prof. dr. R.S. (René) Kahn

prof. dr. R.S. (René) Kahn

Full Professor
prof. dr. R.S. (René) Kahn
  • Psychiatry

Research Programs




Dr René Kahn is Professor and until 2017, was Chair of the Department of Psychiatry and Head of the Division of Neurosciences at the University Medical Center, Utrecht, The Netherlands. In 1995 he received a Fulbright Scholarship for study at Yale and subsequently did a Fellowship in Biological Psychiatry at the Montefiore Hospital and Albert Einstein College of Medicine in New York. He then moved to the Mount Sinai School of Medicine where he conducted schizophrenia research and became Unit Chief of one of the research units.

Dr Kahn has received many grants for his research into the origins and treatment of schizophrenia. His current research interests include neuroimaging in schizophrenia and the genetic dissection of complex traits in specific psychiatric disorders. He has published over 500 research papers and book chapters. He is on the editorial boards of Schizophrenia research, Schizophrenia Bulletin, Early Interventions in Psychiatry and European Neuropsychopharmacology. He was both Treasurer and Vice-President of the European College for Neuropsychopharmacology and currently is President-Elect of the Schizophrenia International Research Society. He sat on the Neuroscience andd Mental Health Board of the Medical Research Council of the UK and was on the scientific advisory group for CNS of the European Medicines Agency. He leads a large EU-funded study, OPTiMiSE, on developing a treatment algorithm in first episode schizophrenia. He is honorary lifetime professor at Jilin University in Changchun, P.R. China and a member of the Royal Netherlands Academy of Arts and Sciences.

As of January 2017, he is appointed head of the Department of Psychiatry at Icahn School of Medicine at Mount Sinai in New York. His main tasks at UMC Utrecht are now: coaching his PhD students and coordinating research projects.

Most recent key publications

1: Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE, EUFEST study group. E
2: van der Schot AC, Vonk R, Brans RG, van Haren NE, Koolschijn PC, Nuboer V, Schnack HG, van Baal GC, Boomsma DI, Nolen WA, Hulshoff Pol HE, Kahn RS. Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Arch Gen Psychiatry. 2009 Feb,66(2):142-51
3: van der Schot AC, Vonk R, Brouwer RM, van Baal GC, Brans RG, van Haren NE, Schnack HG, Boomsma DI, Nolen WA, Pol HE, Kahn RS. Genetic and environmental influences on focal brain density in bipolar disorder. Brain. 2010 Sep 12
4: van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS Changes in cortical thickness during the course of illness in schizophrenia Arch Gen Psychiatry. 2011 Sep,68(9):871-80
5: van Haren NE, Rijsdijk F, Schnack HG, Picchioni MM, Toulopoulou T, Weisbrod M, Sauer ,H, van Erp TG, Cannon TD, Huttunen MO, Boomsma DI, Hulshoff Pol HE, Murray RM, Kahn RS. The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium. Biol Psychiatry. 2012 May 15,71(10):915-21

Side Activities

Chair of the Division of Psychiatry at the Icahn School of Medicine of Mount Sinai (ISMMS) in New York, Icahn School of Medicine at Mount Sinai (ISMMS) since January 1st 2017.


Fellowship and Awards

1985 Fulbright Scholarship
1989 Ramaer Medaille
2009 Member Royal Netherlands Academy for Arts and Sciences

Research Output (1127)

The use of long-acting injectables in early-phase schizophrenia - Authors' reply

Fleischhacker W Wolfgang, Winter-van Rossum Inge, Kahn René S Jul 2023, In: The lancet. Psychiatry. 10 , p. 482-483 2 p.

Cell type deconvolution of bulk blood RNA-Seq to reveal biological insights of neuropsychiatric disorders

Boltz Toni, Schwarz Tommer, Bot Merel, Hou Kangcheng, Caggiano Christa, Lapinska Sandra, Duan Chenda, Boks Marco P, Kahn Rene S, Zaitlen Noah, Pasaniuc Bogdan, Ophoff Roel 25 May 2023,

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Hsu Yu Han H., Pintacuda Greta, Liu Ruize, Nacu Eugeniu, Kim April, Tsafou Kalliopi, Petrossian Natalie, Crotty William, Suh Jung Min, Riseman Jackson, Martin Jacqueline M., Biagini Julia C., Mena Daya, Ching Joshua K.T., Malolepsza Edyta, Li Taibo, Singh Tarjinder, Ge Tian, Egri Shawn B., Tanenbaum Benjamin, Stanclift Caroline R., Apffel Annie M., Ripke Stephan, Neale Benjamin M., Corvin Aiden, Walters James T.R., Farh Kai How, Holmans Peter A., Lee Phil, Bulik-Sullivan Brendan, Collier David A., Huang Hailiang, Pers Tune H., Agartz Ingrid, Agerbo Esben, Albus Margot, Alexander Madeline, Amin Farooq, Bacanu Silviu A., Begemann Martin, Belliveau Richard A., Bene Judit, Bergen Sarah E., Bevilacqua Elizabeth, Cahn Wiepke, Kahn René S., Van Os Jim, Ophoff Roel A., Weinberger Daniel R., Kahn René S., , , , 19 May 2023, In: iScience. 26

Gene expression profiling of monocytes in recent-onset schizophrenia

Kübler Raphael, Ormel Paul R, Sommer Iris E C, Kahn René S, de Witte Lot D 5 May 2023, In: Brain, Behavior, and Immunity. 111 , p. 334-342 9 p.

Development of the PSYCHS:Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS

Woods Scott W, Parker Sophie, Kerr Melissa J, Walsh Barbara C, Wijtenburg S Andrea, Prunier Nicholas, Nunez Angela R, Buccilli Kate, Mourgues-Codern Catalina, Brummitt Kali, Kinney Kyle S, Trankler Carli, Szacilo Julia, Colton Beau-Luke, Ali Munaza, Haidar Anastasia, Billah Tashrif, Huynh Kevin, Ahmed Uzair, Adery Laura L, Corcoran Cheryl M, Perkins Diana O, Schiffman Jason, Perez Jesus, Mamah Daniel, Ellman Lauren M, Powers Albert R, Coleman Michael J, Anticevic Alan, Fusar-Poli Paolo, Kane John M, Kahn Rene S, McGorry Patrick D, Bearden Carrie E, Shenton Martha E, Nelson Barnaby, Calkins Monica E, Hendricks Larry, Bouix Sylvain, Addington Jean, McGlashan Thomas H, Yung Alison R, Allott Kelly, Clark Scott R, Kapur Tina, Lavoie S, Lewandowski Kathryn E, Mathalon Daniel H, Pasternak Ofer, Stone William S, 2 May 2023, In: medRxiv.

Olanzapine/Samidorphan in Young Adults With Schizophrenia, Schizophreniform Disorder, or Bipolar I Disorder Who Are Early in Their Illness:Results of the Randomized, Controlled ENLIGHTEN-Early Study

Kahn René S, Kane John M, Correll Christoph U, Arevalo Christina, Simmons Adam, Graham Christine, Yagoda Sergey, Hu Beibei, McDonnell David May 2023, In: The Journal of clinical psychiatry. 84

Assessment of Neuroanatomical Endophenotypes of Autism Spectrum Disorder and Association With Characteristics of Individuals With Schizophrenia and the General Population

Hwang Gyujoon, Wen Junhao, Sotardi Susan, Brodkin Edward S, Chand Ganesh B, Dwyer Dominic B, Erus Guray, Doshi Jimit, Singhal Pankhuri, Srinivasan Dhivya, Varol Erdem, Sotiras Aristeidis, Dazzan Paola, Kahn Rene S, Schnack Hugo G, Zanetti Marcus V, Meisenzahl Eva, Busatto Geraldo F, Crespo-Facorro Benedicto, Pantelis Christos, Wood Stephen J, Zhuo Chuanjun, Shinohara Russell T, Shou Haochang, Fan Yong, Di Martino Adriana, Koutsouleris Nikolaos, Gur Raquel E, Gur Ruben C, Satterthwaite Theodore D, Wolf Daniel H, Davatzikos Christos 5 Apr 2023, In: JAMA Psychiatry. 80 , p. 498-507 10 p.

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Schijven Dick, Postema Merel C., Fukunaga Masaki, Matsumoto Junya, Miura Kenichiro, de Zwarte Sonja M.C., van Haren Neeltje E.M., Cahn Wiepke, Hulshoff Pol Hilleke E., Kahn René S., Ayesa-Arriola Rosa, Ortiz-García de la Foz Víctor, Tordesillas-Gutierrez Diana, Vázquez-Bourgon Javier, Crespo-Facorro Benedicto, Alnæs Dag, Dahl Andreas, Westlye Lars T., Agartz Ingrid, Andreassen Ole A., Jönsson Erik G., Kochunov Peter, Bruggemann Jason M., Catts Stanley V., Michie Patricia T., Mowry Bryan J., Quidé Yann, Rasser Paul E., Schall Ulrich, Scott Rodney J., Carr Vaughan J., Green Melissa J., Henskens Frans A., Loughland Carmel M., Pantelis Christos, Weickert Cynthia Shannon, Weickert Thomas W., de Haan Lieuwe, Brosch Katharina, Pfarr Julia Katharina, Ringwald Kai G., Stein Frederike, Jansen Andreas, Kircher Tilo T.J., Nenadić Igor, Krämer Bernd, Gruber Oliver, Satterthwaite Theodore D., Bustillo Juan, Janssen Joost, 4 Apr 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120

Generalizability of the Results of Efficacy Trials in First-Episode Schizophrenia:Comparing Outcome and Study Discontinuation of Groups of Participants in the Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) Trial

Nasib Lyliana G, Winter-van Rossum Inge, Zuithoff Nicolaas P A, Boudewijns Zimbo S R M, Leucht Stefan, Kahn René S 29 Mar 2023, In: The Journal of clinical psychiatry. 84 10 p.

Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis:A Longitudinal Analysis of the OPTiMiSE Clinical Trial

Susai Subash Raj, Föcking Melanie, Mongan David, Heurich Meike, Coutts Fiona, Egerton Alice, Whetton Tony, Winter-van Rossum Inge, Unwin Richard D, Pollak Thomas A, Weiser Mark, Leboyer Marion, Rujescu Dan, Byrne Jonah F, Gifford George W, Dazzan Paola, Koutsouleris Nikolaos, Kahn René S, Cotter David R, McGuire Philip 14 Mar 2023, In: Schizophrenia bulletin. 49 , p. 893-902 10 p.

All research output

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