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prof. dr. M.G.E.H. (Marnix) Lam

prof. dr. M.G.E.H. (Marnix) Lam

Full Professor
prof. dr. M.G.E.H. (Marnix) Lam
  • Researchgr. Nucleaire Geneeskunde

Research Programs

Strategic Program Cancer

Biography

Biography

Marnix Lam (1975) studied Pharmaceutical sciences (passed with distinction) and Medicine at Utrecht University. He became a resident in Nuclear Medicine, respectively Radiology and finalized his PhD thesis (2009) on radionuclide therapy in prostate cancer patients with metastatic bone pain. This was followed by a two-year postdoctoral fellowship at Stanford University School of Medicine, USA. In 2016 he was appointed Professor of Nuclear Medicine.
Translational research in molecular medicine has been the scope of his scientific work, with a focus on oncology. Bringing new radiopharmaceuticals to clinical practice. This specifically resulted in the introduction of new oncological treatment modalities in the Netherlands, such as bone seeking radiopharmaceuticals for the palliation of metastatic bone pain (Sm-153-EDTMP, Re-188-HEDP) and radioembolization for treatment of hepatic malignancies (Y-90 and Ho-166 microspheres). Current research is focussed on dosimetry of therapeutic radiopharmaceuticals, image-guided treatment technology, alfa- and beta-emitting isotopes for therapeutic purposes, intra-arterial and intra-tumor treatment approaches, and radio-immunotherapy.

Side Activities

Board Member of the National Education Committee on Nuclear Medicine

National Coordinator on Education of Gastrointestinal Nuclear Medicine and Musculoskeletal Nuclear Medicine

Consultant for BTG and Terumo

Member of the Dutch society of Nuclear Medicine: ‘De Nederlandse Vereniging voor Nucleaire Geneeskunde (NVNG)’.

Member of the Royal Dutch society for promotion of the medical profession: ‘De Koninklijke Nederlandse Maatschappij ter bevordering van de Geneeskunst (KNMG)’.

Member of ‘the European Association of Nuclear Medicine (EANM)’.

Member of ‘the Academy of Molecular Imaging (AMI)’.

Member of the Dutch society of Radiology: ‘De Nederlandse Vereniging voor Radiologie (NVvR)’.

Member of ‘the Radiology Society of North America (RSNA)’.

Member of ‘the European Society of Radiology (ESR)’.

Member of ‘the Society of Interventional Radiology (SIR)’.

Fellowship and Awards

2021 - Research grant from ‘Zorginstituut, Veelbelovende zorg’: SIRT with 166Ho-microspheres in elderly and fragile patients with previously untreated unresectable liver-only metastases of colorectal cancer, CAIRO7 study of the Dutch Colorectal Cancer Group (DCCG)

2021 - Research grant from Quirem: clinical research on the safety and efficacy of holmium-166 (166Ho)-microspheres radioembolization in patients with hepatic malignancies. 

2021 - Research grant from Terumo: Individualized dosimetry for holmium-166 (166Ho)-radioembolization in patients with unresectable hepatocellular carcinoma; a multi-center, interventional, non-randomized, non-comparative, open label, early phase II study: iHEPAR. 

2021 - Research grant from Terumo: The RALLY study: Dose finding study for unilobar radiation lobectomy using holmium-166 (166H0)-microspheres to improve resectability in patients with HCC .

2020 - Research grant from Boston Scientific: Hepatic glass yttrium-90 (90Y)-microspheres radioembolization.

2020 - Awarded CVIR Editors’ Medal for 2020: Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases: International Multicenter Study on Efficacy and Toxicity. Braat, A.J.A.T., Kappadath, S.C., Ahmadzadehfar, H. et al. Cardiovasc Intervent Radiol (2019) 42(3).

2020 - Awarded Editors’ Choice Paper and top 10% downloaded papers in Medical Physics: Kunnen B et al. Feasibility of imaging 90Y microspheres at diagnositc activity levels for hepatic radioembolization treatment planning. Med Phys.

2019 - Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Efficacy of Radioembolization with 166Ho-Microspheres in Salvage Patients with Liver Metastases: A Phase 2 Study. J Nucl Med. 2018 Apr;59(4):582-588.

2018 - Research grant from the Dutch Cancer Society (KWF): Diagnostic accuracy of Gallium-68 PSMA PET/CT in primary staging of prostate cancer

2018 - Research grant from NWO Industrial Doctorates program: Advanced dosimetry for personalized radioembolization treatment (ADOPT)

2018 - Research grant from BTG / Boston Scientific: LUMI DEBIRI and TheraSphere for treatment of metastatic colorectal cancer (DEBIRY)

2018 - Research grant from Health Holland program: Intra-arterial lutetium-177-dotatate for treatment of patients with neuroendocrine tumor liver metastases

2017 - Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Insights into the dose-response relationship of radioembolization with resin yttrium-90 microspheres: a prospective cohort study in patients with colorectal cancer liver metastases. J Nucl Med. 2016 Jul;57(7):1014-9.

2016 - Research grant from the Dutch Cancer Society (KWF): Holmium-166 microspheres for radioembolization in HCC patients: new generation microspheres for individualized treatment

2016 Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Safety of a Scout Dose Preceding Hepatic Radioembolization with 166Ho Microspheres. J Nucl Med. 2015 Jun;56(6):817-23.

2016 - Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries: Prospective Evaluation of Healthy Subjects. J Nucl Med. 2015 Oct;56(10):1534-40.

2016 - Appointed as full professor of Nuclear Medicine at the University of Utrecht, The Netherlands

2014 - Research grant from Alpe d’Huzes / Dutch Cancer Society (KWF): Holmium micro-brachytherapy: an innovative intratumoral treatment modality in head and neck cancer

2014 - Appointed as honorary professor at the medical school of the People’s Liberation Army General Hospital and Military University, Beijing, China

2014 - CIRSE Award of Excellence and Innovation in Interventional Radiology

2010 - Research grant from the Dutch Cancer Society (KWF): translational research in oncology

Research Output (207)

Holmium-166 Radioembolization in NET Patients

Stella M, Braat Arthur, Lam Marnix mei 2021, p. 241-250

Nuclear Medicine Imaging in Neuroblastoma:Current Status and New Developments

Samim Atia, Tytgat Godelieve A M, Bleeker Gitta, Wenker Sylvia T M, Chatalic Kristell L S, Poot Alex J, Tolboom Nelleke, van Noesel Max M, Lam Marnix G E H, de Keizer Bart 4 apr 2021, In: Journal of Personalized Medicine. 11 , p. 1-22

Gamma camera characterization at high holmium-166 activity in liver radioembolization

Stella M, Braat Arthur, Lam Marnix, de Jong Hugo, van Rooij Rob 2 mrt 2021, In: EJNMMI Phys. 8

Interventional respiratory motion compensation by simultaneous fluoroscopic and nuclear imaging:a phantom study

Dietze Martijn M A, Kunnen Britt, Lam Marnix G E H, de Jong Hugo W A M 11 feb 2021, In: Physics in medicine and biology. 66

Current Status and Future Direction of Hepatic Radioembolisation

Alsultan A A, Braat A J A T, Smits M L J, Barentsz M W, Bastiaannet R, Bruijnen R C G, de Keizer B, de Jong H W A M, Lam M G E H, Maccauro M, Chiesa C feb 2021, In: Clinical Oncology. 33 , p. 106-116 11 p.

Lung shunt and lung dose calculation methods for radioembolization treatment planning

Kappadath S Cheenu, Lopez Benjamin P, Salem Riad, Lam Marnix G 4 jan 2021, In: The Quarterly Journal of Nuclear Medicine and Molecular Imaging. 65 , p. 32-42 11 p.

A Rapid and Safe Infusion Protocol for Lu-177 Peptide Receptor Radionuclide Therapy

Ebbers Sander C, Barentsz Maarten W, de Keizer Bart, Krijger Gerard C, Lam Marnix G E H, Braat Arthur J A T 27 nov 2020, In: Journal of Nuclear Medicine. 62 , p. 816-822 7 p.

The Current Status and Future Potential of Theranostics to Diagnose and Treat Childhood Cancer

Poot Alex J, Lam Marnix G E H, van Noesel Max M 19 nov 2020, In: Frontiers in oncology. 10 , p. 1-8

Lutetium-177 PSMA therapie voor patiënten met prostaatkanker – een kort overzicht van de literatuur

van Kalmthout Ludwike W.M., van der Sar Esmée C.A., Braat Arthur J.A.T., de Keizer Bart, Lam Marnix G.E.H. 1 okt 2020, In: Tijdschrift voor Urologie. 10 , p. 141-146 6 p.

Voorwoord bij het themanummer nucleaire geneeskunde:Theranostics voor diagnostiek en behandeling van prostaatkanker

van Kalmthout Ludwike W.M., Lam Marnix G.E.H. 1 okt 2020, In: Tijdschrift voor Urologie. 10 , p. 99-100 2 p.

All research output

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