prof. dr. R.S. (René) Kahn

prof. dr. R.S. (René) Kahn

Full Professor
prof. dr. R.S. (René) Kahn
  • Psychiatry

Research Programs




Dr René Kahn is Professor and until 2017, was Chair of the Department of Psychiatry and Head of the Division of Neurosciences at the University Medical Center, Utrecht, The Netherlands. In 1995 he received a Fulbright Scholarship for study at Yale and subsequently did a Fellowship in Biological Psychiatry at the Montefiore Hospital and Albert Einstein College of Medicine in New York. He then moved to the Mount Sinai School of Medicine where he conducted schizophrenia research and became Unit Chief of one of the research units.

Dr Kahn has received many grants for his research into the origins and treatment of schizophrenia. His current research interests include neuroimaging in schizophrenia and the genetic dissection of complex traits in specific psychiatric disorders. He has published over 500 research papers and book chapters. He is on the editorial boards of Schizophrenia research, Schizophrenia Bulletin, Early Interventions in Psychiatry and European Neuropsychopharmacology. He was both Treasurer and Vice-President of the European College for Neuropsychopharmacology and currently is President-Elect of the Schizophrenia International Research Society. He sat on the Neuroscience andd Mental Health Board of the Medical Research Council of the UK and was on the scientific advisory group for CNS of the European Medicines Agency. He leads a large EU-funded study, OPTiMiSE, on developing a treatment algorithm in first episode schizophrenia. He is honorary lifetime professor at Jilin University in Changchun, P.R. China and a member of the Royal Netherlands Academy of Arts and Sciences.

As of January 2017, he is appointed head of the Department of Psychiatry at Icahn School of Medicine at Mount Sinai in New York. His main tasks at UMC Utrecht are now: coaching his PhD students and coordinating research projects.

Most recent key publications

1: Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE, EUFEST study group. E
2: van der Schot AC, Vonk R, Brans RG, van Haren NE, Koolschijn PC, Nuboer V, Schnack HG, van Baal GC, Boomsma DI, Nolen WA, Hulshoff Pol HE, Kahn RS. Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Arch Gen Psychiatry. 2009 Feb,66(2):142-51
3: van der Schot AC, Vonk R, Brouwer RM, van Baal GC, Brans RG, van Haren NE, Schnack HG, Boomsma DI, Nolen WA, Pol HE, Kahn RS. Genetic and environmental influences on focal brain density in bipolar disorder. Brain. 2010 Sep 12
4: van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS Changes in cortical thickness during the course of illness in schizophrenia Arch Gen Psychiatry. 2011 Sep,68(9):871-80
5: van Haren NE, Rijsdijk F, Schnack HG, Picchioni MM, Toulopoulou T, Weisbrod M, Sauer ,H, van Erp TG, Cannon TD, Huttunen MO, Boomsma DI, Hulshoff Pol HE, Murray RM, Kahn RS. The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium. Biol Psychiatry. 2012 May 15,71(10):915-21

Fellowship and Awards

1985 Fulbright Scholarship
1989 Ramaer Medaille
2009 Member Royal Netherlands Academy for Arts and Sciences

Research Output (1063)

Bipolar episodes after reproductive events in women with bipolar I disorder, A study of 919 pregnancies

Gilden Janneke, Poels Eline M.P., Lambrichts Simon, Vreeker Annabel, Boks Marco P.M., Ophoff Roel A., Kahn René S., Kamperman Astrid M., Bergink Veerle 1 dec 2021, In: Journal of Affective Disorders. 295 , p. 72-79 8 p.

Clinical features and psychiatric comorbidities in military veterans with schizophrenia with or without suicidality

Sher Leo, Kilmade Maureen E., Feinberg Abigail, Govindarajulu Usha, Byne William, Kahn René S., Hazlett Erin A. nov 2021, In: Journal of Psychiatric Research. 143 , p. 262-267 6 p.

DNA methylation differences in cortical grey and white matter in schizophrenia

Berdenis Van Berlekom Amber, Notman Nina, Sneeboer Marjolein A.M., Snijders Gijsje J.L.J., Houtepen Lotte C., Nispeling Danny M., He Yujie, Dracheva Stella, Hol Elly M., Kahn René S., De Witte Lot D., Boks Marco P. 29 jul 2021, In: Epigenomics. 13 , p. 1157-1169 13 p.

Altered effective connectivity within an oculomotor control network in individuals with schizophrenia

Lehet Matthew, Tso Ivy F, Neggers Sebastiaan F W, Thompson Ilse A, Yao Beier, Kahn René S, Thakkar Katharine N 14 jul 2021, In: NeuroImage. Clinical. 31 , p. 102764

A phase 3, multicenter study to assess the 1-year safety and tolerability of a combination of olanzapine and samidorphan in patients with schizophrenia:Results from the ENLIGHTEN-2 long-term extension

Kahn René S, Silverman Bernard L, DiPetrillo Lauren, Graham Christine, Jiang Ying, Yin Jiani, Simmons Adam, Bhupathi Vasudev, Yu Bei, Yagoda Sergey, Hopkinson Craig, McDonnell David 17 mei 2021, In: Schizophrenia Research. 232 , p. 45-53 9 p.

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Mullins Niamh, Forstner Andreas J, O'Connell Kevin S, Coombes Brandon, Coleman Jonathan R I, Qiao Zhen, Als Thomas D, Bigdeli Tim B, Børte Sigrid, Bryois Julien, Charney Alexander W, Drange Ole Kristian, Gandal Michael J, Hagenaars Saskia P, Ikeda Masashi, Kamitaki Nolan, Kim Minsoo, Krebs Kristi, Panagiotaropoulou Georgia, Schilder Brian M, Sloofman Laura G, Steinberg Stacy, Trubetskoy Vassily, Winsvold Bendik S, Won Hong-Hee, Abramova Liliya, Adorjan Kristina, Agerbo Esben, Al Eissa Mariam, Albani Diego, Alliey-Rodriguez Ney, Anjorin Adebayo, Antilla Verneri, Antoniou Anastasia, Awasthi Swapnil, Baek Ji Hyun, Bækvad-Hansen Marie, Bass Nicholas, Bauer Michael, Beins Eva C, Bergen Sarah E, Birner Armin, Bøcker Pedersen Carsten, Bøen Erlend, Boks Marco P, Bosch Rosa, Brum Murielle, Brumpton Ben M, Kahn René S, Ophoff Roel A, 17 mei 2021, In: Nature Genetics. 53 , p. 817-829 13 p.

The role of depression in the prediction of a "late" remission in first-episode psychosis:An analysis of the OPTiMiSE study

Fraguas David, Díaz-Caneja Covadonga M, Pina-Camacho Laura, Winter van Rossum Inge, Baandrup Lone, Sommer Iris E, Glenthøj Birte, Kahn René S, Leucht Stefan, Arango Celso 7 apr 2021, In: Schizophrenia Research. 231 , p. 100-107 8 p.

Phase 3 Safety and Tolerability Results of the Combination Olanzapine and Samidorphan in Patients with Schizophrenia:The 1 Year ENLIGHTEN-2-Extension

Kahn Rene, Silverman Bernard, DiPetrillo Lauren, Graham Christine, Jiang Ying, Yin Jiani, Simmons Adam, Bhupathi Vasudev, Yu Bei, Hopkinson Craig, McDonnell Davidd apr 2021, In: CNS Spectrums. 26 , p. 155-156 2 p.

In memoriam-Larry J. Siever, M.D

Davis Kenneth L, Kahn René S, New Antonia, Aronson Andrew 29 mrt 2021, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 46

The effect of prednisolone on symptom severity in schizophrenia:A placebo-controlled, randomized controlled trial

Nasib Lyliana G, Gangadin Shiral S, Rossum Inge Winter-van, Boudewijns Zimbo S R M, de Witte Lot D, Wilting Ingeborg, Luykx Jurjen, Somers Metten, Veen Natalie, van Baal Caroline, Kahn René S, Sommer Iris E 9 mrt 2021, In: Schizophrenia Research. 230 , p. 79-86 8 p.

All research output

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