prof. dr. R.S. (René) Kahn

Full Professor
prof. dr. R.S. (René) Kahn
  • Psychiatry

Research Programs




Dr René Kahn is Professor and until 2017, was Chair of the Department of Psychiatry and Head of the Division of Neurosciences at the University Medical Center, Utrecht, The Netherlands. In 1995 he received a Fulbright Scholarship for study at Yale and subsequently did a Fellowship in Biological Psychiatry at the Montefiore Hospital and Albert Einstein College of Medicine in New York. He then moved to the Mount Sinai School of Medicine where he conducted schizophrenia research and became Unit Chief of one of the research units.

Dr Kahn has received many grants for his research into the origins and treatment of schizophrenia. His current research interests include neuroimaging in schizophrenia and the genetic dissection of complex traits in specific psychiatric disorders. He has published over 500 research papers and book chapters. He is on the editorial boards of Schizophrenia research, Schizophrenia Bulletin, Early Interventions in Psychiatry and European Neuropsychopharmacology. He was both Treasurer and Vice-President of the European College for Neuropsychopharmacology and currently is President-Elect of the Schizophrenia International Research Society. He sat on the Neuroscience andd Mental Health Board of the Medical Research Council of the UK and was on the scientific advisory group for CNS of the European Medicines Agency. He leads a large EU-funded study, OPTiMiSE, on developing a treatment algorithm in first episode schizophrenia. He is honorary lifetime professor at Jilin University in Changchun, P.R. China and a member of the Royal Netherlands Academy of Arts and Sciences.

As of January 2017, he is appointed head of the Department of Psychiatry at Icahn School of Medicine at Mount Sinai in New York. His main tasks at UMC Utrecht are now: coaching his PhD students and coordinating research projects.

Most recent key publications

1: Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE, EUFEST study group. E
2: van der Schot AC, Vonk R, Brans RG, van Haren NE, Koolschijn PC, Nuboer V, Schnack HG, van Baal GC, Boomsma DI, Nolen WA, Hulshoff Pol HE, Kahn RS. Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Arch Gen Psychiatry. 2009 Feb,66(2):142-51
3: van der Schot AC, Vonk R, Brouwer RM, van Baal GC, Brans RG, van Haren NE, Schnack HG, Boomsma DI, Nolen WA, Pol HE, Kahn RS. Genetic and environmental influences on focal brain density in bipolar disorder. Brain. 2010 Sep 12
4: van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS Changes in cortical thickness during the course of illness in schizophrenia Arch Gen Psychiatry. 2011 Sep,68(9):871-80
5: van Haren NE, Rijsdijk F, Schnack HG, Picchioni MM, Toulopoulou T, Weisbrod M, Sauer ,H, van Erp TG, Cannon TD, Huttunen MO, Boomsma DI, Hulshoff Pol HE, Murray RM, Kahn RS. The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium. Biol Psychiatry. 2012 May 15,71(10):915-21

Fellowship and Awards

1985 Fulbright Scholarship
1989 Ramaer Medaille
2009 Member Royal Netherlands Academy for Arts and Sciences

Research Output (1056)

A phase 3, multicenter study to assess the 1-year safety and tolerability of a combination of olanzapine and samidorphan in patients with schizophrenia:Results from the ENLIGHTEN-2 long-term extension

Kahn René S, Silverman Bernard L, DiPetrillo Lauren, Graham Christine, Jiang Ying, Yin Jiani, Simmons Adam, Bhupathi Vasudev, Yu Bei, Yagoda Sergey, Hopkinson Craig, McDonnell David 17 mei 2021, In: Schizophrenia Research. 232 , p. 45-53 9 p.

The role of depression in the prediction of a "late" remission in first-episode psychosis:An analysis of the OPTiMiSE study

Fraguas David, Díaz-Caneja Covadonga M, Pina-Camacho Laura, Winter van Rossum Inge, Baandrup Lone, Sommer Iris E, Glenthøj Birte, Kahn René S, Leucht Stefan, Arango Celso 7 apr 2021, In: Schizophrenia Research. 231 , p. 100-107 8 p.

In memoriam-Larry J. Siever, M.D

Davis Kenneth L, Kahn René S, New Antonia, Aronson Andrew 29 mrt 2021, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 46

The effect of prednisolone on symptom severity in schizophrenia:A placebo-controlled, randomized controlled trial

Nasib Lyliana G, Gangadin Shiral S, Rossum Inge Winter-van, Boudewijns Zimbo S R M, de Witte Lot D, Wilting Ingeborg, Luykx Jurjen, Somers Metten, Veen Natalie, van Baal Caroline, Kahn René S, Sommer Iris E 9 mrt 2021, In: Schizophrenia Research. 230 , p. 79-86 8 p.

Brain age prediction in schizophrenia:Does the choice of machine learning algorithm matter?

Lee Won Hee, Antoniades Mathilde, Schnack Hugo G, Kahn Rene S, Frangou Sophia 5 mrt 2021, In: Psychiatry Research - Neuroimaging. 310 8 p.

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

Hannon Eilis, Dempster Emma L, Mansell Georgina, Burrage Joe, Bass Nick, Bohlken Marc M, Corvin Aiden, Curtis Charles J, Dempster David, Di Forti Marta, Dinan Timothy G, Donohoe Gary, Gaughran Fiona, Gill Michael, Gillespie Amy, Gunasinghe Cerisse, Hulshoff Hilleke E, Hultman Christina M, Johansson Viktoria, Kahn René S, Kaprio Jaakko, Kenis Gunter, Kowalec Kaarina, MacCabe James, McDonald Colm, McQuillin Andrew, Morris Derek W, Murphy Kieran C, Mustard Colette J, Nenadic Igor, O'Donovan Michael C, Quattrone Diego, Richards Alexander L, Rutten Bart Pf, St Clair David, Therman Sebastian, Toulopoulou Timothea, Van Os Jim, Waddington John L, Sullivan Patrick, Vassos Evangelos, Breen Gerome, Collier David A, Murray Robin M, Schalwyk Leo, Mill Jonathan, 26 feb 2021, In: eLife. 10 , p. 1-53 53 p.

A comparison of depressive symptom profiles between current major depressive disorder and schizophrenia spectrum disorder

Lange Sjors M M, Schirmbeck Frederike, Stek Max L, Murk Jansen Yentl R, van Rooijen Geeske, de Haan Lieuwe, Penninx Brenda W J H, Rhebergen Didi, , Cahn Wiepke, van Os Jim, Kahn René 16 jan 2021, In: Journal of Psychiatric Research. 135 , p. 143-151 9 p.

A loss of mature microglial markers without immune activation in schizophrenia

Snijders Gijsje J.L.J., van Zuiden Welmoed, Sneeboer Marjolein A.M., Berdenis van Berlekom Amber, van der Geest Astrid T., Schnieder Tatiana, MacIntyre Donald J.M., Hol Elly M., Kahn René S., de Witte Lot D. 2021, In: GLIA. 69 , p. 1251-1267 17 p.

Relationship Between Serum NMDA Receptor Antibodies and Response to Antipsychotic Treatment in First-Episode Psychosis

Pollak Thomas A, Vincent Angela, Iyegbe Conrad, Coutinho Ester, Jacobson Leslie, Rujescu Dan, Stone James, Jezequel Julie, Rogemond Veronique, Jamain Stephane, Groc Laurent, David Anthony, Egerton Alice, Kahn Rene S, Honnorat Jerome, Dazzan Paola, Leboyer Marion, McGuire Philip 24 nov 2020, In: Biological Psychiatry. 90 , p. 9-15 7 p.

Symptom Remission and Brain Cortical Networks at First Clinical Presentation of Psychosis:The OPTiMiSE Study

Dazzan Paola, Lawrence Andrew J, Reinders Antje A T S, Egerton Alice, van Haren Neeltje E M, Merritt Kate, Barker Gareth J, Perez-Iglesias Rocio, Sendt Kyra-Verena, Demjaha Arsime, Nam Kie W, Sommer Iris E, Pantelis Christos, Wolfgang Fleischhacker W, van Rossum Inge Winter, Galderisi Silvana, Mucci Armida, Drake Richard, Lewis Shon, Weiser Mark, Martinez Diaz-Caneja Covadonga M, Janssen Joost, Diaz-Marsa Marina, Rodríguez-Jimenez Roberto, Arango Celso, Baandrup Lone, Broberg Brian, Rostrup Egill, Ebdrup Bjørn H, Glenthøj Birte, Kahn Rene S, McGuire Philip, 15 okt 2020, In: Schizophrenia bulletin. 47 , p. 444-455 12 p.

All research output

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