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dr. dr.h.c.mult A.L.G. (Alexander) Leemans Associate Professor

  • Image Sciences Institute

A.L.G. Leemans


Research Programs


Alexander Leemans is a physicist who received his Ph.D. in 2006 at the University of Antwerp, Belgium. From 2007 to 2009, he worked as a postdoctoral researcher at the Cardiff University Brain Research Imaging Center (CUBRIC), Cardiff University, Wales, United Kingdom. In 2009, he joined the Image Sciences Institute (ISI), University Medical Center Utrecht, the Netherlands, where he currently holds a tenured faculty position as Associate Professor. His current research interests include modeling, processing, visualizing and analyzing diffusion MRI data for investigating microstructural and architectural tissue organization. He heads the PROVIDI Lab and is the developer of ExploreDTI, which is a graphical toolbox for investigating diffusion MRI data.

Research line

Diffusion MRI

Most recent key publications

1: C. Lebel, L. Walker, A. Leemans, L. Phillips, C. Beaulieu, "Microstructural Maturation of the Human Brain from Childhood to Adulthood", NeuroImage, 2008, nr. 3, vol. 40, pp. 1044-1055
2: A. Leemans, D.K. Jones, "The B-matrix must be rotated when correcting for subject motion in DTI data", Magnetic Resonance in Medicine, 2009, nr. 1, vol. 62, pp. 1336-1349
3: J.D. Tournier, S. Mori, A. Leemans, "Diffusion tensor imaging and beyond", Magnetic Resonance in Medicine, 2011, nr. 6, vol. 65, pp. 1532-1556
4: B. Jeurissen, A. Leemans, J.D. Tournier, D.K. Jones, J. Sijbers, "Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion MRI", Human Brain Mapping, 2013, nr. 11, vol. 34, pp. 2747-2766
5: S.B. Vos, D.K. Jones, M.A. Viergever, A. Leemans, "Partial volume effect as a hidden covariate in DTI analyses", NeuroImage, 2011, nr. 4, vol. 55, pp. 1566-1576

Fellowship and Awards

  • VIDI (NWO)

    FC-EW (NWO)


    PhD fellowship (IWT)

    Honorary Doctorate (Chubut)

    Young Investigator Award (BHPA)

    Outstanding Teacher Award (ISMRM)

Research Output (192)

Tractography reproducibility challenge with empirical data (TraCED):The 2017 ISMRM diffusion study group challenge

Nath Vishwesh, Schilling Kurt G., Parvathaneni Prasanna, Huo Yuankai, Blaber Justin A., Hainline Allison E., Barakovic Muhamed, Romascano David, Rafael-Patino Jonathan, Frigo Matteo, Girard Gabriel, Thiran Jean Philippe, Daducci Alessandro, Rowe Matt, Rodrigues Paulo, Prčkovska Vesna, Aydogan Dogu B., Sun Wei, Shi Yonggang, Parker William A., Ould Ismail Abdol A., Verma Ragini, Cabeen Ryan P., Toga Arthur W., Newton Allen T., Wasserthal Jakob, Neher Peter, Maier-Hein Klaus, Savini Giovanni, Palesi Fulvia, Kaden Enrico, Wu Ye, He Jianzhong, Feng Yuanjing, Paquette Michael, Rheault Francois, Sidhu Jasmeen, Lebel Catherine, Leemans Alexander, Descoteaux Maxime, Dyrby Tim B., Kang Hakmook, Landman Bennett A. 1 jan 2020, In: Journal of Magnetic Resonance Imaging. 51 , p. 234-249 16 p.

Author Correction:The challenge of mapping the human connectome based on diffusion tractography (Nature Communications, (2017), 8, 1, (1349), 10.1038/s41467-017-01285-x)

Maier-Hein Klaus H., Neher Peter F., Houde Jean Christophe, Côté Marc Alexandre, Garyfallidis Eleftherios, Zhong Jidan, Chamberland Maxime, Yeh Fang Cheng, Lin Ying Chia, Ji Qing, Reddick Wilburn E., Glass John O., Chen David Qixiang, Feng Yuanjing, Gao Chengfeng, Wu Ye, Ma Jieyan, He Renjie, Li Qiang, Westin Carl Fredrik, Deslauriers-Gauthier Samuel, González J. Omar Ocegueda, Paquette Michael, St-Jean Samuel, Girard Gabriel, Rheault François, Sidhu Jasmeen, Tax Chantal M.W., Guo Fenghua, Mesri Hamed Y., Dávid Szabolcs, Froeling Martijn, Heemskerk Anneriet M., Leemans Alexander, Boré Arnaud, Pinsard Basile, Bedetti Christophe, Desrosiers Matthieu, Brambati Simona, Doyon Julien, Sarica Alessia, Vasta Roberta, Cerasa Antonio, Quattrone Aldo, Yeatman Jason, Khan Ali R., Hodges Wes, Alexander Simon, Romascano David, Barakovic Muhamed 4 nov 2019, In: Nature Communications. 10

Physical Performance in Memory Clinic Patients:The Potential Role of the White Matter Network

Verwer Jurre H., Reijmer Yael D., Koek H. L., Biessels Geert Jan, Exalto L. G., Groeneveld O. N., Heinen R., Heringa S. M., Kalsbeek N., Maher C., de Bresser J., Leemans A., Koek H. L., de Wit J. E., Blom K., Hamaker M., Faaij R., Pleizier M., Prins M., Vriens E., 1 sep 2019, In: Journal of the American Geriatrics Society. 67 , p. 1880-1887 8 p.

The adverse effect of gradient nonlinearities on diffusion MRI:From voxels to group studies

Mesri Hamed Y., David Szabolcs, Viergever Max A., Leemans Alexander 30 aug 2019, In: NeuroImage. 205 15 p.

Evaluation of the 3D fractal dimension as a marker of structural brain complexity in multiple-acquisition MRI

Krohn Stephan, Froeling Martijn, Leemans Alexander, Ostwald Dirk, Villoslada Pablo, Finke Carsten, Esteban Francisco J. 1 aug 2019, In: Human Brain Mapping. 40 , p. 3299-3320 22 p.

Diffusion tensor imaging biomarkers to predict motor outcomes in stroke:A narrative review

Moura Luciana M., Luccas Rafael, De Paiva Joselisa P.Q., Amaro Edson, Leemans Alexander, Leite Claudia da C., Otaduy Maria C.G., Conforto Adriana B. 8 mei 2019, In: Frontiers in Neurology. 10 , p. 445

Diffusion MRI fiber tractography of the brain

Jeurissen Ben, Descoteaux Maxime, Mori Susumu, Leemans Alexander apr 2019, In: NMR in Biomedicine. 32

Diffusion MRI of the brain:The naked truth

Leemans Alexander apr 2019, In: NMR in Biomedicine. 32

Identifying No Fly Zones to prevent long-term thinning of the cerebral cortex in glioma after RT

Nagtegaal S., David S., Mesri H., Philippens M., Leemans A., Verhoeff J. apr 2019, In: Radiotherapy and Oncology. 133 , p. S82-S83

The superoanterior fasciculus (SAF):A novel white matter pathway in the human brain?

David Szabolcs, Heemskerk Anneriet M., Corrivetti Francesco, Thiebaut de Schotten Michel, Sarubbo Silvio, Corsini Francesco, De Benedictis Alessandro, Petit Laurent, Viergever Max A., Jones Derek K., Mandonnet Emmanuel, Axer Hubertus, Evans John, Paus Tomáš, Leemans Alexander 5 mrt 2019, In: Frontiers in Neuroanatomy [E]. 13 , p. 24

All Research Output (192)
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