prof. dr. O.W. Kranenburg

prof. dr. O.W. Kranenburg

Full Professor
prof. dr. O.W. Kranenburg
  • Lab Translational Oncology



Onno Kranenburg received his PhD in 1995 from Leiden University (Prof Lex van der Eb). He then studied RAS and RHO small GTPase signaling in cancer in the Netherlands Cancer Institute (Prof Wouter Moolenaar). In 2000 he became senior Post-Doc in the Dept of Medical Oncology in the UMC Utrecht (Prof Emile Voest) where he started his translational studies on the mechanism of action of anti-angiogenic drugs. In 2003 he became Assistant Professor and PI at the Dept. of Surgery (Prof Inne Borel Rinkes) and started to work on the mechanisms of colon cancer metastasis, initially focusing on the role of the K-RAS oncogene.  In 2006 he became Associate Professor, head of the Surgery Lab and staff member at the Dept. of Surgery. In 2012 he became coordinator of the PhD research school Clinical and Translational Oncology. In 2015 he was appointed Professor of Surgical and Translational Tumor Biology at the Cancer Center UMC Utrecht where he continues to design and test novel strategies for the prevention and treatment of colon cancer metastasis. 

Side Activities

2013-present: Coordinator of the PhD program Clinical and Translational Oncology


2005-present Head Laboratory Translational Oncology


2018-present: chair working group translational research Dutch Colorectal Cancer Group (DCCG)


2018-present: Chair U-PORT

Fellowship and Awards

1. KWF2015-8088. Targeting mesenchymal-tyope colon cancer by aggravating oxidative damage. €573.500. 
2. Scope: Modulation of chemotherapy efficacy and toxicity by nutrition in metastatic colorectal cancer. €586.000.
3. ZonMw 2014: PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymal-type colon cancer: A window trial. €108.000
4. Gieskes-Strijbis Fonds 2014: The relationship between primary colorectal tumors and their liver metastases: Biological subgroups and therapy response. €290.000
5. Vrienden UMC Utrecht 2013. Title: Targeting colon tumors at their root: Elimination of Cancer Stem Cells. €217.000   
6. KWF UU2011-5226 Title: LIMK1 control of CD95 function in colorectal cancer. €553.300   
7. KWF UU2011-5135. Suppression of LIMK1 by oncogenic KRAS and RAF1: A critical survival pathway in colorectal cancer? €560.000
8. KWF UU2009-4417. The contribution of CD95 signalling to recurrence of colorectal liver metastases following radiofrequency ablation. €592.100   

Research Output (108)

Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases:A Phase 2 Randomized Clinical Trial

Rovers Koen P., Bakkers Checca, Nienhuijs Simon W., Burger Jacobus W.A., Creemers Geert Jan M., Thijs Anna M.J., Brandt-Kerkhof Alexandra R.M., Madsen Eva V.E., Van Meerten Esther, Tuynman Jurriaan B., Kusters Miranda, Versteeg Kathelijn S., Aalbers Arend G.J., Kok Niels F.M., Buffart Tineke E., Wiezer Marinus J., Boerma Djamila, Los Maartje, De Reuver Philip R., Bremers Andreas J.A., Verheul Henk M.W., Kruijff Schelto, De Groot Derk Jan A., Witkamp Arjen J., Van Grevenstein Wilhelmina M.U., Koopman Miriam, Nederend Joost, Lahaye Max J., Kranenburg Onno, Fijneman Remond J.A., Van 'T Erve Iris, Snaebjornsson Petur, Hemmer Patrick H.J., Dijkgraaf Marcel G.W., Punt Cornelis J.A., Tanis Pieter J., De Hingh Ignace H.J.T. aug 2021, In: JAMA Surgery. 156 , p. 710-720 11 p.

Long-lived human lymphatic endothelial cells to study lymphatic biology and lymphatic vessel/tumor coculture in a 3D microfluidic model

Frenkel Nicola, Poghosyan Susanna, Alarcón Carmen Rubio, García Silvia Bonilla, Queiroz Karla, Van Den Bent Lotte, Laoukili Jamila, Rinkes Inne Borel, Vulto Paul, Kranenburg Onno, Hagendoorn Jeroen 12 jul 2021, In: ACS Biomaterials Science and Engineering. 7 , p. 3030-3042 13 p.

A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity

Wenmaekers Stijn, Viergever Bastiaan J., Kumar Gunjan, Kranenburg Onno, Black Peter C., Daugaard Mads, Meijer Richard P. 20 mei 2021, In: Cells. 10 19 p.

Detection of tumor-derived cell-free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid

van't Erve Iris, Rovers Koen P., Constantinides Alexander, Bolhuis Karen, Wassenaar Emma C.E., Lurvink Robin J., Huysentruyt Clément J., Snaebjornsson Petur, Boerma Djamila, van den Broek Daan, Buffart Tineke E., Lahaye Max J., Aalbers Arend G.J., Kok Niels F.M., Meijer Gerrit A., Punt Cornelis J.A., Kranenburg Onno, de Hingh Ignace H.J.T., Fijneman Remond J.A. mei 2021, In: Journal of Pathology: Clinical Research. 7 , p. 203-208 6 p.

Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

Wensink G Emerens, Elias Sjoerd G, Mullenders Jasper, Koopman Miriam, Boj Sylvia F, Kranenburg Onno W, Roodhart Jeanine M L 12 apr 2021, In: NPJ precision oncology. 5

A review of the sensitivity of metastatic colorectal cancer patients with deficient mismatch repair to standard-of-care chemotherapy and monoclonal antibodies, with recommendations for future research

Wensink Emerens, Bond Marinde, Kucukkose Emre, May Anne, Vink Geraldine, Koopman Miriam, Kranenburg Onno, Roodhart Jeanine apr 2021, In: Cancer Treatment Reviews. 95 12 p.

Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer

Lõhmussaar Kadi, Oka Rurika, Espejo Valle-Inclan Jose, Smits Milou H.H., Wardak Hila, Korving Jeroen, Begthel Harry, Proost Natalie, van de Ven Marieke, Kranenburg Onno W., Jonges Trudy G.N., Zweemer Ronald P., Veersema Sebastiaan, van Boxtel Ruben, Clevers Hans 2021, In: Cell stem cell. 28 , p. 1380-1396.e6

Liver lymphatic drainage patterns follow segmental anatomy in a murine model

Frenkel Nicola C, Poghosyan Susanna, Verheem André, Padera Timothy P, Rinkes Inne H M Borel, Kranenburg Onno, Hagendoorn Jeroen 11 dec 2020, In: Scientific Reports. 10 , p. 21808

Mode of progression after radioembolization in patients with colorectal cancer liver metastases

van Roekel Caren, Jongen Jennifer M J, Smits Maarten L J, Elias Sjoerd G, Koopman Miriam, Kranenburg Onno, Borel Rinkes Inne H M, Lam Marnix G E H 22 sep 2020, In: EJNMMI Research. 10

Surgical outcomes of major hepatectomy following "radiation lobectomy" for hepatic malignancies and insufficiently functional future liver remnant:initial experience

Andel D, Dassen M G, Reinders-Hut M T M, Peters N A, Kranenburg O W, Lam M G E H, Hagendoorn J, Rinkes I H M Borel 16 sep 2020, In: British Journal of Surgery. 107 , p. e609-e610

All research output

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