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dr. F. (Floris) Groenendaal

dr. F. (Floris) Groenendaal

Associate Professor - medical
dr. F. (Floris) Groenendaal
  • Birth Center Neonatology - Medical

Biography

Biography

Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.

Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.

In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic  strategies have been developed and tested in animal models.

He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.

He is member of many professional societies.

Research line

Neonatal neuroprotection

Most recent key publications

1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575

Side Activities

•          Invited speaker on many international courses and symposia

•          Co-inventor of 2-iminobiotin for neonatal neuroprotection

•          Expert witness in several legal cases

•          Reviewer for many international scientific journals

Fellowship and Awards

- Ter Meulen Fonds, KNAW, Amsterdam 1993

- Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995

- NWO AGIKO-stipendium 920-03-039

- Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07

- Dr.W.M.Phelps-Stichting voor Spastici 03.016

- Wilhelmina Kinderziekenhuis Onderzoekfonds 2003

- NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022

- Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.

- NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002

- NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103

- ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005

- ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes.  50-50200-98-060

Research Output (609)

Oxidative Stress Biomarkers and Early Brain Activity in Extremely Preterm Infants:A Prospective Cohort Study

Coviello Caterina, Perrone Serafina, Buonocore Giuseppe, Negro Simona, Longini Mariangela, Groenendaal Floris, Vijlbrief Daniel C, Dani Carlo, Benders Manon J N L, Tataranno Maria Luisa 12 Sep 2022, In: Children (Basel, Switzerland). 9 , p. 1-10

The Mammillary Bodies:A Review of Causes of Injury in Infants and Children

Meys K. M.E., de Vries L. S., Groenendaal F., Vann S. D., Lequin M. H. 1 Jun 2022, In: American Journal of Neuroradiology. 43 , p. 802-812 11 p.

Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN):a first-in-human, open-label intervention study

Baak Lisanne M., Wagenaar Nienke, van der Aa Niek E., Groenendaal Floris, Dudink Jeroen, Tataranno Maria Luisa, Mahamuud Ubah, Verhage Cornelia H., Eijsermans Rian M.J.C., Smit Liesbeth S., Jellema Reint K., de Haan Timo R., ter Horst Hendrik J., de Boode Willem P., Steggerda Sylke J., Prins Henk Jan, de Haar Colin G., de Vries Linda S., van Bel Frank, Heijnen Cobi J., Nijboer Cora H., Benders Manon J.N.L. Jun 2022, In: The Lancet. Neurology. 21 , p. 528-536 9 p.

Corpus callosum injury after neurosurgical intervention for posthemorrhagic ventricular dilatation and association with neurodevelopmental outcome at 2 years

Cizmeci Mehmet N, Groenendaal Floris, van der Aa Niek E, Vandewouw Marlee M, Young Julia M, Han Kuosen, Benders Manon J N L, Taylor Margot J, de Vries Linda S, Woerdeman Peter A 8 Apr 2022, In: Journal of Neurosurgery: Pediatrics. 30 , p. 31-38 8 p.

Outcome Prediction and Inter-Rater Comparison of Four Brain Magnetic Resonance Imaging Scoring Systems of Infants with Perinatal Asphyxia and Therapeutic Hypothermia

Langeslag Juliette F, Groenendaal Floris, Roosendaal Stefan D, de Vries Linda S, Onland Wes, Leeflang Mariska M G, Groot Paul F C, van Kaam Anton H, de Haan Timo R, 31 Mar 2022, In: Neonatology. 119 , p. 311-319 9 p.

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

Parmentier Corline E J, de Vries Linda S, Groenendaal Floris 6 Mar 2022, In: Diagnostics (Basel, Switzerland). 12

Hypoglycemia in infants with hypoxic-ischemic encephalopathy is associated with additional brain injury and worse neurodevelopmental outcome

Parmentier Corline E J, de Vries Linda S, van der Aa Niek E, Eijsermans Rian M J C, Harteman Johanneke C, Lequin Maarten H, Swanenburg de Veye Henriette F N, Koopman Corine, Groenendaal Floris 1 Feb 2022, In: The Journal of Pediatrics. 245 , p. 30-38

Comment on 'value of cranial ultrasound at initiation of therapeutic hypothermia for neonatal encephalopathy'

de Vries L S, Steggerda S J, Groenendaal F, Cowan F M 2022, In: Journal of perinatology. 42 , p. 418-419 2 p.

Autopsy in a neonatal intensive care unit:do we still need it in 2022?

Groenendaal Floris, Nikkels Peter G J 2022, In: Jornal de Pediatria. 98 , p. 442-443 2 p.

Proceedings of the 13th International Newborn Brain Conference:Neuroprotection strategies in the neonate

Abou Mehrem Ayman et al. 2022, In: Journal of neonatal-perinatal medicine. 15 , p. 427-439 13 p.

All research output

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