prof. dr. L.J. (Jaap) Kappelle

prof. dr. L.J. (Jaap) Kappelle

Full Professor
prof. dr. L.J. (Jaap) Kappelle
  • Neurologen

Research Programs



Jaap Kappelle was registered as a clinical neurologist in 1988. He obtained his PhD degree in Utrecht (1990) with Jan van Gijn. He carried out postdoctoral research at the University of Iowa, Iowa City, USA (1991) and the John P. Robarts Research Institute, London (Ontario) Canada (1998). He was appointed assistant professor at the University Utrecht in 1988, associate professor in 1994 and full professor in 2000.  He is former head of the department of cerebrovascular diseases of the University Medical Centre (UMC) Utrecht (2011-2020). As of 2020 he has been appointed medicale safety officer of the UMCU.

His research is embedded in the research lines 'Circulatory Health' and 'Brain' of the UMCU in close collaboration with the departments of neurosurgery, radiology, vascular medicine, vascular surgery, rehabilitation, clinical epidemiology, primary health care and neuropsychology. His current line of research concerns stroke, in particular the diagnosis, treatment and prognosis of patients with TIA or ischaemic stroke. As part of his research activities he is member of steering committees of reserrch programs embedded in 'Cardio-Vasculair Onderzoek Nederland' and serves as expert adjucation panelmeber of several clinical trials.

He is founding president of the Dutch Neurovascular Society. He is a member of the education committee if the Dutch Neurological Society and Dutch delegate for stroke of the European Association of Neurology. Besides his regular education duties in the UMC Utrecht, he is member of the board of supervisors of the Medical student Societÿ 'MSFU SAMS)

Jaap Kappelle is member elect of the European Stroke Council, the World Stroke Organisation and premium professional silver heart memeber  of the American Heart Associatiuon. He holds also memberships of the Dutch Society of Neurology, the Dutch Vascular Society, the European Association of Neurology, the Royal Dutch Association of Medicine and the Dutch Society of Medical Litigation Assessments.

He serves as neutral expert for different courts, insurance companies and health care organisations. 

Research line

Cerebrovascular diseases


Side Activities

As mentioned in the Biography.

Research Output (922)

Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH):prospective, individual participant data meta-analysis of randomised trials

Al-Shahi Salman Rustam, Stephen Jacqueline, Tierney Jayne F., Lewis Steff C., Newby David E., Parry-Jones Adrian R., White Philip M., Connolly Stuart J., Benavente Oscar R., Dowlatshahi Dar, Cordonnier Charlotte, Viscoli Catherine M., Sheth Kevin N., Kamel Hooman, Veltkamp Roland, Larsen Kristin T., Hofmeijer Jeannette, Kerkhoff Henk, Schreuder Floris H.B.M., Shoamanesh Ashkan, Klijn Catharina J.M., van der Worp H. Bart, Klug Didier, Casolla Barbara, Puy Laurent, Coffee Morgane, Kuchcinski Grégory, Labreuche Julien, van Nieuwenhuizen Koen M., Algra Ale, van Gelder Isabelle C., Kappelle L. Jaap, Rinkel Gabriel J.E., Schutgens Roger E.G., Khatri Pooja, Conwit Robin, Falcone Guido, Elm Jordan, Anderson Craig S., Song Lili, Pandian Jeyaraj, Hart Robert G., Sharma Mukul, Aref Hany, Tarhuni Wadea, Fabregas Joan Marti, Diener Hans Christoph, Endres Matthias, Lemmens Robin, Kwon Sun U., Dec 2023, In: The Lancet Neurology. 22 , p. 1140-1149 10 p.

Sex Differences in Poststroke Cognitive Impairment:A Multicenter Study in 2343 Patients With Acute Ischemic Stroke

Exalto Lieza G, Weaver Nick A, Kuijf Hugo J, Aben Hugo P, Bae Hee-Joon, Best Jonathan G, Bordet Régis, Chen Christopher P L H, van der Giessen Ruben S, Godefroy Olivier, Gyanwali Bibek, Hamilton Olivia K L, Hilal Saima, Huenges Wajer Irene M C, Kim Jonguk, Kappelle L Jaap, Kim Beom Joon, Köhler Sebastian, de Kort Paul L M, Koudstaal Peter J, Lim Jae-Sung, Makin Stephen D J, Mok Vincent C T, van Oostenbrugge Robert J, Roussel Martine, Staals Julie, Valdés-Hernández Maria Del C, Venketasubramanian Narayanaswamy, Verhey Frans R J, Wardlaw Joanna M, Werring David J, Xu Xin, van Zandvoort Martine J E, Biesbroek J Matthijs, Chappell Francesca M, Biessels Geert Jan 8 Aug 2023, In: Stroke. 54 , p. 2296-2303 8 p.

Temporal Trends and Determinants of Stroke Risk in Patients With Medically Treated Asymptomatic Carotid Stenosis

Poorthuis Michiel H F, Solomon Yoel, Herings Reinier A R, Visseren Frank L J, Kappelle L Jaap, Bots Michiel L, Rissanen Ina, de Borst Gert J 1 Jul 2023, In: Stroke. 54 , p. 1735-1749 15 p.

Lower haemoglobin concentrations are associated with impaired cognition in patients with carotid artery occlusion

Kuipers Sanne, Willemse Sean W, Greving Jacoba P, Bron Esther E, van Oostenbrugge Robert J, van Osch Matthias J P, Biessels Geert Jan, Kappelle L Jaap, 24 Jun 2023, In: Cerebral Circulation - Cognition and Behavior. 5 , p. 1-5 5 p.

Ischemic stroke recurrence and mortality in different imaging phenotypes of ischemic cerebrovascular disease:The SMART-MR Study

Lucci Carlo, Rissanen Ina, de Jong Pim A, Kappelle L Jaap, Hendrikse Jeroen, Geerlings Mirjam I Jun 2023, In: European Stroke Journal. 8 , p. 522-531 10 p.

Detection of Cardioembolic Sources With Nongated Cardiac Computed Tomography Angiography in Acute Stroke:Results From the ENCLOSE Study

Kauw Frans, Velthuis Birgitta K, Takx Richard A P, Guglielmo Marco, Cramer Maarten J, van Ommen Fasco, Bos Anneloes, Bennink Edwin, Marquering Henk A., Kappelle L Jaap, de Jong Hugo W A M, Dankbaar Jan W 13 Feb 2023, In: Stroke. 54 , p. 821-830 10 p.

Drivers of healthcare costs in patients with ischaemic stroke:a hospital-based retrospective cohort study

Mensing Liselore A., Kappelle L. Jaap, Koffijberg Hendrik, Ruigrok Ynte M. 3 Jan 2023, In: BMJ Open. 13

Twenty-four hour blood pressure variability and the prevalence and the progression of cerebral white matter hyperintensities

Starmans Naomi Lp, Wolters Frank J, Leeuwis Annebet E, Bron Esther E, Brunner La Rocca Hans-Peter, Staals Julie, Biessels Geert Jan, Kappelle L Jaap, 3 Jan 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43 , p. 801-811 11 p.

A research agenda for selective screening for asymptomatic carotid artery stenosis

Poorthuis Michiel H F, Kappelle L Jaap, de Borst Gert J 1 Jan 2023, In: International Journal of Cardiology. 370 , p. 421-422 2 p.

Safety and technical efficacy of early minimally invasive endoscopy-guided surgery for intracerebral haemorrhage:the Dutch Intracerebral haemorrhage Surgery Trial pilot study

Sondag Lotte, Schreuder Floris H.B.M., Pegge Sjoert A.H., Coutinho Jonathan, Dippel Diederik W.J., Janssen Paula M., Vandertop W. Peter, Boogaarts Hieronymus D., Dammers Ruben, Klijn Catharina J.M., Schreuder Floris H.B.M., Boiten Jelis, Brouwers Paul J.A.M., Coutinho Jonathan, den Hertog M. Heleen, Janssen Paula M., Jolink Wilmar M.T., Kappelle L. Jaap, Kho Kuan H., Koot Radboud W., de Kort Paul L.M., Moojen Wouter A., Nanda Dharmin, Teernstra Onno P.M., van der Pol Bram, de Ridder Inger R., Wermer Marieke J.H., van der Zwan Albert, Vandertop W. Peter, Boogaarts Hieronymus D., Dammers Ruben, Holl Dana, Can Anil, 2023, In: Acta Neurochirurgica. 165 , p. 1585-1596 12 p.

All research output

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