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dr. J. (Julia) Drylewicz

dr. J. (Julia) Drylewicz

Assistant Professor
dr. J. (Julia) Drylewicz
  • CTI Computational Immunology Core

Research Programs

Infection & Immunity

Biography

Biography

Julia Drylewicz is a full-time researcher within the Computational Immunology Core of the Center for Translational Immunology (CTI) of the UMC Utrecht bringing methodological support to researchers from the design of a project to its publication.

She was trained in Biostatistics and Epidemiology at Bordeaux School of Public Health (ISPED, France) and graduated in Biomathematics from Paris V University (France) in 2006. She obtained her PhD in biostatistics at Bordeaux University (France) in 2009. From 2010 till 2014, she performed postdoctoral research in computational and quantitative immunology under the supervision of José Borghans in the Department of Immunology at the UMC Utrecht and collaborated with Rob de Boer in the Utrecht Center for Quantitative Immunology at Utrecht University. Her research focused on quantifying cell dynamics in health and disease using mathematical modeling to analyze stable-isotope labeling experiments.

Since 2014, she collaborates with many groups on multidisciplinary projects within the CTI and aim at closing the gap between experimental and theoretical work by using biostatistics, bioinformatics and computational approaches. Some of her most recent projects involve modeling cell homeostasis in human, defining the optimal time of maternal vaccination for RSV infection, determining endotypes of atopic dermatitis patients based on serum biomarkers measured by Luminex and analyses of Olink data.  

Research Output (46)

Long-term effect of hematopoietic cell transplantation on systemic inflammation in patients with mucopolysaccharidoses

van den Broek Brigitte T A, Lindemans Caroline A, Boelens Jaap Jan, Delemarre Eveline M, Drylewicz Julia, Verhoeven-Duif Nanda, van Hasselt Peter M, Nierkens Stefan 24 aug 2021, In: Blood Advances. 5 , p. 3092-3101 10 p.

Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis

Bakker D S, van der Wal M M, Heeb L E M, Giovannone B, Asamoah M, Delemarre E M, Drylewicz J, Nierkens S, Boyman O, de Bruin-Weller M S, Thijs J L, Wijk F van 18 feb 2021, In: Journal of Investigative Dermatology. 141 , p. 1943-1953.e13

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

Baliu Piqué Mariona, van Hoeven Vera, Drylewicz Julia, van der Wagen Lotte E, Janssen Anke, Otto Sigrid A, van Zelm Menno C, de Boer Rob J, Kuball Jürgen Jhe, Borghans Jose Am, Tesselaar Kiki 4 feb 2021, In: eLife. 10 22 p.

EASI p-EASI: Predicting disease severity in atopic dermatitis patients treated with dupilumab using a combination of serum biomarkers

Bakker Daphne S, Ariens Lieneke F M, Giovannone Barbara, Hijnen DirkJan, Delemarre Eveline M, Knol Edward, Nierkens Stefan, de Bruin-Weller Marjolein S, Thijs Judith L, Drylewicz Julia dec 2020, In: Allergy. 75 , p. 3287-3289 3 p.

Broad proteomic screen reveals shared serum proteomic signature in patients with psoriatic arthritis and psoriasis without arthritis

Leijten Emmerik, Tao Weiyang, Pouw Juliette, van Kempen Tessa, Olde Nordkamp Michel, Balak Deepak, Tekstra J, Muñoz-Elías Ernesto, DePrimo Samuel, Drylewicz Julia, Pandit Aridaman, Boes Marianne, Radstake Timothy 13 aug 2020, In: Rheumatology (Oxford, England). 60 , p. 751–761 11 p.

Functional categories of immune inhibitory receptors

Rumpret Matevž, Drylewicz Julia, Ackermans Laura J.E., Borghans José A.M., Medzhitov Ruslan, Meyaard Linde 1 jan 2020, In: Nature Reviews. Immunology. 20 , p. 771-780 10 p.

Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients:First clinical and biomarker results from the BioDay registry

Ariëns Lieneke F M, van der Schaft Jorien, Bakker Daphne S, Balak Deepak, Romeijn Margreet L E, Kouwenhoven Tessa, Kamsteeg Marijke, Giovannone Barbara, Drylewicz Julia, van Amerongen Cynthia Catalina Aurora, Delemarre Evelien M, Knol Edward F, van Wijk Femke, Nierkens Stefan, Thijs Judith L, Schuttelaar Marie L A, de Bruin-Weller Marjolein S 1 jan 2020, In: Allergy. 75 , p. 116-126 11 p.

Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers

Bakker Daphne S, Nierkens Stefan, Knol Edward F, Giovannone Barbara, Delemarre Eveline M, van der Schaft Jorien, van Wijk Femke, de Bruin-Weller Marjolein S, Drylewicz Julia, Thijs Judith L 2020, In: The Journal of Allergy and Clinical Immunology. 147 , p. 189-198 10 p.

Targeted Proteomics Reveals Inflammatory Pathways that Classify Immune Dysregulation in Common Variable Immunodeficiency

Berbers Roos-Marijn, Drylewicz Julia, Ellerbroek Pauline M, van Montfrans Joris M, Dalm Virgil A S H, van Hagen P Martin, Keller Baerbel, Warnatz Klaus, van de Ven Annick, van Laar Jaap M, Nierkens Stefan, Leavis Helen L 2020, In: Journal of Clinical Immunology. 41 , p. 362-373 12 p.

Early identification of atopic dermatitis patients in need of systemic immunosuppressive treatment

Bakker Daphne S., Drylewicz Julia, Nierkens Stefan, Knol Edward F., Giovannone Barbara, Delemarre Eveline M., van der Schaft Jorien, Balak Deepak M.W., de Bruin-Weller Marjolein S., Thijs Judith L. dec 2019, In: Clinical and Experimental Allergy. 49 , p. 1641-1644 4 p.

All research output

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