dr. dr.h.c.mult A.L.G. (Alexander) Leemans

dr. dr.h.c.mult A.L.G. (Alexander) Leemans

Associate Professor
dr. dr.h.c.mult A.L.G. (Alexander) Leemans
  • Image Sciences Institute

Research Programs



Alexander Leemans is a physicist who received his Ph.D. in 2006 at the University of Antwerp, Belgium. From 2007 to 2009, he worked as a postdoctoral researcher at the Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Wales, United Kingdom. In 2009, he joined the Image Sciences Institute (ISI), University Medical Center Utrecht, the Netherlands, where he currently holds a tenured faculty position as Associate Professor. His current research interests include modeling, processing, visualizing and analyzing diffusion MRI data for investigating microstructural and architectural tissue organization. He heads the PROVIDI Lab and is the developer of ExploreDTI, which is a graphical toolbox for investigating diffusion MRI data.

Research line

Diffusion MRI

Most recent key publications

1: C. Lebel, L. Walker, A. Leemans, L. Phillips, C. Beaulieu, "Microstructural Maturation of the Human Brain from Childhood to Adulthood", NeuroImage, 2008, nr. 3, vol. 40, pp. 1044-1055
2: A. Leemans, D.K. Jones, "The B-matrix must be rotated when correcting for subject motion in DTI data", Magnetic Resonance in Medicine, 2009, nr. 1, vol. 62, pp. 1336-1349
3: J.D. Tournier, S. Mori, A. Leemans, "Diffusion tensor imaging and beyond", Magnetic Resonance in Medicine, 2011, nr. 6, vol. 65, pp. 1532-1556
4: B. Jeurissen, A. Leemans, J.D. Tournier, D.K. Jones, J. Sijbers, "Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion MRI", Human Brain Mapping, 2013, nr. 11, vol. 34, pp. 2747-2766
5: S.B. Vos, D.K. Jones, M.A. Viergever, A. Leemans, "Partial volume effect as a hidden covariate in DTI analyses", NeuroImage, 2011, nr. 4, vol. 55, pp. 1566-1576

Fellowship and Awards




PhD fellowship (IWT)

Honorary Doctorate (Chubut)

Young Investigator Award (BHPA)

Outstanding Teacher Award (ISMRM)

Research Output (240)

Diffusion kurtosis imaging of white matter in bipolar disorder

Goghari Vina M, Kusi Mavis, Shakeel Mohammed K, Beasley Clare, David Szabolcs, Leemans Alexander, De Luca Alberto, Emsell Louise 31 jul 2021, In: Psychiatry Research - Neuroimaging. 317 , p. 111341

On the generalizability of diffusion MRI signal representations across acquisition parameters, sequences and tissue types:Chronicles of the MEMENTO challenge

De Luca Alberto, Ianus Andrada, Leemans Alexander, Palombo Marco, Shemesh Noam, Zhang Hui, Alexander Daniel C, Nilsson Markus, Froeling Martijn, Biessels Geert-Jan, Zucchelli Mauro, Frigo Matteo, Albay Enes, Sedlar Sara, Alimi Abib, Deslauriers-Gauthier Samuel, Deriche Rachid, Fick Rutger, Afzali Maryam, Pieciak Tomasz, Bogusz Fabian, Aja-Fernández Santiago, Özarslan Evren, Jones Derek K, Chen Haoze, Jin Mingwu, Zhang Zhijie, Wang Fengxiang, Nath Vishwesh, Parvathaneni Prasanna, Morez Jan, Sijbers Jan, Jeurissen Ben, Fadnavis Shreyas, Endres Stefan, Rokem Ariel, Garyfallidis Eleftherios, Sanchez Irina, Prchkovska Vesna, Rodrigues Paulo, Landman Bennet A, Schilling Kurt G 6 jul 2021, In: NeuroImage. 240 17 p.

White matter microstructure of the neural emotion regulation circuitry in mild traumatic brain injury

van der Horn Harm Jan, Mangina Namrata R., Rakers Sandra E., Kok Jelmer G., Timmerman Marieke E., Leemans Alexander, Spikman Jacoba M., van der Naalt Joukje mei 2021, In: European Journal of Neuroscience. 53 , p. 3463-3475 13 p.

Iranian Brain Imaging Database:A Neuropsychiatric Database of Healthy Brain

Batouli Seyed Amir Hossein, Sisakhti Minoo, Haghshenas Shirin, Dehghani Hamed, Sachdev Perminder, Ekhtiari Hamed, Kochan Nicole, Wen Wei, Leemans Alexander, Kohanpour Mohsen, Oghabian Mohammad Ali jan 2021, In: Basic and clinical neuroscience. 12 , p. 115-131 17 p.

Dose-dependent volume loss in subcortical deep grey matter structures after cranial radiotherapy

Nagtegaal Steven H J, David Szabolcs, Philippens Marielle E P, Snijders Tom J, Leemans Alexander, Verhoeff Joost J C jan 2021, In: Clinical and translational radiation oncology. 26 , p. 35-41 7 p.

Fiber orientation distribution from diffusion MRI:Effects of inaccurate response function calibration

Guo Fenghua, Tax Chantal M W, De Luca Alberto, Viergever Max A, Heemskerk Anneriet, Leemans Alexander 2021, In: Journal of Neuroimaging. 31 , p. 1082-1098 17 p.

The YOUth cohort study:MRI protocol and test-retest reliability in adults

Buimer Elizabeth E.L., Pas Pascal, Brouwer Rachel M., Froeling Martijn, Hoogduin Hans, Leemans Alexander, Luijten Peter, van Nierop Bastiaan J., Raemaekers Mathijs, Schnack Hugo G., Teeuw Jalmar, Vink Matthijs, Visser Fredy, Hulshoff Pol Hilleke E., Mandl René C.W. okt 2020, In: Developmental Cognitive Neuroscience. 45 , p. 1-15

Structural Network Analysis Using Diffusion MRI Tractography in Parkinson's Disease and Correlations With Motor Impairment

Kok Jelmer G., Leemans Alexander, Teune Laura K., Leenders Klaus L., McKeown Martin J., Appel-Cresswell Silke, Kremer Hubertus P.H., de Jong Bauke M. 2 sep 2020, In: Frontiers in Neurology. 11 , p. 841

Spherical deconvolution with tissue-specific response functions and multi-shell diffusion MRI to estimate multiple fiber orientation distributions (mFODs)

De Luca Alberto, Guo Fenghua, Froeling Martijn, Leemans Alexander 31 jul 2020, In: NeuroImage. 222 15 p.

Effect of radiation therapy on cerebral cortical thickness in glioma patients:Treatment-induced thinning of the healthy cortex

Nagtegaal Steven H J, David Szabolcs, Snijders Tom J, Philippens Marielle E P, Leemans Alexander, Verhoeff Joost J C 10 jul 2020, In: Neuro-oncology advances. 2 8 p.

All research output

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