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prof. dr. P.A.F.M. (Pieter A.) Doevendans

Full Professor

  • Department of Cardiology

prof. dr. P.A.F.M. (Pieter A.) Doevendans

Biography

Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books

Side Activities

  •                                    

    • Member of the Scientific Board, Netherlands Heart Institute                                                                                         
    • Chairman Steering committee Heart and Vascular Center                                                                             

Fellowship and Awards

  •  

    Honors

    • Fellow of the European Society of Cardiology, 2000
    • Honorary Professor Yantai Yuhuangding Hospital, China, 2007
    • Visiting Professor Harvard University, USA, 2007-2009
    • Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
    • Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014

     

    Research grants obtained 

    • NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
    • The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".

    • NIH: "The role of the min K gene". Grant with R.S. Kass.

    • The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.

    • The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)

    • The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.

    • Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)

    • The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)

    • ICIN: Molecular genetic basis of cardiovascular disease (2000)

    • ICIN: Human genetics and cardiovascular developement (2000)

    • NHS: Dekker program: Vanessa van Empel (2001-2004)

    • STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)

    • BSIK: Weefsel op maat (2003)

    • Bekales Research Grant – Cardiology 2004, candidature.

    • Bekales Research Grant (2005)

    • NHS: Translational medicine: stem cell applications (2006)

    • ICIN: Stem cells from patients with genetic cardiac disease (2007)

    • BMM: SMARTCARE: cardiac repair with microtissues (2008)

    • NIRM: Stem cells as disease models (2009)

    • ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
      Phase A1 preclinical PL €300.000 (total project  €2.0M)

    • CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
      (Total project 0,5M)

    • CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)

    • Leducq (Total project 6 M€) (2018)

    • RegMed: Cardiovascular Moonshot (4 M€) (2018)

Research Output (920)

Cellular and Molecular Mechanism of Cardiac Regeneration:A Comparison of Newts, Zebrafish, and Mammals

de Wit Lousanne, Fang Juntao, Neef Klaus, Xiao Junjie, A Doevendans Pieter, Schiffelers Raymond M, Lei Zhiyong, Sluijter Joost P G 19 aug 2020, In: Biomolecules. 10 , p. 1-20

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Buikema Jan W, Lee Soah, Goodyer William R, Maas Renee G, Chirikian Orlando, Li Guang, Miao Yi, Paige Sharon L, Lee Daniel, Wu Haodi, Paik David T, Rhee Siyeon, Tian Lei, Galdos Francisco X, Puluca Nazan, Beyersdorf Benjamin, Hu James, Beck Aimee, Venkamatran Sneha, Swami Srilatha, Wijnker Paul, Schuldt Maike, Dorsch Larissa M, van Mil Alain, Red-Horse Kristy, Wu Joy Y, Geisen Caroline, Hesse Michael, Serpooshan Vahid, Jovinge Stefan, Fleischmann Bernd K, Doevendans Pieter A, van der Velden Jolanda, Garcia K Christopher, Wu Joseph C, Sluijter Joost P G, Wu Sean M 2 jul 2020, In: Cell stem cell. 27 , p. 50-63.e5

Epinephrine stress testing during cardiac catheterization in patients with aortic coarctation:Epinephrine stress testing in aortic coarctation

Meijs Timion A., Krings Gregor J., Saad Anan, Molenschot Mirella M.C., Doevendans Pieter A., Voskuil Michiel jul 2020, In: American Heart Journal. 225 , p. 78-87 10 p.

Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice

Lei Zhiyong, Fang Juntao, Deddens Janine C, Metz Corina H G, van Eeuwijk Esther C M, El Azzouzi Hamid, Doevendans Pieter A, Sluijter Joost P G jun 2020, In: Frontiers in Physiology. 11 9 p.

Automatic Triage of 12-Lead ECGs Using Deep Convolutional Neural Networks

van de Leur Rutger R, Blom Lennart J, Gavves Efstratios, Hof Irene E, van der Heijden Jeroen F, Clappers Nick C, Doevendans Pieter A, Hassink Rutger J, van Es René 18 mei 2020, In: Journal of the American Heart Association. 9 18 p.

Development of an algorithm for automatic classification of right ventricle deformation patterns in arrhythmogenic right ventricular cardiomyopathy

Groen Marijn H A, Bosman Laurens P, Teske Arco J, Mast Thomas P, Taha Karim, Van Slochteren Frebus J, Cramer Maarten J, Doevendans Pieter A, van Es René mei 2020, In: Echocardiography. 37 , p. 698-705 8 p.

Control of Angiogenesis via a VHL/miR-212/132 Axis

Lei Zhiyong, Klasson Timothy D., Brandt Maarten M., van de Hoek Glenn, Logister Ive, Cheng Caroline, Doevendans Pieter A., Sluijter Joost P.G., Giles Rachel H. 19 apr 2020, In: Cells. 9 11 p.

Randomised comparison of a balloon-expandable and self-expandable valve with quantitative assessment of aortic regurgitation using magnetic resonance imaging

Kooistra N H M, Abawi M, Voskuil M, Urgel K, Samim M, Nijhoff F, Nathoe H M, Doevendans P A F M, Chamuleau S A J, Leenders G E H, Leiner T, Abrahams A C, van der Worp H B, Agostoni P, Stella P R 3 apr 2020, In: Netherlands Heart Journal. 28 , p. 253-265 13 p.

Plasma Immunoglobulin Levels Prior to Cardiac Transplantation are Associated with Post-Transplantation Survival

van den Hoogen P., Huibers M. M., van den Dolder F. W., de Weger R. A., Siera E., de Jonge N., Doevendans P. A., Sluijter J. P., de Jager S. C., Vink A. apr 2020, In: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 39 , p. S500-S501

Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients

Crnko Sandra, Printezi Markella I, Jansen Tijn P J, Leiteris Laurynas, van der Meer Manon G, Schutte Hilde, van Faassen Martijn, du Pré Bastiaan C, de Jonge Nicolaas, Asselbergs Folkert W, Gaillard Carlo A J M, Kemperman Hans, Doevendans Pieter A, Sluijter Joost P G, van Laake Linda W 31 mrt 2020, In: ESC heart failure. 7 , p. 1224-1233 10 p.

All Research Output (920)