prof.dr. J.C. (Jan C.) Grutters

prof.dr. J.C. (Jan C.) Grutters

Full Professor
prof.dr. J.C. (Jan C.) Grutters
  • Department of Pulmonary Diseases

Research Programs

Infection & Immunity



Jan C. Grutters (1966) studied Medicine at the University of Nijmegen, and was trained in Respiratory Medicine at St. Antonius Hospital Nieuwegein and University Medical Center (UMC) Utrecht, the Netherlands. In 2001 he was awarded an ERS Research Fellowship at the Imperial College and Royal Brompton Hospital London, resulting in the Thesis: ‘Genetic polymorphisms and phenotypes in sarcoidosis’. Since 2002 he works as chest physician at St. Antonius Hospital, where he heads the Interstitial Long Diseases (ILD) Center of Excellence (currently treating >3000 ILD patients/yr), and UMC Utrecht, where he is member of the Lung Transplant Team. From 2009 to 2011 he was head of training Pulmonology & Tuberculosis at St. Antonius Hospital. In 2010 he was appointed Professor of ILD at University Utrecht. His research focuses on genetics, biomarkers and novel therapies for lung fibrosis, sarcoidosis and ultra-rare ILD such as lymphangioleiomyomatosis and pulmonary alveolar proteinosis. Jan Grutters has been/is supervisor of >40 PhD students, published over 300 papers in international scientific journals and books, and is regularly invited as speaker and/or chairman at national and international medical/scientific congresses, seminars and meetings.

Side Activities

chairman Sectie ILD (SIL) NVALT
chairman Prof. Dr. Jaap Swierenga Stichting
vice president World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG)
member wetenschappelijke adviesraad (WAR) St Antonius  Onderzoeksfonds
member wetenschappelijke adviescommissie (WAC) Longfonds
member Horizonscan geneesmiddelen ZiN
member commissie dure geneesmiddelen NVALT
member medische adviesraad
member medische adviesraad Longfibrose patientenvereniging
member medische adviesraad Nationale Vereniging Sjogrenpatienten
medisch adviseur stichting LAM-Nederland
member Editorial Board of the journal SVDLD
member forum CPMS ERN-LUNG
member Nederlands asbestosis panel IAS 
member Adjudication Committee Pliant (Pliant)
member Steering Committee Sphinx trial (Actelion)


Research Output (297)

Association between anti-inflammatory effect of infliximab and small fiber neuropathy symptoms in patients with sarcoidosis

Raasing Lisette, Vogels Oscar J M, Veltkamp Marcel, Grutters Jan C 19 Dec 2022, In: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 39

Safety and tolerability of pirfenidone in asbestosis:a prospective multicenter study

Miedema Jelle R, Moor Catharina C, Veltkamp Marcel, Baart Sara, Lie Natascha S L, Grutters Jan C, Wijsenbeek Marlies S, Mostard Rémy L M Dec 2022, In: Respiratory research. 23 , p. 1-6

Characterization of the PF-ILD phenotype in patients with advanced pulmonary sarcoidosis

Schimmelpennink M C, Meek D B, Vorselaars A D M, Langezaal L C M, van Moorsel C H M, van der Vis J J, Veltkamp M, Grutters J C Dec 2022, In: Respiratory research. 23 , p. 1-10

Potential interstitial lung abnormalities on chest X-rays prior to symptoms of idiopathic pulmonary fibrosis

Hoffman T. W., van Es H. W., Biesma D. H., Grutters J. C. Dec 2022, In: BMC Pulmonary Medicine. 22

Inhaled aviptadil for the possible treatment of COVID-19 in patients at high risk for ARDS:study protocol for a randomized, placebo-controlled, and multicenter trial

Boesing Maria, Abig Kristin, Brändle Michael, Brutsche Martin, Burri Emanuel, Frye Björn C, Giezendanner Stéphanie, Grutters Jan C, Haas Philippe, Heisler Justian, Jaun Fabienne, Leuppi-Taegtmeyer Anne B, Lüthi-Corridori Giorgia, Müller-Quernheim Joachim, Nüesch Reto, Pohl Wolfgang, Rassouli Frank, Leuppi Jörg D Dec 2022, In: Trials. 23

Online mindfulness-based cognitive therapy for fatigue in patients with sarcoidosis (TIRED):a randomised controlled trial

Kahlmann Vivienne, Moor Catharina C, van Helmondt Sanne J, Mostard Rémy L M, van der Lee Marije L, Grutters Jan C, Wijsenbeek Marlies S, Veltkamp Marcel 22 Nov 2022, In: The Lancet Respiratory Medicine.

Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases

Moll Sofia A, Platenburg Mark G J P, Platteel Anouk C M, Vorselaars Adriane D M, Janssen Bonàs Montse, Kraaijvanger Raisa, Roodenburg-Benschop Claudia, Meek Bob, van Moorsel Coline H M, Grutters Jan C Nov 2022, In: PLoS ONE. 17

Pulmonary Hypertension Associated Genetic Variants in Sarcoidosis Associated Pulmonary Hypertension

Groen Karlijn, Huitema Marloes P., van der Vis Joanne J., Post Marco C., Grutters Jan C., Baughman Robert P., van Moorsel Coline H.M. 21 Oct 2022, In: Diagnostics. 12

Clinical features and immune-related protein patterns of anti-MDA5 positive clinically amyopathic dermatomyositis Dutch patients

Hensgens Marjolein P.M., Delemarre Eveline M., Drylewicz Julia, Voortman Mareye, Krol Roline M., Dalm Virgil A.S.H., Miedema Jelle R., Wiertz Ivo, Grutters Jan, Limper Maarten, Nierkens Stefan, Leavis Helen L. 6 Oct 2022, In: Rheumatology (Oxford, England). 61 , p. 4087-4096 10 p.

Efficacy and Safety of Tacrolimus as Treatment for Bleeding Caused by Hereditary Hemorrhagic Telangiectasia:An Open-Label, Pilot Study

Hessels Josefien, Kroon Steven, Boerman Sanne, Nelissen Rik C, Grutters Jan C, Snijder Repke J, Lebrin Franck, Post Marco C, Mummery Christine L, Mager Johannes-Jurgen 7 Sep 2022, In: Journal of Clinical medicine. 11

All research output

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