dr. J.W.M. (Jo ) Hoppener

Associate Professor

  • Group Burgering, section Molecular Cancer Research

dr. J.W.M. (Jo ) Hoppener

Research Programs


Jo Höppener graduated (cum laude) in 1981 in Biology at Utrecht University. He did his Ph.D. (cum laude) in 1988 with Prof. Lips and Prof. Jansz (financed by NWO and Ciba Geigy). Part of the Ph.D. study was performed at the Johns Hopkins Hospital (Baltimore, USA). He was research fellow at Utrecht University until 1989 (financed by STW), when he was awarded a 5-year fellowship from the Royal Netherlands Academy of Arts and Sciences (KNAW). He was appointed senior research scientist in the Faculty of Medicine (presently UMC Utrecht) at the Division of Internal Medicine in 1994. He was appointed Associate Professor at the Division of Biomedical Genetics at UMC Utrecht in 2005 and his research was incorporated in the Laboratory of Translational Immunology in 2013. The major research theme of his group is the role of IAPP and islet amyloid in islet ß-cell dysfunction in Type 2 diabetes mellitus (DM2). To this end they have generated a transgenic mouse model, in which the amyloidogenic human IAPP is expressed in the islet ß-cells. This unique animal model is used for pioneering research on the pathogenesis, diagnosis and therapy of DM2.

Side Activities

  • None

Fellowship and Awards

  • Jo Höppener has been co-promotor of 5 Ph.D. students and is author on more than 100 peer-reviewed papers in international journals. His research has been supported by KNAW (personal 5-year fellowship), Dutch Cancer Society (NKB/KWF), Dutch Diabetes Research Fund, European Union and industry.

Research Output (71)

Ethics: Genetic testing for MEN1-whose responsibility?

Lips C.J.M., Höppener J.W.M. 2012, In: Nature Reviews. Endocrinology. 8 , p. 575-576 2 p.

Variable clinical expression in patients with a germline MEN1 disease gene mutation: clues to a genotype-phenotype correlation.

Lips C.J.M., Dreijerink K.M.A., Hoppener J.W.M. 2012, In: Clinics (São Paulo, Brazil). 67 , p. 49-56 8 p.

The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes

Khemtemourian L.P., Engel M.F.M., Kruijtzer J.A.W., Hoppener J.W.M., Liskamp R.M.J., Killian J.A. 2010, In: European Biophysics Journal. 39 , p. 1359-1364 6 p.

The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition

Khemtemourian L.P., Engel M.F.M., Liskamp R.M.J., Höppener J.W.M., Killian J.A. 2010, In: Biochimica et Biophysica Acta-Biomembranes. 1798 , p. 1805-1811 7 p.

A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity

Timmerman P., Barderas R., Desmet J., Altschuh D., Shochat S., Hollestelle M.J., Hoppener J.W.M., Monasterio A., Casal J.I., Meloen R.H. 2009, In: Journal of Biological Chemistry. 284 , p. 34126-34134 9 p.

The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation.

Dreijerink K.M.A., Varier R.A., van Beekum O., Jeninga E.H., Hoppener J.W.M., Lips C.J.M., Kummer J.A., Kalkhoven E., Timmers H.T.M. 2009, In: Molecular and Cellular Biology. 29 , p. 5060-5069 10 p.

Medullary thyroid carcinoma and biomarkers: past, present and future

van Veelen W., de Groot J.W.B., Acton D.S., Hofstra R.M., Hoppener J.W.M., Links T.P., Lips C.J.M. 2009, In: Journal of Internal Medicine. 266 , p. 126-140 15 p.

P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development.

van Veelen W., Klompmaker R., Gloerich M., van Gasteren C.J.R., Kalkhoven E., Berger R., Lips C.J.M., Medema R.H., Höppener J.W.M., Acton D.S. 2009, In: International Journal of Cancer. 124 , p. 339-345 6 p.

Tissue selectivity in multiple endocrine neoplasia type 1-associated tumorigenesis

Gracanin A., Dreijerink K.M.A., van der Luijt R.B., Lips C.J.M., Hoppener J.W.M. 2009, In: Cancer Research. 69 , p. 6371-6374 4 p.

Impaired processing of human pro-islet amyloid polypeptide is not a causative factor for fibril formation or membrane damage in vitro

Khemtémourian L.P., Lahoz Casarramona G., Suylen D.P., Hackeng T.M., Meeldijk J.D., de Kruijff B., Hoppener J.W.M., Killian J.A. 2009, In: Biochemistry. 48 , p. 10918-10925 8 p.

All Research Output (71)