dr. M.L. Houben

dr. M.L. Houben

Assistant Professor - medical
dr. M.L. Houben
  • Cluster D
  • Integral pediatrics patient care

Research Programs

Child Health



Michiel was trained as a medical doctor (2002) and pediatrician (2010) and as a clinical epidemiologist (2009) at the UMC Utrecht. In 2011 he obtained his PhD on his thesis entitled: RSV Bronchiolitis in Healthy Term Infants, Pathogenesis and Prediction. Since 2010 he works as a general pediatrician in the Wilhelmina Children’s Hospital (UMC Utrecht) and since 2014 he is head of the section of general en social pediatrics. He is the pediatrician and coordinator of the 22q11.2 deletion syndrome childhood outward patient clinic and studies the heterogeneity and prognostic factors of this syndrome, in close collaboration with colleagues of other pediatric, surgery, psychiatric, psychology and genetics specialties. He is also involved in several further studies on the healthy term birth (amniotic fluid) cohort from his PhD trajectory.

Side Activities

  • member of Infectious Diseases section and Geneticis and Congenital Anomalies section of Dutch Pediatric Association (NVK secties I&I en Erfelijke en Aangeboren Afwijkingen)

  • 2014-present Chair of Working Group on Development of Guideline for central venous catheter use, WKZ

  • 2013-present Chair of Working Group on Pediatric orthopedic care; quality and routing, WKZ

  • 2013-present Pediatrician member of Working Group on Medication, WKZ

Fellowship and Awards

  • 2011-12 PhD Curriculum of Training Upcoming Leaders in Pediatric Science (TULIPS), competitive selection
  • 2011 NVK Masterclass, Prof Dr B Prakken, Prof Dr HJ Verkade, competitive selection

  • 2007 NVK Young Investigators, award best poster presentation

  • 2005 ESPID Fellowship Award

  • 2000 UMC Utrecht Students’ Scientific meeting, 2nd price for oral presentation

  • 1992 Theoretical Mathematics Olympiads, team competition, national winner

  • 1992 Applied Mathematics Olympiads, team competition, national winner

Research Output (46)

Executive functioning in preschoolers with 22q11.2 deletion syndrome and the impact of congenital heart defects

Everaert Emma, Vorstman Jacob A.S., Selten Iris S., Slieker Martijn G., Wijnen Frank, Boerma Tessel D., Houben Michiel L. 13 May 2023, In: Journal of neurodevelopmental disorders. 15 , p. 15

Grammatical skills of Dutch children with 22q11.2 Deletion Syndrome in comparison with children with Developmental Language Disorder:Evidence from spontaneous language and standardized assessment

Boerma Tessel, Everaert Emma, Vlieger Dinte, Steggink Maaike, Selten Iris, Houben Michiel, Vorstman Jacob, Gerrits Ellen, Wijnen Frank 9 Mar 2023, In: Frontiers in Communication. 8 16 p.

A grounded theory study on the dynamics of parental grief during the children's end of life

Kochen Eline M, Grootenhuis Martha A, Teunissen Saskia C C M, Boelen Paul A, Tataranno Maria-Luisa, Fahner Jurrianne C, de Jonge Roos R, Houben Michiel L, Kars Marijke C, 20 Feb 2023, In: Acta Paediatrica. 112 , p. 1101-1108 8 p.

Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration

Muffels Irena J.J., Schene Imre F., Rehmann Holger, Massink Maarten P.G., van der Wal Maria M., Bauder Corinna, Labeur Martha, Armando Natalia G., Lequin Maarten H., Houben Michiel L., Giltay Jaques C., Haitjema Saskia, Huisman Albert, Vansenne Fleur, Bluvstein Judith, Pappas John, Shailee Lala V., Zarate Yuri A., Mokry Michal, van Haaften Gijs W., Nieuwenhuis Edward E.S., Refojo Damian, van Wijk Femke, Fuchs Sabine A., van Hasselt Peter M. 5 Jan 2023, In: American Journal of Human Genetics. 110 , p. 146-160 15 p.

Behaviors related to autism spectrum disorder in children with developmental language disorder and children with 22q11.2 deletion syndrome

Selten Iris, Boerma Tessel, Everaert Emma, Gerrits Ellen, Houben Michiel, Wijnen Frank, Vorstman Jacob 1 Jan 2023, In: Autism and Developmental Language Impairments. 8 , p. 1-18

The Language Profile of Preschool Children With 22q11.2 Deletion Syndrome and the Relationship With Speech Intelligibility

Everaert Emma, Selten Iris, Boerma Tessel, Houben Michiel, Vorstman Jacob, de Wilde Hester, Derksen Desiree, Haverkamp Sarah, Wijnen Frank, Gerrits Ellen 13 Dec 2022, In: American journal of speech-language pathology. 32 , p. 128-144 17 p.

Long-term oncological outcomes of endoscopic full-thickness resection after previous incomplete resection of low-risk T1 CRC (LOCAL-study):study protocol of a national prospective cohort study

Zwager L W, Moons L M G, Farina Sarasqueta A, Laclé M M, Albers S C, Hompes R, Peeters K C M J, Bekkering F C, Boonstra J J, Ter Borg F, Bos P R, Bulte G J, Gielisse E A R, Hazen W L, Ten Hove W R, Houben M H M G, Mundt M W, Nagengast W B, Perk L E, Quispel R, Rietdijk S T, Rando Munoz F J, de Ridder R J J, Schwartz M P, Schreuder R M, Seerden T C J, van der Sluis H, van der Spek B W, Straathof J W A, Terhaar Sive Droste J S, Vlug M S, van de Vrie W, Weusten B L A M, de Wijkerslooth T D, Wolters H J, Fockens P, Dekker E, Bastiaansen B A J, 13 Dec 2022, In: BMC Gastroenterology. 22 , p. 1-12

22q11 in Utrecht: zorg, kennisdeling en onderzoek

Houben ML Dec 2022, In: Overleven met 22q11. 8 p.

Ocular findings in 22q11.2 deletion syndrome:A systematic literature review and results of a Dutch multicenter study

von Scheibler Emma N M M, van der Valk Bouman Emy S, Nuijts Myrthe A, Bauer Noël J C, Berendschot Tos T J M, Vermeltfoort Pit, Bok Levinus A, van Eeghen Agnies M, Houben Michiel L, van Amelsvoort Thérèse A M J, Boot Erik, van Egmond-Ebbeling Michelle B 12 Nov 2021, In: American Journal of Medical Genetics. Part A. 188 , p. 569-578 10 p.

22q11.2 deletion syndrome as a human model for idiopathic scoliosis

de Reuver Steven, Homans Jelle F., Schlösser Tom P.C., Houben Michiel L., Deeney Vincent F.X., Crowley Terrence B., Stücker Ralf, Pasha Saba, Kruyt Moyo C., McDonald‐mcginn Donna M., Castelein René M. 20 Oct 2021, In: Journal of Clinical medicine. 10 , p. 1-11

All research output

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