prof. dr. A.D.R. (Alwin) Huitema

prof. dr. A.D.R. (Alwin) Huitema

Full Professor
prof. dr. A.D.R. (Alwin) Huitema
  • Clinical Pharmacy

Research Programs

Strategic Program Cancer

Side Activities

2002 - : Member of the Medical Ethical Committee of Netherlands Cancer Institute

2003 - : Involved in many early clinical trials of novel anticancer agents (not further specified, revenues for Netherlands Cancer Institute)

2016 - 2018: Member of scientific councel "Stichting Kinderen Kankervrij (KiKa)"

2017 - : Member of the working group Oncology & Hematology of "Horizonscan geneesmiddelen", ZorgInstituut Nederland

2018 - : Board member of Dutch Society of Clinical Pharmacology & Biopharmaceutics

Fellowship and Awards

2015 Galenus research prize

2014 Huizinga penning of the Dutch Association of Hospital Pharmacists

Research Output (203)

A Phase I dose-escalation study of two cycles carboplatin-olaparib followed by olaparib monotherapy in patients with advanced cancer

Geenen Jill J J, Dackus Gwen M H E, Schouten Philip C, Pluim Dick, Marchetti Serena, Sonke Gabe S, Jóźwiak Katarzyna, Huitema Alwin D R, Beijnen Jos H, Schellens Jan H M, Linn Sabine C 15 jun 2021, In: International Journal of Cancer. 148 , p. 3041-3050 10 p.

Development and validation of a combined liquid chromatography tandem-mass spectrometry assay for the quantification of aprepitant and dexamethasone in human plasma to support pharmacokinetic studies in pediatric patients

Nijstad A Laura, Tibben Matthijs M, Gebretensae Abadi, Rosing Hilde, de Vos-Kerkhof Evelien, Zwaan C Michel, Huitema Alwin D R, Beijnen Jos H 1 mei 2021, In: Journal of Chromatography B. 1171 7 p.

Immune Monitoring during Therapy Reveals Activitory and Regulatory Immune Responses in High-Risk Neuroblastoma

Szanto Celina L, Cornel Annelisa M, Tamminga Sara M, Delemarre Eveline M, de Koning Coco C H, van den Beemt Denise A M H, Dunnebach Ester, Tas Michelle L, Dierselhuis Miranda P, Tytgat Lieve G A M, van Noesel Max M, Kraal Kathelijne C J M, Boelens Jaap-Jan, Huitema Alwin D R, Nierkens Stefan 1 mei 2021, In: Cancers. 13 18 p.

Antitumor Activity of NLG207 (Formerly CRLX101) in Combination with Enzalutamide in Preclinical Prostate Cancer Models

Schmidt Keith T, Chau Cindy H, Strope Jonathan D, Huitema Alwin D R, Sissung Tristan M, Price Douglas K, Figg William D mei 2021, In: MOLECULAR CANCER THERAPEUTICS. 20 , p. 915-924 10 p.

Prospective experimental treatment of colorectal cancer patients based on organoid drug responses

Ooft S. N., Weeber F., Schipper L., Dijkstra K. K., McLean C. M., Kaing S., van de Haar J., Prevoo W., van Werkhoven E., Snaebjornsson P., Hoes L. R., Chalabi M., van der Velden D., van Leerdam M., Boot H., Grootscholten C., Huitema A. D.R., Bloemendal H. J., Cuppen E., Voest E. E. 19 apr 2021, In: ESMO open. 6 , p. 100103 1 p.

Resistance to second-generation androgen receptor antagonists in prostate cancer

Schmidt Keith T, Huitema Alwin D R, Chau Cindy H, Figg William D apr 2021, In: Nature Reviews. Urology. 18 , p. 209-226 18 p.

CD4+ T-cell reconstitution predicts survival outcomes after acute graft-versus-host-disease:a dual-center validation

de Koning Coco, Prockop Susan, van Roessel Ichelle, Kernan Nancy, Klein Elizabeth, Langenhorst Jurgen, Szanto Celina, Belderbos Mirjam, Bierings Marc, Boulad Farid, Bresters Dorine, Cancio Maria, Curran Kevin, Kollen Wouter, O'Reilly Richard, Scaradavou Andromachi, Spitzer Barbara, Versluijs Birgitta, Huitema Alwin, Lindemans Caroline, Nierkens Stefan, Boelens Jaap Jan 11 feb 2021, In: Blood. 137 , p. 848-855 8 p.

Population Pharmacokinetics of Docetaxel, Paclitaxel, Doxorubicin and Epirubicin in Pregnant Women with Cancer:A Study from the International Network of Cancer, Infertility and Pregnancy (INCIP)

Janssen Julie M, Van Calsteren Kristel, Dorlo Thomas P C, Halaska Michael J, Fruscio Robert, Ottevanger Petronella, Schröder Carolien P, Boere Ingrid, Witteveen Petronella O, Painter Rebecca C, Bekkers Ruud, Drochytek Vit, Beijnen Jos H, Huitema Alwin D R, Amant Frederic C H 28 jan 2021, In: Clinical Pharmacokinetics. 60 , p. 775-784 10 p.

Population Pharmacokinetics of Intracellular 5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine

Janssen Julie M, Jacobs Bart A W, Roosendaal Jeroen, Derissen Ellen J B, Marchetti Serena, Beijnen Jos H, Huitema Alwin D R, Dorlo Thomas P C 8 jan 2021, In: AAPS Journal. 23 9 p.

Prediction of Acute Graft versus Host Disease and Relapse by Endogenous Metabolomic Compounds in Patients Receiving Personalized Busulfan-Based Conditioning

McCune Jeannine S, McKiernan Jožefa S, van Maarseveen Erik, Huitema Alwin D R, Randolph Timothy W, Deeg H Joachim, Nakamura Ryotaro, Baker K Scott 1 jan 2021, In: Journal of Proteome Research. 20 , p. 684-694 11 p.

All research output

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