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dr. F. (Floris) Groenendaal

Associate Professor - medical

  • Birth Center Neonatology - Medical

dr. F. (Floris) Groenendaal

Biography

Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.

Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.

In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic  strategies have been developed and tested in animal models.

He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.

He is member of many professional societies.

Research line

Neonatal neuroprotection

Most recent key publications

1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575

Side Activities

  • •          Invited speaker on many international courses and symposia

    •          Co-inventor of 2-iminobiotin for neonatal neuroprotection

    •          Expert witness in several legal cases

    •          Reviewer for many international scientific journals

Fellowship and Awards

  • - Ter Meulen Fonds, KNAW, Amsterdam 1993

    - Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995

    - NWO AGIKO-stipendium 920-03-039

    - Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07

    - Dr.W.M.Phelps-Stichting voor Spastici 03.016

    - Wilhelmina Kinderziekenhuis Onderzoekfonds 2003

    - NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022

    - Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.

    - NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002

    - NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103

    - ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005

    - ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes.  50-50200-98-060

Research Output (571)

Background incidence rates of adverse pregnancy outcomes in the Netherlands:Data of 2006-2018

Immink Maarten M, Koole Sanne, Bekker Mireille N, Groenendaal Floris, Kemmeren Jeanet M, de Melker Hester E, van der Maas Nicoline A T jan 2021, In: European Journal of Obstetrics, Gynecology and Reproductive Biology. 256 , p. 274-280 7 p.

Translation from animal to clinical studies, choosing the optimal moment

Favié Laurent M A, Peeters-Scholte Cacha M P C D, Bakker Anouk, Tjabbes Huibert, Egberts Toine C G, van Bel Frank, Rademaker Carin M A, Vis Peter, Groenendaal Floris dec 2020, In: Pediatric Research. 88 , p. 836-837 2 p.

Association of early skin breaks and neonatal thalamic maturation:A modifiable risk?

Duerden Emma G, Grunau Ruth E, Chau Vann, Groenendaal Floris, Guo Ting, Chakravarty M Mallar, Benders Manon, Wagenaar Nienke, Eijsermans Rian, Koopman Corine, Synnes Anne, Vries Linda de, Miller Steven P 21 okt 2020, In: Neurology. 95 , p. e3420-e3427

Increased Use of Therapeutic Hypothermia in Infants with Milder Neonatal Encephalopathy due to Presumed Perinatal Asphyxia

Parmentier Corline E J, de Vries Linda S, Toet Mona C, van Haastert Ingrid C, Koopman Corine, Weeke Lauren C, Groenendaal Floris 19 aug 2020, In: Neonatology. 117 , p. 488-494 7 p.

Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation:Outcome at 2 Years

Cizmeci Mehmet N, Groenendaal Floris, Liem Kian D, van Haastert Ingrid C, Benavente-Fernández Isabel, van Straaten Henrica L M, Steggerda Sylke, Smit Bert J, Whitelaw Andrew, Woerdeman Peter, Heep Axel, de Vries Linda S, 12 aug 2020, In: The Journal of Pediatrics. 226 , p. 28-35.e2

Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy

Annink Kim, V, Groenendaal Floris, Cohen Daan, van der Aa Niek E., Alderliesten Thomas, Dudink Jeroen, Benders Manon J. N. L., Wijnen Jannie P. 1 aug 2020, In: Pediatric Research. 88 , p. 279-284 6 p.

Introduction of Ultra-High-Field MR Imaging in Infants:Preparations and Feasibility

Annink K V, van der Aa N E, Dudink J, Alderliesten T, Groenendaal F, Lequin M, Jansen F E, Rhebergen K S, Luijten P, Hendrikse J, Hoogduin H J M, Huijing E R, Versteeg E, Visser F, Raaijmakers A J E, Wiegers E C, Klomp D W J, Wijnen J P, Benders M J N L 30 jul 2020, In: American Journal of Neuroradiology. 41 , p. 1532-1537 6 p.

Non-right-handedness in children born extremely preterm:Relation to early neuroimaging and long-term neurodevelopment

van Heerwaarde Alise A, van der Kamp Laura T, van der Aa Niek E, de Vries Linda S, Groenendaal Floris, Jongmans Marian J, Eijsermans Rian J C, Koopman-Esseboom Corine, van Haastert Inge-Lot C, Benders Manon J N L, Dudink Jeroen 6 jul 2020, In: PLoS ONE. 15

Prediction of drug exposure in critically ill encephalopathic neonates treated with therapeutic hypothermia based on a pooled population pharmacokinetic analysis of seven drugs and five metabolites

Favié Laurent M A, de Haan Timo R, Bijleveld Yuma A, Rademaker Carin M A, Egberts Toine C G, Nuytemans Debbie H G M, Mathôt Ron A A, Groenendaal Floris, Huitema Alwin D R 28 mei 2020, In: Clinical Pharmacology and Therapeutics. 108 , p. 1098-1106 9 p.

Increase in Brain Volumes after Implementation of a Nutrition Regimen in Infants Born Extremely Preterm

van Beek Pauline E, Claessens Nathalie H P, Makropoulos Antonios, Groenendaal Floris, de Vries Linda S, Counsell Serena J, Benders Manon J N L 7 mei 2020, In: The Journal of Pediatrics. 223 , p. 57-63.e5

All Research Output (571)