prof. dr. A.D.R. (Alwin) Huitema

Full Professor

  • Clinical Pharmacy

prof. dr. A.D.R. (Alwin) Huitema

Research Programs

Side Activities

  • 2002 - : Member of the Medical Ethical Committee of Netherlands Cancer Institute

    2003 - : Involved in many early clinical trials of novel anticancer agents (not further specified, revenues for Netherlands Cancer Institute)

    2016 - 2018: Member of scientific councel "Stichting Kinderen Kankervrij (KiKa)"

    2017 - : Member of the working group Oncology & Hematology of "Horizonscan geneesmiddelen", ZorgInstituut Nederland

    2018 - : Board member of Dutch Society of Clinical Pharmacology & Biopharmaceutics

Fellowship and Awards

  • 2015 Galenus research prize

    2014 Huizinga penning of the Dutch Association of Hospital Pharmacists

Research Output (145)

Therapeutic drug monitoring of imatinib in patients with gastrointestinal stromal tumours - Results from daily clinical practice

IJzerman Nikki S, Groenland Stefanie L, Koenen Anne Miek, Kerst Martijn, van der Graaf Winette T A, Rosing Hilde, Beijnen Jos H, Huitema Alwin D R, Steeghs Neeltje sep 2020, In: European Journal of Cancer. 136 , p. 140-148 9 p.

Evaluation of Extrapolation Methods to Predict Trough Concentrations to Guide Therapeutic Drug Monitoring of Oral Anticancer Drugs

Janssen Julie M., Dorlo Thomas P.C., Beijnen Jos H., Huitema Alwin D.R. 1 aug 2020, In: Therapeutic drug monitoring. 42 , p. 532-539 8 p.

Exposure-response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer

van Nuland M, Groenland S L, Bergman A M, Steeghs N, Rosing H, Venekamp N, Huitema A D R, Beijnen J H jun 2020, In: Prostate cancer and prostatic diseases. 23 , p. 244-251 8 p.

Phase I pharmacological study of continuous chronomodulated capecitabine treatment

Roosendaal Jeroen, Jacobs Bart A W, Pluim Dick, Rosing Hilde, de Vries Niels, van Werkhoven Erik, Nuijen Bastiaan, Beijnen Jos H, Huitema Alwin D R, Schellens Jan H M, Marchetti Serena 7 mei 2020, In: Pharmaceutical Research. 37 10 p.

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

van Geel Robin M J M, van Brummelen Emilie M J, Eskens Ferry A L M, Huijberts Sanne C F A, de Vos Filip Y F L, Lolkema Martijn P J K, Devriese Lot A, Opdam Frans L, Marchetti Serena, Steeghs Neeltje, Monkhorst Kim, Thijssen Bas, Rosing Hilde, Huitema Alwin D R, Beijnen Jos H, Bernards René, Schellens Jan H M 9 mrt 2020, In: British Journal of Cancer. 122 , p. 1166-1174 9 p.

Quantification of T Cell Binding Polyclonal Rabbit Anti-thymocyte Globulin in Human Plasma with Liquid Chromatography Tandem-Mass Spectrometry

Amrani Mohsin El, Admiraal Rick, Willaert Lobke, Ebskamp-van Raaij Lysette J C, Lacna Amelia M, Hack C Erik, Huitema Alwin D R, Nierkens Stefan, van Maarseveen Erik M 1 mrt 2020, In: AAPS Journal. 22 8 p.

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development

Yu Huixin, Janssen Julie M, Sawicki Emilia, van Hasselt J G Coen, de Weger Vincent A, Nuijen Bastiaan, Schellens Jan H M, Beijnen Jos H, Huitema Alwin D R mrt 2020, In: Journal of Clinical Pharmacology. 60 , p. 340-350 11 p.

A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance

Langenhorst J B, Boss J, van Kesteren C, Lalmohamed A, Kuball J, Egberts A C G, Boelens J J, Huitema A D R, van Maarseveen E M 18 feb 2020, In: British Journal of Clinical Pharmacology. 86 , p. 1499-1509 11 p.

Unbound Plasma, Total Plasma, and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A., Van Maarseveen Erik M., Hunault Claudine C., Moreno Javier M., Van de Graaf Ed A., Kirkels Johannes H., Verhaar Marianne C., Grutters Jan C., Kesecioglu Jozef, De Lange Dylan W., Huitema Alwin D. R. 16 dec 2019, In: Clinical Pharmacokinetics. 59 , p. 771-780 10 p.

Clinical Pharmacokinetics and Impact of Hematocrit on Monitoring and Dosing of Tacrolimus Early After Heart and Lung Transplantation

Sikma Maaike A, Hunault Claudine C, Huitema Alwin D R, De Lange Dylan W, Van Maarseveen Erik M 10 dec 2019, In: Clinical Pharmacokinetics. 59 , p. 403-408 6 p.

All Research Output (145)