prof. dr. ir. H.M. (Hester M.) den Ruijter

Full Professor
prof. dr. ir. H.M. (Hester M.) den Ruijter
  • Department of Cardiology

Research Programs

Circulatory Health



Welcome to my page. Let me introduce myself, I am Hester den Ruijter, Professor of Cardiovascular disease in women. My aim is to translate knowledge from experimental research to the patient. In women, the diagnosis of heart disease is a problem. Most available diagnostics for heart disease have been tested in men and directly translated to women. Nowadays we are increasingly becoming aware that male-derived tests do not always detect heart disease in women. There are interesting sex differences in the pathophysiology of heart disease that may explain why diagnostic tests developed in men fail to detect heart disease in women. Therefore, my goal is to obtain novel biomarkers that facilitate the diagnosis of heart disease in women. If you have any questions regarding my research, you are welcome to contact me.

Side Activities

  • Vice Chairwoman of the Young Academy of the Royal Netherlands Academy of Sciences 
  • Specialty Chief editor of Frontiers in Cardiovascular Medicine (Sex and gender section)
  • Board member of funding agency “Vrienden UMC Utrecht”. 

Fellowship and Awards

Agnites Vrolikprijs award for research impact UU (2019)

AHA Scott Grundy Award for Excellence in Metabolism Research (2010)

Research Output (193)

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Hartman Robin J G, Owsiany Katie, Ma Lijiang, Koplev Simon, Hao Ke, Slenders Lotte, Civelek Mete, Mokry Michal, Kovacic Jason C, Pasterkamp Gerard, Owens Gary, Björkegren Johan L M, den Ruijter Hester M 16 feb 2021, In: Circulation. 143 , p. 713-726 14 p.

Evaluation of non-invasive imaging parameters in coronary microvascular disease:a systematic review

Groepenhoff F, Klaassen R G M, Valstar G B, Bots S H, Onland-Moret N C, Den Ruijter H M, Leiner T, Eikendal A L M 6 jan 2021, In: BMC medical imaging. 21 , p. 1-23

Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort:design and rationale of the ARGUS Study

Groepenhoff Floor, Eikendal Anouk L M, Bots Sophie Heleen, van Ommen Anne-Mar, Overmars L M, Kapteijn Daniek, Pasterkamp Gerard, Reiber Johan H C, Hautemann David, Menken Roxana, Wittekoek Marianne E, Hofstra Leonard, Onland-Moret N Charlotte, Haitjema Saskia, Hoefer Imo, Leiner Tim, den Ruijter Hester M 15 dec 2020, In: BMJ Open. 10 , p. 1-7

Heart Size Corrected Electrical Dyssynchrony and Its Impact on Sex-specific Response to Cardiac Resynchronization Therapy

Salden Odette A E, van Stipdonk Antonius M W, den Ruijter Hester M, Cramer Maarten Jan, Kloosterman Mariëlle, Rienstra Michiel, Maass Alexander H, Prinzen Frits W, Vernooy Kevin, Meine Mathias 9 dec 2020, In: Circulation. Arrhythmia and electrophysiology. 14 , p. e008452

Preemptive Stenting of the Vulnerable Plaque:Fixing a Dogma?

Pasterkamp Gerard, van der Harst Pim, den Ruijter Hester M 17 nov 2020, In: Journal of the American College of Cardiology. 76 , p. 2302-2304 3 p.

The age- and sex-specific composition of atherosclerotic plaques in vascular surgery patients

de Bakker Marie, Timmerman Nathalie, van Koeverden Ian D, de Kleijn Dominique P V, de Borst Gert J, Pasterkamp Gerard, Boersma Eric, den Ruijter Hester M okt 2020, In: Atherosclerosis. 310 , p. 1-10 10 p.

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Depuydt Marie Ac, Prange Koen Hm, Slenders Lotte, Örd Tiit, Elbersen Danny, Boltjes Arjan, de Jager Saskia Ca, Asselbergs Folkert W, de Borst Gert J, Aavik Einari, Lönnberg Tapio, Lutgens Esther, Glass Christopher K, den Ruijter Hester M, Kaikkonen Minna U, Bot Ilze, Slütter Bram, van der Laan Sander W, Yla-Herttuala Seppo, Mokry Michal, Kuiper Johan, de Winther Menno Pj, Pasterkamp Gerard 28 sep 2020, In: Circulation research. 127 , p. 1437-1455 19 p.

Sex-specific microRNAs in women with diabetes and left ventricular diastolic dysfunction or HFpEF associate with microvascular injury

Florijn Barend W., Valstar Gideon B., Duijs Jacques M.G.J., Menken Roxana, Cramer Maarten J., Teske Arco J., Ghossein-Doha Chahinda, Rutten Frans H., Spaanderman Marc E.A., den Ruijter Hester M., Bijkerk Roel, van Zonneveld Anton Jan 18 aug 2020, In: Scientific Reports. 10

Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Hartman Robin J G, Kapteijn Daniek M C, Haitjema Saskia, Bekker Mireille N, Mokry Michal, Pasterkamp Gerard, Civelek Mete, den Ruijter Hester M 23 jul 2020, In: Scientific Reports. 10 12 p.

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

All research output

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