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prof. dr. M.G.E.H. (Marnix) Lam

Full Professor

  • Researchgr. Nucleaire Geneeskunde

prof. dr. M.G.E.H. (Marnix) Lam

Research Programs

Biography

Marnix Lam (1975) studied Pharmaceutical sciences (passed with distinction) and Medicine at Utrecht University. He became a resident in Nuclear Medicine, respectively Radiology and finalized his PhD thesis (2009) on radionuclide therapy in prostate cancer patients with metastatic bone pain. This was followed by a two-year postdoctoral fellowship at Stanford University School of Medicine, USA. In 2016 he was appointed Professor of Nuclear Medicine.
Translational research in molecular medicine has been the scope of his scientific work, with a focus on oncology. Bringing new radiopharmaceuticals to clinical practice. This specifically resulted in the introduction of new oncological treatment modalities in the Netherlands, such as bone seeking radiopharmaceuticals for the palliation of metastatic bone pain (Sm-153-EDTMP, Re-188-HEDP) and radioembolization for treatment of hepatic malignancies (Y-90 and Ho-166 microspheres). Current research is focussed on dosimetry of therapeutic radiopharmaceuticals, image-guided treatment technology, alfa- and beta-emitting isotopes for therapeutic purposes, intra-arterial and intra-tumor treatment approaches, and radio-immunotherapy.

Side Activities

  • Board Member of the National Education Committee on Nuclear Medicine

    National Coordinator on Education of Gastrointestinal Nuclear Medicine and Musculoskeletal Nuclear Medicine

    Consultant for BTG and Terumo

     

     

Fellowship and Awards

  • Alavi-Mandell award for best publication in Journal of Nuclear Medicine: van den Hoven A, Rosenbaum C, Elias S, de Jong H, Koopman M, Verkooijen H, Alavi A, van den Bosch M, Lam MGEH. Insights into the dose-response relationship of radioembolization with resin yttrium-90 microspheres: a prospective cohort study in patients with colorectal cancer liver metastases. J Nucl Med. 2016 Jul;57(7):1014-9. (2017)

    Research grant from the Dutch Cancer Society (KWF): Holmium-166 microspheres for radioembolization in HCC patients: new generation microspheres for individualized treatment (2016)

    Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Prince JF, van Rooij R, Bol GH, de Jong HW, van den Bosch MA, Lam MGEH. Safety of a Scout Dose Preceding Hepatic Radioembolization with 166Ho Microspheres. J Nucl Med. 2015 Jun;56(6):817-23. (2016)

    Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Blomberg BA, Thomassen A, de Jong PA, Simonsen JA, Lam MGEH, Nielsen AL, Mickley H, Mali WP, Alavi A5, Høilund-Carlsen PF. Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries: Prospective Evaluation of Healthy Subjects. J Nucl Med. 2015 Oct;56(10):1534-40. (2016)

    Research grant from Alpe d’Huzes / Dutch Cancer Society (KWF): Holmium micro-brachytherapy: an innovative intratumoral treatment modality in head and neck cancer (2014)

    Appointed as honorary professor at the medical school of the People’s Liberation Army General Hospital and Military University, Beijing, China (2014)

    CIRSE Award of Excellence and Innovation in Interventional Radiology (2014)

    Research grant from the Dutch Cancer Society (KWF): translational research in oncology (2010)

Research Output (175)

Quantitative 166Ho-microspheres SPECT derived from a dual-isotope acquisition with 99mTc-colloid is clinically feasible

Stella M, Braat Arthur, Lam Marnix, de Jong Hugo, van Rooij Rob 14 jul 2020, In: EJNMMI Physic. 7 12 p.

PSMA PET/CT Identifies Intrapatient Variation in Salivary Gland Toxicity From Iodine-131 Therapy

Mohan Vineet, Vogel Wouter V, Valk Gerlof D, de Boer Jan P, Lam Marnix G E H, de Keizer Bart 4 jul 2020, In: Molecular Imaging. 19 7 p.

The superior predictive value of 166Ho-scout compared with 99mTc-macroaggregated albumin prior to 166Ho-microspheres radioembolization in patients with liver metastases

Smits Maarten L J, Dassen Mathijs G, Prince Jip F, Braat Arthur J A T, Beijst Casper, Bruijnen Rutger C G, de Jong Hugo W A M, Lam Marnix G E H 1 apr 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47 , p. 798-806 9 p.

Prospective Validation of Gallium-68 Prostate Specific Membrane Antigen-Positron Emission Tomography/Computerized Tomography for Primary Staging of Prostate Cancer REPLY:Prospective Validation of Gallium-68 Prostate Specific Membrane Antigen-Positron Emission Tomography/Computerized Tomography for Primary Staging of Prostate Cancer REPLY

van Kalmthout Ludwig W M, van Melick Harm E, Lavalaye Jules, Meijer Richard P, Kooistra Anko, de Klerk John M H, Braat Arthur J A T, Kaldeway H Peter, de Bruin P C, de Keizer Bart, Lam Marnix G E H mrt 2020, In: The Journal of Urology. 203 , p. 545-545 1 p.

The Efficacy of Coil Embolization to Obtain Intrahepatic Redistribution in Radioembolization:Qualitative and Quantitative Analyses

Alsultan Ahmed A, van Roekel Caren, Barentsz Maarten W, Braat Arthur J A T, van Doormaal Pieter Jan, Lam Marnix G E H, Smits Maarten L J mrt 2020, In: Cardiovascular and Interventional Radiology. 43 , p. 391-401 11 p.

Additional holmium-166 radioembolisation after lutetium-177-dotatate in patients with neuroendocrine tumour liver metastases (HEPAR PLuS):a single-centre, single-arm, open-label, phase 2 study

Braat Arthur J A T, Bruijnen Rutger C G, van Rooij Rob, Braat Manon N G J A, Wessels Frank J, van Leeuwaarde Rachel S, van Treijen Mark J C, de Herder Wouter W, Hofland Johannes, Tesselaar Margot E T, de Jong Hugo W A M, Lam Marnix G E H 26 feb 2020, In: LANCET ONCOLOGY. 21 , p. 561-570 10 p.

Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy

Braat A J A T, Ahmadzadehfar H, Kappadath S C, Stothers C L, Frilling A, Deroose C M, Flamen P, Brown D B, Sze D Y, Mahvash A, Lam M G E H feb 2020, In: Cardiovascular and Interventional Radiology. 43 , p. 246-253 8 p.

Preoperative prediction of pathologic response to neoadjuvant chemoradiotherapy in patients with esophageal cancer using 18F-FDG PET/CT and DW-MRI:a prospective multicenter study

Borggreve Alicia S, Goense Lucas, van Rossum Peter S N, Heethuis Sophie E, van Hillegersberg Richard, Lagendijk Jan J W, Lam Marnix G E H, van Lier Astrid L H M W, Mook Stella, Ruurda Jelle P, van Vulpen Marco, Voncken Francine E M, Aleman Berthe M P, Bartels-Rutten Annemarieke, Ma Jingfei, Fang Penny, Musall Benjamin C, Lin Steven H, Meijer Gert J 25 jan 2020, In: International Journal of Radiation Oncology Biology Physics. 106 , p. 998-1009 12 p.

A Prospective Observational Registry Evaluating Clinical Outcomes of Radium-223 Treatment in a Non-study Population

Badrising Sushil K, Louhanepessy Rebecca D, Vd Noort Vincent, Coenen Jules Llm, Hamberg Paul, Beeker Aart, Wagenaar Nils, Lam Marnix, Celik Filiz, Loosveld O J L, Oostdijk Ad, Zuetenhorst Hanneke, Haanen John B, Vegt Erik, Zwart Wilbert, Bergman Andries M, 25 dec 2019, In: International Journal of Cancer. 147 , p. 1143-1151 9 p.

Feasibility of imaging Y-90 microspheres at diagnostic activity levels for hepatic radioembolization treatment planning

Kunnen Britt, Dietze Martijn M A, Braat Arthur J A T, Lam Marnix G E H, Viergever Max A, de Jong Hugo W A M 19 dec 2019, In: Medical Physics. 47 , p. 1105-1114 10 p.

All Research Output (175)