dr. F. (Floris) Groenendaal
dr. F. (Floris) Groenendaal
- Birth Center Neonatology - Medical
Research Programs
Biography
Biography
Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.
Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.
In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic strategies have been developed and tested in animal models.
He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.
He is member of many professional societies.
Research line
Neonatal neuroprotection
Most recent key publications
1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575
Side Activities
• Invited speaker on many international courses and symposia
• Co-inventor of 2-iminobiotin for neonatal neuroprotection
• Expert witness in several legal cases
• Reviewer for many international scientific journals
Fellowship and Awards
- Ter Meulen Fonds, KNAW, Amsterdam 1993
- Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995
- NWO AGIKO-stipendium 920-03-039
- Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07
- Dr.W.M.Phelps-Stichting voor Spastici 03.016
- Wilhelmina Kinderziekenhuis Onderzoekfonds 2003
- NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022
- Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.
- NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002
- NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103
- ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005
- ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes. 50-50200-98-060
Research Output (625)
van Ooijen I. M., Annink K. V., Benders M. J.N.L., Dudink J., Alderliesten T., Groenendaal F., Tataranno M. L., Lequin M. H., Hoogduin J. M., Visser F., Raaijmakers A. J.E., Klomp D. W.J., Wiegers E. C., Wijnen J. P., van der Aa N. E. Jun 2023, In: Neuroimage: Reports. 3 6 p.
de Vries Linda S, Groenendaal Floris 29 Apr 2023, In: Pediatric Research. 94 , p. 870-872 3 p.
van der Veer Marlotte A A, de Haan Timo R, Franken Linda G W, Hodiamont Caspar J, Groenendaal Floris, Dijk Peter H, de Boode Willem P, Simons Sinno, Dijkman Koen P, van Straaten Henrica L M, Rijken Monique, Cools Filip, Nuytemans Debbie H G M, van Kaam Anton H, Bijleveld Yuma A, Mathôt Ron A A 3 Apr 2023, In: Antimicrobial Agents and Chemotherapy. 67
van de Meent Mette, Kleuskens Dianne G, Ganzevoort Wessel, Gordijn Sanne J, Kooi Elisabeth M W, Onland Wes, van Rijn Bas B, Duvekot Johannes J, Kornelisse René F, Al-Nasiry Salwan, Jellema Reint K, Knol H Marieke, Manten Gwendolyn T R, Mulder-de Tollenaer Susanne M, Derks Jan B, Groenendaal Floris, Bekker Mireille N, Schuit Ewoud, Lely A Titia, Kooiman Judith 17 Mar 2023, In: BMJ Open. 13
Lequin Maarten, Groenendaal Floris, Dudink Jeroen, Govaert Paul 11 Mar 2023, In: BMC Neurology. 23
Parmentier Corline E.J., Lequin Maarten H., Alderliesten Thomas, Swanenburg de Veye Henriëtte F.N., van der Aa Niek E., Dudink Jeroen, Benders Manon J.N.L., Harteman Johanna C., Koopman-Esseboom Corine, Groenendaal Floris, de Vries Linda S. 2023, In: The Journal of Pediatrics. 258
Baak Lisanne M, van der Aa Niek E, Verhagen Annemijn A E, Dudink Jeroen, Groenendaal Floris, Nijboer Cora H A, Benders Manon J N L, Wagenaar Nienke 27 Dec 2022, In: Pediatric Research. 94 , p. 20-33 14 p.
Vann Seralynne D, Zachiu Cornel, Meys Karlijn M E, Ambrosino Sara, Durston Sarah, de Vries Linda S, Groenendaal Floris, Lequin Maarten H Dec 2022, In: Neuroimage. Reports. 2 , p. 1-7
Bonthrone Alexandra F, Stegeman Raymond, Feldmann Maria, Claessens Nathalie H P, Nijman Maaike, Jansen Nicolaas J G, Nijman Joppe, Groenendaal Floris, de Vries Linda S, Benders Manon J N L, Haas Felix, Bekker Mirielle N, Logeswaran Thushiha, Reich Bettina, Kottke Raimund, Hagmann Cornelia, Latal Beatrice, Dave Hitendu, Simpson John, Pushparajah Kuberan, Austin Conal, Kelly Christopher J, Arulkumaran Sophie, Rutherford Mary A, Counsell Serena J, Knirsch Walter, Breur Johannes M P J 27 Oct 2022, In: Stroke. 53 , p. 3652-3661 10 p.
Lemmers Petra, Vijlbrief Daniel, Benders Manon, Alderliesten Thomas, Veldhuis Moniek, Baerts Wim, Koopman-Esseboom Corine, Groenendaal Floris, van Bel Frank 11 Oct 2022, In: The Journal of Pediatrics. 254 , p. 25-32 8 p.