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prof. dr. P.W.B. (Patrick W.B.) Derksen

prof. dr. P.W.B. (Patrick W.B.) Derksen

Full Professor
prof. dr. P.W.B. (Patrick W.B.) Derksen
  • Department of Pathology

Research Programs

Strategic Program Cancer

Biography

Biography

Patrick Derksen (1970) obtained his PhD at the department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. Following his graduation in 2003, he moved to the Netherlands Cancer Institute to study the consequences inactivation of cell-cell adhesion in breast cancer development and progression. Here he developed two mouse models for human invasive lobular carcinoma (ILC), by conditional and mammary-specific knockout of E-cadherin and p53. In 2005 he was awarded an independent researcher grant from the Dutch organization for scientific research (NWO-VENI) in 2005. In 2007, he joined the Medical Oncology department as an independent researcher and head of the UMCU Mouse Cancer Clinic. He received a NWO-VIDI award in 2008. In 2010 his position was tenured as an Associate Professor at the Department of Pathology.

His group is aiming at combining expertise on adhesion molecules, cell signaling and clinically relevant mouse models to study the downstream effectors of the adherens junction complex that propel breast cancer development and progression.

Research in the Derksen laboratory is currently sponsored by grants from NWO, KWF, H2020, STW and Breast Cancer Now.

Side Activities

Chair European Lobular Breast Cancer Consortium (ELBCC)

Chair COST Action #19138 LOBSTERPOT

Scientific Advisory Board Member of the Lobular Breast Cancer Alliance (LBCA)

co-investigator POSEIDON-2-Lobular Clinical intervention trial

Fellowship and Awards

NWO-VENI 916.56.135. (2006)

AICR 07-585. (2007)

Pink Ribbon  Award (2008)

NWO-VIDI 016.096.318. (2009)

KWF-UU 2011-5230 (2011)

Stichting Vrienden UMC Utrecht (2011)

KWF UU 2013-5801 (2013)

KWF-UU 2014-7201 (2015)

Research Output (47)

Correction:Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Rätze Max A K, Koorman Thijs, Sijnesael Thijmen, Bassey-Archibong Blessing, van de Ven Robert, Enserink Lotte, Visser Daan, Jaksani Sridevi, Viciano Ignacio, Bakker Elvira R M, Richard François, Tutt Andrew, O'Leary Lynda, Fitzpatrick Amanda, Roca-Cusachs Pere, van Diest Paul J, Desmedt Christine, Daniel Juliet M, Isacke Clare M, Derksen Patrick W B 24 May 2022, In: Oncogene. 41 , p. 3507-3509 3 p.

Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer

Van Baelen K, Geukens T, Maetens M, Tjan-Heijnen V, Lord C J, Linn S, Bidard F-C, Richard F, Yang W W, Steele R E, Pettitt S J, Van Ongeval C, De Schepper M, Isnaldi E, Nevelsteen I, Smeets A, Punie K, Voorwerk L, Wildiers H, Floris G, Vincent-Salomon A, Derksen P W B, Neven P, Senkus E, Sawyer E, Kok M, Desmedt C 20 May 2022, In: Annals of oncology : official journal of the European Society for Medical Oncology. 33 , p. 769-785 17 p.

Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Rätze Max A K, Koorman Thijs, Sijnesael Thijmen, Bassey-Archibong Blessing, van de Ven Robert, Enserink Lotte, Visser Daan, Jaksani Sridevi, Viciano Ignacio, Bakker Elvira R M, Richard François, Tutt Andrew, O'Leary Lynda, Fitzpatrick Amanda, Roca-Cusachs Pere, van Diest Paul J, Desmedt Christine, Daniel Juliet M, Isacke Clare M, Derksen Patrick W B 20 May 2022, In: Oncogene. 41 , p. 2932-2944 13 p.

FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

Tavares Sandra, Liv Nalan, Pasolli Milena, Opdam Mark, Rätze Max A K, Saornil Manuel, Sluimer Lilian M, Hengeveld Rutger C C, van Es Robert, van Werkhoven Erik, Vos Harmjan, Rehmann Holger, Burgering Boudewijn M T, Oosterkamp Hendrika M, Lens Susanne M A, Klumperman Judith, Linn Sabine C, Derksen Patrick W B 5 Apr 2022, In: Cell Reports. 39 , p. 1-24

Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment

Koorman Thijs, Jansen Karin A, Khalil Antoine, Haughton Peter D, Visser Daan, Rätze Max A K, Haakma Wisse E, Sakalauskaitè Gabrielè, van Diest Paul J, de Rooij Johan, Derksen Patrick W B 15 Mar 2022, In: Oncogene. 41 , p. 2458-2469 12 p.

Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer

De Schepper Maxim, Vincent-Salomon Anne, Christgen Matthias, Van Baelen Karen, Richard François, Tsuda Hitoshi, Kurozumi Sasagu, Brito Maria Jose, Cserni Gabor, Schnitt Stuart, Larsimont Denis, Kulka Janina, Fernandez Pedro Luis, Rodríguez-Martínez Paula, Olivar Ana Aula, Melendez Cristina, Van Bockstal Mieke, Kovacs Aniko, Varga Zsuzsanna, Wesseling Jelle, Bhargava Rohit, Boström Pia, Franchet Camille, Zambuko Blessing, Matute Gustavo, Mueller Sophie, Berghian Anca, Rakha Emad, van Diest Paul J., Oesterreich Steffi, Derksen Patrick W.B., Floris Giuseppe, Desmedt Christine 2022, In: Modern Pathology.

Atlas of Lobular Breast Cancer Models:Challenges and Strategic Directions

Sflomos George, Schipper Koen, Koorman Thijs, Fitzpatrick Amanda, Oesterreich Steffi, Lee Adrian V, Jonkers Jos, Brunton Valerie G, Christgen Matthias, Isacke Clare, Derksen Patrick W B, Brisken Cathrin 1 Nov 2021, In: Cancers. 13

Lobular breast cancer:Histomorphology and different concepts of a special spectrum of tumors

Christgen Matthias, Cserni Gábor, Floris Giuseppe, Marchio Caterina, Djerroudi Lounes, Kreipe Hans, Derksen Patrick W.B., Vincent-Salomon Anne 1 Aug 2021, In: Cancers. 13 , p. 1-34 34 p.

Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma

Christgen Matthias, Kandt Leonie Donata, Antonopoulos Wiebke, Bartels Stephan, Van Bockstal Mieke R, Bredt Martin, Brito Maria Jose, Christgen Henriette, Colpaert Cecile, Cserni Bálint, Cserni Gábor, Daemmrich Maximilian E, Danebrock Raihanatou, Dedeurwaerdere Franceska, van Deurzen Carolien Hm, Erber Ramona, Fathke Christine, Feist Henning, Fiche Maryse, Gonzalez Claudia Aura, Ter Hoeve Natalie D, Kooreman Loes, Krech Till, Kristiansen Glen, Kulka Janina, Laenger Florian, Lafos Marcel, Lehmann Ulrich, Martin-Martinez Maria Dolores, Mueller Sophie, Pelz Enrico, Raap Mieke, Ravarino Alberto, Reineke-Plaass Tanja, Schaumann Nora, Schelfhout Anne-Marie, De Schepper Maxim, Schlue Jerome, Van de Vijver Koen, Waelput Wim, Wellmann Axel, Graeser Monika, Gluz Oleg, Kuemmel Sherko, Nitz Ulrike, Harbeck Nadia, Desmedt Christine, Floris Giuseppe, Derksen Patrick Wb, van Diest Paul J, Vincent-Salomon Anne, Kreipe Hans 2021, In: The journal of pathology. Clinical research. 8 , p. 191-205 15 p.

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

Vervoort Stephin J., de Jong Olivier G., Guy Roukens M., Frederiks Cynthia L., Vermeulen Jeroen F., Lourenço Ana Rita, Bella Laura, Vidakovic Ana Tufegdzic, Sandoval José L., Moelans Cathy, van Amersfoort Miranda, Dallman Margaret J., Bruna Alejandra, Caldas Carlos, Nieuwenhuis Edward, van der Wall Elsken, Derksen Patrick, van Diest Paul, Verhaar Marianne C., Lam Eric W.F., Mokry Michal, Coffer Paul J. 3 Dec 2018, In: eLife. 7

All research output

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