dr. L. (Laura) Hondebrink

dr. L. (Laura) Hondebrink

Assistant Professor
dr. L. (Laura) Hondebrink
  • Clinical Toxicology

Research Programs



I have over 10 years experience as a European registered toxicologist, with a focus on research in neurotoxicity and clinical toxicology. What I like most, is working on research projects that have an impact on society.

My research focuses primarily on poisonings with psychoactive substances via observational human studies. In clinical toxicology, such data are often the sole source of information. Also, such data is valuable to protect public health and develop policy strategies.

Specialities: research, clinical toxicology, neurotoxicology, risk assessment, drugs (MDMA, novel psychoactive substances (NPS), nitrous oxide)

Skills: analytical, project coordination, perseverance, well-organized and structured.

Side Activities


Committee Member ‘Coordinatiepunt Assessment en Monitoring Nieuwe Drugs’ (CAM)

  • Committee risk assessment 3-MMC
  • Member of Workgroup update risk assessment by CAM.

Board Member EAPCCT (European Association of Poisons Centres and Clinical Toxicologists)

  • Chair of Workgroup contract Publisher Taylor and Francis
  • Member of Workgroup website renewal
  • Member of Workgroup Research on Covid-19 effect on EU Poisons Centres.
  • Abstract reviewer for annual EAPCCT congresses (since 2019)


Scientific and Meetings Committee Member EAPCCT 


2019-current     Member of the Research Pool UMCU – research policy

2013-current     Reviewer for several journals in Toxicology


Research Output (36)

Alarming increase in poisonings from recreational nitrous oxide use after a change in EU-legislation, inquiries to the Dutch Poisons Information Center

van Riel Antoinette, Hunault C C, van den Hengel-Koot I S, Nugteren-van Lonkhuyzen Annette, de Lange D W, Hondebrink L 6 nov 2021, In: The International journal on drug policy. 100 , p. 103519

Toenemend aantal gezondheidsincidenten met partydrug 3-MMC

de Lange Prof.dr. D.W. (Dylan), Nugteren-van Lonkhuyzen Annette, Franssen Eric , van Riel Antoinette, Hondebrink Laura 4 jun 2021, In: Pharmaceutisch Weekblad. 156 , p. 18-20

Frequent hospitalization for synthetic cathinone poisonings: a case series reported to the Dutch Poisons Information Center

Nugteren-van Lonkhuyzen Johanna J., Rietjens Saskia J., van Riel Antoinette J. H. P., van den Hengel-Koot Irma S., Contrucci Ramon R., de Lange Dylan W., Hondebrink Laura 3 jun 2021, In: Clinical Toxicology. 59 , p. 555-556

The Clinical Toxicology of 4-Bromo-2,5-dimethoxyphenethylamine (2C-B):The Severity of Poisoning After Exposure to Low to Moderate and High Doses

Nugteren-van Lonkhuyzen Johanna J, de Lange Dylan W, van Riel Antoinette J H P, Vrolijk Ruben Q, Ohana Dana, Hondebrink Laura 2 jun 2020, In: Annals of Emergency Medicine. 76 , p. 303-317 15 p.

Recreational nitrous oxide use rises dramatically after change in EU legislation

van Riel Antoinette J. H. P., van Den Hengel-Koot Irma S., Nugteren-van Lonkhuyzen Annette J. J., Rietjens Saskia J., Hondebrink Laura, de Vries Irma, de Lange Dylan W. 2 jun 2020, In: Clinical Toxicology. 58 , p. 564-565

Hyperthermia exacerbates the acute effects of psychoactive substances on neuronal activity measured using microelectrode arrays (MEAs) in rat primary cortical cultures in vitro

Zwartsen Anne, Hondebrink Laura, de Lange Dylan W, Westerink Remco H S 19 apr 2020, In: Toxicology and Applied Pharmacology. 397 8 p.

New psychoactive substances (NPS) in the Netherlands:occurrence in forensic drug samples, consumer drug samples and poisons center exposures between 2013 and 2017

Hondebrink Laura, Nugteren-van Lonkhuyzen Johanna J, Hunault Claudine C, van den Berg Jorrit, van der Gouwe Daan, van Riel Antoinette J H P apr 2020, In: Addiction. 115 , p. 716-725 10 p.

Predicting the need for hospitalization of intoxicated patients: a pilot study

Hunault C. C., Hondebrink L., Rietjens S. J., Dekker D., de Vries I., de Lange D. W. 15 okt 2019, In: Toxicology Letters. 314 , p. S86-S87

Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings

Zwartsen Anne, de Korte Tessa, Nacken Peter, de Lange Dylan W, Westerink Remco H S, Hondebrink Laura 14 sep 2019, In: Journal of Molecular and Cellular Cardiology. 136 , p. 102-112 11 p.

A quarter of admitted poisoned patients have a mild poisoning and require no treatment:An observational study

Hondebrink L., Rietjens Saskia J., Donker Dirk W., Hunault Claudine C., van den Hengel-Koot Irma, Verputten Pauline M., de Vries Irma, Kaasjager Karin A.H., Dekker D., de Lange Dylan W. 18 mei 2019, In: European journal of internal medicine. 66 , p. 41-47 7 p.

All research output

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