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prof. dr. R.S. (René) Kahn

prof. dr. R.S. (René) Kahn

Full Professor
prof. dr. R.S. (René) Kahn
  • Psychiatry

Research Programs

Brain

Biography

Biography

Dr René Kahn is Professor and until 2017, was Chair of the Department of Psychiatry and Head of the Division of Neurosciences at the University Medical Center, Utrecht, The Netherlands. In 1995 he received a Fulbright Scholarship for study at Yale and subsequently did a Fellowship in Biological Psychiatry at the Montefiore Hospital and Albert Einstein College of Medicine in New York. He then moved to the Mount Sinai School of Medicine where he conducted schizophrenia research and became Unit Chief of one of the research units.

Dr Kahn has received many grants for his research into the origins and treatment of schizophrenia. His current research interests include neuroimaging in schizophrenia and the genetic dissection of complex traits in specific psychiatric disorders. He has published over 500 research papers and book chapters. He is on the editorial boards of Schizophrenia research, Schizophrenia Bulletin, Early Interventions in Psychiatry and European Neuropsychopharmacology. He was both Treasurer and Vice-President of the European College for Neuropsychopharmacology and currently is President-Elect of the Schizophrenia International Research Society. He sat on the Neuroscience andd Mental Health Board of the Medical Research Council of the UK and was on the scientific advisory group for CNS of the European Medicines Agency. He leads a large EU-funded study, OPTiMiSE, on developing a treatment algorithm in first episode schizophrenia. He is honorary lifetime professor at Jilin University in Changchun, P.R. China and a member of the Royal Netherlands Academy of Arts and Sciences.

As of January 2017, he is appointed head of the Department of Psychiatry at Icahn School of Medicine at Mount Sinai in New York. His main tasks at UMC Utrecht are now: coaching his PhD students and coordinating research projects.

Most recent key publications

1: Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE, EUFEST study group. E
2: van der Schot AC, Vonk R, Brans RG, van Haren NE, Koolschijn PC, Nuboer V, Schnack HG, van Baal GC, Boomsma DI, Nolen WA, Hulshoff Pol HE, Kahn RS. Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Arch Gen Psychiatry. 2009 Feb,66(2):142-51
3: van der Schot AC, Vonk R, Brouwer RM, van Baal GC, Brans RG, van Haren NE, Schnack HG, Boomsma DI, Nolen WA, Pol HE, Kahn RS. Genetic and environmental influences on focal brain density in bipolar disorder. Brain. 2010 Sep 12
4: van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS Changes in cortical thickness during the course of illness in schizophrenia Arch Gen Psychiatry. 2011 Sep,68(9):871-80
5: van Haren NE, Rijsdijk F, Schnack HG, Picchioni MM, Toulopoulou T, Weisbrod M, Sauer ,H, van Erp TG, Cannon TD, Huttunen MO, Boomsma DI, Hulshoff Pol HE, Murray RM, Kahn RS. The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium. Biol Psychiatry. 2012 May 15,71(10):915-21

Side Activities

Chair of the Division of Psychiatry at the Icahn School of Medicine of Mount Sinai (ISMMS) in New York, Icahn School of Medicine at Mount Sinai (ISMMS) since January 1st 2017.

 

Fellowship and Awards

1985 Fulbright Scholarship
1989 Ramaer Medaille
2009 Member Royal Netherlands Academy for Arts and Sciences

Research Output (1103)

Cognitive dysfunction in schizophrenia:An expert group paper on the current state of the art

Harvey Philip D., Bosia Marta, Cavallaro Roberto, Howes Oliver D., Kahn René S., Leucht Stefan, Müller Daniel R., Penadés Rafael, Vita Antonio Sep 2022, In: Schizophrenia Research: Cognition. 29 , p. 1-13 13 p.

Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function

Haas Shalaila S, Doucet Gaelle E, Antoniades Mathilde, Modabbernia Amirhossein, Corcoran Cheryl M, Kahn René S, Kambeitz Joseph, Kambeitz-Ilankovic Lana, Borgwardt Stefan, Brambilla Paolo, Upthegrove Rachel, Wood Stephen J, Salokangas Raimo K R, Hietala Jarmo, Meisenzahl Eva, Koutsouleris Nikolaos, Frangou Sophia Sep 2022, In: Schizophrenia Research: Cognition. 29 , p. 100252

Powerful eQTL mapping through low-coverage RNA sequencing

Schwarz Tommer, Boltz Toni, Hou Kangcheng, Bot Merel, Duan Chenda, Loohuis Loes Olde, Boks Marco P, Kahn René S, Ophoff Roel A, Pasaniuc Bogdan 14 Jul 2022, In: HGG advances. 3 , p. 1-12

Olanzapine/samidorphan in young adults with schizophrenia, schizophreniform disorder, or bipolar I disorder who are early in their illness: Results of the enlighten-early study

Kahn Rene S., Correll Christoph, Kane John M., Arevalo Christina, Simmons Adam, Graham Christine, Yagoda Sergey, McDonnell David Jul 2022, In: Bipolar Disorders. 24 , p. 29-29

Accelerated Global and Local Brain Aging Differentiate Cognitively Impaired From Cognitively Spared Patients With Schizophrenia

Haas Shalaila S., Ge Ruiyang, Sanford Nicole, Modabbernia Amirhossein, Reichenberg Abraham, Whalley Heather C., Kahn René S., Frangou Sophia 22 Jun 2022, In: Frontiers in Psychiatry. 13

The Association Between Emotion Recognition, Affective Empathy, and Structural Connectivity in Schizophrenia Patients

Koevoets Martijn G.J.C., Prikken Merel, Hagenaar Doesjka A., Kahn René S., van Haren Neeltje E.M. 15 Jun 2022, In: Frontiers in Psychiatry. 13

Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model

Berdenis van Berlekom Amber, Kübler Raphael, Hoogeboom Jeske W, Vonk Daniëlle, Sluijs Jacqueline A, Pasterkamp R Jeroen, Middeldorp Jinte, Kraneveld Aletta D, Garssen Johan, Kahn René S, Hol Elly M, de Witte Lot D, Boks Marco P 2 May 2022, In: Nutrients. 14 , p. 1-19

Schizophrenia and Bipolar Polygenic Risk Scores in Relation to Intracranial Volume

de Zwarte Sonja M C, Brouwer Rachel M, Kahn René S, van Haren Neeltje E M 14 Apr 2022, In: Genes. 13

Scalability of the Positive and Negative Syndrome Scale in first-episode schizophrenia assessed by Rasch models

Baandrup Lone, Allerup Peter, Nielsen Mette Ø, Düring Signe W, Bojesen Kirsten B, Leucht Stefan, Galderisi Silvana, Mucci Armida, Bucci Paola, Arango Celso, Díaz-Caneja Covadonga M, Dazzan Paola, McGuire Philip, Demjaha Arsime, Ebdrup Bjørn H, Fleischhacker Wolfgang W, Kahn René S, Glenthøj Birte Y 13 Apr 2022, In: Acta Psychiatrica Scandinavica. 146 , p. 21-35 15 p.

Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia

Palmer Duncan S, Howrigan Daniel P, Chapman Sinéad B, Adolfsson Rolf, Bass Nick, Blackwood Douglas, Boks Marco P M, Chen Chia-Yen, Churchhouse Claire, Corvin Aiden P, Craddock Nicholas, Curtis David, Di Florio Arianna, Dickerson Faith, Freimer Nelson B, Goes Fernando S, Jia Xiaoming, Jones Ian, Jones Lisa, Jonsson Lina, Kahn Rene S, Landén Mikael, Locke Adam E, McIntosh Andrew M, McQuillin Andrew, Morris Derek W, O'Donovan Michael C, Ophoff Roel A, Owen Michael J, Pedersen Nancy L, Posthuma Danielle, Reif Andreas, Risch Neil, Schaefer Catherine, Scott Laura, Singh Tarjinder, Smoller Jordan W, Solomonson Matthew, Clair David St, Stahl Eli A, Vreeker Annabel, Walters James T R, Wang Weiqing, Watts Nicholas A, Yolken Robert, Zandi Peter P, Neale Benjamin M 11 Apr 2022, In: Nature Genetics. 54 , p. 541-547 7 p.

All research output

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