prof. dr. J. (Joost) Frenkel

prof. dr. J. (Joost) Frenkel

Full Professor
prof. dr. J. (Joost) Frenkel
  • Physician assistant children

Research Programs

Child Health



Joost Frenkel is a professor of pediatrics with a focus on family and patient centered education

He is a distinguished medical teacher with ample experience in development and provision of education to medical students residents and faculty.

He is an experienced pediatrician with a profound interest and expertise in autoinflammatory diseases.

These are disorders in which the innate inflammatory response runs out of control.

For these rare patients Frenkel leads an (inter)national clinical, genetic and research reference center.

Research has focused on the hyper IgD periodic fever syndrome due to mevalonate kinase deficiency.

International collaboration includes the Eurofever network and the international association for autoinflammatory diseases, as well as bilateral collaboration with the NIH.

Side Activities

  • Member scientific board Eurofever
  • Member scientific board International Society for Autoinflammatory Diseases
  • Member of advisory board to Novartis Pharma on autoinflammatory diseases
  • Member of the Dutch pediatric residency council (consilium paediatricum)
  • Member of ERN RITA
  • Member of the national steering committee for pediatric neurology subspecialization.

Potential Conflicts of Interest

Dr. Frenkel has regular interaction with pharmaceutical and other industrial partners. He has not received any personal fees or other personal benefits.

UMCU received minor funding (€1,000-10,000 per industrial partner) for consultation and invited lectures by Novartis and SOBI

Research Output (161)

Isolated neurological presentations of mevalonate kinase deficiency

Hoytema van Konijnenburg Eva M.M., Oussoren Esmeralda, Frenkel Joost, van Hasselt Peter M. Jan 2023, In: JIMD Reports. 64 , p. 53-56 4 p.

Patients as Feedback Providers:Exploring Medical Students' Credibility Judgments

Eijkelboom M. C.L., de Kleijn R. A.M., van Diemen W. J.M., Maljaars C. D.N., van der Schaaf M. F., Frenkel J. 2023, In: Perspectives on medical education. 12 , p. 129-140 12 p.

The 2021 EULAR/American College of Rheumatology points to consider for diagnosis, management and monitoring of the interleukin-1 mediated autoinflammatory diseases:cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of the interleukin-1 receptor antagonist

Romano Micol, Arici Z. Serap, Piskin David, Alehashemi Sara, Aletaha Daniel, Barron Karyl S., Benseler Susanne, Berard Roberta, Broderick Lori, Dedeoglu Fatma, Diebold Michelle, Durrant Karen L., Ferguson Polly, Foell Dirk, Hausmann Jonathan, Jones Olcay Y., Kastner Daniel L., Lachmann Helen J., Laxer Ronald M., Rivera Dorelia, Ruperto Nicolino, Simon Anna, Twilt Marinka, Frenkel Joost, Hoffman Hal, De Jesus Adriana A., Kuemmerle-Deschner Jasmin Beate, Ozen Seza, Gattorno Marco, Goldbach-Mansky Raphaela, Demirkaya Erkan 1 Jul 2022, In: Annals of the rheumatic diseases. 81 , p. 907-921 15 p.

Making knowledge clips with patients:What learning mechanisms are triggered in medical students?

Eijkelboom M. C.L.(Charlotte), Kalee M. (Melanie), de Kleijn R. A.M.(Renske), van Wijngaarden J. J.(Jacqueline), de Jonge R. R.(Roos), van der Schaaf M. F.(Marieke), Frenkel J. (Joost) 2022, In: Patient Education and Counseling. 105 , p. 3096-3102 7 p.

Long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency:results from the randomised Phase 3 CLUSTER trial

Jeyaratnam Jerold, Simon Anna, Calvo Inmaculada, Constantin Tamas, Shcherbina Anna, Hofer Michael, Gattorno Marco, Martini Alberto, Bader-Meunier Brigitte, Vastert Bas, Levy Jeremy, Dekker Elise, de Benedetti Fabrizio, Frenkel Joost 23 Sep 2021, In: Rheumatology (Oxford, England). 61 , p. 2088-2094 7 p.

Improving Handoff by Deliberate Cognitive Processing:Results from a Randomized Controlled Experimental Study

van Heesch Gwen, Frenkel Joost, Kollen Wouter, Zwaan Laura, Mamede Sílvia, Schmidt Henk, de Hoog Matthijs Apr 2021, In: The Joint Commission Journal on Quality and Patient Safety. 47 , p. 234-241 8 p.

Auto-inflammatie in de dermatologie

Mulders-Manders C. M., Frenkel J. 2021, In: Nederlands Tijdschrift voor Dermatologie en Venereologie. 31 , p. 10-14 5 p.

INSAID Variant Classification and Eurofever Criteria Guide Optimal Treatment Strategy in Patients with TRAPS:Data from the Eurofever Registry

Papa Riccardo, Lane Thirusha, Minden Kirsten, Touitou Isabelle, Cantarini Luca, Cattalini Marco, Obici Laura, Jansson Annette F, Belot Alexandre, Frenkel Joost, Anton Jordi, Wolska-Kusnierz Beata, Berendes Rainer, Remesal Agustin, Jelusic Marija, Hoppenreijs Esther, Espada Graciela, Nikishina Irina, Maggio Maria Cristina, Bovis Francesca, Masini Marta, Youngstein Taryn, Rezk Tamer, Papadopoulou Charalampia, Brogan Paul A, Hawkins Philip N, Woo Patricia, Ruperto Nicolino, Gattorno Marco, Lachmann Helen J, 9 Nov 2020, In: The journal of allergy and clinical immunology. In practice. 9 , p. 783-791.e4

How autoinflammation may turn into autoimmune inflammation:Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases

ter Haar N. M., Jansen M. H.A., Frenkel J. F., Vastert S. J. Oct 2020, In: Clinical Immunology. 219 8 p.

Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever

Van Gorp Hanne, Huang Linyan, Saavedra Pedro, Vuylsteke Marnik, Asaoka Tomoko, Prencipe Giusi, Insalaco Antonella, Ogunjimi Benson, Jeyaratnam Jerold, Cataldo Ilaria, Jacques Peggy, Vermaelen Karim, Dullaers Melissa, Joos Rik, Sabato Vito, Stella Alessandro, Frenkel Joost, De Benedetti Fabrizio, Dehoorne Joke, Haerynck Filomeen, Calamita Giuseppe, Portincasa Piero, Lamkanfi Mohamed 1 Jul 2020, In: Annals of the Rheumatic Diseases. 79 , p. 960-968 9 p.

All research output

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