drs. L.G. (Lieza) Exalto

drs. L.G. (Lieza) Exalto

Assistant Professor - medical
  • Neurologen



Lieza Exalto, is currently finishing her medical training in the UMC Utrecht to become a neurologist. In 2014 she obtained her PhD degree with the thesis “Diabetes and Dementia, the bitter taste of a sweet disease”. Afterwards she continued her research in the Vascular Cognitive Impairment group of prof. Biessels and introduced sex and gender differences as relevant research topic. Lieza received funding from Alzheimer Nederland for her project “Does sex modulate the phenotype and prognosis of vascular cognitive impairment”.


Lieza is work-package leader “sex differences” in the Dutch Heart-Brain Consortium study. She collaborates with the META-VCI MAP consortium on research projects on sex differences in post-stroke cognitive impairment. In the European multicenter H2020 study RECOGNISED, she is work-package leader of the cognitive testing. In February 2020 she received the prize for best integration of sex and gender considerations in cardiovascular research plans, during the Libin International Trainee Symposium: Research is Better with Sex and Gender! 

Research Output (26)

Sex and Cardiovascular Function in Relation to Vascular Brain Injury in Patients with Cognitive Complaints

Kuipers Sanne, Biessels Geert Jan, Greving Jacoba P, Amier Raquel P, de Bresser Jeroen, Bron Esther E, van der Flier Wiesje M, van der Geest Rob J, Hooghiemstra Astrid M, van Oostenbrugge Robert J, van Osch Matthias J P, Kappelle L Jaap, Exalto Lieza G, 26 okt 2021, In: Journal of Alzheimer's Disease. 84 , p. 261-271 11 p.

Cerebral Perfusion and the Burden of Small Vessel Disease in Patients Referred to a Memory Clinic

Onkenhout Laurien, Appelmans Nadine, Kappelle L Jaap, Koek Dineke, Exalto Lieza, de Bresser Jeroen, Biessels Geert Jan, nov 2020, In: Cerebrovascular diseases (Basel, Switzerland). 49 , p. 481-486 6 p.

Diabetes-specific dementia risk score (DSDRS) predicts cognitive performance in patients with type 2 diabetes at high cardio-renal risk

Verhagen Chloë, Janssen Jolien, Exalto Lieza G, van den Berg Esther, Johansen Odd Erik, Biessels Geert Jan 16 jul 2020, In: Journal of Diabetes and its Complications. 34

Author response: Clinical relevance of acute cerebral microinfarct in vascular cognitive impairment:Clinical relevance of acute cerebral microinfarcts in vascular cognitive impairment

Ferro Doeschka A, van den Brink Hilde, Exalto Lieza G, Boomsma Jooske M F, Barkhof Frederik, Prins Niels D, van der Flier Wiesje M, Biessels Geert Jan 18 feb 2020, In: Neurology. 94 , p. 330-330 1 p.

Prediction of poor clinical outcome in vascular cognitive impairment:TRACE-VCI study

Boomsma Jooske M F, Exalto Lieza G, Barkhof Frederik, Chen Christopher L H, Hilal Saima, Leeuwis Anna E, Prins Niels D, Saridin Francis N, Scheltens Philip, Teunissen Charlotte E, Verwer Jurre H, Weinstein Henry C, van der Flier Wiesje M, Biessels Geert Jan, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12 , p. 1-12

Small vessel disease lesion type and brain atrophy:The role of co-occurring amyloid

Heinen Rutger, Groeneveld Onno N, Barkhof Frederik, de Bresser Jeroen, Exalto Lieza G, Kuijf Hugo J, Prins Niels D, Scheltens Philip, van der Flier Wiesje M, Biessels Geert Jan, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12 , p. 1-11

Sex differences in memory clinic patients with possible vascular cognitive impairment

Exalto Lieza G, Boomsma Jooske M F, Babapour Mofrad Rosha, Barkhof Frederik, Groeneveld Onno N, Heinen Rutger, Kuijf Hugo J, Leeuwis Anna E, Prins Niels D, Biessels Geert Jan, Vd Flier Wiesje M, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12 , p. 1-10

Performance of five automated white matter hyperintensity segmentation methods in a multicenter dataset

Heinen Rutger, Steenwijk Martijn D., Barkhof Frederik, Biesbroek J. Matthijs, van der Flier Wiesje M., Kuijf H. J., Prins N. D., Vrenken Hugo, Biessels Geert Jan, de Bresser Jeroen, van den Berg E., Boomsma J. M. F., Exalto L. G., Ferro D. A., Frijns C. J. M., Groeneveld O. N., van Kalsbeek N. M., Verwer J. H., de Bresser Jeroen, Kuijf H. J., Emmelot-Vonk M. E., Koek H. L., Benedictus M. R., Bremer J., Leeuwis A. E., Leijenaar J., Prins N. D., Scheltens P., Tijms B. M., Wattjes M. P., Teunissen C. E., Koene T., Boomsma J. M. F., Weinstein H. C., Hamaker M., Faaij R., Pleizier M., Prins M., Vriens E., 14 nov 2019, In: Scientific Reports. 9

Physical Performance in Memory Clinic Patients:The Potential Role of the White Matter Network

Verwer Jurre H., Reijmer Yael D., Koek H. L., Biessels Geert Jan, Exalto L. G., Groeneveld O. N., Heinen R., Heringa S. M., Kalsbeek N., Maher C., de Bresser J., Leemans A., Koek H. L., de Wit J. E., Blom K., Hamaker M., Faaij R., Pleizier M., Prins M., Vriens E., 1 sep 2019, In: Journal of the American Geriatrics Society. 67 , p. 1880-1887 8 p.

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients:a lesion–symptom mapping study

Leeuwis Anna E., Weaver Nick A., Biesbroek J. Matthijs, Exalto Lieza G., Kuijf Hugo J., Hooghiemstra Astrid M., Prins Niels D., Scheltens Philip, Barkhof Frederik, van der Flier Wiesje M., Biessels Geert Jan 25 apr 2019, In: Journal of Psychiatry and Neuroscience. 44 , p. E1-E10 10 p.

All research output

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