prof. dr. L.J. (Jaap) Kappelle

prof. dr. L.J. (Jaap) Kappelle

Full Professor
prof. dr. L.J. (Jaap) Kappelle
  • Neurologen

Research Programs



Jaap Kappelle was registered as a clinical neurologist in 1988. He obtained his PhD degree in Utrecht (1990) with Jan van Gijn. He carried out postdoctoral research at the University of Iowa, Iowa City, USA (1991) and the John P. Robarts Research Institute, London (Ontario) Canada (1998). He was appointed assistant professor at the University Utrecht in 1988, associate professor in 1994 and full professor in 2000.  He is former head of the department of cerebrovascular diseases of the University Medical Centre (UMC) Utrecht (2011-2020). As of 2020 he has been appointed medicale safety officer of the UMCU.

His research is embedded in the research lines 'Circulatory Health' and 'Brain' of the UMCU in close collaboration with the departments of neurosurgery, radiology, vascular medicine, vascular surgery, rehabilitation, clinical epidemiology, primary health care and neuropsychology. His current line of research concerns stroke, in particular the diagnosis, treatment and prognosis of patients with TIA or ischaemic stroke. As part of his research activities he is member of steering committees of reserrch programs embedded in 'Cardio-Vasculair Onderzoek Nederland' and serves as expert adjucation panelmeber of several clinical trials.

He is founding president of the Dutch Neurovascular Society. He is a member of the education committee if the Dutch Neurological Society and Dutch delegate for stroke of the European Association of Neurology. Besides his regular education duties in the UMC Utrecht, he is member of the board of supervisors of the Medical student Societÿ 'MSFU SAMS)

Jaap Kappelle is member elect of the European Stroke Council, the World Stroke Organisation and premium professional silver heart memeber  of the American Heart Associatiuon. He holds also memberships of the Dutch Society of Neurology, the Dutch Vascular Society, the European Association of Neurology, the Royal Dutch Association of Medicine and the Dutch Society of Medical Litigation Assessments.

He serves as neutral expert for different courts, insurance companies and health care organisations. 

Research line

Cerebrovascular diseases


Side Activities

As mentioned in the Biography.

Research Output (874)

Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes

Sharif Shahnam, Van der Graaf Y, Cramer M J, Kapelle L J, de Borst G J, Visseren Frank L J, Westerink Jan, 9 nov 2021, In: Cardiovascular Diabetology. 20 , p. 220

External applicability of SGLT2 inhibitor cardiovascular outcome trials to patients with type 2 diabetes and cardiovascular disease

Smidt Lisanne C.A., Visseren Frank L.J., de Ranitz-Greven Wendela L., Nathoe Hendrik M., Kappelle L. Jaap, de Borst Gert J., de Valk Harold W., Westerink Jan, 8 sep 2021, In: Cardiovascular Diabetology. 20

Clinical Response to Procedural Stroke Following Carotid Endarterectomy:A Delphi Consensus Study

Meershoek Armelle J A, de Waard Djurre D, Trappenburg Jaap, Zeebregts Clark J, Bulbulia Richard, Kappelle Jaap L J, de Borst Gert J, sep 2021, In: European Journal of Vascular and Endovascular Surgery. 62 , p. 350-357 8 p.

Apparent treatment resistant hypertension and the risk of recurrent cardiovascular events and mortality in patients with established vascular disease

Groenland Eline H, Bots Michiel L, Asselbergs Folkert W, de Borst Gert J, Kappelle L Jaap, Visseren Frank L J, Spiering Wilko, 1 jul 2021, In: International Journal of Cardiology. 334 , p. 135-141 7 p.

The diagnostic value of skin biopsies in Sneddon syndrome

Starmans N. L.P., Zoetemeyer S., van Dijk M. R., Kappelle L. J., Frijns C. J.M. 28 jun 2021, In: PLoS ONE. 16

Strategic infarct locations for post-stroke cognitive impairment:a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Weaver Nick A., Kuijf Hugo J., Aben Hugo P., Abrigo Jill, Bae Hee Joon, Barbay Mélanie, Best Jonathan G., Bordet Régis, Chappell Francesca M., Chen Christopher P.L.H., Dondaine Thibaut, van der Giessen Ruben S., Godefroy Olivier, Gyanwali Bibek, Hamilton Olivia K.L., Hilal Saima, Huenges Wajer Irene M.C., Kang Yeonwook, Kappelle L. Jaap, Kim Beom Joon, Köhler Sebastian, de Kort Paul L.M., Koudstaal Peter J., Kuchcinski Gregory, Lam Bonnie Y.K., Lee Byung Chul, Lee Keon Joo, Lim Jae Sung, Lopes Renaud, Makin Stephen D.J., Mendyk Anne Marie, Mok Vincent C.T., Oh Mi Sun, van Oostenbrugge Robert J., Roussel Martine, Shi Lin, Staals Julie, Del C Valdés-Hernández Maria, Venketasubramanian Narayanaswamy, Verhey Frans R.J., Wardlaw Joanna M., Werring David J., Xin Xu, Yu Kyung Ho, van Zandvoort Martine J.E., Zhao Lei, Biesbroek J. Matthijs, Biessels Geert Jan 23 apr 2021, In: Lancet Neurology. 20 , p. 448-459 12 p.

Comparison between EQ-5D-5L and PROMIS-10 to evaluate health-related quality of life 3 months after stroke:a cross-sectional multicenter study

de Graaf Joris A, Visser-Meily Johanna M, Schepers Vera P, Baars Annette, Kappelle L Jaap, Passier Patricia E, Wermer Marieke J, de Wit Daniëlle C, Post Marcel W 15 jan 2021, In: European Journal of Physical and Rehabilitation Medicine. 57 , p. 337-346 10 p.

Effect of intravenous thrombolysis in stroke depends on pattern of intracranial internal carotid artery calcification

Kauw Frans, de Jong Pim A, Takx Richard A P, de Jong Hugo W A M, Kappelle L Jaap, Velthuis Birgitta K, Dankbaar Jan W, jan 2021, In: Atherosclerosis. 316 , p. 8-14 7 p.

Sneddon syndrome: a comprehensive clinical review of 53 patients

Starmans N L P, van Dijk M R, Kappelle L J, Frijns C J M 2021, In: Journal of Neurology. 268 , p. 2450-2457 8 p.

Applicability of Blood Pressure-Lowering Drug Trials to Real-World Patients With Cardiovascular Disease

Bonekamp Nadia E, Spiering Wilko, Nathoe Hendrik M, Kappelle L Jaap, de Borst Gert J, Visseren Frank L J, Westerink Jan, 2021, In: Hypertension (Dallas, Tex. : 1979). 77 , p. 357-366 10 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet