prof. dr. R.S. (René) Kahn

Full Professor

  • Psychiatry

prof. dr. R.S. (René) Kahn

Research Programs


Dr René Kahn is Professor and until 2017, was Chair of the Department of Psychiatry and Head of the Division of Neurosciences at the University Medical Center, Utrecht, The Netherlands. In 1995 he received a Fulbright Scholarship for study at Yale and subsequently did a Fellowship in Biological Psychiatry at the Montefiore Hospital and Albert Einstein College of Medicine in New York. He then moved to the Mount Sinai School of Medicine where he conducted schizophrenia research and became Unit Chief of one of the research units.

Dr Kahn has received many grants for his research into the origins and treatment of schizophrenia. His current research interests include neuroimaging in schizophrenia and the genetic dissection of complex traits in specific psychiatric disorders. He has published over 500 research papers and book chapters. He is on the editorial boards of Schizophrenia research, Schizophrenia Bulletin, Early Interventions in Psychiatry and European Neuropsychopharmacology. He was both Treasurer and Vice-President of the European College for Neuropsychopharmacology and currently is President-Elect of the Schizophrenia International Research Society. He sat on the Neuroscience andd Mental Health Board of the Medical Research Council of the UK and was on the scientific advisory group for CNS of the European Medicines Agency. He leads a large EU-funded study, OPTiMiSE, on developing a treatment algorithm in first episode schizophrenia. He is honorary lifetime professor at Jilin University in Changchun, P.R. China and a member of the Royal Netherlands Academy of Arts and Sciences.

As of January 2017, he is appointed head of the Department of Psychiatry at Icahn School of Medicine at Mount Sinai in New York. His main tasks at UMC Utrecht are now: coaching his PhD students and coordinating research projects.

Most recent key publications

1: Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE, EUFEST study group. E
2: van der Schot AC, Vonk R, Brans RG, van Haren NE, Koolschijn PC, Nuboer V, Schnack HG, van Baal GC, Boomsma DI, Nolen WA, Hulshoff Pol HE, Kahn RS. Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Arch Gen Psychiatry. 2009 Feb,66(2):142-51
3: van der Schot AC, Vonk R, Brouwer RM, van Baal GC, Brans RG, van Haren NE, Schnack HG, Boomsma DI, Nolen WA, Pol HE, Kahn RS. Genetic and environmental influences on focal brain density in bipolar disorder. Brain. 2010 Sep 12
4: van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS Changes in cortical thickness during the course of illness in schizophrenia Arch Gen Psychiatry. 2011 Sep,68(9):871-80
5: van Haren NE, Rijsdijk F, Schnack HG, Picchioni MM, Toulopoulou T, Weisbrod M, Sauer ,H, van Erp TG, Cannon TD, Huttunen MO, Boomsma DI, Hulshoff Pol HE, Murray RM, Kahn RS. The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium. Biol Psychiatry. 2012 May 15,71(10):915-21

Fellowship and Awards

  • 1985 Fulbright Scholarship
    1989 Ramaer Medaille
    2009 Member Royal Netherlands Academy for Arts and Sciences

Research Output (998)

The association between antibodies to neurotropic pathogens and bipolar disorder:A study in the Dutch Bipolar (DB) Cohort and meta-analysis

Snijders Gijsje J.L.J., van Mierlo Hans C., Boks Marco P., Begemann Marieke J.H., Sutterland Arjen L., Litjens Manja, Ophoff Roel A., Kahn René S., de Witte Lot D. 20 nov 2019, In: Translational Psychiatry. 9 13 p.

Comparative genetic architectures of schizophrenia in East Asian and European populations

Lam Max, Chen Chia-Yen, Li Zhiqiang, Martin Alicia R, Bryois Julien, Ma Xixian, Gaspar Helena, Ikeda Masashi, Benyamin Beben, Brown Brielin C, Liu Ruize, Zhou Wei, Guan Lili, Kamatani Yoichiro, Kim Sung-Wan, Kubo Michiaki, Kusumawardhani Agung A A A, Liu Chih-Min, Ma Hong, Periyasamy Sathish, Takahashi Atsushi, Xu Zhida, Yu Hao, Zhu Feng, Chen Wei J, Faraone Stephen, Glatt Stephen J, He Lin, Hyman Steven E, Hwu Hai-Gwo, McCarroll Steven A, Neale Benjamin M, Sklar Pamela, Wildenauer Dieter B, Yu Xin, Zhang Dai, Mowry Bryan J, Lee Jimmy, Holmans Peter, Xu Shuhua, Sullivan Patrick F, Ripke Stephan, O'Donovan Michael C, Daly Mark J, Qin Shengying, Sham Pak, Iwata Nakao, Hong Kyung S, Schwab Sibylle G, Kahn René S, 18 nov 2019, In: Nature Genetics. 51 , p. 1670-1678 9 p.

Functional connectome of the fetal brai

Turk Elise, van den Heuvel Marion I., Benders Manon J., de Heus Roel, Franx Arie, Manning Janessa H., Hect Jasmine L., Hernandez-Andrade Edgar, Hassan Sonia S., Romero Roberto, Kahn René S., Thomason Moriah E., van den Heuvel Martijn P. 4 nov 2019, In: Journal of Neuroscience. 39 , p. 9716-9724 9 p.

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal Claudia L., Adams Hieab H.H., Hibar Derrek P., White Charles C., Knol Maria J., Stein Jason L., Scholz Markus, Sargurupremraj Muralidharan, Jahanshad Neda, Roshchupkin Gennady V., Smith Albert V., Bis Joshua C., Jian Xueqiu, Luciano Michelle, Hofer Edith, Teumer Alexander, van der Lee Sven J., Yang Jingyun, Yanek Lisa R., Lee Tom V., Li Shuo, Hu Yanhui, Koh Jia Yu, Eicher John D., Desrivières Sylvane, Arias-Vasquez Alejandro, Chauhan Ganesh, Athanasiu Lavinia, Rentería Miguel E., Kim Sungeun, Hoehn David, Armstrong Nicola J., Chen Qiang, Holmes Avram J., den Braber Anouk, Kloszewska Iwona, Andersson Micael, Abramovic Lucija, Bohlken Marc M., Klein Marieke, Boks Marco P., van Eijk Kristel R., Cahn Wiepke, Hulshoff Pol Hilleke E., Ikram M. Kamran, Brouwer Rachel M., Kahn René S., Ophoff Roel A., van Haren Neeltje E.M., Schmidt Reinhold, 1 nov 2019, In: Nature Genetics. 51 , p. 1624-1636 13 p.

Connectome-Based Patterns of First-Episode Medication-Naive Patients With Schizophrenia

Cui Long Biao, Wei Yongbin, Xi Yi Bin, Griffa Alessandra, De Lange Siemon C., Kahn René S., Yin Hong, Van Den Heuvel Martijn P. nov 2019, In: Schizophrenia Bulletin. 45 , p. 1291-1299 9 p.

Multiscale Neuroscience of Psychiatric Disorders

van den Heuvel Martijn P, Scholtens Lianne H, Kahn René S 1 okt 2019, In: Biological Psychiatry. 86 , p. 512-522 11 p.

B-cells and schizophrenia:A promising link or a finding lost in translation?

van Mierlo Hans C, Broen Jasper C A, Kahn René S, de Witte Lot D okt 2019, In: Brain, Behavior, and Immunity. 81 , p. 52-62 11 p.

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

van Leeuwen Judith M. C., Vinkers C. H., Vink M., Kahn R. S., Joels M., Hermans E. J. sep 2019, In: Psychoneuroendocrinology. 107 , p. 65-65

Phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients (from the OPTiMiSE cohort)

Pandit R, Cianci D, Ter Hark S E, Winter-van Rossum I, Ebdrup B H, Broberg B V, Garcia-Portilla M P, Bobes J, Vinkers C H, Kahn R S, Guloksuz S, Huitema A D R, Luykx J J sep 2019, In: Acta Psychiatrica Scandinavica. 140 , p. 283-290 8 p.

Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

de Lange Siemon C., Scholtens Lianne H., van den Berg Leonard H., Boks Marco P., Bozzali Marco, Cahn Wiepke, Dannlowski Udo, Durston Sarah, Geuze Elbert, van Haren Neeltje E.M., Hillegers Manon H.J., Koch Kathrin, Jurado María Ángeles, Mancini Matteo, Marqués-Iturria Idoia, Meinert Susanne, Ophoff Roel A., Reess Tim J., Repple Jonathan, Kahn René S., van den Heuvel Martijn P., 5 aug 2019, In: NATURE HUMAN BEHAVIOUR. 3 , p. 988-998 11 p.

All Research Output (998)