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prof. dr. M.G.E.H. (Marnix) Lam

Full Professor

  • Researchgr. Nucleaire Geneeskunde

prof. dr. M.G.E.H. (Marnix) Lam

Research Programs

Biography

Marnix Lam (1975) studied Pharmaceutical sciences (passed with distinction) and Medicine at Utrecht University. He became a resident in Nuclear Medicine, respectively Radiology and finalized his PhD thesis (2009) on radionuclide therapy in prostate cancer patients with metastatic bone pain. This was followed by a two-year postdoctoral fellowship at Stanford University School of Medicine, USA. In 2016 he was appointed Professor of Nuclear Medicine.
Translational research in molecular medicine has been the scope of his scientific work, with a focus on oncology. Bringing new radiopharmaceuticals to clinical practice. This specifically resulted in the introduction of new oncological treatment modalities in the Netherlands, such as bone seeking radiopharmaceuticals for the palliation of metastatic bone pain (Sm-153-EDTMP, Re-188-HEDP) and radioembolization for treatment of hepatic malignancies (Y-90 and Ho-166 microspheres). Current research is focussed on dosimetry of therapeutic radiopharmaceuticals, image-guided treatment technology, alfa- and beta-emitting isotopes for therapeutic purposes, intra-arterial and intra-tumor treatment approaches, and radio-immunotherapy.

Side Activities

  • Board Member of the National Education Committee on Nuclear Medicine

    National Coordinator on Education of Gastrointestinal Nuclear Medicine and Musculoskeletal Nuclear Medicine

    Consultant for BTG and Terumo

     

     

Fellowship and Awards

  • Alavi-Mandell award for best publication in Journal of Nuclear Medicine: van den Hoven A, Rosenbaum C, Elias S, de Jong H, Koopman M, Verkooijen H, Alavi A, van den Bosch M, Lam MGEH. Insights into the dose-response relationship of radioembolization with resin yttrium-90 microspheres: a prospective cohort study in patients with colorectal cancer liver metastases. J Nucl Med. 2016 Jul;57(7):1014-9. (2017)

    Research grant from the Dutch Cancer Society (KWF): Holmium-166 microspheres for radioembolization in HCC patients: new generation microspheres for individualized treatment (2016)

    Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Prince JF, van Rooij R, Bol GH, de Jong HW, van den Bosch MA, Lam MGEH. Safety of a Scout Dose Preceding Hepatic Radioembolization with 166Ho Microspheres. J Nucl Med. 2015 Jun;56(6):817-23. (2016)

    Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Blomberg BA, Thomassen A, de Jong PA, Simonsen JA, Lam MGEH, Nielsen AL, Mickley H, Mali WP, Alavi A5, Høilund-Carlsen PF. Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries: Prospective Evaluation of Healthy Subjects. J Nucl Med. 2015 Oct;56(10):1534-40. (2016)

    Research grant from Alpe d’Huzes / Dutch Cancer Society (KWF): Holmium micro-brachytherapy: an innovative intratumoral treatment modality in head and neck cancer (2014)

    Appointed as honorary professor at the medical school of the People’s Liberation Army General Hospital and Military University, Beijing, China (2014)

    CIRSE Award of Excellence and Innovation in Interventional Radiology (2014)

    Research grant from the Dutch Cancer Society (KWF): translational research in oncology (2010)

Research Output (192)

Suppression of myocardial glucose metabolism in FDG PET/CT:impact of dose variation in heparin bolus pre-administration

Scholtens A M, van den Berk A M, van der Sluis N L, Esser J P, Lammers G K, de Klerk J M H, Lam M G E H, Verberne H J okt 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47 , p. 2698-2702 5 p.

Mode of progression after radioembolization in patients with colorectal cancer liver metastases

van Roekel Caren, Jongen Jennifer M J, Smits Maarten L J, Elias Sjoerd G, Koopman Miriam, Kranenburg Onno, Borel Rinkes Inne H M, Lam Marnix G E H 22 sep 2020, In: EJNMMI Research. 10

Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation

Ropers Fabienne G, van Mossevelde Robin M P, Bleeker-Rovers Chantal P, van Velden Floris H P, van Assema Danielle M E, Adam Judit A, Lam Marnix G E H, Tolboom Nelleke, Dekkers Olaf M, de Geus-Oei Lioe-Fee, Frings Virginie 18 sep 2020, In: Diagnostics (Basel, Switzerland). 10 15 p.

Surgical outcomes of major hepatectomy following "radiation lobectomy" for hepatic malignancies and insufficiently functional future liver remnant:initial experience

Andel D, Dassen M G, Reinders-Hut M T M, Peters N A, Kranenburg O W, Lam M G E H, Hagendoorn J, Rinkes I H M Borel 16 sep 2020, In: British Journal of Surgery. 107 , p. e609-e610

Verification Study of Residual Activity Measurements After Yttrium-90 Radioembolization with Glass Microspheres

Ebbers S C, Kunnen B, van Nierop B J, Bemelmans J L M, Krijger G C, Lam M G E H, Braat A J A T sep 2020, In: Cardiovascular and Interventional Radiology. 43 , p. 1378-1383 6 p.

Toxicity and dosimetry in SORAMIC study

Reinders Margot, Braat Arthur, Lam Marnix sep 2020, In: Journal of Hepatology. 73 , p. 734-735 2 p.

Evaluation of the Safety and Feasibility of Same-Day Holmium-166 -Radioembolization Simulation and Treatment of Hepatic Metastases

van Roekel Caren, Harlianto Netanja I, Braat Arthur J A T, Prince Jip F, van den Hoven Andor F, Bruijnen Rutger C G, Lam Marnix G E H, Smits Maarten L J 26 aug 2020, In: Journal of Vascular and Interventional Radiology. 31 , p. 1593-1599 7 p.

The utility of 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT/CT for selective internal radiation therapy in hepatocellular carcinoma

Labeur Tim A, Cieslak Kasia P, Van Gulik Thomas M, Takkenberg R Bart, van der Velden Sandra, Lam Marnix G E H, Klümpen Heinz-Josef, Bennink Roel J, van Delden Otto M aug 2020, In: Nuclear Medicine Communications. 41 , p. 740-749 10 p.

Treating infections with ionizing radiation:a historical perspective and emerging techniques

van Dijk B, Lemans J V C, Hoogendoorn R M, Dadachova E, de Klerk J M H, Vogely H C, Weinans H, Lam M G E H, van der Wal B C H 31 jul 2020, In: Antimicrobial Resistance and Infection Control. 9 , p. 121

Quantitative 166Ho-microspheres SPECT derived from a dual-isotope acquisition with 99mTc-colloid is clinically feasible

Stella M, Braat Arthur, Lam Marnix, de Jong Hugo, van Rooij Rob 14 jul 2020, In: EJNMMI Physic. 7 12 p.

All Research Output (192)