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prof. dr. S. (Sarah) Durston

Full Professor
prof. dr. S. (Sarah) Durston
  • Psychiatry

Research Programs

Brain

Biography

Biography

Sarah Durston obtained her PhD at the Rudolf Magnus Institute for Neuroscience in 2003, working with Professors van Engeland, Buitelaar and Hilleke Hulshoff Pol. In her thesis, she combined structural and functional neuroimaging techniques and she spent two formative years working with Professor BJ Casey at the Sackler Institute for Developmental Psychobiology in New York. When she returned, she successfully defended her PhD and started a faculty position at the Department of Child- and Adolescent Psychiatry. Here, she started her lab, the NICHE Neuroimaging lab, and continued to collaborate actively with Professor Casey in New York. In that first year, she managed to obtain a VENI grant from NWO, providing essential funding for her work. The lab worked on developmental disorders. The first PhD-students were Martijn Mulder (currently post-doc at the UvA), Marieke Langen (who stayed with the lab as a faculty member after her PhD defence and only recently left) and Tim Ziermans (currently post-doc at the Karolinska Institute in Stockholm), working respectively on ADHD, autism and adolescents risk for psychosis. In 2006, Sarah obtained an NWO VIDI grant and new PhD-students joined, Patrick de Zeeuw (currently post-doc with the lab, and simultaneously training as a clinical psychologist), Janna van Belle (completing her PhD) and Sanne de Wit (completing her PhD). The lab was further strengthened by the addition of several RAs to work on the various projects.  With the award of a VICI-grant, as well as several other collaborative grants, the lab grew again and currently includes approximately 15 people (RAs, PhD-students, post-docs, as well as Bob Oranje who is a faculty member and vice-head of the lab). Our work continues to focus on how (genetic and environmental) risks for developmental disorders translate to brain function, structure and connectivity and how this in turn – ultimately- translates to behavioural development. 

Research line

Brain development in developmental disorders

Most recent key publications

1: De Zeeuw P, Weusten J, Van Dijk S, Van Belle J, Durston S: Deficits in cognitive control, timing and reward processing are dissociable in ADHD. PlosOne, in press
2: De Zeeuw P, Mandl RM, Hulshoff Pol HE, Van Engeland H, Durston S: Decreased fronto-striatal structural connectivity in ADHD. Human Brain Mapping, 2012;33(8):1941-1951
3: Durston S, van Belle J, de Zeeuw P: Differentiating frontostriatal and fronto-cerebellar circuits in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2011;69(12):1178-1184
4: Langen M, Schnack HG, Nederveen H, Bos D, Lahuis BE, van Engeland H, Durston S: Changes in developmental trajectories of striatum in autism. Biol Psychiatry, 2009;66(4):327-333
5: Durston S, Fossella JA, Casey BJ, Hulshoff Pol HE, Galvan, A, Schnack HG, Steenhuis MP, Minderaa RB, Buitelaar JK, Kahn RS, Van Engeland H: Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with Attention Deficit Hyperactivity Disorder, their unaffected siblings and controls. Molecular Psychiatry 2005;10(7):678-685

Side Activities

  • None

Fellowship and Awards

  • NWO Gravitation grant ‘Individual development’; co-applicant (2012)
    EU FP7 Translational interventions in Compulsive Syndromes (TACTICS); co-applicant (2012)
    NWO VICI grant ‘ADHD: from behaviour to biology’ (2011)
    NWO VIDI grant ‘Profiling ADHD: genes, brain and behaviour’ (2006)
    NWO VENI grant ‘Genetic risk for ADHD in brain function’ (2003)

Research Output (137)

Gray matter covariations and core symptoms of autism:the EU-AIMS Longitudinal European Autism Project

Mei Ting, Llera Alberto, Floris Dorothea L., Forde Natalie J., Tillmann Julian, Durston Sarah, Moessnang Carolin, Banaschewski Tobias, Holt Rosemary J., Baron-Cohen Simon, Rausch Annika, Loth Eva, Dell'Acqua Flavio, Charman Tony, Murphy Declan G.M., Ecker Christine, Beckmann Christian F., Buitelaar Jan K., 1 dec 2020, In: Molecular Autism. 11

Towards an integrated account of the development of self-regulation from a neurocognitive perspective:A framework for current and future longitudinal multi-modal investigations

Vink Matthijs, Gladwin Thomas Edward, Geeraets Sanne, Pas Pascal, Bos Dienke, Hofstee Marissa, Durston Sarah, Vollebergh Wilma 25 jul 2020, In: Developmental Cognitive Neuroscience. 45

Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders:Findings From the ENIGMA ADHD, ASD, and OCD Working Groups

Boedhoe Premika S W, van Rooij Daan, Hoogman Martine, Twisk Jos W R, Schmaal Lianne, Abe Yoshinari, Alonso Pino, Ameis Stephanie H, Anikin Anatoly, Anticevic Alan, Arango Celso, Arnold Paul D, Asherson Philip, Assogna Francesca, Auzias Guillaume, Banaschewski Tobias, Baranov Alexander, Batistuzzo Marcelo C, Baumeister Sarah, Baur-Streubel Ramona, Behrmann Marlene, Bellgrove Mark A, Benedetti Francesco, Beucke Jan C, Biederman Joseph, Bollettini Irene, Bose Anushree, Bralten Janita, Bramati Ivanei E, Brandeis Daniel, Brem Silvia, Brennan Brian P, Busatto Geraldo F, Calderoni Sara, Calvo Anna, Calvo Rosa, Castellanos Francisco X, Cercignani Mara, Chaim-Avancini Tiffany M, Chantiluke Kaylita C, Cheng Yuqi, Cho Kang Ik K, Christakou Anastasia, Coghill David, Conzelmann Annette, Cubillo Ana I, Durston Sarah, Janssen Joost, Oranje Bob, Shook Devon, 16 jun 2020, In: American Journal of Psychiatry. 177 , p. 834-843 10 p.

Structural and functional MRI of altered brain development in a novel adolescent rat model of quinpirole-induced compulsive checking behavior

Straathof Milou, Blezer Erwin L.A., van Heijningen Caroline, Smeele Christel E., van der Toorn Annette, Buitelaar Jan K., de Ruiter Saskia, Naaijen Jilly, Akkermans Sophie, Mennes Maarten, Zwiers Marcel, Ilbegi Shahrzad, Hennissen Leonie, Glennon Jeffrey C., van de Vondervoort Ilse, Kapusta Katarzyna, Bielczyk Na AAtalia, Amiri Houshang, Havenith Martha, Franke Barbara, Poelmans Geert, Bralten Janita, Heskes Tom, Sokolova Elena, Groot Perry, Williams Steven, Murphy De AAclan, Lythgoe David, Bruchhage Muriel, Dud Iulia, Voinescu Bogdan, Dittmann Ralf, Banaschewski Tobias, Brandeis Daniel, Mechler Konstantin, Berg Ruth, Wolf Isabella, Häge Alexander, Landauer Michael, Hohmann Sarah, Schlier Regina Boecker, Ruff Matthias, Mandl René, Dijkhuizen Rick, Blezer Erwin, Mol Wouter, Otte Willem, Durston Sarah, Oranje Bob, Dijkhuizen Rick, 1 apr 2020, In: European Neuropsychopharmacology. 33 , p. 58-70 13 p.

Include me if you can!: Reasons for low enrollment of pediatric patients in a psychopharmacological trial

Haege A., Mechler K., Niemeyer L., Buitelaar J., Durston S., Gooskens B. R., Oranje B., Banaschewski T., Dittmann R. W. mrt 2020, In: Pharmacopsychiatry. 53 , p. 96-96

Social brain activation during mentalizing in a large autism cohort:The Longitudinal European Autism Project

Moessnang Carolin, Baumeister Sarah, Tillmann Julian, Goyard David, Charman Tony, Ambrosino Sara, Baron-Cohen Simon, Beckmann Christian, Bölte Sven, Bours Carsten, Crawley Daisy, Dell'Acqua Flavio, Durston Sarah, Ecker Christine, Frouin Vincent, Hayward Hannah, Holt Rosemary, Johnson Mark, Jones Emily, Lai Meng Chuan, Lombardo Michael V., Mason Luke, Oldenhinkel Marianne, Persico Antonio, Cáceres Antonia San José, Spooren Will, Loth Eva, Murphy Declan G.M., Buitelaar Jan K., Banaschewski Tobias, Brandeis Daniel, Tost Heike, Meyer-Lindenberg Andreas, 22 feb 2020, In: Molecular Autism. 11

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Postema Merel C., van Rooij Daan, Anagnostou Evdokia, Arango Celso, Auzias Guillaume, Behrmann Marlene, Filho Geraldo Busatto, Calderoni Sara, Calvo Rosa, Daly Eileen, Deruelle Christine, Di Martino Adriana, Dinstein Ilan, Duran Fabio Luis S., Durston Sarah, Ecker Christine, Ehrlich Stefan, Fair Damien, Fedor Jennifer, Feng Xin, Fitzgerald Jackie, Floris Dorothea L., Freitag Christine M., Gallagher Louise, Glahn David C., Gori Ilaria, Haar Shlomi, Hoekstra Liesbeth, Jahanshad Neda, Jalbrzikowski Maria, Janssen Joost, King Joseph A., Kong Xiang Zhen, Lazaro Luisa, Lerch Jason P., Luna Beatriz, Martinho Mauricio M., McGrath Jane, Medland Sarah E., Muratori Filippo, Murphy Clodagh M., Murphy Declan G.M., O’Hearn Kirsten, Oranje Bob, Parellada Mara, Puig Olga, Retico Alessandra, Rosa Pedro, Rubia Katya, Shook Devon, 31 okt 2019, In: Nature Communications. 10

Tackling missing heritability by use of an optimum curve:A systematic review and meta-analysis

Sleeswijk Anneke Wegener, Heijungs Reinout, Durston Sarah 2 okt 2019, In: International journal of molecular sciences. 20

Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

de Lange Siemon C., Scholtens Lianne H., van den Berg Leonard H., Boks Marco P., Bozzali Marco, Cahn Wiepke, Dannlowski Udo, Durston Sarah, Geuze Elbert, van Haren Neeltje E.M., Hillegers Manon H.J., Koch Kathrin, Jurado María Ángeles, Mancini Matteo, Marqués-Iturria Idoia, Meinert Susanne, Ophoff Roel A., Reess Tim J., Repple Jonathan, Kahn René S., van den Heuvel Martijn P., 5 aug 2019, In: NATURE HUMAN BEHAVIOUR. 3 , p. 988-998 11 p.

Dissecting the Heterogeneous Cortical Anatomy of Autism Spectrum Disorder Using Normative Models

Zabihi Mariam, Oldehinkel Marianne, Wolfers Thomas, Frouin Vincent, Goyard David, Loth Eva, Charman Tony, Tillmann Julian, Banaschewski Tobias, Dumas Guillaume, Holt Rosemary, Baron-Cohen Simon, Durston Sarah, Bölte Sven, Murphy Declan, Ecker Christine, Buitelaar Jan K., Beckmann Christian F., Marquand Andre F. jun 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4 , p. 567-578 12 p.

All research output