prof. dr. E.M. (Elly) Hol

prof. dr. E.M. (Elly) Hol

Full Professor
prof. dr. E.M. (Elly) Hol
  • Translational Neuroscience

Research Programs



Elly Hol is professor of “Glia biology of brain diseases” at the Utrecht University and a member of the Academia Europaea. She is head of the department of Translational Neuroscience at the University Medical Center Utrecht Brain Center. Her research is focused on the role of glial cells in brain diseases. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases. Elly was trained as a medical biologist with a specialization in molecular neurobiology. After her PhD in Utrecht, she obtained a Max-Planck Fellowship to work at the Max-Planck-Institute for Psychiatry in Martinsried. In 1997, she started as a post-doc at the Netherlands Institute for Neuroscience in Amsterdam, and between 2003 and 2013 she headed the group “Astrocyte Biology & Neurodegeneration”. She was appointed professor of "Biology of glia and neural stem cells” at the University of Amsterdam in 2012. As of 2013 she works as a principal investigator at the department of translational neuroscience, UMC Utrecht Brain Center. She is in the editorial board of Glia, chair of the scientific advisory board of Parkinson Nederland, chair of GliaNed, director of the Neuroscience Master and PhD program of the Utrecht University Graduate School of Life Sciences, and director of education Division Neuroscience at the UMCU.

Side Activities

Board member, MMBG (medical, biomedical and health sciences), KNAW

Board member, Stichting vrienden van het Herseninstituut

Chair Scientific Advisory Board, Parkinson Nederland

Board member, David de Wied Foundation for Neurosciences

Member Scientific advisory board EndParalysis Foundation

Member editorial board, Glia (scientific journal)

Fellowship and Awards

  • 2022 member of Royal Netherlands Academy of Arts and Sciences (KNAW)
  • 2019 NWO Gravitation grant
  • 2019 member of the Academia Europaea
  • Nominated by NWO for AcademiaNet - Expert Database for Outstanding Female Scientists and Scholars.
  • 2009 VICI (NWO-ALW)
  • 2000 Hersenstichting fellowship
  • 1995 Max-Planck Fellowship

Research Output (199)

Glial cell response and microthrombosis in aneurysmal subarachnoid hemorrhage patients:An autopsy study

Koopman Inez, Van Dijk Bart J., Zuithoff Nicolaas P.A., Sluijs Jacqueline A., Van Der Kamp Marije J., Baldew Zelonna A.V., Frijns Catharina J.M., Rinkel Gabriel J.E., Hol Elly M., Vergouwen Mervyn D.I. 21 Jul 2023, In: Journal of Neuropathology and Experimental Neurology. 82 , p. 798-805 8 p.

Reactive astrogliosis in the era of single-cell transcriptomics

Matusova Zuzana, Hol Elly M., Pekny Milos, Kubista Mikael, Valihrach Lukas 2023, In: Frontiers in Cellular Neuroscience. 17

Corrigendum:Reactive astrogliosis in the era of single-cell transcriptomics (Front. Cell. Neurosci., (2023), 17, (1173200), 10.3389/fncel.2023.1173200)

Matusova Zuzana, Hol Elly M, Pekny Milos, Kubista Mikael, Valihrach Lukas 2023, In: Frontiers in Cellular Neuroscience. 17 , p. 1212975

In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging

Meerwaldt Anu E., Straathof Milou, Oosterveld Wija, van Heijningen Caroline L., van Leent Mandy M.T., Toner Yohana C., Munitz Jazz, Teunissen Abraham J.P., Daemen Charlotte C., van der Toorn Annette, van Vliet Gerard, van Tilborg Geralda A.F., De Feyter Henk M., de Graaf Robin A., Hol Elly M., Mulder Willem J.M., Dijkhuizen Rick M. 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43 , p. 778-790 13 p.

Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease

Fernández Zapata Camila, Giacomello Ginevra, Spruth Eike J, Middeldorp Jinte, Gallaccio Gerardina, Dehlinger Adeline, Dames Claudia, Leman Julia K H, van Dijk Roland E, Meisel Andreas, Schlickeiser Stephan, Kunkel Desiree, Hol Elly M, Paul Friedemann, Parr Maria Kristina, Priller Josef, Böttcher Chotima 23 Nov 2022, In: Nature Communications. 13

Prevention of microgliosis halts early memory loss in a mouse model of Alzheimer's disease

Kater Mandy S J, Huffels Christiaan F M, Oshima Takuya, Renckens Niek S, Middeldorp Jinte, Boddeke Erik W G M, Smit August B, Eggen Bart J L, Hol Elly M, Verheijen Mark H G 18 Oct 2022, In: Brain, Behavior, and Immunity. 107 , p. 225-241 17 p.

Determining glioma cell invasion and proliferation in ex vivo organotypic mouse brain slices using whole-mount immunostaining and tissue clearing

van Asperen Jessy V, van Bodegraven Emma J, Robe Pierre A J T, Hol Elly M 21 Sep 2022, In: STAR protocols. 3

Aß Pathology and Neuron-Glia Interactions:A Synaptocentric View

Huffels Christiaan F M, Middeldorp Jinte, Hol Elly M 17 Aug 2022, In: Neurochemical Research. 48 , p. 1026-1046 21 p.

Systemic Injection of Aged Blood Plasma in Adult C57BL/6 Mice Induces Neurophysiological Impairments in the Hippocampal CA1

Huffels Christiaan F M, van Dijk Roland E, Karst Henk, Meye Frank J, Hol Elly M, Middeldorp Jinte 16 Jul 2022, In: Journal of Alzheimer's Disease. 89 , p. 283-297 15 p.

All research output

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