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prof. dr. A.D.R. (Alwin) Huitema

Full Professor

  • Clinical Pharmacy

Research Output (142)

Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

Steen-Louws Cristine, Boross Peter, Prado Judith, Meeldijk Jan, Langenhorst Jurgen B, Huitema Alwin D R, den Hartog Marcel T, Boon Louis, Lafeber Floris P J G, Hack C Erik, Eijkelkamp Niels, Popov-Celeketic Jelena dec 2019, In: Pharmaceutical Research. 37

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A, Hunault Claudine C, Van Maarseveen Erik M, Huitema Alwin D R, Van de Graaf Ed A, Kirkels Johannes H, Verhaar Marianne C, Grutters Jan C, Kesecioglu Jozef, De Lange Dylan W 19 nov 2019, In: European journal of drug metabolism and pharmacokinetics. 45 , p. 123-134 12 p.

Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry - A tutorial

El Amrani Mohsin, Donners Anouk A.M., Hack C. Erik, Huitema Alwin D.R., van Maarseveen Erik M. 8 nov 2019, In: Analytica Chimica Acta. 1080 , p. 22-34 13 p.

Pharmacokinetics of capecitabine and four metabolites in a heterogeneous population of cancer patients:a comprehensive analysis

Jacobs Bart A W, Deenen Maarten J, Joerger Markus, Rosing Hilde, de Vries Niels, Meulendijks Didier, Cats Annemieke, Beijnen Jos H, Schellens Jan H M, Huitema Alwin D R 25 okt 2019, In: CPT: Pharmacometrics and Systems Pharmacology. 8 , p. 940-950 11 p.

Doxorubicin-induced skeletal muscle atrophy:elucidating the underlying molecular pathways

Hiensch Anouk E, Bolam Kate A, Mijwel Sara, Jeneson Jeroen A L, Huitema Alwin D R, Kranenburg Onno, van der Wall Elsken, Rundqvist Helene, Wengstrom Yvonne, May Anne M 10 okt 2019, In: Acta physiologica (Oxford, England). 229 18 p.

Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer

van Nuland Merel, Bergman Andries M, Rosing Hilde, de Vries Niels, Huitema Alwin D R, Beijnen Jos H 9 okt 2019, In: Pharmacotherapy. 39 , p. 1137-1145 9 p.

Therapeutic Drug Monitoring of Oral Anticancer Drugs:The Dutch Pharmacology Oncology Group-Therapeutic Drug Monitoring Protocol for a Prospective Study

Groenland Stefanie L, van Eerden Ruben A G, Verheijen Remy B, Koolen Stijn L W, Moes Dirk Jan A R, Desar Ingrid M E, Reyners Anna K L, Gelderblom Hans J, van Erp Nielka P, Mathijssen Ron H J, Huitema Alwin D R, Steeghs Neeltje okt 2019, In: Therapeutic Drug Monitoring. 41 , p. 561-567 7 p.

Simultaneous Quantification of Free Adalimumab and Infliximab in Human Plasma Using a Target-Based Sample Purification and Liquid Chromatography-Tandem Mass Spectrometry

El Amrani Mohsin, Bosman Sabine M, Egas Annelies C, Hack C Erik, Huitema Alwin D R, van Maarseveen Erik M okt 2019, In: Therapeutic Drug Monitoring. 41 , p. 640-647 8 p.

Drug Rediscovery Protocol: Expanded use of existing anticancer drugs

Voest E. E., van der Velden D. L., Hoes L., Van der Wijngaart H., Henegouwen M. Van Berge, Van Werkhoven E., Roepman P., Huitema A. D. R., van Herpen C., de Groot D. J., Devriese L., de Jonge M. J. A., Chalabi M., Smit E. F., Mehra N., Labots M., Sleijfer S., Cuppen E., Verheul H. M. W., Gelderblom H. okt 2019, In: Annals of Oncology. 30

The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs

van der Velden D L, Hoes L R, van der Wijngaart H, van Berge Henegouwen J M, van Werkhoven E, Roepman P, Schilsky R L, de Leng W W J, Huitema A D R, Nuijen B, Nederlof P M, van Herpen C M L, de Groot D J A, Devriese L A, Hoeben A, de Jonge M J A, Chalabi M, Smit E F, de Langen A J, Mehra N, Labots M, Kapiteijn E, Sleijfer S, Cuppen E, Verheul H M W, Gelderblom H, Voest E E okt 2019, In: Nature. 574 , p. 127-131 5 p.