prof. dr. E.M. (Elly) Hol

Full Professor

  • Translational Neuroscience

prof. dr. E.M. (Elly) Hol

Research Programs


Elly Hol is professor of “Glia biology of brain diseases” at the Utrecht University and professor of "Biology of glia and neural stem cells” at the University of Amsterdam. She leads a research group at the University Medical Center Utrecht Brain Center ( Her research is focused on the role of glial cells in brain diseases, including Alzheimer’s disease, stroke, schizophrenia and glioma. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases.

Elly was trained as a medical biologist with a specialization in molecular neurobiology. After her PhD in Utrecht, she obtained a Max-Planck Fellowship to work for 2 years at the Max-Planck-Institute for Psychiatry in Martinsried, Germany. In 1997, she started as a post-doc at the Netherlands Institute for Brain Research in Amsterdam, where she acquired substantial funding, including a fellowship of the Netherlands Brain foundation. Between 2003 and 2013 she headed the group “Astrocyte Biology & Neurodegeneration” at the Netherlands Institute for Neuroscience. As of 2013 she works as a principal investigator at the department of translational neuroscience, at the UMC Utrecht Brain Center. She is a member of Academia Europaea, member of the editorial board of Glia, chair of the scientific advisory board of Alzheimer Nederland, chair of GliaNed, director of the Neuroscience Master and PhD program of the Utrecht University Graduate School of Life Sciences, and director of education for the Division Brain at the UMCU. Her work is published in leading journals such as Nature communications, Brain, Molecular Psychiatry, Science, and Stem Cells Translational Medicine. She is regularly invited as a speaker at dedicated research conferences and at events for the general public.

Side Activities

  • Board member, Stichting vrienden van het Herseninstituut

    Chair Scientific Advisory Board, Alzheimer Nederland

    Member Scientific advisory board EndParalysis Foundation

    Member editorial board, Glia (scientific journal)

    Member scientific advisory board, Hersenstichting (until 1 Dec 2019)

    Special professor of Biology of glia and neural stem cells, University of Amsterdam

Fellowship and Awards

    • 2019 NWO Gravitation grant
    • 2019 member of the Academia Europaea
    • Nominated by NWO for AcademiaNet - Expert Database for Outstanding Female Scientists and Scholars.
    • 2009 VICI (NWO-ALW)
    • 2000 Hersenstichting fellowship
    • 195 Max-Planck Fellowship

Research Output (155)

Synapse Pathology in Schizophrenia:A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies

Berdenis van Berlekom Amber, Muflihah Cita H, Snijders Gijsje J L J, MacGillavry Harold D, Middeldorp Jinte, Hol Elly M, Kahn René S, de Witte Lot D 13 jun 2019, In: Schizophrenia Bulletin. 46 , p. 374-386 13 p.

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease

Donega Vanessa, Burm Saskia M., van Strien Miriam E., van Bodegraven Emma J., Paliukhovich Iryna, Geut Hanneke, van de Berg Wilma D.J., Li Ka Wan, Smit August B., Basak Onur, Hol Elly M. 3 jun 2019, In: Acta neuropathologica communications. 7 , p. 84 1 p.

Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated

Sneeboer Marjolein A.M., Snijders Gijsje J.L.J., Berdowski Woutje M., Fernández-Andreu Alba, van Mierlo Hans C., Berdenis van Berlekom Amber, Litjens Manja, Kahn René S., Hol Elly M., de Witte Lot D., 24 mei 2019, In: Translational Psychiatry. 9

DNA methylation changes related to nutritional deprivation:A genome-wide analysis of population and in vitro data

He Yujie, De Witte Lot D., Houtepen Lotte C., Nispeling Danny M., Xu Zhida, Yu Qiong, Yu Yaqin, Hol Elly M., Kahn René S., Boks Marco P. 16 mei 2019, In: Clinical Epigenetics. 11

Increased number of T-lymphocytes in post-mortem brain tissue of patients with schizophrenia.

Sneeboer Marjolein A.M., van Mierlo Hans C., Stotijn Evi, MacIntyre Donald J., Smith Colin, Kahn René S., Hol Elly M., de Witte Lot D. 1 jan 2019, In: Schizophrenia Research.

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

Böttcher Chotima, Schlickeiser Stephan, Sneeboer Marjolein A.M., Kunkel Desiree, Knop Anniki, Paza Evdokia, Fidzinski Pawel, Kraus Larissa, Snijders Gijsje J.L., Kahn René S., Schulz Axel R., Mei Henrik E., Hol Elly M., Siegmund Britta, Glauben Rainer, Spruth Eike J., de Witte Lot D., Priller Josef, 1 jan 2019, In: Nature Neuroscience. 22 , p. 78-90 13 p.

Liprin alfa 2 gene expression is increased by cannabis use and associated with neuropsychological function

He Yujie, de Witte Lot D., Schubart Chris D., Van Gastel Willemijn A., Koeleman Bobby P.C., de Jong Simone, Ophoff Roel A., Hol Elly M., Boks Marco P. 1 jan 2019, In: European Neuropsychopharmacology. 29 , p. 643-652

Importance of GFAP isoform-specific analyses in astrocytoma

van Bodegraven Emma J., van Asperen Jessy V., Robe Pierre A.J., Hol Elly M. 1 jan 2019, In: GLIA. 67 , p. 1417-1433 17 p.

Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Antonovaite Nelda, Beekmans Steven V., Hol Elly M., Wadman Wytse J., Iannuzzi Davide 1 dec 2018, In: Scientific Reports. 8

Microglia innately develop within cerebral organoids

Ormel Paul R., Vieira de Sá Renata, van Bodegraven Emma J., Karst Henk, Harschnitz Oliver, Sneeboer Marjolein A.M., Johansen Lill Eva, van Dijk Roland E., Scheefhals Nicky, Berdenis van Berlekom Amber, Ribes Martínez Eduardo, Kling Sandra, MacGillavry Harold D., van den Berg Leonard H., Kahn René S., Hol Elly M., de Witte Lot D., Pasterkamp R. Jeroen 1 dec 2018, In: Nature Communications [E]. 9

All Research Output (155)