prof. dr. S. (Sarah) Durston

Full Professor

  • Psychiatry

prof. dr. S. (Sarah) Durston

Research Programs


Sarah Durston obtained her PhD at the Rudolf Magnus Institute for Neuroscience in 2003, working with Professors van Engeland, Buitelaar and Hilleke Hulshoff Pol. In her thesis, she combined structural and functional neuroimaging techniques and she spent two formative years working with Professor BJ Casey at the Sackler Institute for Developmental Psychobiology in New York. When she returned, she successfully defended her PhD and started a faculty position at the Department of Child- and Adolescent Psychiatry. Here, she started her lab, the NICHE Neuroimaging lab, and continued to collaborate actively with Professor Casey in New York. In that first year, she managed to obtain a VENI grant from NWO, providing essential funding for her work. The lab worked on developmental disorders. The first PhD-students were Martijn Mulder (currently post-doc at the UvA), Marieke Langen (who stayed with the lab as a faculty member after her PhD defence and only recently left) and Tim Ziermans (currently post-doc at the Karolinska Institute in Stockholm), working respectively on ADHD, autism and adolescents risk for psychosis. In 2006, Sarah obtained an NWO VIDI grant and new PhD-students joined, Patrick de Zeeuw (currently post-doc with the lab, and simultaneously training as a clinical psychologist), Janna van Belle (completing her PhD) and Sanne de Wit (completing her PhD). The lab was further strengthened by the addition of several RAs to work on the various projects.  With the award of a VICI-grant, as well as several other collaborative grants, the lab grew again and currently includes approximately 15 people (RAs, PhD-students, post-docs, as well as Bob Oranje who is a faculty member and vice-head of the lab). Our work continues to focus on how (genetic and environmental) risks for developmental disorders translate to brain function, structure and connectivity and how this in turn – ultimately- translates to behavioural development. 

Research line

Brain development in developmental disorders

Most recent key publications

1: De Zeeuw P, Weusten J, Van Dijk S, Van Belle J, Durston S: Deficits in cognitive control, timing and reward processing are dissociable in ADHD. PlosOne, in press
2: De Zeeuw P, Mandl RM, Hulshoff Pol HE, Van Engeland H, Durston S: Decreased fronto-striatal structural connectivity in ADHD. Human Brain Mapping, 2012;33(8):1941-1951
3: Durston S, van Belle J, de Zeeuw P: Differentiating frontostriatal and fronto-cerebellar circuits in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2011;69(12):1178-1184
4: Langen M, Schnack HG, Nederveen H, Bos D, Lahuis BE, van Engeland H, Durston S: Changes in developmental trajectories of striatum in autism. Biol Psychiatry, 2009;66(4):327-333
5: Durston S, Fossella JA, Casey BJ, Hulshoff Pol HE, Galvan, A, Schnack HG, Steenhuis MP, Minderaa RB, Buitelaar JK, Kahn RS, Van Engeland H: Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with Attention Deficit Hyperactivity Disorder, their unaffected siblings and controls. Molecular Psychiatry 2005;10(7):678-685

Side Activities

  • None

Fellowship and Awards

  • NWO Gravitation grant ‘Individual development’; co-applicant (2012)
    EU FP7 Translational interventions in Compulsive Syndromes (TACTICS); co-applicant (2012)
    NWO VICI grant ‘ADHD: from behaviour to biology’ (2011)
    NWO VIDI grant ‘Profiling ADHD: genes, brain and behaviour’ (2006)
    NWO VENI grant ‘Genetic risk for ADHD in brain function’ (2003)

Research Output (130)

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Postema Merel C., van Rooij Daan, Anagnostou Evdokia, Arango Celso, Auzias Guillaume, Behrmann Marlene, Filho Geraldo Busatto, Calderoni Sara, Calvo Rosa, Daly Eileen, Deruelle Christine, Di Martino Adriana, Dinstein Ilan, Duran Fabio Luis S., Durston Sarah, Ecker Christine, Ehrlich Stefan, Fair Damien, Fedor Jennifer, Feng Xin, Fitzgerald Jackie, Floris Dorothea L., Freitag Christine M., Gallagher Louise, Glahn David C., Gori Ilaria, Haar Shlomi, Hoekstra Liesbeth, Jahanshad Neda, Jalbrzikowski Maria, Janssen Joost, King Joseph A., Kong Xiang Zhen, Lazaro Luisa, Lerch Jason P., Luna Beatriz, Martinho Mauricio M., McGrath Jane, Medland Sarah E., Muratori Filippo, Murphy Clodagh M., Murphy Declan G.M., O’Hearn Kirsten, Oranje Bob, Parellada Mara, Puig Olga, Retico Alessandra, Rosa Pedro, Rubia Katya, Shook Devon, 31 okt 2019, In: Nature Communications. 10

Tackling missing heritability by use of an optimum curve:A systematic review and meta-analysis

Sleeswijk Anneke Wegener, Heijungs Reinout, Durston Sarah 2 okt 2019, In: International journal of molecular sciences. 20

Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

de Lange Siemon C., Scholtens Lianne H., van den Berg Leonard H., Boks Marco P., Bozzali Marco, Cahn Wiepke, Dannlowski Udo, Durston Sarah, Geuze Elbert, van Haren Neeltje E.M., Hillegers Manon H.J., Koch Kathrin, Jurado María Ángeles, Mancini Matteo, Marqués-Iturria Idoia, Meinert Susanne, Ophoff Roel A., Reess Tim J., Repple Jonathan, Kahn René S., van den Heuvel Martijn P., 5 aug 2019, In: NATURE HUMAN BEHAVIOUR. 3 , p. 988-998 11 p.

Dissecting the Heterogeneous Cortical Anatomy of Autism Spectrum Disorder Using Normative Models

Zabihi Mariam, Oldehinkel Marianne, Wolfers Thomas, Frouin Vincent, Goyard David, Loth Eva, Charman Tony, Tillmann Julian, Banaschewski Tobias, Dumas Guillaume, Holt Rosemary, Baron-Cohen Simon, Durston Sarah, Bölte Sven, Murphy Declan, Ecker Christine, Buitelaar Jan K., Beckmann Christian F., Marquand Andre F. jun 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4 , p. 567-578 12 p.

Individualized Prediction of Transition to Psychosis in 1,676 Individuals at Clinical High Risk:Development and Validation of a Multivariable Prediction Model Based on Individual Patient Data Meta-Analysis

Malda Aaltsje, Boonstra Nynke, Barf Hans, de Jong Steven, Aleman Andre, Addington Jean, Pruessner Marita, Nieman Dorien, de Haan Lieuwe, Morrison Anthony, Riecher-Rössler Anita, Studerus Erich, Ruhrmann Stephan, Schultze-Lutter Frauke, An Suk Kyoon, Koike Shinsuke, Kasai Kiyoto, Nelson Barnaby, McGorry Patrick, Wood Stephen, Lin Ashleigh, Yung Alison Y, Kotlicka-Antczak Magdalena, Armando Marco, Vicari Stefano, Katsura Masahiro, Matsumoto Kazunori, Durston Sarah, Ziermans Tim, Wunderink Lex, Ising Helga, van der Gaag Mark, Fusar-Poli Paolo, Pijnenborg Gerdina Hendrika Maria 21 mei 2019, In: Frontiers in Psychiatry. 10

10Kin1day: A Bottom-Up Neuroimaging Initiative

van den Heuvel Martijn P. et al. 9 mei 2019, In: Frontiers in Neurology. 10 , p. 425 7 p.

Brain Imaging of the Cortex in ADHD:A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples

Hoogman Martine et al. 24 apr 2019, In: American Journal of Psychiatry. 176 , p. 531-542 12 p.

Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project

Tillmann Julian, Caceres Antonia San Jose, Chatham Chris H., Crawley Daisy, Holt Rosemary, Oakley Bethany, Banaschewski Tobias, Baron-Cohen Simon, Boelte Sven, Buitelaar Jan K., Durston Sarah, Ham Lindsay, Loth Eva, Simonoff Emily, Spooren Will, Murphy Declan G., Charman Tony, Ahmad Jumana, Ambrosino Sara, Auyeung Bonnie, Baumeister Sarah, Beckmann Christian, Bourgeron Thomas, Bours Carsten, Brammer Michael, Brandeis Daniel, Brogna Claudia, de Bruijn Yvette, Chakrabarti Bhismadev, Cornelissen Ineke, Dell'Acqua Flavio, Dumas Guillaume, Ecker Christine, Faulkner Jessica, Frouin Vincent, Garces Pilar, Goyard David, Hayward Hannah, Hipp Joerg, Johnson Mark H., Jones Emily J. H., Kundu Prantik, Lai Meng-Chuan, D'ardhuy Xavier Liogier, Lombardo Michael, Lythgoe David J., Mandl Rene, Mason Luke, Meyer-Lindenberg Andreas, Oranje Bob 11 feb 2019, In: Autism Research. 12 , p. 645-657

Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder:Results from the EU-AIMS Longitudinal European Autism Project

Oldehinkel Marianne, Mennes Maarten, Marquand Andre, Charman Tony, Tillmann Julian, Ecker Christine, Dell'Acqua Flavio, Brandeis Daniel, Banaschewski Tobias, Baumeister Sarah, Moessnang Carolin, Baron-Cohen Simon, Holt Rosemary, Bölte Sven, Durston Sarah, Kundu Prantik, Lombardo Michael V., Spooren Will, Loth Eva, Murphy Declan G.M., Beckmann Christian F., Buitelaar Jan K., Ahmad Jumana, Ambrosino Sara, Auyeung Bonnie, Bourgeron Thomas, Bours Carsten, Brammer Michael, Brogna Claudia, de Bruijn Yvette, Chakrabarti Bhismadev, Cornelissen Ineke, Crawley Daisy, Dumas Guillaume, Faulkner Jessica, Frouin Vincent, Garcés Pilar, Goyard David, Ham Lindsay, Hayward Hannah, Hipp Joerg, Johnson Mark H., Jones Emily J.H., Lai Meng Chuan, Liogier D'ardhuy Xavier, Lythgoe David J., Mandl René, Mason Luke, Meyer-Lindenberg Andreas, Oranje Bob, 1 jan 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4 , p. 260-270 11 p.

A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder

Shaw Philip, Ishii-Takahashi Ayaka, Park Min Tae, Devenyi Gabriel A., Zibman Chava, Kasparek Steven, Sudre Gustavo, Mangalmurti Aman, Hoogman Martine, Tiemeier Henning, von Polier Georg, Shook Devon, Muetzel Ryan, Chakravarty M. Mallar, Konrad Kerstin, Durston Sarah, White Tonya 1 okt 2018, In: Journal of Child Psychology and Psychiatry and Allied Disciplines. 59 , p. 1114-1123 10 p.

All Research Output (130)