prof.dr. J.C. (Jan C.) Grutters

prof.dr. J.C. (Jan C.) Grutters

Full Professor
prof.dr. J.C. (Jan C.) Grutters
  • Department of Pulmonary Diseases

Research Programs

Infection & Immunity



Jan C. Grutters (1966) studied Medicine at the University of Nijmegen, and was trained in Respiratory Medicine at St. Antonius Hospital Nieuwegein and University Medical Center (UMC) Utrecht, the Netherlands. In 2001 he was awarded an ERS Research Fellowship at the Imperial College and Royal Brompton Hospital London, resulting in the Thesis: ‘Genetic polymorphisms and phenotypes in sarcoidosis’. Since 2002 he works as chest physician at St. Antonius Hospital, where he is head of the Interstitial Long Diseases (ILD)  Center of Excellence (currently treating >3000 ILD patients/yr), and UMC Utrecht, where he is member of the Lung Transplant Team. From 2009 to 2011 he was head of training Pulmonology & Tuberculosis at St. Antonius Hospital. In 2010 he was appointed Professor of ILD at University Utrecht. His research focuses on genetics, biomarkers and novel therapies for lung fibrosis, sarcoidosis and ultra-rare ILD such as lymphangioleiomyomatosis and pulmonary alveolar proteinosis. Jan Grutters has been/is supervisor of >20 PhD students, published >200 papers in international scientific journals and books, and is regularly invited as speaker and/or chairman at national and international medical/scientific congresses, seminars and meetings.

Side Activities

Head ILD Center of Excellence St. Antonius Hospital Nieuwegein

Project leader "Domeinaanvraag TopZorg Experiment Longcentrum St. Antonius Hospital"

Coordinator Lung Transplantation Program at St. Antonius Hospital 

Chairman Section ILD of Dutch Association of Chest Physicians (NVALT)

Chairman Prof. Dr. Jaap Swierenga Foundation

Member Scientific Advisory board St. Antonius Research Fund

Member Innovation Committee St. Antonius

Member Scientific Advisory Board Dutch Lung Fund

Ambassador for the Netherlands Respiratory Society (NRS)

Member of Medical Advisory Board of Dutch Pulmonary Fibrosis Patient Coalition

Member Medical Advisory Board of Dutch Sarcoidosis Patient Coalition

Member Medical Advisory Board of Dutch Lymphangioleiomyomatosis Patient Coalition

Member Executive Committee of World Association of Sarcoidosis and other Granulomatous Disorders (WASOG)

Member Editorial Board of journal Sarcoidosis, Vasculitis and Diffuse Lung Diseases

Member Taskforce Sarcoidosis treatment of the European Respiratory Society (ERS)

Guest Editor for Seminars in Respiratory and Critical Care Medicine


Research Output (149)

Predictors for progressive fibrosis in patients with connective tissue disease associated interstitial lung diseases

Chiu Yu Hsiang, Spierings Julia, de Jong Pim A., Hoesein Firdaus Mohamed, Grutters Jan C., van Laar Jacob M., Voortman Mareye 18 aug 2021, In: Respiratory Medicine. 187 8 p.

Effectiveness and safety of infliximab in cardiac Sarcoidosis

Bakker A. L.M., Mathijssen H., Azzahhafi J., Swaans M. J., Veltkamp M., Keijsers R. G.M., Akdim F., Post M. C., Grutters J. C. 1 mei 2021, In: International Journal of Cardiology. 330 , p. 179-185 7 p.

Sarcoidosis-Associated Pulmonary Hypertension

Huitema Marloes P, Mathijssen Harold, Mager Johannes J, Snijder Repke J, Grutters Jan C, Post Marco C okt 2020, In: Seminars in Respiratory and Critical Care Medicine. 41 , p. 659-672 14 p.

Predicting pulmonary hypertension in sarcoidosis; value of PH probability on echocardiography

Huitema M. P., Bakker A. L.M., Mager J. J., Snijder R. J., Rensing B. J.W.M., Swaans M. J., Grutters J. C., Post M. C. 1 aug 2020, In: International Journal of Cardiovascular Imaging. 36 , p. 1497-1505 9 p.

Altered splenic [Zr-89]Zr-rituximab uptake in patients with interstitial lung disease not responding to rituximab: could this indicate a splenic immune-mediated mechanism?

Adams Human, Meek Bob, van de Garde Ewoudt M. W., van Moorsel Coline H. M., Vugts Danielle J., Keijsers Ruth G., Grutters Jan C. aug 2020, In: American Journal of Nuclear Medicine and Molecular Imaging [E]. 10 , p. 168-177


van der Vis Joanne J, van der Smagt Jasper J, Hennekam Frederic A M, Grutters Jan C, van Moorsel Coline H M 18 apr 2020, In: Chest. 158 , p. 612-619 8 p.

Lung Transplantation Has a Strong Impact on the Distribution and Phenotype of Monocyte Subsets

Schreurs I., Meek B., Hijdra D., van Moorsel C. H.M., Luijk H. D., Kwakkel-van Erp J. M., Oudijk E., van Kessel D. A., Grutters J. C. apr 2020, In: Transplantation Proceedings. 52 , p. 958-966 9 p.

Safety of macitentan in sarcoidosis-associated pulmonary hypertension:A case-series

Mathijssen H, Huitema M P, Bakker A L M, Mager J J, Snijder R J, Grutters J C, Post M C 25 mrt 2020, In: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 37 , p. 74-78 5 p.

Monocyte derived macrophages from lung transplantation patients have an increased M2 profile

Schreurs I., Meek B., van Moorsel C. H.M., van Kessel D. A., Luijk H. D., Grutters J. C. mrt 2020, In: Transplantation Reports. 5 , p. 1-4

From organ to cell:Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis

van Batenburg Aernoud A, Kazemier Karin M, van Oosterhout Matthijs F M, van der Vis Joanne J, van Es Hendrik W, Grutters Jan C, Goldschmeding Roel, van Moorsel Coline H M 7 jan 2020, In: PLoS ONE. 15 15 p.

All research output

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