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prof. dr. J.H.E. Kuball

Full Professor

  • Laboratory for Translational Immunology (LTI)
  • Department of Medical Oncology

prof. dr. J.H.E. Kuball

Biography

Prof. Dr. Jürgen Kuball received his medical degree as hematologists at the University of Mainz, Germany, and was further trained at the Fred Hutchinson Cancer Center in Seattle, WA, USA. Prof. Kuball joined the Department of Hematology at the University Medical Center in Utrecht in The Netherlands in 2007 as hematologists and immunologist. He became a VIDI-laureate in 2010 and chairs the section applied & tumor-immunology within the laboratory of translation immunology. Since 2013 he is chairing the Department of Hematology (adults). His clinical activities are focusing on treating patients with hematological malignancies including stem cell transplantation. His clinical-translational efforts and patient care are driven by his role as Director of the Bone Marrow Transplantation Program at the University Medical Center Utrecht, as well as active membership of the leukemia working party and stem cell working party of HOVON. His current laboratory activities are focusing on the understanding of innate immune cells and their receptors to recognize malignant cells and virally infected cells as well as the genetic engineering of a transplant.

Side Activities

  • Board activities

    • EBMT Executive Board, Treasurer
    • HOVON General board 
    • KWF adviesraad  

    Translational Valorisation

    •  Cofounder and shareholder of Gadeta      

    Memberships

    • ASH
    • CIMT Regulatory Research Group
    • EBMT
    • EHA Member
    • HOVON Leukemia working party
    • HOVON SCT working party 

    External positions

    • Scientific advisor, GADETA, 2018 → 2020
    • Scientific Advisory Board, JAZZ pharmaceuticals, 11 Sep 2016
    • Scientific cofounder and CSO, GADETA, 2015 → 2018
    • Shareholder, GADETA, 2015 → …
    • Grant Support, speaker and joint patent application, Miltenyi Biotec, 2015 → …
    • Grant and Scientific advisory board, Novartis, 2015 → …

Fellowship and Awards

  • American Association of Cancer Research-GlaxoSmithKline Scholar in Cancer Research Award (2001)
    Stipendiat der Deutschen Krebshilfe (2005-2007)
    Team Science recognition award of the „Society for Immunotherapy of Cancer“ to Jürgen Kuball and the University of Washington, USA (2010)
    VIDI-Laureate ZonMW, The Netherlands (2010)
    KWF project Transit (534.100 euro) (2014)

Research Output (140)

A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance

Langenhorst J B, Boss J, van Kesteren C, Lalmohamed A, Kuball J, Egberts A C G, Boelens J J, Huitema A D R, van Maarseveen E M 18 feb 2020, In: British Journal of Clinical Pharmacology. 86 , p. 1499-1509 11 p.

TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product

Straetemans Trudy, Janssen Anke, Jansen Koen, Doorn Ruud, Aarts Tineke, van Muyden Anna D D, Simonis Marieke, Bergboer Judith, de Witte Moniek, Sebestyen Zsolt, Kuball Jurgen 14 dec 2019, In: Molecular Therapy. 28 , p. 561-571 11 p.

Management of adults and children undergoing chimeric antigen receptor T-cell therapy:best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Yakoub-Agha Ibrahim, Chabannon Christian, Bader Peter, Basak Grzegorz W, Bonig Halvard, Ciceri Fabio, Corbacioglu Selim, Duarte Rafael F, Einsele Hermann, Hudecek Michael, Kersten Marie José, Köhl Ulrike, Kuball Jürgen, Mielke Stephan, Mohty Mohamad, Murray John, Nagler Arnon, Robinson Stephen, Saccardi Riccardo, Sanchez-Guijo Fermin, Snowden John A, Srour Micha, Styczynski Jan, Urbano-Ispizua Alvaro, Hayden Patrick J, Kröger Nicolaus 21 nov 2019, In: Haematologica. 105 , p. 297-316 20 p.

Post-Transplantation Cyclophosphamide after Allogeneic Hematopoietic Stem Cell Transplantation:Results of the Prospective Randomized HOVON-96 Trial in Recipients of Matched Related and Unrelated Donors

De Jong Cornelis N., Meijer Ellen, Bakunina Katerina, Nur Erfan, van Marwijk Kooij Marinus, de Groot Marco R., van Gelder Michel, Maertens Johan A., Kuball Jurgen H.E., Deeren Dries, van der Holt Bronno, Cornelissen Jan J., Broers Annoek E.C. 13 nov 2019, In: Blood. 134 , p. 1 1 p.

Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors:a European Society for Blood and Marrow Transplantation registry retrospective analysis

Shouval Roni, Fein Joshua A, Labopin Myriam, Kröger Nicolaus, Duarte Rafael F, Bader Peter, Chabannon Christian, Kuball Jurgen, Basak Grzegorz Wladyslaw, Dufour Carlo, Galimard Jacques-Emmanuel, Polge Emmanuelle, Lankester Arjan, Montoto Silvia, Snowden John A, Styczynski Jan, Yakoub-Agha Ibrahim, Mohty Mohamad, Nagler Arnon nov 2019, In: Lancet haematology. 6 , p. e573-e584

Identification of a tumor-specific allo-HLA-restricted γδTCR

Kierkels G J J, Scheper W, Meringa A D, Johanna I, Beringer D X, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen J H W, San José E, Fuchs K, Griffioen M, Falkenburg J H, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck A J R, Shultz L D, Ishikawa F, Nishimura M I, Sebestyén Z, Kuball J 8 okt 2019, In: Blood Advances. 3 , p. 2870-2882 13 p.

Indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders:current practice in Europe, 2019

Duarte Rafael F., Labopin Myriam, Bader Peter, Basak Grzegorz W., Bonini Chiara, Chabannon Christian, Corbacioglu Selim, Dreger Peter, Dufour Carlo, Gennery Andrew R., Kuball Jürgen, Lankester Arjan C., Lanza Francesco, Montoto Silvia, Nagler Arnon, Peffault de Latour Régis, Snowden John A., Styczynski Jan, Yakoub-Agha Ibrahim, Kröger Nicolaus, Mohty Mohamad, 1 okt 2019, In: Bone Marrow Transplantation. 54 , p. 1525-1552 28 p.

Double Umbilical Cord Blood Transplantation in High-Risk Hematological Patients:A Phase II Study Focusing on the Mechanism of Graft Predominance

Kalin Burak, Ter Borg Mariëtte, Wijers Rebecca, Somers Judith A E, van der Holt Bronno, van Bergen Cornelis A M, Petersen Eefke J, Kuball Jurgen, Meijer Ellen, Schaap Nicolaas P M, Zeerleder Sacha S, Broers Annoek E, Braakman Eric, Falkenburg J H Frederik, Lamers Cor H J, Cornelissen Jan J okt 2019, In: HemaSphere. 3

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

Sebestyen Zsolt, Prinz Immo, Déchanet-Merville Julie, Silva-Santos Bruno, Kuball Jurgen 6 sep 2019, In: Nature Reviews. Drug Discovery. 19 , p. 169-184 16 p.

Fludarabine exposure in the conditioning prior to allogeneic hematopoietic cell transplantation predicts outcomes

Langenhorst J. B., van Kesteren C., van Maarseveen E. M., Dorlo T. P. C., Nierkens Stefan, Lindemans C. A., de Witte M. A., van Rhenen A., Raijmakers R., Bierings M., Kuball J., Huitema A. D. R., Boelens J. J. 23 jul 2019, In: Blood Advances. 3 , p. 2179-2187 9 p.

All Research Output (140)