prof. dr. P.A.F.M. (Pieter A.) Doevendans
prof. dr. P.A.F.M. (Pieter A.) Doevendans
- Division of Heart & Lungs
Research Programs
Biography
Biography
Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books
Side Activities
- Member of the Scientific Board, Netherlands Heart Institute
- Chairman Steering committee Heart and Vascular Center
- Advisor AMT Utrecht
- Advisor and shareholder HeartEye
Fellowship and Awards
Honors
- Fellow of the European Society of Cardiology, 2000
- Honorary Professor Yantai Yuhuangding Hospital, China, 2007
- Visiting Professor Harvard University, USA, 2007-2009
- Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
- Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014
Research grants obtained
- NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
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The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".
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NIH: "The role of the min K gene". Grant with R.S. Kass.
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The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.
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The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)
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The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.
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Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)
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The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)
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ICIN: Molecular genetic basis of cardiovascular disease (2000)
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ICIN: Human genetics and cardiovascular developement (2000)
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NHS: Dekker program: Vanessa van Empel (2001-2004)
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STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)
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BSIK: Weefsel op maat (2003)
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Bekales Research Grant – Cardiology 2004, candidature.
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Bekales Research Grant (2005)
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NHS: Translational medicine: stem cell applications (2006)
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ICIN: Stem cells from patients with genetic cardiac disease (2007)
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BMM: SMARTCARE: cardiac repair with microtissues (2008)
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NIRM: Stem cells as disease models (2009)
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ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
Phase A1 preclinical PL €300.000 (total project €2.0M) -
CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
(Total project 0,5M) -
CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)
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Leducq (Total project 6 M€) (2018)
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RegMed: Cardiovascular Moonshot (4 M€) (2018)
Research Output (983)
van den Hoogen Patricia, Huibers Manon M.H., van den Dolder Floor W., de Weger Roel, Siera-de Koning Erica, Oerlemans Marish I.F., de Jonge Nicolaas, van Laake Linda W., Doevendans Pieter A., Sluijter Joost P.G., Vink Aryan, de Jager Saskia C.A. Jan 2023, In: Biology. 12
Chirico Nino, Kessler Elise L, Maas Renée G C, Fang Juntao, Qin Jiabin, Dokter Inge, Daniels Mark, Šarić Tomo, Neef Klaus, Buikema Jan-Willem, Lei Zhiyong, Doevendans Pieter A, Sluijter Joost P G, van Mil Alain 27 Dec 2022, In: Stem Cell Research & Therapy [E]. 13 , p. 1-18
Wouters Philippe C, van de Leur Rutger R, Vessies Melle B, van Stipdonk Antonius M W, Ghossein Mohammed A, Hassink Rutger J, Doevendans Pieter A, van der Harst Pim, Maass Alexander H, Prinzen Frits W, Vernooy Kevin, Meine Mathias, van Es René 7 Nov 2022, In: European heart journal. 44 , p. 680-692 13 p.
Peters Marijn C., Maas Renee G.C., van Adrichem Iris, Doevendans Pieter A.M., Mercola Mark, Šarić Tomo, Buikema Jan W., van Mil Alain, Chamuleau Steven A.J., Sluijter Joost P.G., Hnatiuk Anna P., Neef Klaus 21 Oct 2022, In: Stem cells translational medicine. 11 , p. 1040-1051 12 p.
Arsyad Dian Sidik, Hamsyah Esliana Fitrida, Qalby Nurul, Qanitha Andriany, Westerink Jan, Cramer Maarten J., Visseren Frank L. J., Doevendans Pieter A., Ansariadi Ansariadi 1 Sep 2022, In: BMC Health Services Research. 22
Groen Marijn H.A., Van Driel Vincent J.H.M., Neven Kars, Van Wessel Harry, De Bakker Jacques M.T., Doevendans Pieter A.F., Wittkampf Fred H.M., Loh Peter, Van Es René 1 Aug 2022, In: Circulation: Arrhythmia and Electrophysiology. 15 , p. 510-518 9 p.
Buist Thomas J., Groen Marijn H.A., Wittkampf Fred H.M., Loh Peter, Doevendans Pieter A.F.M., van Es René, Elvan Arif 16 Jun 2022, In: Cardiovascular Engineering and Technology. 14 , p. 60-66 7 p.
Peters Marijn C., Di Martino Sofia, Boelens Thomas, Qin Jiabin, van Mil Alain, Doevendans Pieter A., Chamuleau Steven A.J., Sluijter Joost P.G., Neef Klaus 9 Jun 2022, In: Molecular Therapy - Methods and Clinical Development. 25 , p. 3-16 14 p.
Zabihi Sammani Arjan, van de Leur Rutger R, Henkens Michiel T H M, Meine Mathias, Loh Peter, Hassink Rutger J, Oberski Daniel L, Heymans Stephane R B, Doevendans Pieter A, Asselbergs Folkert W, te Riele Anneline S J M, van Es René 1 Jun 2022, In: Europace. 24 , p. 1645-1654 10 p.
van de Leur R. R., Bleijendaal H., Taha K., Mast T., Gho J. M.I.H., Linschoten M., van Rees B., Henkens M. T.H.M., Heymans S., Sturkenboom N., Tio R. A., Offerhaus J. A., Bor W. L., Maarse M., Haerkens-Arends H. E., Kolk M. Z.H., van der Lingen A. C.J., Selder J. J., Wierda E. E., van Bergen P. F.M.M., Winter M. M., Zwinderman A. H., Doevendans P. A., van der Harst P., Pinto Y. M., Asselbergs F. W., van Es R., Tjong F. V.Y., Jun 2022, In: Netherlands Heart Journal. 30 , p. 312-318 7 p.