prof. dr. H.E. (Hilleke) Hulshoff Pol

prof. dr. H.E. (Hilleke) Hulshoff Pol

Full Professor
prof. dr. H.E. (Hilleke) Hulshoff Pol
  • Psychiatry

Research Programs




Hilleke Hulshoff Pol completed her MS degree in psychophysiology with Rien Verbaten in Utrecht (1987), her internship in neuropsychology and neuroimaging with Nelson Butters at the University of California in San Diego (1988), and subsequently her PhD degree in Utrecht (September 25, 1995) with Jan van Ree (neuropharmacology), Max Viergever (imaging), and Cees Tulleken (neurosurgery). Topic of her thesis was memory processes in the frontal cortex of the human brain. Between 1996 and 2006 she set up and headed the brain imaging research lab at the Department of Psychiatry in Utrecht. Since 2007 she is full professor of neuroscience in particular of psychiatric disorders at the Brain Center Rudolf Magnus.

Her research focuses on structural and functional brain plasticity throughout life in health and in psychiatric disease, and the influences of genes and environment on brain plasticity. For this purpose she studies individuals and their (twin) family members, using magnetic resonance imaging at (ultra) high field. She has received a VIDI award from the Netherlands Scientific Organization NWO, and a High Potential award from the Utrecht University. Her work was published in >220 publications, her current h-index is 64, and has been cited >15.800 times.

Research line

Brain plasticity

Most recent key publications

1:Teeuw J., Brouwer R.M., Guimarães, J.P.O.F.T., Brandner, P., Koenis M., Swagerman S., Verwoert, M., Boomsma D.I., Hulshoff Pol H.E. (2019) Genetic and environmental influences on functional connectivity within and between canonical cortical resting-state networks throughout adolescent development in boys and girls. Neuroimage. doi: 10.1016/j.neuroimage.2019.116073

2:Brouwer RM Panizzon MS Glahn DC, Hibar DP, Hua X, Jahanshad N, Abramovic L, de Zubicaray GI Franz CE, Hansell NK, Hickie IB, Koenis MMG, Martin NG, Mather KA, McMahon KL, Schnack HG, Strike LT, Swagerman SC, Thalamuthu A, Wen W, Gilmore JH, Gogtay N, Kahn RS, Sachdev PS, Wright MJ, Boomsma DI, Kremen WS, Thompson PM, Hulshoff Pol HE. (2017). Genetic influences on longitudinal changes in global and subcortical brain volumes: results of the ENIGMA Plasticity Working Group. Hum Brain Mapp. 38(9):4444-4458

3:Bohlken MM, Brouwer RM, Mandl RC, Van den Heuvel MP, Hedman AM, De Hert M, Cahn W, Kahn RS, Hulshoff Pol HE. (2016). Structural Brain Connectivity as a Genetic Marker for Schizophrenia. JAMA Psychiatry. 73(1):11-9.

4:Svatkova A, Mandl RC, Scheewe TW, Cahn W, Kahn RS, Hulshoff Pol HE. (2015). Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls. Schizophr Bull.41(4):869-78.

5:Schnack HG, van Haren NE, Brouwer RM, Evans A, Durston S, Boomsma DI, Kahn RS, Hulshoff Pol HE. (2015). Changes in thickness and surface area of the human cortex and their relationship with intelligence. Cereb Cortex. 25(6):1608-17.

6:Marsman A, Mandl RC, Klomp DW, Bohlken MM, Boer VO, Andreychenko A, Cahn W, Kahn RS, Luijten PR, Hulshoff Pol HE. (2014). GABA and glutamate in schizophrenia: a 7 T ¹H-MRS study. Neuroimage Clin. 15;6:398-407.

Side Activities


Fellowship and Awards

Alzheimer's Association Zenith Award Program (subaward PI) 2020

NWA Ideas Generator (one of the PIs) 2020

NIH ENIGMA World Aging Center (subward PI) 2018

NWA NeuroLabNL (subward PI) 2018

Dutch Brain Foundation (subaward PI) 2018

NWO National Roadmap BBMRI-NL2.0 (one of the PIs) 2014

NWO Gravitation Grant CID (one of the PIs), 2012

NWO  NIHC Brain and Cognition, programmes of excellence (PI), 2010

High Potential Program Utrecht University (one of the two PIs), 2007

Marie Curie research training network (PI for Utrecht), 2007

NWO ZON-MW VIDI program (PI), 2004

Research Output (287)

Self-regulation in the pre-adolescent brain

Pas P., Hulshoff Pol H. E., Raemaekers M., Vink M. okt 2021, In: Developmental Cognitive Neuroscience. 51

De‐identification procedures for magnetic resonance images and the impact on structural brain measures at different ages

Buimer Elizabeth, Schnack Hugo, Caspi Yaron, van Haren Neeltje, Milchenko Mikhail, Pas P, ADNI , Hulshoff Pol Hilleke, Brouwer Rachel 11 mei 2021, In: Human Brain Mapping. 42 , p. 3643-3655

Reliability modelling of resting-state functional connectivity

Teeuw Jalmar, Hulshoff Pol Hilleke E., Boomsma Dorret I., Brouwer Rachel M. 1 mei 2021, In: NeuroImage. 231 12 p.

Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia

Teeuw Jalmar, Ori Anil P S, Brouwer Rachel M, de Zwarte Sonja M C, Schnack Hugo G, Hulshoff Pol Hilleke E, Ophoff Roel A 17 apr 2021, In: Schizophrenia Research. 231 , p. 189-197 9 p.

Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients

Gangadin Shiral S, Cahn Wiepke, Scheewe Thomas W, Hulshoff Pol Hilleke E, Bossong Matthijs G 26 mrt 2021, In: Journal of Psychiatric Research. 138 , p. 83-88 6 p.

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Sønderby Ida E, van der Meer Dennis, Moreau Clara, Kaufmann Tobias, Walters G Bragi, Ellegaard Maria, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Micael, Armstrong Nicola J, Bernard Manon, Blackburn Nicholas B, Blangero John, Boomsma Dorret I, Brodaty Henry, Brouwer Rachel M, Bülow Robin, Bøen Rune, Cahn Wiepke, Calhoun Vince D, Caspers Svenja, Ching Christopher R K, Cichon Sven, Ciufolini Simone, Crespo-Facorro Benedicto, Curran Joanne E, Dale Anders M, Dalvie Shareefa, Dazzan Paola, de Geus Eco J C, de Zubicaray Greig I, de Zwarte Sonja M C, Desrivieres Sylvane, Doherty Joanne L, Donohoe Gary, Draganski Bogdan, Ehrlich Stefan, Eising Else, Espeseth Thomas, Fejgin Kim, Fisher Simon E, Fladby Tormod, Frei Oleksandr, Frouin Vincent, Fukunaga Masaki, Gareau Thomas, Hillegers Manon H J, Hulshoff Pol Hilleke E, Ophoff Roel A, 22 mrt 2021, In: Translational Psychiatry. 11 16 p.

The Speed of Development of Adolescent Brain Age Depends on Sex and Is Genetically Determined

Brouwer Rachel M, Schutte Jelle, Janssen Ronald, Boomsma Dorret I, Hulshoff Pol Hilleke E, Schnack Hugo G 19 okt 2020, In: Cerebral Cortex. 31 , p. 1296-1306 11 p.

The YOUth study:Rationale, design, and study procedures

Onland-Moret N. Charlotte, Buizer-Voskamp Jacobine E., Albers Maria E.W.A., Brouwer Rachel M., Buimer Elizabeth E.L., Hessels Roy S., de Heus Roel, Huijding Jorg, Junge Caroline M.M., Mandl René C.W., Pas Pascal, Vink Matthijs, van der Wal Juliëtte J.M., Hulshoff Pol Hilleke E., Kemner Chantal 7 okt 2020, In: Developmental Cognitive Neuroscience. 46 , p. 1-16

The YOUth cohort study:MRI protocol and test-retest reliability in adults

Buimer Elizabeth E.L., Pas Pascal, Brouwer Rachel M., Froeling Martijn, Hoogduin Hans, Leemans Alexander, Luijten Peter, van Nierop Bastiaan J., Raemaekers Mathijs, Schnack Hugo G., Teeuw Jalmar, Vink Matthijs, Visser Fredy, Hulshoff Pol Hilleke E., Mandl René C.W. okt 2020, In: Developmental Cognitive Neuroscience. 45 , p. 1-15

Dissimilarity in Sulcal Width Patterns in the Cortex can be Used to Identify Patients With Schizophrenia With Extreme Deficits in Cognitive Performance

Janssen Joost, Díaz-Caneja Covadonga M, Alloza Clara, Schippers Anouck, de Hoyos Lucía, Santonja Javier, Gordaliza Pedro M, Buimer Elizabeth E L, van Haren Neeltje E M, Cahn Wiepke, Arango Celso, Kahn René S, Hulshoff Pol Hilleke E, Schnack Hugo G 23 sep 2020, In: Schizophrenia bulletin. 47 , p. 552-561 10 p.

All research output

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