dr. L. (Laura) Hondebrink

dr. L. (Laura) Hondebrink

Assistant Professor
dr. L. (Laura) Hondebrink
  • NVIC bedrijfsvoering

Research Programs




I have over 10 years experience as a European registered toxicologist, with a focus on research in neurotoxicity and clinical toxicology. What I like most, is working on research projects that have an impact on society.

My research focuses primarily on poisonings with psychoactive substances via observational human studies. In clinical toxicology, such data are often the sole source of information. Also, such data is valuable to protect public health and develop policy strategies.

Specialities: research, clinical toxicology, neurotoxicology, risk assessment, drugs (MDMA, novel psychoactive substances (NPS), nitrous oxide)

Skills: analytical, project coordination, perseverance, well-organized and structured.

Side Activities


Committee Member ‘Coordinatiepunt Assessment en Monitoring Nieuwe Drugs’ (CAM)

  • Committee risk assessment 3-MMC
  • Member of Workgroup update risk assessment by CAM.

Board Member EAPCCT (European Association of Poisons Centres and Clinical Toxicologists)

  • Chair of Workgroup contract Publisher Taylor and Francis
  • Member of Workgroup website renewal
  • Member of Workgroup Research on Covid-19 effect on EU Poisons Centres.
  • Abstract reviewer for annual EAPCCT congresses (since 2019)


Scientific and Meetings Committee Member EAPCCT 


2019-current     Member of the Research Pool UMCU – research policy

2013-current     Reviewer for several journals in Toxicology


Research Output (66)

High Incidence of Signs of Neuropathy and Self-Reported Substance Use Disorder for Nitrous Oxide in Patients Intoxicated with Nitrous Oxide

Nugteren-Van Lonkhuyzen Johanna J, van der Ben Lot, van den Hengel-Koot Irma S, de Lange Dylan W, van Riel Antoinette J H P, Hondebrink Laura 2023, In: European Addiction Research. 29 , p. 202-212 11 p.

3-Methylmethcathinone (3-MMC) Poisonings:Acute Clinical Toxicity and Time Trend Between 2013 and 2021 in the Netherlands

Nugteren-van Lonkhuyzen Johanna J, Essink Sharon, Rietjens Saskia J, Ohana Dana, de Lange Dylan W, van Riel Antoinette J H P, Hondebrink Laura 22 Jun 2022, In: Annals of Emergency Medicine. 80 , p. 203-212 10 p.

Alarming increase in poisonings from recreational nitrous oxide use after a change in EU-legislation, inquiries to the Dutch Poisons Information Center

van Riel Antoinette, Hunault C C, van den Hengel-Koot I S, Nugteren-van Lonkhuyzen Annette, de Lange D W, Hondebrink L Feb 2022, In: The International journal on drug policy. 100 , p. 1-4

Significant toxicity following an increase in poisonings with designer benzodiazepines in the Netherlands between 2010 and 2020

Essink Sharon, Nugteren-van Lonkhuyzen Johanna J, van Riel Antoinette J H P, Dekker Douwe, Hondebrink Laura 31 Dec 2021, In: Drug and Alcohol Dependence. 231 , p. 1-8

Impact of the COVID crisis on European Poison Centres

Lonati D., Hondebrink L., Faber K., Hogberg L., Hermanns-Clausen M., Zammit M., Thiermann H. Sep 2021, In: Toxicology Letters. 350 , p. S19-S19

Toenemend aantal gezondheidsincidenten met partydrug 3-MMC

de Lange Prof.dr. D.W. (Dylan), Nugteren-van Lonkhuyzen Annette, Franssen Eric , van Riel Antoinette, Hondebrink Laura 4 Jun 2021, In: Pharmaceutisch Weekblad. 156 , p. 18-20

Frequent hospitalization for synthetic cathinone poisonings: a case series reported to the Dutch Poisons Information Center

Nugteren-van Lonkhuyzen Johanna J., Rietjens Saskia J., van Riel Antoinette J. H. P., van den Hengel-Koot Irma S., Contrucci Ramon R., de Lange Dylan W., Hondebrink Laura 3 Jun 2021, In: Clinical Toxicology. 59 , p. 555-556

The impact of the first wave of COVID-19 on Poison Centre (PC) activities in 4 European countries: a pilot study

Hondebrink Laura, Faber Katrin, Zammit Mark, Hoegberg Lotte C. G., Lonati Davide 3 Jun 2021, In: Clinical Toxicology. 59 , p. 542-542

Predicting hypertension using subjective symptoms in recreational drug users at first-aid stations at dance events

Prins Yoram P., Hondebrink Laura, van den Hengel-Koot Irma S., Litsenburg Ronald, Dekker Douwe 3 Jun 2021, In: Clinical Toxicology. 59 , p. 553-554

Combining ecstasy and ethanol: higher risk for toxicity? A review

Vercoulen Eefje, Hondebrink Laura 2 Jan 2021, In: Critical Reviews in Toxicology. 51 , p. 1-14 14 p.

All research output

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