prof. dr. R.M. (Rick M.) Dijkhuizen

Full Professor

  • Biomedical MR Imaging and Spectroscopy Group

prof. dr. R.M. (Rick M.) Dijkhuizen

Research Programs


Rick Dijkhuizen received his Ph.D. at Utrecht University in 1998 (thesis title: 'Magnetic Resonance Imaging and Spectroscopy in Experimental Cerebral Ischemia'). From 1999 until 2002 he worked at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School (Charlestown/Boston, MA, USA), first as Postdoctoral Fellow and later as Instructor. There his research focused on elucidating spontaneous and therapy-induced recovery after cerebrovascular injury (e.g. stroke) with different MRI techniques in patients and experimental models. In 2002 he became head of the Biomedical MR Imaging and Spectroscopy group, part of the Center for Image Sciences, at the University Medical Center Utrecht. He was a Visiting Associate Professor at the Department of Radiology at Stanford University School of Medicine from 2013 until 2014.

His current research interests include multiparametric imaging of brain structure and function in health and disease, with a particular focus on i) development of tools for improved diagnosis of brain pathophysiology, ii) characterization of neural network (re)organization, and iii) monitoring of neuroprotective and -restorative therapies. He has recently initiated a translational research project that aims to establish safe and effective modulation of neural networks to enhance functional recovery after stroke through non-invasive brain stimulation in stroke animal models and patients.

He has teamed up with different colleagues of the UMCU Brain Center for preclinical imaging studies on stroke, epilepsy and neurodevelopmental disorders, and he collaborates with various national and international institutions on topics such as brain plasticity and molecular imaging. Rick Dijkhuizen has been workpackage leader in two EU-FP7 research programs (EUSTROKE and TACTICS). He served/serves on the Board of Directors of the International Society for Cerebral Blood Flow and Metabolism, and the Editorial Boards of the Journal of Cerebral Blood Flow and Metabolism, Translational Stroke Research, and Stroke. He is Associate Editor of Frontiers in Neurology|Stroke and the Journal of Cerebral Blood Flow and Metabolism.

Research line

Experimental and Translational Neuroimaging

Most recent key publications

1: Otte WM, van der Marel K, van Meer MP, van Rijen PC, Gosselaar PH, Braun KP, Dijkhuizen RM. Altered contralateral sensorimotor system organization after experimental hemispherectomy: a structural and functional connectivity study. J Cereb Blood Flow Metab. 2015;35:1358-67.
2: Dijkhuizen RM, Zaharchuk G, Otte WM. Assessment and modulation of resting-state neural networks after stroke. Curr Opin Neurol. 2014;27:637-43.
3: Dijkhuizen RM. Imaging neuronal loss and recovery in compromised but viable brain tissue. Brain. 2013;136:1689-91.
4: van Meer MP, Otte WM, van der Marel K, Nijboer CH, Kavelaars A, van der Sprenkel JW, Viergever MA, Dijkhuizen RM. Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity. J Neurosci. 2012;32:4495-507.
5: Schaechter JD, van Oers CA, Groisser BN, Salles SS, Vangel MG, Moore CI, Dijkhuizen RM. Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients. Neurorehabil Neural Repair. 2012;26:325-34.

Side Activities

  • Member of the Editorial Board of Translational Stroke Research

    Member of the Editorial Board of Stroke

    Associate Editor of Frontiers in Neurology|Stroke

    Associate Editor of the Journal for Cerebral Blood Flow and Metabolism

Fellowship and Awards

  • VICI award, Netherlands Organization for Scientific Research (2013)

    ‘High Potential’ award, Utrecht University (2007)

    VIDI award, Netherlands Organization for Scientific Research (2006)

    Royal Netherlands Academy of Arts and Sciences (KNAW) Fellowship (2002)

    Postdoctoral Fellowship Award (New England Affiliate), American Heart Association (2000)

    Talent Fellowship Award, Netherlands Organization for Scientific Research (1998)

Research Output (158)

Does upper limb strength play a prominent role in health-related quality of life in stroke patients discharged from inpatient rehabilitation?

Lieshout Eline C.C.van, van de Port Ingrid G., Dijkhuizen Rick M., Visser-Meily Johanna M.A. 2 okt 2020, In: Topics in Stroke Rehabilitation. 27 , p. 525-533 9 p.

Active Recharge Burst and Tonic Spinal Cord Stimulation Engage Different Supraspinal Mechanisms:A Functional Magnetic Resonance Imaging Study in Peripherally Injured Chronic Neuropathic Rats

Meuwissen Koen P.V., van der Toorn Annette, Gu Jianwen Wendy, Zhang Tianhe C., Dijkhuizen Rick M., Joosten Elbert A.J. 1 jun 2020, In: Pain Practice. 20 , p. 510-521 12 p.

Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

Senders Max L., Meerwaldt Anu E., van Leent Mandy M.T., Sanchez-Gaytan Brenda L., van de Voort Jan C., Toner Yohana C., Maier Alexander, Klein Emma D., Sullivan Nathaniel A.T., Sofias Alexandros Marios, Groenen Hannah, Faries Christopher, Oosterwijk Roderick S., van Leeuwen Esther M., Fay Francois, Chepurko Elena, Reiner Thomas, Duivenvoorden Raphael, Zangi Lior, Dijkhuizen Rick M., Hak Sjoerd, Swirski Filip K., Nahrendorf Matthias, Pérez-Medina Carlos, Teunissen Abraham J.P., Fayad Zahi A., Calcagno Claudia, Strijkers Gustav J., Mulder Willem J.M. 1 mei 2020, In: Nature nanotechnology. 15 , p. 398-405 8 p.

Design and Evaluation of a Rodent-Specific Transcranial Magnetic Stimulation Coil:An In Silico and In Vivo Validation Study

Boonzaier Julia, Petrov Petar I., Otte Willem M., Smirnov Nickolay, Neggers Sebastiaan F.W., Dijkhuizen Rick M. 1 apr 2020, In: Neuromodulation. 23 , p. 324-334 11 p.

Comparison of self-reported vs observational clinical measures of improvement in upper limb capacity in patients after stroke

Van Lieshout Eline C.C., Visser-Meily Johanna M.A., Nijland Rinske H.M., Dijkhuizen Rick M., Kwakkel Gert apr 2020, In: Journal of Rehabilitation Medicine. 52 7 p.

Animal Functional Magnetic Resonance Imaging:Trends and Path Toward Standardization

Mandino Francesca, Cerri Domenic H., Garin Clement M., Straathof Milou, van Tilborg Geralda A.F., Chakravarty M. Mallar, Dhenain Marc, Dijkhuizen Rick M., Gozzi Alessandro, Hess Andreas, Keilholz Shella D., Lerch Jason P., Shih Yen Yu Ian, Grandjean Joanes 22 jan 2020, In: Frontiers in Neuroinformatics. 13 24 p.

Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain

Straathof Milou, Sinke Michel R T, Roelofs Theresia J M, Blezer Erwin L A, Sarabdjitsingh R Angela, van der Toorn Annette, Schmitt Oliver, Otte Willem M, Dijkhuizen Rick M 9 jan 2020, In: Scientific Reports. 10 14 p.

Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration

Karel Peter, Van der Toorn Annette, Vanderschuren Louk, Guo Chao, Sadighi Alvandi Mina, Reneman Liesbeth, Dijkhuizen Rick, Verheij Michel M.M., Homberg Judith R. 1 jan 2020, In: Addiction Biology. 25

The JCBFM Symposium at BRAIN 2019

Dijkhuizen Rick M. jan 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40 , p. 225-227 3 p.

Timing of Repetitive Transcranial Magnetic Stimulation Onset for Upper Limb Function After Stroke:A Systematic Review and Meta-Analysis

van Lieshout Eline C.C., van der Worp H. Bart, Visser-Meily Johanna M.A., Dijkhuizen Rick M. 3 dec 2019, In: Frontiers in Neurology. 10 , p. 1269

All Research Output (158)