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prof. dr. L.J. (Jaap) Kappelle

prof. dr. L.J. (Jaap) Kappelle

Full Professor
prof. dr. L.J. (Jaap) Kappelle
  • Neurologen

Research Programs

Biography

Biography

Jaap Kappelle was registered as a clinical neurologist in 1988. He obtained his PhD degree in Utrecht (1990) with Jan van Gijn. He carried out postdoctoral research at the University of Iowa, Iowa City, USA (1991) and the John P. Robarts Research Institute, London (Ontario) Canada (1998). He was appointed assistant professor at the University Utrecht in 1988, associate professor in 1994 and full professor in 2000.  He is former head of the department of cerebrovascular diseases of the University Medical Centre (UMC) Utrecht (2011-2020). As of 2020 he has been appointed medicale safety officer of the UMCU.

His research is embedded in the research lines 'Circulatory Health' and 'Brain' of the UMCU in close collaboration with the departments of neurosurgery, radiology, vascular medicine, vascular surgery, rehabilitation, clinical epidemiology, primary health care and neuropsychology. His current line of research concerns stroke, in particular the diagnosis, treatment and prognosis of patients with TIA or ischaemic stroke. As part of his research activities he is member of steering committees of reserrch programs embedded in 'Cardio-Vasculair Onderzoek Nederland' and serves as expert adjucation panelmeber of several clinical trials.

He is founding president of the Dutch Neurovascular Society. He is a member of the education committee if the Dutch Neurological Society and Dutch delegate for stroke of the European Association of Neurology. Besides his regular education duties in the UMC Utrecht, he is member of the board of supervisors of the Medical student Societÿ 'MSFU SAMS)

Jaap Kappelle is member elect of the European Stroke Council, the World Stroke Organisation and premium professional silver heart memeber  of the American Heart Associatiuon. He holds also memberships of the Dutch Society of Neurology, the Dutch Vascular Society, the European Association of Neurology, the Royal Dutch Association of Medicine and the Dutch Society of Medical Litigation Assessments.

He serves as neutral expert for different courts, insurance companies and health care organisations. 

Research line

Cerebrovascular diseases

publications

https://pubmed.ncbi.nlm.nih.gov/?term=Kappelle+LJ&sort=pubdate

https://pubmed.ncbi.nlm.nih.gov/?term=Kapelle+LJ&sort=pubdate

https://pubmed.ncbi.nlm.nih.gov/?term=Kappelle+J&sort=pubdate

Side Activities

As mentioned in the Biography.

Research Output (899)

Antitrombotica ter preventie van cardiovasculaire complicaties:De voor- en nadelen van ‘dual pathway inhibition’

Nugteren Michael J., de Borst Gert J., van den Broek Wout W.A., Ten Berg Jur M., Kappelle L. Jaap, Ünlü Çağdaş 22 Jun 2022, In: Nederlands Tijdschrift voor Geneeskunde. 166 , p. 1-8

Screen-detected abnormal ankle brachial index:A risk indicator for future cardiovascular morbidity and mortality in patients with manifest cardiovascular disease

Jagt Vivianne L., Hazenberg Constantijn E.V.B., Kapelle Jaap, Cramer Maarten J., Visseren Frank L.J., Westerink Jan 10 Mar 2022, In: PLoS ONE. 17 , p. 1-17

A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease

Kuipers Sanne, Overmars L Malin, van Es Bram, de Bresser Jeroen, Bron Esther E, Hoefer Imo E, Kappelle L Jaap, Teunissen Charlotte E, Biessels Geert Jan, Haitjema Saskia 27 Jan 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42 , p. 1282-1293 12 p.

Network impact score is an independent predictor of post-stroke cognitive impairment:A multicenter cohort study in 2341 patients with acute ischemic stroke

Biesbroek J Matthijs, Weaver Nick A, Aben Hugo P, Kuijf Hugo J, Abrigo Jill, Bae Hee-Joon, Barbay Mélanie, Best Jonathan G, Bordet Régis, Chappell Francesca M, Chen Christopher P L H, Dondaine Thibaut, van der Giessen Ruben S, Godefroy Olivier, Gyanwali Bibek, Hamilton Olivia K L, Hilal Saima, Huenges Wajer Irene M C, Kang Yeonwook, Kappelle L Jaap, Kim Beom Joon, Köhler Sebastian, de Kort Paul L M, Koudstaal Peter J, Kuchcinski Gregory, Lam Bonnie Y K, Lee Byung-Chul, Lee Keon-Joo, Lim Jae-Sung, Lopes Renaud, Makin Stephen D J, Mendyk Anne-Marie, Mok Vincent C T, Oh Mi Sun, van Oostenbrugge Robert J, Roussel Martine, Shi Lin, Staals Julie, Valdés-Hernández Maria Del C, Venketasubramanian Narayanaswamy, Verhey Frans R J, Wardlaw Joanna M, Werring David J, Xin Xu, Yu Kyung-Ho, van Zandvoort Martine J E, Zhao Lei, Biessels Geert Jan 2022, In: NeuroImage. Clinical. 34 , p. 1-7

Perforating artery flow velocity and pulsatility in patients with carotid occlusive disease. A 7 tesla MRI study

Onkenhout L. P., Arts Tine, Ferro D., Oudeman E. A., van Osch M. J.P., Zwanenburg J. J.M., Hendrikse J., Kappelle L. J., Biessels G. J., 2022, In: Cerebral Circulation - Cognition and Behavior. 3 , p. 1-7

Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes

Sharif Shahnam, Van der Graaf Y, Cramer M J, Kapelle L J, de Borst G J, Visseren Frank L J, Westerink Jan, 9 Nov 2021, In: Cardiovascular Diabetology. 20 , p. 1-8

Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19:A Multicenter Cohort Study

Sluis Wouter M, Linschoten Marijke, Buijs Julie E, Biesbroek J Matthijs, den Hertog Heleen M, Ribbers Tessa, Nieuwkamp Dennis J, van Houwelingen Reinier C, Dias Andreas, van Uden Ingeborg W M, Kerklaan Joost P, Bienfait H Paul, Vermeer Sarah E, de Jong Sonja W, Ali Mariam, Wermer Marieke J H, de Graaf Marieke T, Brouwers Paul J A M, Asselbergs Folkert W, Kappelle L Jaap, van der Worp H Bart, Algra Annemijn M, 4 Nov 2021, In: Stroke. 52 , p. 3978-3986 9 p.

Sex Differences in Risk Profile, Stroke Cause and Outcome in Ischemic Stroke Patients With and Without Migraine

Linstra Katie M., van Os Hendrikus J.A., Ruigrok Ynte M., Nederkoorn Paul J., van Dijk Ewoud J., Kappelle L. Jaap, Koudstaal Peter J., Visser Marieke C., Ferrari Michel D., MaassenVanDenBrink Antoinette, Terwindt Gisela M., Wermer Marieke J.H., 3 Nov 2021, In: Frontiers in Neuroscience. 15 , p. 1-7 7 p.

Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF):a randomised, open-label, phase 2 trial

Schreuder Floris H B M, van Nieuwenhuizen Koen M, Hofmeijer Jeannette, Vermeer Sarah E, Kerkhoff Henk, Zock Elles, Luijckx Gert-Jan, Messchendorp Gert P, van Tuijl Julia, Bienfait H Paul, Booij Suzanne J, van den Wijngaard Ido R, Remmers Michel J M, Schreuder Antonia H C M L, Dippel Diederik W, Staals Julie, Brouwers Paul J A M, Wermer Marieke J H, Coutinho Jonathan M, Kwa Vincent I H, van Gelder Isabelle C, Schutgens Roger E G, Zweedijk Berber, Algra Ale, van Dalen Jan Willem, Jaap Kappelle L, Rinkel Gabriel J E, van der Worp H Bart, Klijn Catharina J M, Nov 2021, In: The Lancet. Neurology. 20 , p. 907-916 10 p.

Sex and Cardiovascular Function in Relation to Vascular Brain Injury in Patients with Cognitive Complaints

Kuipers Sanne, Biessels Geert Jan, Greving Jacoba P, Amier Raquel P, de Bresser Jeroen, Bron Esther E, van der Flier Wiesje M, van der Geest Rob J, Hooghiemstra Astrid M, van Oostenbrugge Robert J, van Osch Matthias J P, Kappelle L Jaap, Exalto Lieza G, 26 Oct 2021, In: Journal of Alzheimer's Disease. 84 , p. 261-271 11 p.

All research output

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