prof. dr. J.H.E. (Jurgen) Kuball

prof. dr. J.H.E. (Jurgen) Kuball

Full Professor
prof. dr. J.H.E. (Jurgen) Kuball
  • Center for Translational Immunology (CTI) Research
  • Department of Hematology



Prof. Dr. Jürgen Kuball received his medical degree as hematologists at the University of Mainz, Germany, and was further trained at the Fred Hutchinson Cancer Center in Seattle, WA, USA. Prof. Kuball joined the Department of Hematology at the University Medical Center in Utrecht in The Netherlands in 2007 as hematologists and immunologist. He became a VIDI-laureate in 2010 and chairs the section applied & tumor-immunology within the laboratory of translation immunology. Since 2013 he is chairing the Department of Hematology (adults). His clinical activities are focusing on treating patients with hematological malignancies including stem cell transplantation. His clinical-translational efforts and patient care are driven by his role as Director of the Bone Marrow Transplantation Program at the University Medical Center Utrecht, as well as active membership of the leukemia working party and stem cell working party of HOVON. His current laboratory activities are focusing on the understanding of innate immune cells and their receptors to recognize malignant cells and virally infected cells as well as the genetic engineering of a transplant.

For more information on experimental and translational research please visit Kuball Laboratories

Side Activities

Board activities

  • Chair Immunology Community Utrecht Life Science 2023-
  • Secretary-Team of GoCART Coalition 2023-
  • EBMT Chair Legal and Regulatory Affairs Committee 2019-
  • HOVON General board 2014-
  • KWF PPS commissie 2022-
  • KWF adviesraad  2016-2022
  • Wetenschappelijke raad KIKA 2018-2021

Translational Valorisation

  • Cofounder and shareholder of Gadeta  2015- 2023
  • Patent holder on multipe inventions  licensed to Gadeta-follow up company Century Therapeuitcs and Miltenyi Biotech  2012-
  • Via Gadeta Founders since 2024 Shareholder of Century Therapeutics
  • Receiving revenues from licensed patents in the field of genetic engineering 2021-


  • ASH
  • EBMT
  • EHA Member
  • HOVON Leukemia working party
  • HOVON SCT working party 

External positions

  • Scientific advisor, GADETA, 2018 → 2020
  • Scientific Advisory Board, JAZZ pharmaceuticals, 11 Sep 2016
  • Scientific cofounder and CSO, GADETA, 2015 → 2018
  • Grant Support, speaker and joint patent application, Miltenyi Biotec, 2015 → …
  • Grant and Scientific advisory board, Novartis, 2015 → …

Fellowship and Awards

American Association of Cancer Research-GlaxoSmithKline Scholar in Cancer Research Award (2001)
Stipendiat der Deutschen Krebshilfe (2005-2007)
Team Science recognition award of the „Society for Immunotherapy of Cancer“ to Jürgen Kuball and the University of Washington, USA (2010)
VIDI-Laureate ZonMW, The Netherlands (2010)

Research Output (210)

Basics of advanced therapy medicinal product development in academic pharma and the role of a GMP simulation unit

Johanna I., Daudeij A., Devina F., Nijenhuis C., Nuijen B., Romberg B., de Haar C., Haanen J., Dolstra H., Bremer E., Sebestyen Z., Straetemans T., Jedema I., Kuball J. Dec 2023, In: Immuno-Oncology and Technology. 20 9 p.

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

Mamedov Murad R, Vedova Shane, Freimer Jacob W, Sahu Avinash Das, Ramesh Amrita, Arce Maya M, Meringa Angelo D, Ota Mineto, Chen Peixin Amy, Hanspers Kristina, Nguyen Vinh Q, Takeshima Kirsten A, Rios Anne C, Pritchard Jonathan K, Kuball Jürgen, Sebestyen Zsolt, Adams Erin J, Marson Alexander 30 Aug 2023, In: Nature. 621 , p. 188-195 8 p.

The European Society for Blood and Marrow Transplantation (EBMT) roadmap and perspectives to improve nutritional care in patients undergoing hematopoietic stem cell transplantation on behalf of the Cellular Therapy and Immunobiology Working Party (CTIWP) and the Nurses Group (NG) of the EBMT

Casirati Amanda, Salcedo Isabel, Cereda Emanuele, Chabannon Christian, Ruggeri Annalisa, Kuball Jurgen, Clout Ruth, Mooyaart Jarl E., Kenyon Michelle, Caccialanza Riccardo, Pedrazzoli Paolo, Kisch Annika M., , 5 Jul 2023, In: Bone Marrow Transplantation. 58 , p. 965-972 8 p.

Graft engineering:how long can you wait, how low can you go, and pandemic readiness

Nijssen Klaartje, Westinga Kasper, Stuut Anniek, Janssen Anke, van Rhenen Anna, van der Wagen Lotte, Daenen Laura G M, Oostvogels Rimke, de Witte Moniek A, Kuball Jürgen 3 Apr 2023, In: Bone Marrow Transplantation. 58 , p. 820-822 3 p.

Activity of ex vivo graft and DLI Engineering within the last decade increases, a survey from the EBMT Cellular Therapy & Immunobiology Working Party

de Witte M A, Mooyaart J E, Hoogenboom J D, Chabannon C, Malard F, Ruggeri A, Kuball J 18 Mar 2023, In: Bone Marrow Transplantation. 58 , p. 719-722 4 p.

Serpin B9 controls tumor cell killing by CAR T cells

Kimman Thomas, Slomp Anne, Martens Anne, Grabherr Sarah, Li Shuang, van Diest Eline, Meeldijk Jan, Kuball Jurgen, Minnema Monique C., Eldering Eric, Bovenschen Niels, Sebestyén Zsolt, Peperzak Victor 17 Mar 2023, In: Journal for ImmunoTherapy of Cancer. 11

Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Ruggeri Annalisa, de Wreede Liesbeth C., Müller Carlheinz R., Crivello Pietro, Bonneville Edouard F., Petersdorf Effie W., Socié Gerard, Dubois Valérie, Niittyvuopio Riitta, Peräsaari Juha, Yakoub-Agha Ibrahim, Cornelissen Jan J., Wieten Lotte, Gedde-Dahl Tobias, Forcade Edouard, Crawley Charles R., Marsh Steven G.E., Gandemer Virginie, Tholouli Eleni, Bulabois Claude Eric, Huynh Anne, Choi Goda, Deconinck Eric, Itäla-Remes Maija, Lenhoff Stig, Bengtsson Mats, Johansson Jan Erik, van Gorkom Gwendolyn, Hoogenboom Jorinde D., Vago Luca, Rocha Vanderson, Bonini Chiara, Chabannon Christian, Fleischhauer Katharina, Clausen Johannes, Holter Wolfgang, Kalhs Peter, Beguin Yves, Bron Dominique, Deeren Dries, Lung Wu Ka, Kerre Tessa, Poiré Xavier, Selleslag Dominik, Schroyens Wilfried, Jindra Pavel, Mayer Jiri, Vydra Jan, Zák Pavel, Kuball Jürgen, 1 Feb 2023, In: Haematologica. 108 , p. 645-652 8 p.

The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

van Diest Eline, Nicolasen Mara J T, Kramer Lovro, Zheng Jiali, Hernández-López Patricia, Beringer Dennis X, Kuball Jürgen 5 Jan 2023, In: Frontiers in Immunology. 13

Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies

Meringa A D, Hernández-López P, Cleven A, de Witte M, Straetemans T, Kuball J, Beringer D X, Sebestyen Z 2023, In: Frontiers in Immunology. 14 , p. 1-7

Disseminated nontuberculous mycobacterial infections after allogeneic hematopoietic stem cell transplantation:a risk-based strategy for early diagnosis

Daenen Laura G M, van der Bruggen Jan-Tom, Leguit Roos J, van der Wagen Lotte E, van Rhenen Anna, Wunderink Herman F, de Witte Moniek A, Bruns Anke H W, Kuball Jurgen 2023, In: Bone Marrow Transplantation. 58 , p. 956-958 3 p.

All research output

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