prof. dr. G.F. Houben

prof. dr. G.F. Houben

Full Professor
prof. dr. G.F. Houben
  • Laboratory for Translational Immunology (LTI)

Research Programs

Infection & Immunity



Geert Houben is Principal Scientist Food Allergy and Immunotoxicology at the Netherlands Organisation for Applied Scientific Research TNO, The Netherlands, and Professor Food-borne Risk Factors for Allergic and Inflammatory Diseases at the University Medical Center Utrecht and the Faculty of Medicine, University of Utrecht, the Netherlands.Prior to his current positions, he has had various research and management positions at TNO and various research positions at the University of Utrecht and the University Medical Center Utrecht,the Netherlands. Geert was trained as a Biologist and Toxicologist.


His major scientific specializations are food allergy, food and feed toxicology and immunotoxicology, and particularly risk assessment in these areas. He has a strong international involvement in the development and application of probabilistic approaches in food allergy risk assessment and risk management. Geert has had the managerial and scientific responsibility of the TNO Food Safety research and services for many years prior to choosing to focus on his scientific career in 2014. Main current research interests are on the immune health effects of proteins in food, effect assessment and risk-benefit assessment of immune health interventions and (approaches to study) complex food-borne exposome effects in immune health and disease


Side Activities

Deputy Member of the Future Food Utrecht Program Council, Utrecht University, Utrecht, The Netherlands

Member of the Expert Group "A framework to help define an appropriate level of protection for consumers with food allergies ", ILSI Europe, Brussels, Belgium
Member of the Roadmap Committee Theme Food Safety, Topsector Agri&Food, the Netherlands
Member of the Corporate Food Safety Advisory board, FrieslandCampina, Amersfoort, The Netherlands
Member of the Scientific Working Group on Food Safety, European Technology Platform “Food for Life”
Member of the Foreign Food Safety Expert Advisory Panel, Shanghai FDA, Shanghai
Principal Scientist, Netherlands Organisation for Applied Scientific Reseach TNO
Member of the VITAL Scientific Expert Panel, Australian-New Zealand Allergen Bureau, Australia
Member of the Allergens Expert Group, Food and Drink Europe, Brussels, Belgium
Member of the ESFA Focal Point The Netherlands Advisory Committee, Food and Consumer Product Safety Authority, The Hague, The Netherlands
Member of the Supervisory Board, Post Graduate Education in Toxicology, The Netherlands
Member of the Knowledge Network, The Netherlands Nutrition Centre, The Netherlands

Research Output (78)

Allergen risk assessment:Food intake levels of the general population represent those of food allergic patients

Blom W. Marty, van Os-Medendorp Harmieke, Bijlsma Sabina, van Dijk Anne, Kruizinga Astrid G., Rubingh Carina, Michelsen-Huisman Anouska D., Knulst André C., Houben Geert F. dec 2020, In: Food and Chemical Toxicology. 146 9 p.

Can we define a level of protection for allergic consumers that everyone can accept?

Madsen Charlotte B, van den Dungen Myrthe W, Cochrane Stella, Houben Geert F, Knibb Rebecca C, Knulst André C, Ronsmans Stefan, Yarham Ross A R, Schnadt Sabine, Turner Paul J, Baumert Joseph, Cavandoli Elisa, Chan Chun-Han, Warner Amena, Crevel René W R 5 aug 2020, In: Regulatory Toxicology and Pharmacology. 117 , p. 1-12

Vulvar and vaginal neoplasia in women with inflammatory bowel disease

Rouvroye Maxine D., Tack Greetje J., Mom Constantijne H., Lissenberg-Witte Birgit I., Pierik Marieke J., Neefjes-Borst E. Andra, de Boer Nanne K.H., Löwenberg M., Bodelier A., Verbeek W. H., Schoon E., Witteman E. M., Herwaarden M. A., Van Der Woude C. J., Lutgens M., Kouw E., Van Der Veek P. J., van der Hulst R. W., Sipkema H., Nissen L. H.C., Bus P. J., van der Meulen A. E., De Bruijne F. H., van der Waaij L. A., Noomen C. G., Jharap B., Schmittgens S., Jansen J. M., Hoentjen F., Lammertink M. H.A., Houben G. M.P., Minderhoud I. M., Dijkstra G., Oldenburg B., Sikkens M. S.G., Van Tuyl S. A., van Bodegraven A. A., feb 2020, In: Digestive and liver disease. 52 , p. 149-155 7 p.

Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens

Westerhout Joost, Baumert Joseph L., Blom W. Marty, Allen Katrina J., Ballmer-Weber Barbara, Crevel René W.R., Dubois Anthony E.J., Fernández-Rivas Montserrat, Greenhawt Matthew J., Hourihane Jonathan O.B., Koplin Jennifer J., Kruizinga Astrid G., Le Thuy My, Sampson Hugh A., Shreffler Wayne G., Turner Paul J., Taylor Steve L., Houben Geert F., Remington Benjamin C. 1 nov 2019, In: Journal of Allergy and Clinical Immunology. 144 , p. 1290-1309 20 p.

Allergenicity prediction of novel and modified proteins:Not a mission impossible! Development of a Random Forest allergenicity prediction model

Westerhout Joost, Krone Tanja, Snippe Almar, Babé Lilia, McClain Scott USRE, Ladics Gregory S., Houben Geert GF, Verhoeckx Kitty CM okt 2019, In: Regulatory Toxicology and Pharmacology. 107

Defining the targets for the assessment of IgE-mediated allergenicity of new or modified food proteins

Houben Geert, Blom Marty, Alvito Paula, Assunção Ricardo, Crevel René, Fæste Christiane Kruse, Le Thuy My, Madsen Charlotte Bernhard, Remington Ben, Stroheker Thomas, Vassilopoulou Emilia, Verhoeckx Kitty, Žiarovská Jana, Constable Anne 1 mei 2019, In: Food and Chemical Toxicology. 127 , p. 61-69 9 p.

Sensitivity analysis to derive a food consumption point estimate for deterministic food allergy risk assessment

Blom W. Marty, Remington Benjamin C., Baumert Joseph L., Bucchini Luca, Crépet Amélie, Crevel René W.R., Madsen Charlotte B., Taylor Steve L., Houben Geert F., Kruizinga Astrid G. 1 mrt 2019, In: Food and Chemical Toxicology. 125 , p. 413-421 9 p.

Accidental allergic reactions in food allergy:Causes related to products and patient's management

Michelsen-Huisman Anouska D., van Os-Medendorp Harmieke, Blom W. Marty, Versluis Astrid, Castenmiller Jacqueline J.M., Noteborn Hubert P.J.M., Kruizinga Astrid G., Houben Geert F., Knulst André C. 1 dec 2018, In: Allergy. 73 , p. 2377-2381 5 p.

Sensitization to Cor a 9 or Cor a 14 has a strong impact on the distribution of thresholds to hazelnut

Masthoff Laury J.N., Blom W. Marty, Rubingh Carina M., Klemans Rob J.B., Remington Ben C., Bruijnzeel-Koomen Carla A.F.M., van Hoffen Els, Houben Geert F., Meyer Yolanda, Pasmans Suzanne G.M.A., Knulst André C. 1 nov 2018, In: Journal of Allergy and Clinical Immunology: In Practice. 6 , p. 2112-2114.e1

Legume Protein Consumption and the Prevalence of Legume Sensitization

Smits Mark, Le Thuy My, Welsing Paco, Houben Geert, Knulst André, Verhoeckx Kitty 19 okt 2018, In: Nutrients. 10

All research output

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