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prof. dr. E.M. (Elly) Hol

Full Professor
prof. dr. E.M. (Elly) Hol
  • Translational Neuroscience

Research Programs

Biography

Biography

Elly Hol is professor of “Glia biology of brain diseases” at the Utrecht University and professor of "Biology of glia and neural stem cells” at the University of Amsterdam. She leads a research group at the University Medical Center Utrecht Brain Center (www.ellyhollab.eu). Her research is focused on the role of glial cells in brain diseases, including Alzheimer’s disease, stroke, schizophrenia and glioma. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases.

Elly was trained as a medical biologist with a specialization in molecular neurobiology. After her PhD in Utrecht, she obtained a Max-Planck Fellowship to work for 2 years at the Max-Planck-Institute for Psychiatry in Martinsried, Germany. In 1997, she started as a post-doc at the Netherlands Institute for Brain Research in Amsterdam, where she acquired substantial funding, including a fellowship of the Netherlands Brain foundation. Between 2003 and 2013 she headed the group “Astrocyte Biology & Neurodegeneration” at the Netherlands Institute for Neuroscience. As of 2013 she works as a principal investigator at the department of translational neuroscience, at the UMC Utrecht Brain Center. She is a member of Academia Europaea, member of the editorial board of Glia, chair of the scientific advisory board of Alzheimer Nederland, chair of GliaNed, director of the Neuroscience Master and PhD program of the Utrecht University Graduate School of Life Sciences, and director of education for the Division Brain at the UMCU. Her work is published in leading journals such as Nature communications, Brain, Molecular Psychiatry, Science, and Stem Cells Translational Medicine. She is regularly invited as a speaker at dedicated research conferences and at events for the general public.

Side Activities

Board member, Stichting vrienden van het Herseninstituut

Chair Scientific Advisory Board, Alzheimer Nederland

Member Scientific advisory board EndParalysis Foundation

Member editorial board, Glia (scientific journal)

Member scientific advisory board, Hersenstichting (until 1 Dec 2019)

Special professor of Biology of glia and neural stem cells, University of Amsterdam

Fellowship and Awards

  • 2019 NWO Gravitation grant
  • 2019 member of the Academia Europaea
  • Nominated by NWO for AcademiaNet - Expert Database for Outstanding Female Scientists and Scholars.
  • 2009 VICI (NWO-ALW)
  • 2000 Hersenstichting fellowship
  • 195 Max-Planck Fellowship

Research Output (166)

How the COVID-19 pandemic highlights the necessity of animal research (vol 30, pg R1014, 2020):How the COVID-19 pandemic highlights the necessity of animal research (Current Biology (2020) 30(18) (R1014–R1018), (S0960982220311842), (10.1016/j.cub.2020.08.030))

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen J.J.P., Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., van Dam Anne Marie, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernhard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes J.A.G., Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer Jaap, Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi M.B., Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 2 nov 2020, In: Current Biology. 30 , p. 4328-4328 1 p.

Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue

Alsema Astrid M., Jiang Qiong, Kracht Laura, Gerrits Emma, Dubbelaar Marissa L., Miedema Anneke, Brouwer Nieske, Hol Elly M., Middeldorp Jinte, van Dijk Roland, Woodbury Maya, Wachter Astrid, Xi Simon, Möller Thomas, Biber Knut P., Kooistra Susanne M., Boddeke Erik W.G.M., Eggen Bart J.L. 28 okt 2020, In: Frontiers in Molecular Neuroscience. 13 , p. 1-14

How the COVID-19 pandemic highlights the necessity of animal research

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen, Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., Dam Anne Marie van, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes, Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer J., Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi, Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 21 sep 2020, In: Current Biology. 30 , p. R1014-R1018

The impact of antidiabetic treatment on human hypothalamic infundibular neurons and microglia

Kalsbeek Martin Jt, Wolff Samantha Ec, Korpel Nikita L., la Fleur Susanne E., Romijn Johannes A., Fliers Eric, Kalsbeek Andries, Swaab Dick F., Huitinga Inge, Hol Elly M., Yi Chun Xia 20 aug 2020, In: JCI Insight. 5 , p. 1-13

Cannabinoids and psychotic symptoms:A potential role for a genetic variant in the P2X purinoceptor 7 (P2RX7) gene

Boks Marco P, He Yujie, Schubart Chris D, van Gastel Willemijn, Elkrief Laurent, Huguet Guillaume, van Eijk Kristel, Vinkers Christiaan H, Kahn René S, Paus Tomás, Conrod Patricia, Hol Elly M, de Witte Lot D 21 apr 2020, In: Brain, Behavior, and Immunity. 88 , p. 573-581 9 p.

Increased number of T-lymphocytes in post-mortem brain tissue of patients with schizophrenia.

Sneeboer Marjolein A.M., van Mierlo Hans C., Stotijn Evi, MacIntyre Donald J., Smith Colin, Kahn René S., Hol Elly M., de Witte Lot D. feb 2020, In: Schizophrenia Research. 216 , p. 526-528 3 p.

A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells

Ormel Paul R., Böttcher Chotima, Gigase Frederieke A.J., Missall Roy D., van Zuiden Welmoed, Fernández Zapata M. Camila, Ilhan Dilara, de Goeij Michelle, Udine Evan, Sommer Iris E.C., Priller Josef, Raj Towfique, Kahn René S., Hol Elly M., de Witte Lot D. 1 jan 2020, In: Brain, Behavior, and Immunity. 90 , p. 196-207 12 p.

Microglial activation in schizophrenia:Is translocator 18 kDa protein (TSPO) the right marker?

Sneeboer Marjolein A.M., van der Doef Thalia, Litjens Manja, Psy N. B.B., Melief J., Hol Elly M., Kahn René S., de Witte Lot D. jan 2020, In: Schizophrenia Research. 215 , p. 167-172 6 p.

Denser brain capillary network with preserved pericytes in Alzheimer's disease

Fernandez-Klett Francisco, Brandt Lasse, Fernández-Zapata Camila, Abuelnor Basim, Middeldorp Jinte, Sluijs Jacqueline A., Curtis Maurice, Faull Richard, Harris Laura W., Bahn Sabine, Hol Elly M., Priller Josef 2020, In: Brain Pathology. 30 , p. 1071-1086 16 p.

The adult human subventricular zone:partial ependymal coverage and proliferative capacity of cerebrospinal fluid

de Sonnaville Sophia F A M, van Strien Miriam E, Middeldorp Jinte, Sluijs Jacqueline A, van den Berge Simone A, Moeton Martina, Donega Vanessa, van Berkel Annemiek, Deering Tasmin, De Filippis Lidia, Vescovi Angelo L, Aronica Eleonora, Glass Rainer, van de Berg Wilma D J, Swaab Dick F, Robe Pierre A, Hol Elly M 2020, In: Brain communications. 2

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