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dr. F. (Floris) Groenendaal

Associate Professor - medical

  • Birth Center Neonatology - Medical

dr. F. (Floris) Groenendaal

Biography

Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.

Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.

In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic  strategies have been developed and tested in animal models.

He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.

He is member of many professional societies.

Research line

Neonatal neuroprotection

Most recent key publications

1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575

Side Activities

  • •          Invited speaker on many international courses and symposia

    •          Co-inventor of 2-iminobiotin for neonatal neuroprotection

    •          Expert witness in several legal cases

    •          Reviewer for many international scientific journals

Fellowship and Awards

  • - Ter Meulen Fonds, KNAW, Amsterdam 1993

    - Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995

    - NWO AGIKO-stipendium 920-03-039

    - Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07

    - Dr.W.M.Phelps-Stichting voor Spastici 03.016

    - Wilhelmina Kinderziekenhuis Onderzoekfonds 2003

    - NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022

    - Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.

    - NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002

    - NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103

    - ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005

    - ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes.  50-50200-98-060

Research Output (560)

Non-right-handedness in children born extremely preterm:Relation to early neuroimaging and long-term neurodevelopment

van Heerwaarde Alise A, van der Kamp Laura T, van der Aa Niek E, de Vries Linda S, Groenendaal Floris, Jongmans Marian J, Eijsermans Rian J C, Koopman-Esseboom Corine, van Haastert Inge-Lot C, Benders Manon J N L, Dudink Jeroen 6 jul 2020, In: PLoS ONE.

Morphine affects brain activity and volumes in preterms:An observational multi-center study

Tataranno M L, Gui L, Hellström-Westas L, Toet M, Groenendaal F, Claessens N H P, Schuurmans J, Fellman V, Sävman K, de Vries L S, Huppi P, Benders M J N L 7 apr 2020, In: Early Human Development. 144 8 p.

Preterm infants with isolated cerebellar hemorrhage show bilateral cortical alterations at term equivalent age

Dijkshoorn Aicha B C, Turk Elise, Hortensius Lisa M, van der Aa Niek E, Hoebeek Freek E, Groenendaal Floris, Benders Manon J N L, Dudink Jeroen 24 mrt 2020, In: Scientific Reports. 10 12 p.

The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy

Annink Kim V, de Vries Linda S, Groenendaal Floris, Vijlbrief Daniel C, Weeke Lauren C, Roehr Charles C, Lequin Maarten, Reiss Irwin K M, Govaert Paul, Benders Manon J N L, Dudink Jeroen 1 mrt 2020, In: Pediatric Research. 87 , p. 59-66 8 p.

Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy

Annink Kim, V, Groenendaal Floris, Cohen Daan, van der Aa Niek E., Alderliesten Thomas, Dudink Jeroen, Benders Manon J. N. L., Wijnen Jannie P. 1 jan 2020, In: Pediatric Research. 6 p.

Neonatal care bundles are associated with a reduction in the incidence of intraventricular haemorrhage in preterm infants:a multicentre cohort study

de Bijl-Marcus Karen, Brouwer Annemieke Johanna, De Vries Linda S, Groenendaal Floris, Wezel-Meijler Gerda van 15 nov 2019, In: Archives of Disease in Childhood Fetal and Neonatal Edition. 105 , p. 419-424 6 p.

Early prediction of unilateral cerebral palsy in infants at risk:MRI versus the hand assessment for infants

Wagenaar Nienke, Verhage Cornelia H, de Vries Linda S, van Gasselt Bram P L, Koopman-Esseboom Corine, Leemans Alexander, Groenendaal Floris, Benders Manon J N L, van der Aa Niek E 13 nov 2019, In: Pediatric Research. 87 , p. 932-939 8 p.

Periventricular Hemorrhagic Infarction in Very Preterm Infants:Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years

Cizmeci Mehmet N, de Vries Linda S, Ly Linh G, van Haastert Ingrid C, Groenendaal Floris, Kelly Edmond N, Traubici Jeffrey, Whyte Hilary E, Leijser Lara M 6 nov 2019, In: The Journal of Pediatrics. 217 , p. 79-85.e1

Signal Change in the Mammillary Bodies after Perinatal Asphyxia

Molavi M, Vann S D, de Vries L S, Groenendaal F, Lequin M 6 nov 2019, In: American Journal of Neuroradiology. 40 , p. 1829-1834 6 p.

Brain Activity and Cerebral Oxygenation After Perinatal Arterial Ischemic Stroke Are Associated With Neurodevelopment

Wagenaar Nienke, van den Berk Daphne J. M., Lemmers Petra M. A., van der Aa Niek E., Dudink Jeroen, van Bel Frank, Groenendaal Floris, de Vries Linda S., Benders Manon J. N. L., Alderliesten Thomas 8 aug 2019, In: Stroke. 50 , p. 2668-2676 9 p.

All Research Output (560)