prof. dr. D.E. Grobbee

prof. dr. D.E. Grobbee

Full Professor
prof. dr. D.E. Grobbee
  • Department of Epidemiology
  • Julius Center Research Program Cardiovascular Epidemiology

Research Programs

Circulatory Health



Biographical Sketch

Diederick (Rick) E. Grobbee was trained as a medical doctor at Utrecht University. He then conducted PhD research in the field of hypertension at Erasmus University in Rotterdam (12/83-6/1986). After a residency in Internal Medicine, he returned to the Erasmus University as an associate professor and then Full professor of Clinical Epidemiology (1993). In Rotterdam he was responsible for the cardiovascular disease research program of the Department of Epidemiology, and was one of the founders of the Rotterdam Study ( In 1996 he was appointed professor of Clinical Epidemiology at Utrecht University and founded of the Julius Center for Health Sciences and Primary Care (1996), a division of the University Medical Center Utrecht (UMCU) currently employing approximately 500 staff ( In 2008 he founded Julius Clinical Ltd., a full service Academic Clinical Research Organization ( of which he serves as Chief Medical Officer and Statutory Director. At the University Medical Center Utrecht, he just finished his term as the chair of the Center for Circulatory Health at the UMCU governing cardiovascular patient care, research and education. Previous positions include director of the Rotterdam Medical Research Foundation, member of the board of Erasmus University Medical Center, and visiting Associate Professor at Harvard University, Boston. He holds honorary appointments in Sydney and Kuala Lumpur.  At Utrecht University he was appointed Distinguished University Professor in 2010.

Rick Grobbee has been a (principal) investigator in many large-scale epidemiologic studies and randomized intervention trials relating to the prevention and treatment of cardiovascular, cardiometabolic, and cardiorenal disease. In addition he works on the principles and methods of treatment research, trial design and (big-) data analysis. In the Netherlands he was member of the supervisory board of the Netherlands Heart Foundation and acted in several roles in committees of the National Research Council (ZonMW). He is chair of the Dutch National Research Agenda (NWA) route "Prevention". He has been listed in the top 100 global most influential biomedical researchers (Eur J Clin Invest 2013 Dec;43(12):1339-65) and has consistently been ranked as highly cited author by Web of Science over the last decades.

Rick Grobbee has been on the editorial boards of several journals and (inter) national scientific, search, and site-visit committees. Current journal roles include editor-in-chief of Global Heart (, senior consulting editor of the European Journal of Preventive Cardiology of which he served as editor-in-chief for eight years. He is immediate past-president of the European Association for Preventive Cardiology and member of the board of the European Society of Cardiology (ESC) and chair of the ESC Global Affairs Committee. He is member of the board of the World Heart Federation Rick Grobbee is fellow of the Royal Dutch Academy of Sciences and served as the chair of its Medical Section and Advisory Council for the Medical Sciences. He is honorary fellow of the Indonesian Heart Association and of the Romanian Society of Cardiology.  In recent years his attention has increasingly been directed towards global circulatory health ( ), and on-line education for which he founded Elevate, a platform providing global post graduate courses, masters programs and eductional consultancy ( ).  Rick Grobbee was a recipient of a 2019 NWO Gravitation Award "Exposomics" and current coordinator of three EU grants. In 2017 he was knighted by the Dutch King (Knight in the Order of the Dutch Lion). To date, Prof. Grobbee has authored or co-authored over 1,300 scientific papers (PubMed), chapters, and books, and has supervised more than 150 PhD fellows. His Hirsch index (Web of Science) is 151.


Side Activities


  • Chief Scientific Officer and Statutory Director, Julius Clinical Ltd. Academic Clinical Research Organization (0.5 Fte)
  • Director, Utrecht University MSc and PhD in Epidemiology Programmes
  • Chair Missieteam 1 (Prevention), Health Holland (2020)
  • Chair ("Boegbeeld"), National Research Agenda (NWA) Route Health Research, Prevention and Treatment
  • Member, Board of Studies, Graduate School Life Sciences, Utrecht University
  • Fellow, Royal Dutch Academy of Sciences
  • Fellow, European Society of Cardiology
  • Member, Board, European Society of Cardiology
  • Member, Board, World Heart Federation
  • Chair, Global Affairs Committee, European Society of Cardiology
  • Member, Practice Guidelines Committee, European Society of Cardiology
  • Past-President, European Association for Cardiovascular Prevention and Rehabilitation
  • Member Executive Board, European Association for Cardiovascular Prevention and Rehabilitation
  • Chair, International Scientific Advisory Board, BBMRI (Biobanking Netherlands)
  • Editor in Chief, Global Heart
  • Senior Consulting Editor, European Journal of Cardiovascular Prevention and Rehabilitation
  • Member, Editorial Board Netherlands Journal of Medicine
  • Member, Editorial Board, Current Cardiovascular Risk Reports
  • Member, Editorial Board Cardiovascular Risk
  • Member, Various Scientific Advisory, Safety Monitoring en Adjudication Committees International Clinical Trials


Fellowship and Awards

  • 2008 Prevention award. German Society of Cardiology
  • 2008 Catharijne Prize
  • 2009 David de Wied lecture
  • 2009 Fellow of the Netherlands Royal Academy of Sciences
  • 2010 Distinguished University Professor of International Health Sciences and Global Health, Utrecht University
  • 2016 Honorary Fellow, Indonesian Heart Association
  • 2016 Romanian Society of Cardiology
  • 2017 Knight. Order of the Dutch Lion

Research Output (1725)

Validation of the GetReal Trial Tool - Facilitating discussion and understanding more pragmatic design choices and their implications

Boateng Daniel, Kumke Thomas, Vernooij Robin, Goetz Iris, Meinecke Anna Katharina, Steenhuis Charlotte, Grobbee Diederick, Zuidgeest Mira GP 15 Dec 2022, In: Contemporary Clinical Trials.

A cross-sectional survey on the early impact of COVID-19 on the uptake of decentralised trial methods in the conduct of clinical trials

Suman Arnela, van Es Jasmijn, Gardarsdottir Helga, Grobbee Diederick E., Hawkins Kimberly, Heath Megan A., Mackenzie Isla S., van Thiel Ghislaine, Zuidgeest Mira G.P., Dec 2022, In: Trials. 23

Comparative performance of cardiovascular risk prediction models in people living with HIV

Tahir Irtiza, Vos Alinda, Damen Johanna, Barth Roos, Tempelman Hugo, Grobbee Diederick, Scheuermaier Karine, Venter Willem, Klipstein-Grobusch Kerstin 15 Nov 2022, In: Southern African Journal of HIV Medicine. 23

Improvement of non-invasive tests of liver steatosis and fibrosis as indicators for non-alcoholic fatty liver disease in type 2 diabetes mellitus patients with elevated cardiovascular risk profile using the PPAR-α/γ agonist aleglitazar

Grobbee Esmée J, de Jong Vivian D, Schrieks Ilse C, Tushuizen Maarten E, Holleboom Adriaan G, Tardif Jean-Claude, Lincoff A Michael, Schwartz Gregory G, Castro Cabezas Manuel, Grobbee Diederick E 15 Nov 2022, In: PLoS ONE. 17 , p. 1-12

CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research

Kotecha Dipak, Asselbergs Folkert W., Achenbach Stephan, Anker Stefan D., Atar Dan, Baigent Colin, Banerjee Amitava, Beger Birgit, Brobert Gunnar, Casadei Barbara, Ceccarelli Cinzia, Cowie Martin R., Crea Filippo, Cronin Maureen, Denaxas Spiros, Derix Andrea, Fitzsimons Donna, Fredriksson Martin, Gale Chris P., Gkoutos Georgios V., Goettsch Wim, Hemingway Harry, Ingvar Martin, Jonas Adrian, Kazmierski Robert, Løgstrup Susanne, Thomas Lumbers R., Lüscher Thomas F., McGreavy Paul, Piña Ileana L., Roessig Lothar, Steinbeisser Carl, Sundgren Mats, Tyl Benoît, van Thiel Ghislaine, van Bochove Kees, Vardas Panos E., Villanueva Tiago, Vrana Marilena, Weber Wim, Weidinger Franz, Windecker Stephan, Wood Angela, Grobbee Diederick E., 7 Oct 2022, In: European heart journal. 43 , p. 3578-3588 11 p.

Tuberculosis treatment and resulting abnormal blood glucose:a scoping review of studies from 1981 - 2021

Williams Victor, Onwuchekwa Chukwuemeka, Vos Alinda G, Grobbee Diederick E, Otwombe Kennedy, Klipstein-Grobusch Kerstin 30 Sep 2022, In: Global Health Action. 15 , p. 1-11

Structured diabetes self-management education and glycaemic control in low- and middle-income countries:A systematic review

Lamptey Roberta, Robben Maud P, Amoakoh-Coleman Mary, Boateng Daniel, Grobbee Diederick E, Davies Melanie J, Klipstein-Grobusch Kerstin Aug 2022, In: Diabetic Medicine. 39

Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima-Media Thickness:An Individual Participant Data Meta-Analysis

Nonterah Engelbert A, Crowther Nigel J, Klipstein-Grobusch Kerstin, Oduro Abraham R, Kavousi Maryam, Agongo Godfred, Anderson Todd J, Asiki Gershim, Boua Palwendé R, Choma Solomon S R, Couper David J, Engström Gunnar, de Graaf Jacqueline, Kauhanen Jussi, Lonn Eva M, Mathiesen Ellisiv B, Micklesfield Lisa K, Okazaki Shuhei, Polak Joseph F, Rundek Tatjana, Salonen Jukka T, Tollman Stephen M, Tuomainen Tomi-Pekka, Grobbee Diederick E, Ramsay Michéle, Bots Michiel L, 25 Jul 2022, In: Journal of the American Heart Association. 11

When is it impractical to ask informed consent?:A systematic review

Laurijssen Sara Jm, van der Graaf Rieke, van Dijk Wouter B, Schuit Ewoud, Groenwold Rolf Hh, Grobbee Diederick E, de Vries Martine C 1 Jul 2022, In: Clinical Trials. 19 , p. 545-560 16 p.

Prevalence of Cardioprotective Medication Use in Coronary Heart Disease Patients in South America:Systematic review and Meta-Analysis

Marzà-Florensa A, Drotos E, Gulayin P, Grobbee D E, Irazola V, Klipstein-Grobusch K, Vaartjes I 8 Jun 2022, In: Global Heart. 17 , p. 1-21

All research output

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