prof.dr. J.C. (Jan C.) Grutters

Full Professor

  • Department of Pulmonary Diseases

prof.dr. J.C. (Jan C.) Grutters

Research Programs


Jan C. Grutters (1966) studied Medicine at the University of Nijmegen, and was trained in Respiratory Medicine at St. Antonius Hospital Nieuwegein and University Medical Center (UMC) Utrecht, the Netherlands. In 2001 he was awarded an ERS Research Fellowship at the Imperial College and Royal Brompton Hospital London, resulting in the Thesis: ‘Genetic polymorphisms and phenotypes in sarcoidosis’. Since 2002 he works as chest physician at St. Antonius Hospital, where he is head of the Interstitial Long Diseases (ILD)  Center of Excellence (currently treating >3000 ILD patients/yr), and UMC Utrecht, where he is member of the Lung Transplant Team. From 2009 to 2011 he was head of training Pulmonology & Tuberculosis at St. Antonius Hospital. In 2010 he was appointed Professor of ILD at University Utrecht. His research focuses on genetics, biomarkers and novel therapies for lung fibrosis, sarcoidosis and ultra-rare ILD such as lymphangioleiomyomatosis and pulmonary alveolar proteinosis. Jan Grutters has been/is supervisor of >20 PhD students, published >200 papers in international scientific journals and books, and is regularly invited as speaker and/or chairman at national and international medical/scientific congresses, seminars and meetings.

Side Activities

  • Head ILD Center of Excellence St. Antonius Hospital Nieuwegein

    Project leader "Domeinaanvraag TopZorg Experiment Longcentrum St. Antonius Hospital"

    Coordinator Lung Transplantation Program at St. Antonius Hospital 

    Chairman Section ILD of Dutch Association of Chest Physicians (NVALT)

    Chairman Prof. Dr. Jaap Swierenga Foundation

    Member Scientific Advisory board St. Antonius Research Fund

    Member Innovation Committee St. Antonius

    Member Scientific Advisory Board Dutch Lung Fund

    Ambassador for the Netherlands Respiratory Society (NRS)

    Member of Medical Advisory Board of Dutch Pulmonary Fibrosis Patient Coalition

    Member Medical Advisory Board of Dutch Sarcoidosis Patient Coalition

    Member Medical Advisory Board of Dutch Lymphangioleiomyomatosis Patient Coalition

    Member Executive Committee of World Association of Sarcoidosis and other Granulomatous Disorders (WASOG)

    Member Editorial Board of journal Sarcoidosis, Vasculitis and Diffuse Lung Diseases

    Member Taskforce Sarcoidosis treatment of the European Respiratory Society (ERS)

    Guest Editor for Seminars in Respiratory and Critical Care Medicine


Research Output (139)

From organ to cell:Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis

van Batenburg Aernoud A, Kazemier Karin M, van Oosterhout Matthijs F M, van der Vis Joanne J, van Es Hendrik W, Grutters Jan C, Goldschmeding Roel, van Moorsel Coline H M 7 jan 2020, In: PLoS ONE. 15 15 p.

Unbound Plasma, Total Plasma, and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A., Van Maarseveen Erik M., Hunault Claudine C., Moreno Javier M., Van de Graaf Ed A., Kirkels Johannes H., Verhaar Marianne C., Grutters Jan C., Kesecioglu Jozef, De Lange Dylan W., Huitema Alwin D. R. 16 dec 2019, In: Clinical Pharmacokinetics. 59 , p. 771-780 10 p.

Pulmonary fibrosis linked to variants in the ACD gene, encoding the telomere protein TPP1

Hoffman Thijs W., Van Der Vis Joanne J., Van Der Smagt Jasper J., Massink Maarten P.G., Grutters Jan C., Van Moorsel Coline H.M. 1 dec 2019, In: European Respiratory Journal. 54

Publisher Correction:Sarcoidosis (Nature Reviews Disease Primers, (2019), 5, 1, (45), 10.1038/s41572-019-0096-x)

Grunewald Johan, Grutters Jan C., Arkema Elizabeth V., Saketkoo Lesley Ann, Moller David R., Müller-Quernheim Joachim 1 dec 2019, In: Nature Reviews Disease Primers. 5 1 p.

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A, Hunault Claudine C, Van Maarseveen Erik M, Huitema Alwin D R, Van de Graaf Ed A, Kirkels Johannes H, Verhaar Marianne C, Grutters Jan C, Kesecioglu Jozef, De Lange Dylan W 19 nov 2019, In: European journal of drug metabolism and pharmacokinetics. 45 , p. 123-134 12 p.

Prevalence of pulmonary hypertension in pulmonary sarcoidosis:the first large European prospective study

Huitema Marloes P., Bakker Annelies L.M., Mager Johannes J., Rensing Benno J.W.M., Smits Fokko, Snijder Repke J., Grutters Jan C., Post Marco C. 1 okt 2019, In: The European respiratory journal. 54

Results of the standard set for pulmonary sarcoidosis:feasibility and multicentre outcomes

Kampstra Nynke A, van der Nat Paul B, Dijksman Lea M, van Beek Frouke T, Culver Daniel A, Baughman Robert P, Renzoni Elisabetta A, Wuyts Wim, Kouranos Vasilis, Zanen Pieter, Wijsenbeek Marlies S, Eijkemans Marinus J C, Biesma Douwe H, van der Wees Philip J, Grutters Jan C okt 2019, In: BMJ open [E]. 5

Should vitamin K be supplemented instead of antagonised in patients with idiopathic pulmonary fibrosis?

De Brouwer Bart, Piscaer Ianthe, Von Der Thusen Jan H., Grutters Jan C., Schutgens Roger E.G., Wouters Emiel F.M., Janssen Rob 4 mrt 2018, In: Expert Review of Respiratory Medicine. 12 , p. 169-175 7 p.

Course of SP-D, YKL-40, CCL18 and CA 15-3 in adult patients hospitalised with community-acquired pneumonia and their association with disease severity and aetiology:A post-hoc analysis

Spoorenberg Simone M C, Vestjens Stefan M T, Voorn G P, van Moorsel Coline H M, Meek Bob, Zanen Pieter, Rijkers Ger T, Bos Willem Jan W, Grutters Jan C, 2018, In: PLoS ONE [E]. 13

Short telomere length in IPF lung associates with fibrotic lesions and predicts survival

Snetselaar Reinier, van Batenburg Aernoud A., van Oosterhout Matthijs F., Kazemier Karin M., Roothaan Suzan M., Peeters Ton, Van Der Vis Joanne J., Goldschmeding Roel, Grutters Jan C., Van Moorsel Coline H.M. 1 dec 2017, In: PLoS ONE [E]. 12

All Research Output (139)