dr. W.P. (Wigard) Kloosterman
Associate Professor
- Group De Ridder, section Genetics
Contact
Research Output (88)
Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses
de Witte Chris Jenske, Espejo Valle-Inclan Jose, Hami Nizar, Lõhmussaar Kadi, Kopper Oded, Vreuls Celien Philomena Henrieke, Jonges Geertruida Nellie, van Diest Paul, Nguyen Luan, Clevers Hans, Kloosterman Wigard Pieter, Cuppen Edwin, Snippert Hugo Johannes Gerhardus, Zweemer Ronald Peter, Witteveen Petronella Oda, Stelloo Ellen 16 jun 2020, In: Cell Reports. 31 8 p.
Multi-contact 4C:long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies
Vermeulen Carlo, Allahyar Amin, Bouwman Britta A.M., Krijger Peter H.L., Verstegen Marjon J.A.M., Geeven Geert, Valdes-Quezada Christian, Renkens Ivo, Straver Roy, Kloosterman Wigard P., de Ridder Jeroen, de Laat Wouter 1 feb 2020, In: Nature Protocols. 15 , p. 364-397 34 p.
Prioritization of genes driving congenital phenotypes of patients with de novo genomic structural variants
Middelkamp Sjors, Vlaar Judith M, Giltay Jacques, Korzelius Jerome, Besselink Nicolle, Boymans Sander, Janssen Roel, de la Fonteijne Lisanne, van Binsbergen Ellen, van Roosmalen Markus J, Hochstenbach Ron, Giachino Daniela, Talkowski Michael E, Kloosterman Wigard P, Cuppen Edwin 4 dec 2019, In: Genome Medicine. 11
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene
Nersisyan Lilit, Nikoghosyan Maria, Arakelyan Arsen, Francioli Laurent C., Menelaou Androniki, Pulit Sara L., Elbers Clara C., Kloosterman Wigard P., van Setten Jessica, Nijman Isaäc J., Renkens Ivo, de Bakker Paul I.W., van Dijk Freerk, Neerincx Pieter B.T., Deelen Patrick, Kanterakis Alexandros, Dijkstra Martijn, Byelas Heorhiy, van der Velde K. Joeri, Platteel Mathieu, Swertz Morris A., Wijmenga Cisca, Palamara Pier Francesco, Pe’er Itsik, Ye Kai, Ye Kai, Lameijer Eric Wubbo, Moed Matthijs H., Beekman Marian, de Craen Anton J.M., Suchiman H. Eka D., Slagboom P. Eline, Guryev Victor, Abdellaoui Abdel, Jan Hottenga Jouke, Kattenberg Mathijs, Willemsen Gonneke, Boomsma Dorret I., van Leeuwen Elisabeth M., Karssen Lennart C., Amin Najaf, Rivadeneira Fernando, Isaacs Aaron, Hofman Albert, Uitterlinden André G., van Duijn Cornelia M., van Oven Mannis, Kayser Manfred, Veldink Jan H., van den Berg Leonard H., 1 dec 2019, In: Scientific Reports. 9
Micronuclei-based model system reveals functional consequences of chromothripsis in human cells
Kneissig M, Keuper K, de Pagter Mirjam, van Roosmalen Mark, Martin J, Otto H, Passerini V, Campos Sparr A, Renkens Ivo , Kropveld F, Vasudevan A, Sheltzer JM, Kloosterman Wigard, Storchova Zuzana 28 nov 2019, In: eLife. 8
Detection of disease causing repeats by multi-locus CRISPR-Cas enrichment and nanopore sequencing
Elferink M. G., Renkens I. J., Dooijes D., van Roosmalen M. J., Raimondeau E., Bowen R., Heron A. J., Graham J. E., van Amstel H. Ploos, Kloosterman W. P., van Gassen K. L. okt 2019, In: European Journal of Human Genetics. 27 , p. 1658-1658
Detection of disease causing repeats by multi-locus CRISPR-Cas enrichment and nanopore sequencing
Elferink Martin, Renkens Ivo , Dooijes Dennis, van Roosmalen Mark, Ploos van Amstel Hans Kristian, Kloosterman Wigard, van Gassen Koen 16 jun 2019,
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Kopper Oded, de Witte Chris J, Lõhmussaar Kadi, Valle-Inclan Jose Espejo, Hami Nizar, Kester Lennart, Balgobind Anjali Vanita, Korving Jeroen, Proost Natalie, Begthel Harry, van Wijk Lise M, Revilla Sonia Aristín, Theeuwsen Rebecca, van de Ven Marieke, van Roosmalen Markus J, Ponsioen Bas, Ho Victor W H, Neel Benjamin G, Bosse Tjalling, Gaarenstroom Katja N, Vrieling Harry, Vreeswijk Maaike P G, van Diest Paul J, Witteveen Petronella O, Jonges Trudy, Bos Johannes L, van Oudenaarden Alexander, Zweemer Ronald P, Snippert Hugo J G, Kloosterman Wigard P, Clevers Hans mei 2019, In: Nature Medicine. 25 , p. 838-849 12 p.
Skewed X-inactivation is common in the general female population
Shvetsova Ekaterina, Sofronova Alina, Monajemi Ramin, Gagalova Kristina, Draisma Harmen H.M., White Stefan J., Santen Gijs W.E., Chuva de Sousa Lopes Susana M., Heijmans Bastiaan T., van Meurs Joyce, Jansen Rick, Franke Lude, Kiełbasa Szymon M., den Dunnen Johan T., ‘t Hoen Peter A.C., Heijmans Bastiaan T., ’t Hoen Peter Ac, van Meurs Joyce, Boomsma Dorret I., Pool René, van Dongen Jenny, Hottenga Jouke J., van Greevenbroek Marleen Mj, Stehouwer Coen Da, van der Kallen Carla Jh, Schalkwijk Casper G., Wijmenga Cisca, Zhernakova Sasha, Tigchelaar Ettje F., Slagboom P. Eline, Beekman Marian, Deelen Joris, van Heemst Diana, Veldink Jh, van den Berg Leonard H., Deelen Patrick, Francioli Lc, Pulit Sl, Guryev V., Kloosterman Wp, Deelen Patrick, van Leeuwen Em, van Setten J., Nijman Ij, Renkens I., Veldink Jh, van den Berg Leonard H., Li Y., Wang J., de Bakker Pi, , 1 mrt 2019, In: European Journal of Human Genetics. 27 , p. 455-465 11 p.
Integrated clinical and omics approach to rare diseases:Novel genes and oligogenic inheritance in holoprosencephaly
Kim Artem et al. 1 jan 2019, In: Brain. 142 , p. 35-49 15 p.