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prof. dr. O.W. Kranenburg

Full Professor
prof. dr. O.W. Kranenburg
  • Lab Translational Oncology

Biography

Biography

Onno Kranenburg received his PhD in 1995 from Leiden University (Prof Lex van der Eb). He then studied RAS and RHO small GTPase signaling in cancer in the Netherlands Cancer Institute (Prof Wouter Moolenaar). In 2000 he became senior Post-Doc in the Dept of Medical Oncology in the UMC Utrecht (Prof Emile Voest) where he started his translational studies on the mechanism of action of anti-angiogenic drugs. In 2003 he became Assistant Professor and PI at the Dept. of Surgery (Prof Inne Borel Rinkes) and started to work on the mechanisms of colon cancer metastasis, initially focusing on the role of the K-RAS oncogene.  In 2006 he became Associate Professor, head of the Surgery Lab and staff member at the Dept. of Surgery. In 2012 he became coordinator of the PhD research school Clinical and Translational Oncology. In 2015 he was appointed Professor of Surgical and Translational Tumor Biology at the Cancer Center UMC Utrecht where he continues to design and test novel strategies for the prevention and treatment of colon cancer metastasis. 

Side Activities

Fellowship and Awards

  • 1. KWF2015-8088. Targeting mesenchymal-tyope colon cancer by aggravating oxidative damage. €573.500. 
    2. Scope: Modulation of chemotherapy efficacy and toxicity by nutrition in metastatic colorectal cancer. €586.000.
    3. ZonMw 2014: PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymal-type colon cancer: A window trial. €108.000
    4. Gieskes-Strijbis Fonds 2014: The relationship between primary colorectal tumors and their liver metastases: Biological subgroups and therapy response. €290.000
    5. Vrienden UMC Utrecht 2013. Title: Targeting colon tumors at their root: Elimination of Cancer Stem Cells. €217.000   
    6. KWF UU2011-5226 Title: LIMK1 control of CD95 function in colorectal cancer. €553.300   
    7. KWF UU2011-5135. Suppression of LIMK1 by oncogenic KRAS and RAF1: A critical survival pathway in colorectal cancer? €560.000
    8. KWF UU2009-4417. The contribution of CD95 signalling to recurrence of colorectal liver metastases following radiofrequency ablation. €592.100   

Research Output (101)

Liver lymphatic drainage patterns follow segmental anatomy in a murine model

Frenkel Nicola C, Poghosyan Susanna, Verheem André, Padera Timothy P, Rinkes Inne H M Borel, Kranenburg Onno, Hagendoorn Jeroen 11 dec 2020, In: Scientific Reports. 10 , p. 21808

Mode of progression after radioembolization in patients with colorectal cancer liver metastases

van Roekel Caren, Jongen Jennifer M J, Smits Maarten L J, Elias Sjoerd G, Koopman Miriam, Kranenburg Onno, Borel Rinkes Inne H M, Lam Marnix G E H 22 sep 2020, In: EJNMMI Research. 10

Surgical outcomes of major hepatectomy following "radiation lobectomy" for hepatic malignancies and insufficiently functional future liver remnant:initial experience

Andel D, Dassen M G, Reinders-Hut M T M, Peters N A, Kranenburg O W, Lam M G E H, Hagendoorn J, Rinkes I H M Borel 16 sep 2020, In: British Journal of Surgery. 107 , p. e609-e610

NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer

Knoll Gertrud, Riffelsberger Petra, Raats Danielle, Kranenburg Onno, Ehrenschwender Martin 1 apr 2020, In: Cell Death and Disease. 11 , p. 1-11

Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms

Koeberle Solveigh C, Gollowitzer André, Laoukili Jamila, Kranenburg Onno, Werz Oliver, Koeberle Andreas, Kipp Anna P jan 2020, In: Redox biology. 28 , p. 1-12

Associations of non-pedunculated T1 colorectal adenocarcinoma outcome with consensus molecular subtypes, immunoscore, and microsatellite status:a multicenter case-cohort study

Haasnoot Krijn J.C., Backes Yara, Moons Leon M.G., Kranenburg Onno, Trinh Anne, Vermeulen Louis, Noë Michaël, Tuynman Jurriaan B., van Lent Anja U.G., van Ginneken Rosaline, Seldenrijk Cornelis A., Raicu Mihaela G., Trumpi Kari, Ubink Inge, Milne Anya N., Boonstra Jurjen J., Groen John N., Schwartz Matthijs P., Wolfhagen Frank H.J., Geesing Joost M.J., ter Borg Frank, Brosens Lodewijk A.A., van Bergeijk Jeroen, Spanier Bernhard W.M., de Vos tot Nederveen Cappel Wouter H., Kessels Koen, Seerden Tom C.J., Vleggaar Frank P., Offerhaus G. Johan A., Siersema Peter D., Elias Sjoerd G., Laclé Miangela M., 2020, In: Modern Pathology. 33 , p. 2626-2636 11 p.

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

Driehuis Else, Van Hoeck Arne, Moore Kat, Kolders Sigrid, Francies Hayley E., Gulersonmez M. Can, Stigter Edwin C.A., Burgering Boudewijn, Geurts Veerle, Gracanin Ana, Bounova Gergana, Morsink Folkert H., Vries Robert, Boj Sylvia, Van Es Johan, Offerhaus G. Johan A., Kranenburg Onno, Garnett Mathew J., Wessels Lodewyk, Cuppen Edwin, Brosens Lodewijk A.A., Clevers Hans 9 dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116 , p. 26580-26590 11 p.

Concomitant intraperitoneal and systemic chemotherapy for extensive peritoneal metastases of colorectal origin:Protocol of the multicentre, open-label, phase I, dose-escalation INTERACT trial

De Boer Nadine Leonie, Brandt-Kerkhof Alexandra R.M., Madsen Eva V.E., DIepeveen Marjolein, Van Meerten Esther, Van Eerden Ruben A.G., De Man Femke M., Bouamar Rachida, Koolen Stijn L.W., De Hingh Ignace H.J.T., Bakkers Checca, Rovers Koen P., Creemers Geert Jan M., Deenen Maarten J., Kranenburg Onno W., Constantinides Alexander, Mathijssen Ron H.J., Verhoef Cornelis, Burger Jacobus W.A. 8 dec 2019, In: BMJ Open. 9 , p. e034508

Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures

van der Waals Lizet M, Laoukili Jamila, Jongen Jennifer M J, Raats Danielle A, Borel Rinkes Inne H M, Kranenburg Onno 1 dec 2019, In: Scientific Reports. 9

Tumor Seeding During Colonoscopy as a Possible Cause for Metachronous Colorectal Cancer

Backes Yara, Seerden Tom C.J., van Gestel Rosanne S.F.E., Kranenburg Onno, Ubink Inge, Schiffelers Raymond M., van Straten Demian, van der Capellen Malu S., van de Weerd Simone, de Leng Wendy W.J., Siersema Peter D., Offerhaus G. Johan A., Morsink Folkert H., Ramphal Winesh, Terhaar Sive Droste Jochiim, van Lent Anja U.G., Geesing Joost M.J., Vleggaar Frank P., Elias Sjoerd G., Lacle Miangela M., Moons Leon M.G. 1 nov 2019, In: Gastroenterology. 157 , p. 1222-1232.e4

All research output