prof. dr. ir. H.M. (Hester M.) den Ruijter

Full Professor

  • Department of Cardiology

prof. dr. ir. H.M. (Hester M.) den Ruijter

Research Programs


Welcome to my page. Let me introduce myself, I am Hester den Ruijter, Professor of Cardiovascular disease in women. My aim is to translate knowledge from experimental research to the patient. In women, the diagnosis of heart disease is a problem. Most available diagnostics for heart disease have been tested in men and directly translated to women. Nowadays we are increasingly becoming aware that male-derived tests do not always detect heart disease in women. There are interesting sex differences in the pathophysiology of heart disease that may explain why diagnostic tests developed in men fail to detect heart disease in women. Therefore, my goal is to obtain novel biomarkers that facilitate the diagnosis of heart disease in women. If you have any questions regarding my research, you are welcome to contact me.

Side Activities

    • Vice Chairwoman of the Young Academy of the Royal Netherlands Academy of Sciences 
    • Specialty Chief editor of Frontiers in Cardiovascular Medicine (Sex and gender section)
    • Board member of funding agency “Vrienden UMC Utrecht”. 

Fellowship and Awards

  • Agnites Vrolikprijs award for research impact UU (2019)

    AHA Scott Grundy Award for Excellence in Metabolism Research (2010)

Research Output (181)

Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Hartman Robin J G, Kapteijn Daniek M C, Haitjema Saskia, Bekker Mireille N, Mokry Michal, Pasterkamp Gerard, Civelek Mete, den Ruijter Hester M 23 jul 2020, In: Scientific Reports. 10 12 p.

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

Mortality after hospital admission for heart failure:improvement over time, equally strong in women as in men

Buddeke J, Valstar G B, van Dis I, Visseren F L J, Rutten F H, den Ruijter H M, Vaartjes I, Bots M L, 10 jan 2020, In: BMC Public Health. 20 10 p.

Sex-specific thoracic aortic dimensions and clinical implications

Groepenhoff Floor, den Ruijter Hester M 1 jan 2020, In: Heart. 106 , p. 97-98 2 p.

Reported adverse drug reactions in women and men:Aggregated evidence from globally collected individual case reports during half a century

Watson Sarah, Caster Ola, Rochon Paula A., den Ruijter Hester 1 dec 2019, In: EClinicalMedicine. 17 10 p.

Associations of autozygosity with a broad range of human phenotypes

Clark David W et al. 1 dec 2019, In: Nature Communications. 10

Platelet RNA modules point to coronary calcification in asymptomatic women with former preeclampsia

Hartman Robin J.G., Korporaal Suzanne J.A., Mokry Michal, de Jager Saskia C.A., Meeuwsen John A.L., van der Laan Sander W., Lansu Nico R., Zoet Gerbrand A., Pasterkamp Gerard, Urbanus Rolf T., Hoefer Imo E., Franx Arie, Velthuis Birgitta K., van Rijn Bas B., den Ruijter Hester M., 1 dec 2019, In: Atherosclerosis. 291 , p. 114-121 8 p.

Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure

van den Hoogen Patricia, de Jager Saskia C.A., Huibers Manon M.H., Schoneveld Arjan H., Puspitasari Yustina M., Valstar Gideon B., Oerlemans Marish I.F.J., de Weger Roel A., Doevendans Pieter A., den Ruijter Hester M., Laman Jon D., Vink Aryan, Sluijter Joost P.G. 26 sep 2019, In: Journal of Cellular and Molecular Medicine. 23 , p. 7505-7516 12 p.

The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

Prestel Matthias, Prell-Schicker Caroline, Webb Tom, Malik Rainer, Lindner Barbara, Ziesch Natalie, Rex-Haffner Monika, Röh Simone, Viturawong Thanatip, Lehm Manuel, Mokry Michal, den Ruijter Hester, Haitjema Saskia, Asare Yaw, Söllner Flavia, Najafabadi Maryam Ghaderi, Aherrahrou Rédouane, Civelek Mete, Samani Nilesh J, Mann Matthias, Haffner Christof, Dichgans Martin 10 sep 2019, In: Stroke. 50 , p. 2651-2660 10 p.

Enhancing cardiovascular artificial intelligence (AI) research in the Netherlands:CVON-AI consortium

Benjamins J. W., van Leeuwen K., Hofstra L., Rienstra M., Appelman Y., Nijhof W., Verlaat B., Everts I., den Ruijter H. M., Isgum I., Leiner T., Vliegenthart R., Asselbergs F. W., Juarez-Orozco L. E., van der Harst P. 1 sep 2019, In: Netherlands Heart Journal. 27 , p. 414-425 12 p.

All Research Output (181)