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prof. dr. C.E. (Erik) Hack

Professor Emeritus

  • Laboratory for Translational Immunology (LTI)

Biography

Erik Hack (1952) is Professor of Immunology at the UMCU since 2009. He studied medicine at the University of Amsterdam (the Netherlands) and obtained a MD in 1978, and a PhD in medicine in 1984, from the same university . After his thesis he held several positions in the former Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, now Sanquin Blood Supply Foundation, ranging from principal investigator to head of the Department of Immunopathology. He was appointed as Professor in Immunology at the Free University Medical Center in 1994. In 2004 he left Sanquin to become head of the Protein Biologics Group of Crucell, Leiden, the Netherlands. He has assisted to found the Dutch patients association of hereditary and Quincke’s edema. Erik Hack’s research interests are the role of inflammation and coagulation in experimental and human diseases. He has performed a number of clinical and experimental studies on C1-inhibitor in angioedema as well as in other diseases such as sepsis, and amongst others has initiated studies on recombinant C1-inhibitor, which is among the first Dutch biotech products approved by the EMA. His current research is on the modulation of inflammatory and coagulation responses in human disease with antibodies against key mediators, or with so-called synerkines, which are new fusion proteins of cytokines. In addition, he focuses on the pathogenesis of hereditary and idiopathic angioedema. Erik Hack has co-authored over 500 peer-reviewed papers, which have been cited more than 23,000 times (H-index 81). In addition, he has written >10 patents.

 

Side Activities

  • Member medical scientific advisory board Dutch Society for angioedema

    Ad hoc consultant to various Biotech companies

    Share-holder and non-executive director of Prothix, a Dutch biotech company (www.Prothix.com)

Fellowship and Awards

  • NWO program grant (together with MR Daha; 2000) on interventions targeting the complement system

    Various grants a/o from NWO, Dutch League against Rheumatism, Dutch Heart Foundation, Dutch Kidney Foundation and other

    (Principal) Investigator of one Eurostars project and 2 LSH projects

Research Output (79)

Quantification of T Cell Binding Polyclonal Rabbit Anti-thymocyte Globulin in Human Plasma with Liquid Chromatography Tandem-Mass Spectrometry

Amrani Mohsin El, Admiraal Rick, Willaert Lobke, Ebskamp-van Raaij Lysette J C, Lacna Amelia M, Hack C Erik, Huitema Alwin D R, Nierkens Stefan, van Maarseveen Erik M 1 mrt 2020, In: AAPS Journal. 22 8 p.

Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

Steen-Louws Cristine, Boross Peter, Prado Judith, Meeldijk Jan, Langenhorst Jurgen B, Huitema Alwin D R, den Hartog Marcel T, Boon Louis, Lafeber Floris P J G, Hack C Erik, Eijkelkamp Niels, Popov-Celeketic Jelena dec 2019, In: Pharmaceutical Research. 37

Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry - A tutorial

El Amrani Mohsin, Donners Anouk A.M., Hack C. Erik, Huitema Alwin D.R., van Maarseveen Erik M. 8 nov 2019, In: Analytica Chimica Acta. 1080 , p. 22-34 13 p.

Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Heidt Sebastiaan, Haasnoot Geert W., Witvliet Marian D., van der Linden-van Oevelen Marissa J.H., Kamburova Elena G., Wisse Bram W., Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., van Reekum Franka E., van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, van Duijnhoven Elly M., Gelens Marielle A.C.J., Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, van der Pant Karlijn A.M.I., van der Weerd Neelke C., ten Berge Ineke J.M., Bemelman Frederike J., Hoitsma Andries, van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Otten Henny G., Roelen Dave L., Claas Frans H.J. okt 2019, In: American Journal of Transplantation. 19 , p. 2926-2933 8 p.

Simultaneous Quantification of Free Adalimumab and Infliximab in Human Plasma Using a Target-Based Sample Purification and Liquid Chromatography-Tandem Mass Spectrometry

El Amrani Mohsin, Bosman Sabine M, Egas Annelies C, Hack C Erik, Huitema Alwin D R, van Maarseveen Erik M okt 2019, In: Therapeutic Drug Monitoring. 41 , p. 640-647 8 p.

High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

Hofman Zonne L.M., Van West Nikki, Hack C. Erik, Knulst André C., Maas Coen, Röckmann Heike 12 jul 2019, In: Clinical and Translational Allergy. 9 5 p.

A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival

Michielsen Laura A, Wisse Bram W, Kamburova Elena G, Verhaar Marianne C, Joosten Irma, Allebes Wil A, van der Meer Arnold, Hilbrands Luuk B, Baas Marije C, Spierings Eric, Hack Erik, van Reekum Franka E, Bots Michiel L, Drop Adriaan C A D, Plaisier Loes, Seelen Marc A J, Sanders Jan-Stephan F, Hepkema Bouke G, Lambeck Annechien J, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christien E, Wieten Lotte, van Duijnhoven Elizabeth M, Gelens Mariëlle, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Shaikh A, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A, van der Weerd Neelke C, Ten Berge Ineke J M, Bemelman Frederike J, Hoitsma Andries, van der Boog Paul J M, de Fijter Johan W, Betjes Michiel G H, Heidt Sebastiaan, Roelen Dave L, Claas Frans H, Otten Henderikus G, van Zuilen Arjan D 1 jun 2019, In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 34 , p. 1056-1063 8 p.

The autoimmune-associated single nucleotide polymorphism within PTPN22 correlates with clinical outcome after lung transplantation

Budding Kevin, Van Setten Jessica, Van De Graaf Eduard A., Van Rossum Oliver A., Kardol-Hoefnagel Tineke, Kwakkel-Van Erp Johanna M., Oudijk Erik Jan D., Hack C. Erik, Otten Henderikus G. 17 jan 2019, In: Frontiers in Immunology. 9

Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; An exploratory study

Van Helvoort E. M., Popov-Celeketic J., Eijkelkamp N., Coeleveld K., Tryfonidou M. A., Wijne C. D., Hack C. E., Lafeber F. P.J.G., Mastbergen S. C. 1 jan 2019, In: PLoS ONE. 14 18 p.

Antibodies against ARHGDIB are associated with long-term kidney graft loss

Kamburova Elena G, Gruijters Maartje L, Kardol-Hoefnagel Tineke, Wisse Bram W, Joosten Irma, Allebes Wil A, van der Meer Arnold, Hilbrands Luuk B, Baas Marije C, Spierings Eric, Hack Cornelis E, van Reekum Franka E, van Zuilen Arjan D, Verhaar Marianne C, Bots Michiel L, Drop Adriaan C A D, Plaisier Loes, Melchers Rowena C A, Seelen Marc A J, Sanders Jan Stephan, Hepkema Bouke G, Lambeck Annechien J A, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christina E, Wieten Lotte, van Duijnhoven Elly M, Gelens Mariëlle A C J, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Shaikh A, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A M I, van der Weerd Neelke C, Ten Berge Ineke J M, Hoitsma Andries, van der Boog Paul J M, de Fijter Johan W, Betjes Michiel G H, Heidt Sebastiaan, Roelen Dave L, Claas Frans H, Bemelman Frederike J, Otten Henny G 2019, In: American Journal of Transplantation. 19 , p. 3335-3344 11 p.

All Research Output (79)