dr. E.F. Knol

dr. E.F. Knol

Associate Professor
dr. E.F. Knol
  • Center for Translational Immunology (CTI) Research
  • Dermatology and Allergology

Research Programs

Infection & Immunity



Edward Knol is a biomedical scientist and immunologist in the departments of Immunology and Dermatology/Allergology at the University Medical Center Utrecht. He did his PhD training in the Blood Transfusion Service of the University of Amsterdam and had a postdoc position at Johns Hopkins University in Baltimore. His scientific research focuses on allergic diseases, in particularly eczema and food allergy. The research focusses on 1) improved insights in pathomechanisms, 2) explore new treatment options, 3) improve current diagnostics and establish new diagnostics platforms. In his career Edward Knol discovered CD63 as the basophil activation marker, described the important role of the peanut allergen Ara h 2 and described A20/TNFAIP3 dysregulation in atopic dermatitis. He is involved in several (inter)national collaborations and is Secretary General of the Dutch Society of Immunology (~1400 members).

Within the University Medical Center he holds a teaching position and chairs the education committee of the University Utrecht graduate school Immunity and Infection (50 master and 170 PhD students). He is coordinator and examiner of: 1) Course Clinical Immunology for 3rd years students Biomedical Sciences, 2) Course Immune Therapy for 2nd years student Medicine and 3) Course Infection and Immunity for 3rd years Students at the Technical University Eindhoven. 

At the international level Edward Knol has organised 3 European Academy of Allergy and Clinical Immunology (EAACI) Winter schools and was the chair of the Scientific Program Committee of the EAACI annual meetings in 2014-2016. In addition, since 2019 he is Vice President Congresses of EAACI. 

Specialties: Immunology, Allergy, Food Allergy, Atopic Dermatitis, Basophilic granulocytes, T lymphocytes, allergy diagnostic tests, basophil activation test



Google Scholar:

Scopus H-factor: h-index: 51

Research gate: h-index: 54, : RG score: 46,95

Google Scholar: h-index: 60 


Side Activities

2009- Chair Educational committee Master and PhD program Graduate School Immunity and Infection, University van Utrecht. Supervising the training program of 50 Master students and 180 PhD students.

2013- Co-director FOCIS Center of Excellence, Utrecht Infection and Immunity Center.

2014- Member taskforce IgE diagnostics, EAACI

2015- Member guideline committee Allergy Immunotherapy, EAACI

2015-2018 Steering committee member FOCIS, representing EAACI

2014-2016 Chair Scientific Program Committee (SPC) EAACI, coordinating EAACI annual meetings in 2015 (Barcelona) and 2016 (Vienna).

2019- Vice President EAACI Congresses and Events, coordinating all scientific meetings of European Academy of Allergy and Clinical Immunology ranging from 8500 participants to 280 participants per meeting


Editorial Board memberships:

- Dutch Journal for Allergology

- Clinical and Translational Allergy

- Clinical and Experimental Allergy




Research Output (266)

EAACI Molecular Allergology User's Guide 2.0

Dramburg Stephanie et al. Mar 2023, In: Pediatric Allergy and Immunology. 34

Inflammatory markers in cerebrospinal fluid of paediatric spinal muscular atrophy patients receiving nusinersen treatment

Scheijmans F. E.V., Cuppen I., Zwartkruis M. M., Signoria I., van Ekris C., Asselman F., Wadman R. I., Knol E. F., van der Pol W. L., Groen E. J.N. Jan 2023, In: European Journal of Paediatric Neurology. 42 , p. 34-41 8 p.

Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy

Genuneit Jon, Jayasinghe Sashini, Riggioni Carmen, Peters Rachel Louise, Chu Derek K., Munblit Daniel, Boyle Robert J., Du Toit George, Skypala Isabel, Santos Alexandra F., Akdis Cezmi A., Alvarez-Perea Alberto, Lozano Montserrat Alvaro, Asero Riccardo, Ballmer-Weber Barbara, Barber Domingo, Barni Simona, Pajno Giovanni Battista, Beyer Kirsten, Bindslev-Jensen Carsten, Brough Helen, Buyuktiryaki Betul, de Oliveira Lucila Camargo Lopes, Cianferoni Antonella, Chinthrajah R. Sharon, Parker Sean N., Giacco Stefano Del, DunnGalvin Audrey, Eberlein Bernadette, Ebisawa Motohiro, Eigenmann Philippe, Eiwegger Thomas, Faber Margaretha, Fernandez-Rivas Montserrat, Feeney Mary, Fisher Helen, Giovannini Mattia, Halken Susanne, Hoffmann-Sommergruber Karin, Jaumdally Hannah, Jones Christina J., Knibb Rebecca, Knol Edward, Konstantinou George N., Krawiec Marta, Lau Susanne, Mayorga Lina, Marques-Mejias M. Andreina, Meyer Rosan, Moya Beatriz, Jan 2022, In: Pediatric Allergy and Immunology. 33 , p. 1-8

Unraveling heterogeneity in pediatric atopic dermatitis::identification of serum biomarker based patient clusters

Bakker D., de Graaf M., Nierkens S., Delemarre E., Knol E., van Wijk F., de Bruin-Weller M., Drylewicz J., Thijs J. Jan 2022, In: Journal of Investigative Dermatology. 149 , p. 125-134 10 p.

Measurement of IgE to hazelnut allergen components cannot replace hazelnut challenge in Dutch adults

Lyons Sarah A, Welsing Paco M J, Hakobyan Mariam, Kansen Hannah M, Knol Edward F, Otten Henny G, van Ree Ronald, Knulst André C, Le Thuy-My 16 Nov 2021, In: Allergy. 77 , p. 1559-1569 11 p.

Risk factors for conjunctivitis in atopic dermatitis patients treated with dupilumab: results from the bioday registry

Achten R., Van der Rijst L., Bakker D., Spekhorst L., Boesjes C., Zuithoff N., Knol E., Van Luijk C., De Boer J., Thijs J., De Graaf M., De Bruin-Weller M. Nov 2021, In: Allergy. 76 , p. 11-11

T-cell subsets in the skin and their role in inflammatory skin disorders

Kortekaas Krohn Inge, Aerts Joeri L, Breckpot Karine, Goyvaerts Cleo, Knol Edward, Van Wijk Femke, Gutermuth Jan 6 Oct 2021, In: Allergy. 77 , p. 827-842 16 p.

Seeking diagnostic and prognostic biomarkers for childhood bacterial pneumonia in sub-Saharan Africa:study protocol for an observational study

Valim Clarissa, Olatunji Yekin Ajauoi, Isa Yasir Shitu, Salaudeen Rasheed, Golam Sarwar, Knol Edward F, Kanyi Sheriffo, Jammeh Abdoulie, Bassat Quique, de Jager Wilco, Diaz Alejandro A, Wiegand Roger C, Ramirez Julio, Moses Marsha A, D'Alessandro Umberto, Hibberd Patricia L, Mackenzie Grant A 30 Sep 2021, In: BMJ Open. 11 , p. 1-10 10 p.

Allergy:Type I, II, III, and IV

Knol Edward F, Gilles Stefanie 14 Jul 2021, 268 , p. 31-41 11 p.

Systemic and local evidence for complement involvement in chronic spontaneous urticaria

Alizadeh Aghdam Mehran, van den Elzen Mignon, van Os-Medendorp Harmieke, van Dijk Marijke R, Knol Edward F, Knulst André C, Röckmann Heike, Otten Henny G Jul 2021, In: Clinical and Translational Allergy. 11 , p. 1-8

All research output

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