prof.dr. J.C. (Jan C.) Grutters

prof.dr. J.C. (Jan C.) Grutters

Full Professor
prof.dr. J.C. (Jan C.) Grutters
  • Department of Pulmonary Diseases

Research Programs

Infection & Immunity



Jan C. Grutters (1966) studied Medicine at the University of Nijmegen, and was trained in Respiratory Medicine at St. Antonius Hospital Nieuwegein and University Medical Center (UMC) Utrecht, the Netherlands. In 2001 he was awarded an ERS Research Fellowship at Imperial College and Royal Brompton Hospital London, resulting in his Thesis: ‘Genetic polymorphisms and phenotypes in sarcoidosis’. Since 2002 he works as a pulmonologist at St. Antonius Hospital, where he is head of the Interstitial Lung Diseases (ILD) Center of Excellence. He is also a member of the Lung Transplant Team at UMC Utrecht. From 2009 to 2011 he was head of training Pulmonology & Tuberculosis at St. Antonius Hospital. Additionally, he has been a Professor of ILD at University Utrecht since 2010, with his research focusing on genetics, biomarkers and novel therapies for progressive lung fibrosis, sarcoidosis, and various auto-immune, exposure-related and ultra-rare ILD. Throughout his career Prof. Grutters has supervised over 25 PhD students, authored and co-authored more than 300 scientific articles, and is regularly invited as speaker or chairman at international medical and scientific conferences. Lastly, he is a member of the editorial board of Sarcoidosis Vasculitis and Diffuse Lung Diseases, and President Elect of the World Association of Sarcoidosis and Other Granulomatous Disorders.

Side Activities

president elect World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG)
chairman Prof. Dr. Jaap Swierenga Stichting
member Sectie ILD (SIL) NVALT
member wetenschappelijke adviesraad (WAR) St Antonius  Onderzoeksfonds
member wetenschappelijke adviescommissie (WAC) Longfonds
member Horizonscan geneesmiddelen ZiN
member commissie dure geneesmiddelen NVALT
member medische adviesraad
member medische adviesraad Longfibrose patientenvereniging
member medische adviesraad Nationale Vereniging Sjogrenpatienten
medisch adviseur stichting LAM-Nederland
member Editorial Board of the journal SVDLD
member forum CPMS ERN-LUNG
member Nederlands asbestosis panel IAS 
member Adjudication Committee Pliant (Pliant)
member Steering Committee Sphinx trial (Actelion)


Research Output (325)

Outcomes in pulmonary sarcoidosis:results of a newly implemented prednisone protocol

Kampstra Nynke, Van der Wees Philip J, Van Beek Frouke T, Biesma Douwe H, Grutters Jan C, Van der Nat Paul B 28 Mar 2023, In: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 40

Potential limitations of activity tracking devices in monitoring effects of treatment for sarcoidosis

Klein Rebecca, Judson Marc, Barkes Briana, Maier Lisa, Zeigler Joyce, Culver Daniel, Sweiss Nadera, Chen Edward, Hamzeh Nabeel, Grutters Jan, Valeyre Dominique, Singh Noopur, Spitzer Ginger, Shivas Tricha, Baughman Robert 28 Mar 2023, In: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 40

Latent class analysis-based subgroups and response to corticosteroids in hospitalised community-acquired pneumonia patients:a validation study

Wittermans Esther, van der Zee Philip A, Qi Hongchao, Grutters Jan C, Voorn G Paul, Bos Willem Jan W, van de Garde Ewoudt M W, Endeman Henrik Mar 2023, In: ERJ Open Research. 9

[89Zr]-immuno-PET prediction of response to rituximab treatment in patients with therapy refractory interstitial pneumonitis:a phase 2 trial

Adams H, van de Garde E M W, Vugts D J, Grutters J C, Oyen Wim J G, Keijsers R G 24 Feb 2023, In: European Journal of Nuclear Medicine and Molecular Imaging. 50 , p. 1929-1939 11 p.

Decreased Survival and Lung Function in Progressive Pulmonary Fibrosis

Platenburg Mark G J P, van der Vis Joanne J, Grutters Jan C, van Moorsel Coline H M 5 Feb 2023, In: Medicina (Kaunas, Lithuania). 59

Genetic Variant Overlap Analysis Identifies Established and Putative Genes Involved in Pulmonary Fibrosis

Groen Karlijn, van der Vis Joanne J., van Batenburg Aernoud A., Kazemier Karin M., Grutters Jan C., van Moorsel Coline H.M. Feb 2023, In: International Journal of Molecular Sciences. 24 17 p.

Optimizing Screening for Early Disease Detection in Familial Pulmonary Fibrosis (FLORIS):A Prospective Cohort Study Design

Maus Martijn T.K., Groen Karlijn, van der Vis Joanne J., Grutters Jan C., van Moorsel Coline H.M. Jan 2023, In: Journal of Clinical medicine. 12 11 p.

Improved Survival of IPF patients Treated With Antifibrotic Drugs Compared With Untreated Patients

Platenburg Mark G.J.P., van Moorsel Coline H.M., Wiertz Ivo A., van der Vis Joanne J., Vorselaars Adriane D.M., Veltkamp Marcel, Grutters Jan C. 2023, In: Lung. 201 , p. 335-343 9 p.

MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis

van der Vis Joanne J, Prasse Antje, Renzoni Elisabetta A, Stock Carmel J W, Caliskan Canay, Maher Toby M, Bonella Francesco, Borie Raphael, Crestani Bruno, Petrek Martin, Wuyts Wim A, Wind Anne E, Molyneaux Philip L, Grutters Jan C, van Moorsel Coline H M 26 Dec 2022, In: Respirology. 28 , p. 455-464 10 p.

European Respiratory Society Statement on Familial Pulmonary Fibrosis

Borie Raphael, Kannengiesser C, Antoniou Katerina, Bonella Francesco, Crestani Bruno, Fabre Aurélie, Froidure Antoine, Galvin Liam, Griese Matthias, Grutters Jan C, Molina-Molina Maria, Poletti Venerino, Prasse Antje, Renzoni Elisabetta, van der Smagt Jasper, van Moorsel Coline H M 22 Dec 2022, In: The European respiratory journal. 61

All research output

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