drs. L.G. (Lieza) Exalto

drs. L.G. (Lieza) Exalto

Assistant Professor - medical
  • Neurologen



Lieza Exalto, is a neurologist who has received her medical training in the UMC Utrecht. In 2014 she obtained her PhD degree with the thesis “Diabetes and Dementia, the bitter taste of a sweet disease”. Afterwards she continued her research in the Vascular Cognitive Impairment group of prof. Biessels and introduced sex and gender differences as relevant research topic. Lieza received funding from Alzheimer Nederland for her project “Does sex modulate the phenotype and prognosis of vascular cognitive impairment”.


Lieza is work-package leader “sex differences” in the Dutch Heart-Brain Consortium study. She collaborates with the META-VCI MAP consortium on research projects on sex differences in post-stroke cognitive impairment. In the European multicenter H2020 study RECOGNISED, she is work-package leader of the cognitive testing. In February 2020 she received the prize for best integration of sex and gender considerations in cardiovascular research plans, during the Libin International Trainee Symposium: Research is Better with Sex and Gender! 

Research Output (34)

Rhabdomyolysis, encephalopathy, epilepsy and cardiac arrhythmia

Toeback Jonas, De Pagter Mirjam, Exalto Lieza, Koop K, Van Der Heijden Joris 1 Aug 2023, In: Practical Neurology. 23 , p. 356-359 4 p.

Strategic white matter hyperintensity locations for cognitive impairment:A multicenter lesion-symptom mapping study in 3525 memory clinic patients

Coenen Mirthe, Kuijf Hugo J, Huenges Wajer Irene M C, Duering Marco, Wolters Frank J, Fletcher Evan F, Maillard Pauline M, Barkhof Frederik, Barnes Josephine, Benke Thomas, Boomsma Jooske M F, Chen Christopher P L H, Dal-Bianco Peter, Dewenter Anna, Enzinger Christian, Ewers Michael, Exalto Lieza G, Franzmeier Nicolai, Groeneveld Onno, Hilal Saima, Hofer Edith, Koek Dineke L, Maier Andrea B, McCreary Cheryl R, Padilla Catarina S, Papma Janne M, Paterson Ross W, Pijnenburg Yolande A L, Rubinski Anna, Schmidt Reinhold, Schott Jonathan M, Slattery Catherine F, Smith Eric E, Steketee Rebecca M E, Sudre Carole H, van den Berg Esther, van der Flier Wiesje M, Venketasubramanian Narayanaswamy, Vernooij Meike W, Xin Xu, DeCarli Charles, Biessels Geert Jan, Biesbroek J Matthijs, 12 Dec 2022, In: Alzheimer's & Dementia. 19 , p. 2420-2432 13 p.

Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease-related brain injury

De Luca Alberto, Kuijf Hugo, Exalto Lieza, Thiebaut de Schotten Michel, Biessels Geert-Jan, , Koek Dineke Sep 2022, In: Brain structure & function. 227 , p. 2553-2567 15 p.

Neuropsychiatric Symptoms as Predictor of Poor Clinical Outcome in Patients With Vascular Cognitive Impairment

Sep Yoni C P, Leeuwis Anna E, Exalto Lieza G, Boomsma Jooske M, Prins Niels D, Verwer Jurre H, Scheltens Philip, van der Flier Wiesje M, Biessels Geert Jan, 2 Jan 2022, In: The American Journal of Geriatric Psychiatry. 30 , p. 813-824 12 p.

Neuropsychiatric symptoms in patients with possible vascular cognitive impairment, does sex matter?

Exalto L G, Boomsma J M, Sep Ycp, Leeuwis A E, Scheltens P, Biessels G J, van der Flier W M, 2022, In: Cerebral Circulation - Cognition and Behavior. 3

Vascular Cognitive Impairment and cognitive decline; a longitudinal study comparing different types of vascular brain injury - The TRACE-VCI study

Boomsma Jooske Mf, Exalto Lieza G, Barkhof Frederik, Leeuwis Anna E, Prins Niels D, Scheltens Philip, Teunissen Charlotte E, Weinstein Henry C, Biessels Geert Jan, van der Flier Wiesje M, On-Behalf-Of-The-Trace-Vci-Study-Group 2022, In: Cerebral Circulation - Cognition and Behavior. 3

Females with type 2 diabetes are at higher risk for accelerated cognitive decline than males:CAROLINA-COGNITION study

Verhagen Chloë, Janssen Jolien, Biessels Geert Jan, Johansen Odd Erik, Exalto Lieza G 27 Oct 2021, In: NMCD : Nutrition metabolism and cardiovascular diseases. 32 , p. 355-364 10 p.

Sex and Cardiovascular Function in Relation to Vascular Brain Injury in Patients with Cognitive Complaints

Kuipers Sanne, Biessels Geert Jan, Greving Jacoba P, Amier Raquel P, de Bresser Jeroen, Bron Esther E, van der Flier Wiesje M, van der Geest Rob J, Hooghiemstra Astrid M, van Oostenbrugge Robert J, van Osch Matthias J P, Kappelle L Jaap, Exalto Lieza G, 26 Oct 2021, In: Journal of Alzheimer's Disease. 84 , p. 261-271 11 p.

Call Characteristics of Patients Suspected of Transient Ischemic Attack (TIA) or Stroke During Out-of-Hours Service:A Comparison Between Men and Women

Exalto Lieza G., van Doorn Sander, Erkelens D. Carmen A., Smit Karin, Rutten Frans H., Kappelle L. Jaap, Zwart Dorien L.M. 14 Jun 2021, In: Frontiers in Neurology. 12

Cerebral Perfusion and the Burden of Small Vessel Disease in Patients Referred to a Memory Clinic

Onkenhout Laurien, Appelmans Nadine, Kappelle L Jaap, Koek Dineke, Exalto Lieza, de Bresser Jeroen, Biessels Geert Jan, Nov 2020, In: Cerebrovascular diseases (Basel, Switzerland). 49 , p. 481-486 6 p.

All research output

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