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prof. dr. P.A.F.M. (Pieter A.) Doevendans Full Professor

  • Department of Cardiology

P.A.F.M. Doevendans


Research Programs


Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books

Side Activities


    • Member of the Scientific Board, Netherlands Heart Institute                                                                                         
    • Chairman Steering committee Heart and Vascular Center                                                                             

Fellowship and Awards



    • Fellow of the European Society of Cardiology, 2000
    • Honorary Professor Yantai Yuhuangding Hospital, China, 2007
    • Visiting Professor Harvard University, USA, 2007-2009
    • Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
    • Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014


    Research grants obtained 

    • NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
    • The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".

    • NIH: "The role of the min K gene". Grant with R.S. Kass.

    • The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.

    • The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)

    • The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.

    • Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)

    • The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)

    • ICIN: Molecular genetic basis of cardiovascular disease (2000)

    • ICIN: Human genetics and cardiovascular developement (2000)

    • NHS: Dekker program: Vanessa van Empel (2001-2004)

    • STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)

    • BSIK: Weefsel op maat (2003)

    • Bekales Research Grant – Cardiology 2004, candidature.

    • Bekales Research Grant (2005)

    • NHS: Translational medicine: stem cell applications (2006)

    • ICIN: Stem cells from patients with genetic cardiac disease (2007)

    • BMM: SMARTCARE: cardiac repair with microtissues (2008)

    • NIRM: Stem cells as disease models (2009)

    • ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
      Phase A1 preclinical PL €300.000 (total project  €2.0M)

    • CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
      (Total project 0,5M)

    • CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)

    • Leducq (Total project 6 M€) (2018)

    • RegMed: Cardiovascular Moonshot (4 M€) (2018)

Research Output (690)

High intensity interval training after cardiac resynchronization therapy:An explorative randomized controlled trial

Spee Ruud F., Niemeijer Victor M., Schoots Thijs, Tuinenburg Anton, Houthuizen Patrick, Wijn Pieter F., Doevendans Pieter A., Kemps Hareld M. 15 jan 2020, In: International Journal of Cardiology. 299 , p. 169-174 6 p.

Cancer Therapy-Related Cardiac Dysfunction of Nonanthracycline Chemotherapeutics. What Is the Evidence?

Kamphuis Janine, Linschoten Marijke, Cramer Maarten J, Gort Eelke, van Rhenen Anna, Asselbergs Folkert, Doevendans PA, Teske Arco 1 dec 2019, In: JACC. Cardio Oncology. 1 , p. 280-290 10 p.

Are there gender disparities in symptom presentation or triage of patients with chest discomfort at primary care out-of-hours services?:An observational study

van der Meer Manon G, Appelman Yolande, Rutten Karlijn H G, van der Graaf Yolanda, Nathoe Hendrik M, Doevendans Pieter A, Smit Michelle, Verheij Emmy, Botermans Anne, Rutten Frans H 19 nov 2019, In: BMJ Open. 9

Impact of baseline cigarette smoking status on clinical outcome after transcatheter aortic valve replacement

Abawi Masieh, van Gils Lennart, Agostoni Pierfrancesco, van Mieghem Nicolas M., Kooistra Nynke H. M., van Dongen Charlotte S., van Jaarsveld Romy C., de Jaegere Peter P. T., Doevendans Pieter A. F. M., Stella Pieter R. 15 nov 2019, In: Catheterization and Cardiovascular Interventions. 94 , p. 795-805 11 p.

Survival analysis of patients with rheumatic MS after PBMV compared with MVS in a low-to-middle-income country

Ambari A. M., Setianto B., Santoso A., Dwiputra B., Radi B., Alkatiri A. A., Adji A. B., Susilowati E., Tulrahmi F., Cramer M. J.M., Doevendans P. A. nov 2019, In: Netherlands Heart Journal. 27 , p. 559-564 6 p.

Coronary microvascular function in athletes with abnormal exercise test results

van de Sande D. A.J.P., Barneveld P. C., Hoogsteen J., Doevendans P. A., Kemps H. M.C. 25 okt 2019, In: Netherlands Heart Journal. 27 , p. 621-628 8 p.

Fiber Scaffold Patterning for Mending Hearts:3D Organization Bringing the Next Step

Kristen Marleen, Ainsworth Madison J., Chirico Nino, van der Ven Casper F.T., Doevendans Pieter A., Sluijter Joost P.G., Malda Jos, van Mil Alain, Castilho Miguel 11 okt 2019, In: Advanced Healthcare Materials. 9 21 p.

Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics

Mol Emma A, Lei Zhiyong, Roefs Marieke T, Bakker Maarten H, Goumans Marie-José, Doevendans Pieter A, Dankers Patricia Y W, Vader Pieter, Sluijter Joost P G okt 2019, In: Advanced Healthcare Materials. 8

Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure

van den Hoogen Patricia, de Jager Saskia C.A., Huibers Manon M.H., Schoneveld Arjan H., Puspitasari Yustina M., Valstar Gideon B., Oerlemans Marish I.F.J., de Weger Roel A., Doevendans Pieter A., den Ruijter Hester M., Laman Jon D., Vink Aryan, Sluijter Joost P.G. 26 sep 2019, In: Journal of Cellular and Molecular Medicine. 23 , p. 7505-7516 12 p.

Leducq Transatlantic Network of Excellence to Cure Phospholamban-Induced Cardiomyopathy (CURE-PLaN)

Doevendans Pieter A., Glijnis Pieter C., Kranias Evangelia G. 13 sep 2019, In: Circulation research. 125 , p. 720-724 5 p.

All Research Output (690)
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