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prof. dr. A.D.R. (Alwin) Huitema Full Professor

  • Clinical Pharmacy

A.D.R. Huitema

Contact

Research Programs

Side Activities

  • 2002 - : Member of the Medical Ethical Committee of Netherlands Cancer Institute

    2003 - : Involved in many early clinical trials of novel anticancer agents (not further specified, revenues for Netherlands Cancer Institute)

    2016 - 2018: Member of scientific councel "Stichting Kinderen Kankervrij (KiKa)"

    2017 - : Member of the working group Oncology & Hematology of "Horizonscan geneesmiddelen", ZorgInstituut Nederland

    2018 - : Board member of Dutch Society of Clinical Pharmacology & Biopharmaceutics

Fellowship and Awards

  • 2015 Galenus research prize

    2014 Huizinga penning of the Dutch Association of Hospital Pharmacists

Research Output (137)

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

van Geel Robin M J M, van Brummelen Emilie M J, Eskens Ferry A L M, Huijberts Sanne C F A, de Vos Filip Y F L, Lolkema Martijn P J K, Devriese Lot A, Opdam Frans L, Marchetti Serena, Steeghs Neeltje, Monkhorst Kim, Thijssen Bas, Rosing Hilde, Huitema Alwin D R, Beijnen Jos H, Bernards René, Schellens Jan H M 9 mrt 2020, In: British Journal of Cancer. 122 , p. 1166-1174 9 p.

Quantification of T Cell Binding Polyclonal Rabbit Anti-thymocyte Globulin in Human Plasma with Liquid Chromatography Tandem-Mass Spectrometry

Amrani Mohsin El, Admiraal Rick, Willaert Lobke, Ebskamp-van Raaij Lysette J C, Lacna Amelia M, Hack C Erik, Huitema Alwin D R, Nierkens Stefan, van Maarseveen Erik M 1 mrt 2020, In: AAPS Journal. 22 8 p.

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development

Yu Huixin, Janssen Julie M, Sawicki Emilia, van Hasselt J G Coen, de Weger Vincent A, Nuijen Bastiaan, Schellens Jan H M, Beijnen Jos H, Huitema Alwin D R mrt 2020, In: Journal of Clinical Pharmacology. 60 , p. 340-350 11 p.

Clinical Pharmacokinetics and Impact of Hematocrit on Monitoring and Dosing of Tacrolimus Early After Heart and Lung Transplantation

Sikma Maaike A, Hunault Claudine C, Huitema Alwin D R, De Lange Dylan W, Van Maarseveen Erik M 10 dec 2019, In: Clinical Pharmacokinetics. 59 , p. 403-408 6 p.

Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

Crombag Marie-Rose B S, Koolen Stijn L W, Wijngaard Sophie, Joerger Markus, Dorlo Thomas P C, van Erp Nielka P, Mathijssen Ron H J, Beijnen Jos H, Huitema Alwin D R 1 dec 2019, In: Pharmaceutical Research. 36

Exposure to Docetaxel in the Elderly Patient Population:a Population Pharmacokinetic Study

Crombag Marie-Rose B S, Dorlo Thomas P C, van der Pan Ellen, van Straten Anoek, Bergman Andries M, van Erp Nielka P, Beijnen Jos H, Huitema Alwin D R 1 dec 2019, In: Pharmaceutical Research. 36

Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

Steen-Louws Cristine, Boross Peter, Prado Judith, Meeldijk Jan, Langenhorst Jurgen B, Huitema Alwin D R, den Hartog Marcel T, Boon Louis, Lafeber Floris P J G, Hack C Erik, Eijkelkamp Niels, Popov-Celeketic Jelena dec 2019, In: Pharmaceutical Research. 37

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A, Hunault Claudine C, Van Maarseveen Erik M, Huitema Alwin D R, Van de Graaf Ed A, Kirkels Johannes H, Verhaar Marianne C, Grutters Jan C, Kesecioglu Jozef, De Lange Dylan W 19 nov 2019, In: European journal of drug metabolism and pharmacokinetics. 45 , p. 123-134 12 p.

Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry - A tutorial

El Amrani Mohsin, Donners Anouk A.M., Hack C. Erik, Huitema Alwin D.R., van Maarseveen Erik M. 8 nov 2019, In: Analytica Chimica Acta. 1080 , p. 22-34 13 p.

Pharmacokinetics of capecitabine and four metabolites in a heterogeneous population of cancer patients:a comprehensive analysis

Jacobs Bart A W, Deenen Maarten J, Joerger Markus, Rosing Hilde, de Vries Niels, Meulendijks Didier, Cats Annemieke, Beijnen Jos H, Schellens Jan H M, Huitema Alwin D R 25 okt 2019, In: CPT: Pharmacometrics and Systems Pharmacology. 8 , p. 940-950 11 p.

All Research Output (137)
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