prof. dr. ir. H.M. (Hester M.) den Ruijter

Full Professor

  • Department of Cardiology

prof. dr. ir. H.M. (Hester M.) den Ruijter

Research Programs


Welcome to my page. Let me introduce myself, I am Hester den Ruijter, Professor of Cardiovascular disease in women. My aim is to translate knowledge from experimental research to the patient. In women, the diagnosis of heart disease is a problem. Most available diagnostics for heart disease have been tested in men and directly translated to women. Nowadays we are increasingly becoming aware that male-derived tests do not always detect heart disease in women. There are interesting sex differences in the pathophysiology of heart disease that may explain why diagnostic tests developed in men fail to detect heart disease in women. Therefore, my goal is to obtain novel biomarkers that facilitate the diagnosis of heart disease in women. If you have any questions regarding my research, you are welcome to contact me.

Side Activities

    • Vice Chairwoman of the Young Academy of the Royal Netherlands Academy of Sciences 
    • Specialty Chief editor of Frontiers in Cardiovascular Medicine (Sex and gender section)
    • Board member of funding agency “Vrienden UMC Utrecht”. 

Fellowship and Awards

  • Agnites Vrolikprijs award for research impact UU (2019)

    AHA Scott Grundy Award for Excellence in Metabolism Research (2010)

Research Output (188)

Evaluation of non-invasive imaging parameters in coronary microvascular disease:a systematic review

Groepenhoff F, Klaassen R G M, Valstar G B, Bots S H, Onland-Moret N C, Den Ruijter H M, Leiner T, Eikendal A L M 6 jan 2021, In: BMC medical imaging. 21 , p. 5

Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort:design and rationale of the ARGUS Study

Groepenhoff Floor, Eikendal Anouk L M, Bots Sophie Heleen, van Ommen Anne-Mar, Overmars L M, Kapteijn Daniek, Pasterkamp Gerard, Reiber Johan H C, Hautemann David, Menken Roxana, Wittekoek Marianne E, Hofstra Leonard, Onland-Moret N Charlotte, Haitjema Saskia, Hoefer Imo, Leiner Tim, den Ruijter Hester M 15 dec 2020, In: BMJ Open. 10 , p. e040712

Preemptive Stenting of the Vulnerable Plaque:Fixing a Dogma?

Pasterkamp Gerard, van der Harst Pim, den Ruijter Hester M 17 nov 2020, In: Journal of the American College of Cardiology. 76 , p. 2302-2304 3 p.

The age- and sex-specific composition of atherosclerotic plaques in vascular surgery patients

de Bakker Marie, Timmerman Nathalie, van Koeverden Ian D, de Kleijn Dominique P V, de Borst Gert J, Pasterkamp Gerard, Boersma Eric, den Ruijter Hester M okt 2020, In: Atherosclerosis. 310 , p. 1-10 10 p.

Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Hartman Robin J G, Kapteijn Daniek M C, Haitjema Saskia, Bekker Mireille N, Mokry Michal, Pasterkamp Gerard, Civelek Mete, den Ruijter Hester M 23 jul 2020, In: Scientific Reports. 10 12 p.

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

Cerebral Small Vessel Disease in Standard Pre-operative Imaging Reports Is Independently Associated with Increased Risk of Cardiovascular Death Following Carotid Endarterectomy

Timmerman Nathalie, Rots Marjolijn L, van Koeverden Ian D, Haitjema Saskia, van Laarhoven Constance J H C M, Vuurens Annemiek M, den Ruijter Hester M, Pasterkamp Gerard, Kappelle L Jaap, de Kleijn Dominique P V, de Borst Gert J jun 2020, In: European Journal of Vascular and Endovascular Surgery. 59 , p. 872-880 9 p.

Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Meeuwsen John A L, de Vries Judith, Zoet Gerbrand A, Franx Arie, Fauser Bart C J M, Maas Angela H E M, Velthuis Birgitta K, Appelman Yolande E, Visseren Frank L, Pasterkamp Gerard, Hoefer Imo E, van Rijn Bas B, den Ruijter Hester M, de Jager Saskia C A 18 feb 2020, In: Cells. 9

Mortality after hospital admission for heart failure:improvement over time, equally strong in women as in men

Buddeke J, Valstar G B, van Dis I, Visseren F L J, Rutten F H, den Ruijter H M, Vaartjes I, Bots M L, 10 jan 2020, In: BMC Public Health. 20 10 p.

Family history and polygenic risk of cardiovascular disease:Independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy

Timmerman Nathalie, de Kleijn Dominique P.V., de Borst Gert J., den Ruijter Hester M., Asselbergs Folkert W., Pasterkamp Gerard, Haitjema Saskia, van der Laan Sander W. 1 jan 2020, In: Atherosclerosis. 307 , p. 121-129 9 p.

All Research Output (188)