dr. M.I. (Mirjam) Geerlings

dr. M.I. (Mirjam) Geerlings

Associate Professor
dr. M.I. (Mirjam) Geerlings
  • Department of Epidemiology
  • Julius Center Research Program Cardiovascular Epidemiology

Research Programs



I received my MSc degree in Neuropsychology and PhD degree in Epidemiology from the VU medical center Amsterdam, the Netherlands. From 2000 until 2002, I worked as a post-doc at the Department of Epidemiology & Biostatistics of the Erasmus Medical Center, Rotterdam where I studied steroid hormones as risk factors for dementia using data from the Rotterdam Study. Since 2002, I work at the Julius Center for Health Sciences and Primary Care (University Medical Center Utrecht). I initiate, conduct, and supervise research within the department of Epidemiology and develop, coordinate and teach epidemiology courses within the Biomedical Sciences (BSc), Medicine (BSc and MSc), and MSc Epidemiology curriculum. I supervised around 40 MSc and BSc students during their research and completing their MSc or BSc thesis. Additionally, I have mentored a substantial number of research assistants, PhD candidates, and postdoctoral fellows. I am a PI of the research programs Circulatory Health (research theme Cerebrovascular disease) and Brain within the UMC Utrecht. 

Within the UMC Utrecht, I lead the SMART-MR study, a sub-study of the UCC-SMART study. The SMART-MR study is an ongoing prospective cohort study among 1309 non-demented, independently living middle-aged to older adults with manifest arterial disease, aimed to investigate determinants and consequences of brain changes on MRI, including depression and cognitive decline. Individuals were assessed at up to three visits: at baseline, 4 years, and 12 years follow-up. I am also PI of the Medea 7T study, a cohort study in the UMC Utrecht, aimed to investigate determinants and consequences of microstructural brain abnormalities on 7 tesla brain MRI. With the UCC-SMART study and SMART-MR study I participate in national and international consortia, including the Netherlands Consortium for Dementia Cohorts (NCDC), the Psychosocial factors and cancer incidence (PSY-CA) consortium, and the CHARGE consortium.

Internationally, I have longstanding collaborations with the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, USA (dr. Lenore Launer) where I published using data from the Honolulu Asia Aging Study and the AGES-Reykjavik Study.


Research line

Epidemiology of cerebrovascular disease and brain health.



Research Output (210)

Association of White Matter Hyperintensity Markers on MRI and Long-term Risk of Mortality and Ischemic Stroke:The SMART-MR Study

Ghaznawi Rashid, Geerlings Mirjam, Jaarsma-Coes Myriam, Hendrikse Jeroen, de Bresser Jeroen, 16 mrt 2021, In: Neurology. 96 , p. e2172-e2183

Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia:A systematic review and meta-analysis

Vonk Jet M J, Twait Emma L, Scholten Rob J P M, Geerlings Mirjam I 19 okt 2020, In: Mechanisms of Ageing and Development. 192 , p. 1-13

Vascular Risk Factors of Hippocampal Subfield Volumes in Persons without Dementia:The Medea 7T Study

Blom Kim, Koek Huiberdina L, Zwartbol Maarten H T, Ghaznawi Rashid, Kuijf Hugo J, Witkamp Theo D, Hendrikse Jeroen, Biessels Geert Jan, Geerlings Mirjam I, 5 sep 2020, In: Journal of Alzheimer's Disease. 77 , p. 1223-1239 17 p.

Intracranial Atherosclerosis on 7T MRI and Cognitive Functioning - the SMART-MR study

Zwartbol Maarten H T, van der Kolk Anja G, Ghaznawi Rashid, van der Graaf Yolanda, Hendrikse Jeroen, Geerlings Mirjam I, 6 jul 2020, In: Neurology. 95 , p. e1351-e1361

How Far Can We Take Vessel Wall MRI for Intracranial Atherosclerosis? The Tissue is Still the Issue REPLY

Zwartbol M H T, van der Kolk A G, Geerlings M I 30 apr 2020, In: AJNR. American journal of neuroradiology. 41 , p. E32-E32

Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer's disease:A 7 Tesla MRI study

Bouvy Willem H, van Veluw Susanne J, Kuijf Hugo J, Zwanenburg Jaco Jm, Kappelle Jaap L, Luijten Peter R, Koek Huiberdina L, Geerlings Mirjam I, Biessels Geert J, 1 apr 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40 , p. 739-746 8 p.

Intracranial vessel wall lesions on 7T MRI and MRI features of cerebral small vessel disease-The SMART-MR study

Zwartbol Maarten Ht, van der Kolk Anja G, Kuijf Hugo J, Witkamp Theo D, Ghaznawi Rashid, Hendrikse Jeroen, Geerlings Mirjam I, 2020, In: Journal of Cerebral Blood Flow and Metabolism. 41 , p. 1219-1228 10 p.

Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis:The SMART-MR Study

Zwartbol M. H. T., Geerlings M. I., Ghaznawi R., Hendrikse J., van der Kolk A. G., Asselbergs F. W., Nathoe H. M., de Borst G. J., Bots M. L., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren F. L. J., Westerink J., 5 dec 2019, In: American Journal of Neuroradiology. 40 , p. 2016-2022 7 p.

Progress update from the hippocampal subfields group

Olsen Rosanna K, Carr Valerie A, Daugherty Ana M, La Joie Renaud, Amaral Robert S C, Amunts Katrin, Augustinack Jean C, Bakker Arnold, Bender Andrew R, Berron David, Boccardi Marina, Bocchetta Martina, Burggren Alison C, Chakravarty M Mallar, Chételat Gaël, de Flores Robin, DeKraker Jordan, Ding Song-Lin, Geerlings Mirjam I, Huang Yushan, Insausti Ricardo, Johnson Elliott G, Kanel Prabesh, Kedo Olga, Kennedy Kristen M, Keresztes Attila, Lee Joshua K, Lindenberger Ulman, Mueller Susanne G, Mulligan Elizabeth M, Ofen Noa, Palombo Daniela J, Pasquini Lorenzo, Pluta John, Raz Naftali, Rodrigue Karen M, Schlichting Margaret L, Lee Shing Yee, Stark Craig E L, Steve Trevor A, Suthana Nanthia A, Wang Lei, Werkle-Bergner Markus, Yushkevich Paul A, Yu Qijing, Wisse Laura E M, 1 dec 2019, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11 , p. 439-449 11 p.

Risk factors of mortality in older patients with dementia in psychiatric care

Goluke Nienke M S, Geerlings Mirjam I, van de Vorst Irene E, Vaartjes Ilonca H, de Jonghe Annemarieke, Bots Michiel L, Koek Huiberdina L 10 nov 2019, In: International Journal of Geriatric Psychiatry. 35 , p. 174-181 8 p.

All research output

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