Jun Lucy S., Moskowitz Samuel M., Prieto-Centurion Valentin, Tian Simon, Waltz David, Xuan Fengjuan, Zhang Yaohua, Rowe Steven M., Polineni Deepika 26 Aug 2021, In: New England Journal of Medicine. 385 , p. 815-825 11 p.

Individual and Group Response of Treatment with Ivacaftor on Airway and Gut Microbiota in People with CF and a S1251N Mutation

Kristensen Maartje I, de Winter-de Groot Karin M, Berkers Gitte, Chu Mei Ling J N, Arp Kayleigh, Ghijsen Sophie, Heijerman Harry G M, Arets Hubertus G M, Majoor Christof J, Janssens Hettie M, van der Meer Renske, Bogaert Debby, van der Ent Cornelis K May 2021, In: Journal of Personalized Medicine. 11 , p. 1-9

Exhaled volatile organic compounds detect pulmonary exacerbations early in children with cystic fibrosis:results of a 1 year observational pilot study

van Horck Marieke, Smolinska Agnieszka, Wesseling Geertjan, de Winter-de Groot Karin, de Vreede Ilja, Winkens Bjorn, Jöbsis Quirijn, Dallinga Jan, Dompeling Edward, van Schooten Frederik-Jan 25 Feb 2021, In: Journal of Breath Research. 15

Defining key outcomes to evaluate performance of newborn screening programmes for cystic fibrosis

Munck Anne, Southern Kevin W., Castellani Carlo, de Winter-de Groot Karin M., Gartner Silvia, Kashirskaya Nataliya, Linnane Barry, Mayell Sarah J., Proesmans Marijke, Sands Dorota, Sommerburg Olaf, Barben Jürg, 2021, In: Journal of Cystic Fibrosis. 20 , p. 820-823 4 p.

R117H-CFTR function and response to VX-770 correlate with mRNA and protein expression in intestinal organoids

Van Mourik Peter, van Haaren Paul, Kruisselbrink Evelien, Korkmaz Cemil, Janssens Hettie M., de Winter – de Groot Karin M., van der Ent Cornelis K., Hagemeijer Marne C., Beekman Jeffrey M. Sep 2020, In: Journal of Cystic Fibrosis. 19 , p. 728-732 5 p.

The impact of ivacaftor on sinonasal pathology in S1251N-mediated cystic fibrosis patients

Gostelie Romee, Stegeman Inge, Berkers Gitte, Bittermann Joost, Ligtenberg-van der Drift Ivonne, Kipshagen Peter-Jan van, Speleman Lucienne, de Winter-de Groot Karin Jul 2020, In: PLoS ONE. 15

Long-term effects of ivacaftor on nonpulmonary outcomes in individuals with cystic fibrosis, heterozygous for a S1251N mutation

Burghard M., Berkers G., Ghijsen S., Hollander-Kraaijeveld F. M., de Winter-de Groot K. M., van der Ent C. K., Heijerman H. G.M., Takken T., Hulzebos H. J. Jun 2020, In: Pediatric Pulmonology. 55 , p. 1400-1405 6 p.

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Geurts Maarten H., de Poel Eyleen, Amatngalim Gimano D., Oka Rurika, Meijers Fleur M., Kruisselbrink Evelien, van Mourik Peter, Berkers Gitte, de Winter-de Groot Karin M., Michel Sabine, Muilwijk Danya, Aalbers Bente L., Mullenders Jasper, Boj Sylvia F., Suen Sylvia W.F., Brunsveld Jesse E., Janssens Hettie M., Mall Marcus A., Graeber Simon Y., van Boxtel Ruben, van der Ent Cornelis K., Beekman Jeffrey M., Clevers Hans 2 Apr 2020, In: Cell stem cell. 26 , p. 503-510.e7

Clinical effect of lumacaftor/ivacaftor in F508del homozygous CF patients with FEV<sub>1</sub> ≥ 90% predicted at baseline

Aalbers B L, de Winter-de Groot K M, Arets H G M, Hofland R W, de Kiviet A C, van Oirschot-van de Ven M M M, Kruijswijk M A, Schotman S, Michel S, van der Ent C K, Heijerman H G M 7 Jan 2020, In: Journal of Cystic Fibrosis. 19 , p. 654-658 5 p.

Development of the gut microbiota in early life:The impact of cystic fibrosis and antibiotic treatment

Kristensen Maartje, Prevaes Sabine M.P.J., Kalkman Gino, Tramper-Stranders Gerdien A., Hasrat Raiza, de Winter- de Groot Karin M., Janssens Hettie M., Tiddens Harm A., van Westreenen Mireille, Sanders Elisabeth A.M., Arets Bert, Keijser Bart, van der Ent Cornelis K., Bogaert Debby 1 Jan 2020, In: Journal of Cystic Fibrosis. 19 , p. 553-561 9 p.

All research output

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